Non-genomic androgen action regulates proliferative/migratory signaling in stromal cells.

abstract：:Follicle stimulating hormone (FSH) plays a key role in human reproduction through, among others, induction of spermatogenesis in men and production of estrogen in women. The function FSH is performed upon binding to its cognate receptor-follicle-stimulating hormone receptor (FSHR) expressed on the surface of target ce...

journal_title：Frontiers in endocrinology

authors： Szymańska K,Kałafut J,Przybyszewska A,Paziewska B,Adamczuk G,Kiełbus M,Rivero-Müller A

更新日期：2018-12-13 00:00:00

abstract：:Hypothyroidism has been reported to improve survival in cancer patients but only recently has the putative mechanism been identified as a receptor for thyroxine and tri-iodothyronine on integrin αvβ3. Recognition of divergence of action of the pro-oncogenic L-thyroxine (T4) from pro-metabolic 3,5,3'-triiodo-L-thyronin...

journal_title：Frontiers in endocrinology

authors： Hercbergs A

更新日期：2019-08-23 00:00:00

abstract：:It is now well-established that the pathways that control lymphocyte metabolism and function are intimately linked, and changes in lymphocyte metabolism can influence and direct cellular function. Interestingly, a number of recent advances indicate that lymphocyte identity and metabolism is partially controlled via ep...

journal_title：Frontiers in endocrinology

authors： Warren JL,MacIver NJ

更新日期：2019-07-11 00:00:00

abstract：:Introduction: We have previously shown that fetuses of mothers with gestational diabetes mellitus (GDM) and insulin resistance exhibit a prolongation of fetal auditory event-related brain responses (fAER) compared to fetuses of normal glucose tolerant women during an oral glucose tolerance test (oGTT). This implies th...

journal_title：Frontiers in endocrinology

authors： Schleger F,Linder K,Walter L,Heni M,Brändle J,Brucker S,Pauluschke-Fröhlich J,Weiss M,Häring HU,Preissl H,Fritsche A

更新日期：2018-11-20 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is the commonest endocrine abnormality in women of reproductive age typically presenting with chronic oligo- or anovulation, clinical, or biochemical hyperandrogenism and polycystic ovarian morphology (PCOM). Restoring mono-ovulation is the ultimate goal of ovulation induction and most...

journal_title：Frontiers in endocrinology

authors： Laven JSE

更新日期：2019-02-12 00:00:00

abstract：:JAK2 is a member of the Janus kinase (JAKs) family of non-receptor protein tyrosine kinases, which includes JAK1-3 and TYK2. JAKs serve as the cytoplasmic signaling components of cytokine receptors and are activated through cytokine-mediated trans-phosphorylation, which leads to receptor phosphorylation and recruitmen...

journal_title：Frontiers in endocrinology

authors： Hubbard SR

更新日期：2018-01-05 00:00:00

abstract：:In neuroendocrine cells, prohormones move from the endoplasmic reticulum to the Golgi complex (GC), where they are sorted and packed into secretory granules. The GC is considered the central station of the secretory pathway of proteins and lipids en route to their final destination. In most mammalian cells, it is form...

journal_title：Frontiers in endocrinology

authors： Martínez-Alonso E,Tomás M,Martínez-Menárguez JA

更新日期：2013-03-28 00:00:00

abstract：:Recent evidence indicates that autophagy-mediated mitochondrial homeostasis is crucial for oxidative stress-related brain damage and repair. The highest concentration of melatonin is in the mitochondria of cells, and melatonin exhibits well-known antioxidant properties. We investigated the impact and mechanism involve...

journal_title：Frontiers in endocrinology

authors： Wang DD,Jin MF,Zhao DJ,Ni H

更新日期：2019-08-08 00:00:00

abstract：:The extracellular signal-regulated kinases (ERKs) are key components of multiple important cell signaling pathways regulating diverse biological responses. This signaling is characterized by phosphorylation cascades leading to ERK1/2 activation and promoted by various cell surface receptors including G protein-coupled...

journal_title：Frontiers in endocrinology

authors： Ayoub MA,Trebaux J,Vallaghe J,Charrier-Savournin F,Al-Hosaini K,Gonzalez Moya A,Pin JP,Pfleger KD,Trinquet E

更新日期：2014-06-23 00:00:00

abstract：:Introduction: Secondary hyperparathyroidism (sHPT) is a common hormonal complication of chronic kidney disease. There are several therapeutic options for sHPT management aiming at calcium-phosphorus balance normalization and decrease of parathormone secretion. Objectives: The aim of this retrospective, observational s...

journal_title：Frontiers in endocrinology

authors： Zawierucha J,Malyszko J,Malyszko JS,Prystacki T,Marcinkowski WP,Dryl-Rydzynska T

更新日期：2019-02-05 00:00:00

abstract：:Insulin-like growth factor-binding proteins (IGFBPs) are multifunctional proteins that possess IGF-dependent and -independent actions. Recent studies suggest that its IGF-independent action appeared early and that the IGF-binding function may have been acquired later in evolution. The timing of the emergence of IGF-de...

journal_title：Frontiers in endocrinology

authors： Zhong Y,Duan C

更新日期：2017-01-18 00:00:00

abstract：:The insulin/IGF system plays an important role in cancer progression. Accordingly, elevated levels of circulating insulin have been associated with an increased cancer risk as well as with aggressive and metastatic cancer phenotypes. Numerous studies have documented that estrogens cooperate with the insulin/IGF system...

journal_title：Frontiers in endocrinology

authors： De Marco P,Cirillo F,Vivacqua A,Malaguarnera R,Belfiore A,Maggiolini M

更新日期：2015-03-06 00:00:00

abstract：:The placenta is the chief regulator of nutrient supply to the growing embryo during gestation. As such, adequate placental function is instrumental for developmental progression throughout intrauterine development. One of the most common complications during pregnancy is insufficient growth of the fetus, a problem ter...

journal_title：Frontiers in endocrinology

authors： Woods L,Perez-Garcia V,Hemberger M

更新日期：2018-09-27 00:00:00

abstract：:Microtubule-associated protein tau assists in stabilizing microtubules and has been particularly implicated in Alzheimer's disease (AD). Given the importance of tau to AD pathogenesis and therapies, it is important to understand non-classic physiological functions for this protein inside and outside the central nervou...

journal_title：Frontiers in endocrinology

authors： Gonçalves RA,Wijesekara N,Fraser PE,De Felice FG

更新日期：2020-03-12 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) is a pleotropic metabolic regulator, expression of which is elevated during fasting. To this end, the precise role played by FGF21 in the biology of fasting has been the subject of several recent studies, which have demonstrated contributions to the regulation of both lipid and carb...

journal_title：Frontiers in endocrinology

authors： Antonellis PJ,Hayes MP,Adams AC

更新日期：2016-06-30 00:00:00

abstract：:Autophagy requires the conjugation of autophagy-related protein 12 (ATG12) to autophagy-related protein 5 (ATG5) through covalent attachment. However, the signals regulating ATG12-ATG5 conjugation are unclear. The larval midgut of lepidopteran insects performs autophagy and apoptosis sequentially during the transition...

journal_title：Frontiers in endocrinology

authors： Li YB,Yang T,Wang JX,Zhao XF

更新日期：2018-02-07 00:00:00

abstract：:Obstructive sleep apnea-hypopnea syndrome (OSAHS) is frequently present in patients with severe obesity, but its prevalence especially in women is not well defined. OSAHS and non-alcoholic fatty liver disease are common conditions, frequently associated in patients with central obesity and metabolic syndrome and are b...

journal_title：Frontiers in endocrinology

authors： Scartabelli G,Querci G,Marconi L,Ceccarini G,Piaggi P,Fierabracci P,Salvetti G,Cizza G,Mazzeo S,Vitti J,Berger S,Palla A,Santini F

更新日期：2018-06-06 00:00:00

abstract：:Bone marrow adipose tissue (MAT) is distinct from white adipose tissue (WAT) or brown adipose tissue (BAT) for its location, feature and function. As a largely ignored adipose depot, it is situated in bone marrow space and resided with bone tissue side-by-side. MAT is considered not only as a regulator of bone metabol...

journal_title：Frontiers in endocrinology

authors： Li Y,Meng Y,Yu X

更新日期：2019-02-08 00:00:00

abstract：Context:Ustekinumab is a human IgG1 monoclonal antibody that targets interleukin (IL)-12 and IL-23, which may be useful in the treatment of autoimmune conditions such as psoriasis, psoriatic arthritis, and Crohn's disease. Hypophysitis is an immune-derived inflammatory condition of the pituitary gland that may lead to ...

journal_title：Frontiers in endocrinology

authors： Ramos-Leví AM,Gargallo M,Serrano-Somavilla A,Sampedro-Núñez MA,Fraga J,Marazuela M

更新日期：2018-03-09 00:00:00

abstract：:Exercise training triggers numerous positive adaptations through the regulation of genes controlling muscle structure and function. Epigenetic modifications, including DNA methylation, participate in transcriptional activation by allowing the recruitment of the transcription machinery to gene promoters. Exercise induc...

journal_title：Frontiers in endocrinology

authors： Pattamaprapanont P,Garde C,Fabre O,Barrès R

更新日期：2016-12-23 00:00:00

abstract：Objective:To analyze association between different perioperative glycemic control strategies and postoperative outcomes in patients with diabetes undergoing cardiac surgery. Methods:MEDLINE, Cochrane Library, Web of Science, EMBASE, Wanfang Data, China National Knowledge Infrastructure (CNKI) and China Biology Medicin...

journal_title：Frontiers in endocrinology

authors： Jin X,Wang J,Ma Y,Li X,An P,Wang J,Mao W,Mu Y,Chen Y,Chen K

更新日期：2020-12-17 00:00:00

abstract：:Catecholamine (CA) secretion from the adrenal medullary tissue is a key step of the adaptive response triggered by an organism to cope with stress. Whereas molecular and cellular secretory processes have been extensively studied at the single chromaffin cell level, data available for the whole gland level are much sca...

journal_title：Frontiers in endocrinology

authors： De Nardi F,Lefort C,Bréard D,Richomme P,Legros C,Guérineau NC

更新日期：2017-09-25 00:00:00

abstract：:[This corrects the article on p. 26 in vol. 9, PMID: 29487564.]. ...

journal_title：Frontiers in endocrinology

authors： Konya J,Spurgeon BEJ,Al Qaissi A,Sathyapalan T,Ajjan R,Madden L,Naseem KM,Garrett AT,Kilpatrick E,Atkin SL

更新日期：2018-06-07 00:00:00

abstract：:Gonadotropin-releasing hormone (GnRH) is the primary regulator of mammalian reproductive function in both males and females. It acts via G-protein coupled receptors on gonadotropes to stimulate synthesis and secretion of the gonadotropin hormones luteinizing hormone and follicle-stimulating hormone. These receptors co...

journal_title：Frontiers in endocrinology

authors： Perrett RM,McArdle CA

更新日期：2013-11-20 00:00:00

abstract：:Most of the described structures of podocytes in health and disease have been inferred from light and electron microscopic studies of rodent models. The variation in filtration barrier features is measured on micrographs, the aim being statistical significance. This is the technical campaign waged against kidney disea...

journal_title：Frontiers in endocrinology

authors： Neal CR

更新日期：2015-02-23 00:00:00

abstract：:Neuropeptides are the largest group of insect hormones. They are produced in the central and peripheral nervous systems and affect insect development, reproduction, feeding, and behavior. A variety of neuropeptide families have been identified in insects. One of these families is the PBAN/pyrokinin family defined by a...

journal_title：Frontiers in endocrinology

authors： Choi MY,Vander Meer RK

更新日期：2012-02-24 00:00:00

abstract：:Given that obesity and associated disorder type II diabetes mellitus have reached epidemic proportions worldwide, the development of efficient prevention and therapeutic interventions is a global public health interest. There is now a large body of evidence suggesting that the micro-organisms colonizing the human gut,...

journal_title：Frontiers in endocrinology

authors： Gérard C,Vidal H

更新日期：2019-01-30 00:00:00

abstract：:The increase of life expectancy has led to the increase of age-related diseases such as osteoporosis. Osteoporosis is characterized by bone weakening promoting the occurrence of fractures with defective bone regeneration. Men aged over 50 have a prevalence for osteoporosis of 20%, which is related to a decline in sex ...

journal_title：Frontiers in endocrinology

authors： Beranger GE,Djedaini M,Battaglia S,Roux CH,Scheideler M,Heymann D,Amri EZ,Pisani DF

更新日期：2015-05-19 00:00:00

abstract：:The relaxin-like RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/tumor necrosis factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor, RXFP1, with functions in brain cancer....

journal_title：Frontiers in endocrinology

authors： Thanasupawat T,Glogowska A,Burg M,Wong GW,Hoang-Vu C,Hombach-Klonisch S,Klonisch T

更新日期：2015-08-13 00:00:00

abstract：:The receptor tyrosine kinase superfamily comprises many cell-surface receptors including the insulin receptor (IR) and type 1 insulin-like growth factor receptor (IGF1R) that are constitutively homodimeric transmembrane glycoproteins. Therefore, these receptors require ligand-triggered domain rearrangements rather tha...

journal_title：Frontiers in endocrinology

authors： Mohammadiarani H,Vashisth H

更新日期：2016-06-20 00:00:00