Homogeneous time-resolved fluorescence-based assay to monitor extracellular signal-regulated kinase signaling in a high-throughput format.

abstract：:Thyroid hormone concentrations only become sufficient to maintain a euthyroid state through appropriate stimulation by pituitary thyroid-stimulating hormone (TSH). In such a dynamic system under constant high pressure, guarding against overstimulation becomes vital. Therefore, several defensive mechanisms protect agai...

journal_title：Frontiers in endocrinology

authors： Hoermann R,Midgley JE,Larisch R,Dietrich JW

更新日期：2016-11-07 00:00:00

abstract：:Gonadotropin-releasing hormone 1 (GnRH1) and its receptor (GnRHR1) drive mammalian reproduction via regulation of the gonadotropins. Yet, a second form of GnRH (GnRH2) and its receptor (GnRHR2) also exist in mammals. GnRH2 has been completely conserved throughout 500 million years of evolution, signifying high selecti...

journal_title：Frontiers in endocrinology

authors： Desaulniers AT,Cederberg RA,Lents CA,White BR

更新日期：2017-12-11 00:00:00

abstract：:Despite the long-held belief that growth hormone supplementation provides psychosocial benefits to patients with Turner syndrome (TS), this assumption has never been rigorously tested in a randomized control trial. As a sub-study of the Canadian growth-hormone trial, parent-, and patient-completed standardized questio...

journal_title：Frontiers in endocrinology

authors： Rovet JF,Van Vliet G

更新日期：2019-03-13 00:00:00

abstract：:Hypothyroidism has been reported to improve survival in cancer patients but only recently has the putative mechanism been identified as a receptor for thyroxine and tri-iodothyronine on integrin αvβ3. Recognition of divergence of action of the pro-oncogenic L-thyroxine (T4) from pro-metabolic 3,5,3'-triiodo-L-thyronin...

journal_title：Frontiers in endocrinology

authors： Hercbergs A

更新日期：2019-08-23 00:00:00

abstract：:Background: The relative contribution of reduced insulin sensitivity (Si) or insulin secretion to impaired fasting glucose (IFG) or diabetes mellitus (DM) has not been clarified in active acromegaly. An intravenous glucose tolerance test (IVGTT) was never used for the calculation of Si, acute insulin response (AIRg), ...

journal_title：Frontiers in endocrinology

authors： Niculescu DA,Dusceac R,Caragheorgheopol A,Popescu N,Poiana C

更新日期：2019-09-18 00:00:00

abstract：Background:The risk of spontaneous abortion in patients with polycystic ovary syndrome (PCOS) undergoing assisted reproductive treatment (ART) is higher than that in patients without PCOS, however, no definitive risk factors have been confirmed to associate with the high spontaneous abortion rate in PCOS patients under...

journal_title：Frontiers in endocrinology

authors： Sun YF,Zhang J,Xu YM,Cao ZY,Wang YZ,Hao GM,Gao BL

更新日期：2020-12-03 00:00:00

abstract：:We are witnessing a rapid worldwide increase in the incidence of papillary thyroid carcinoma (PTC) in the last thirty years. Extensive implementation of cancer screening and wide availability of neck ultrasound or other imaging studies is the main reason responsible for this phenomenon. It resulted in a detection of a...

journal_title：Frontiers in endocrinology

authors： Krajewska J,Kukulska A,Oczko-Wojciechowska M,Kotecka-Blicharz A,Drosik-Rutowicz K,Haras-Gil M,Jarzab B,Handkiewicz-Junak D

更新日期：2020-10-06 00:00:00

abstract：:Aims: This study aimed to investigate the clinical courses and outcomes of diabetes mellitus patients with coronavirus disease 2019 (COVID-19) in Wuhan. Methods: This study enrolled 1,880 consecutive patients with confirmed COVID-19 in Leishenshan Hospital. We collected and analyzed their data, including demographic d...

journal_title：Frontiers in endocrinology

authors： Liu Z,Li J,Huang J,Guo L,Gao R,Luo K,Zeng G,Zhang T,Yi M,Huang Y,Chen J,Yang Y,Wu X

更新日期：2020-07-14 00:00:00

abstract：:Last two decades of structure-function studies performed in numerous laboratories provided substantial progress in understanding basic science, physiological, pathophysiological, pharmacological, and comparative aspects of glycoprotein hormones (GPHs) and their cognate receptors. Multiple concepts and models developed...

journal_title：Frontiers in endocrinology

authors： Szkudlinski MW

更新日期：2015-10-19 00:00:00

abstract：Context:Ustekinumab is a human IgG1 monoclonal antibody that targets interleukin (IL)-12 and IL-23, which may be useful in the treatment of autoimmune conditions such as psoriasis, psoriatic arthritis, and Crohn's disease. Hypophysitis is an immune-derived inflammatory condition of the pituitary gland that may lead to ...

journal_title：Frontiers in endocrinology

authors： Ramos-Leví AM,Gargallo M,Serrano-Somavilla A,Sampedro-Núñez MA,Fraga J,Marazuela M

更新日期：2018-03-09 00:00:00

abstract：:Over the last decades, thyroid hormone metabolites (THMs) received marked attention as it has been demonstrated that they are bioactive compounds. Their concentrations were determined by immunoassay or mass-spectrometry methods. Among those metabolites, 3,5-diiodothyronine (3,5-T2), occurs at low nanomolar concentrati...

journal_title：Frontiers in endocrinology

authors： Köhrle J,Lehmphul I,Pietzner M,Renko K,Rijntjes E,Richards K,Anselmo J,Danielsen M,Jonklaas J

更新日期：2020-01-08 00:00:00

abstract：:Classically, the modulation of brain function and behavior by steroid hormones was linked exclusively to secretion by peripheral endocrine glands. Subsequently, steroid actions within the brain were shown dependent upon either synthesis and secretion by peripheral organs or by production within the CNS itself using pe...

journal_title：Frontiers in endocrinology

authors： Remage-Healey L,Saldanha CJ,Schlinger BA

更新日期：2011-09-29 00:00:00

abstract：:Diabetes mellitus (DM) is associated with several microvascular and macrovascular complications, such as retinopathy, nephropathy, neuropathy, and cardiovascular diseases. The pathogenesis of these complications is complex, and involves metabolic and hemodynamic disturbances, including hyperglycemia, insulin resistanc...

journal_title：Frontiers in endocrinology

authors： Verhulst MJL,Loos BG,Gerdes VEA,Teeuw WJ

更新日期：2019-02-18 00:00:00

abstract：:Sleep duration has become increasingly recognized as an important influencer of health. Epidemiologic and observational studies have shown associations between short sleep duration and increased risk for chronic cardiometabolic disorders, including obesity, type 2 diabetes, and cardiovascular disease. These associatio...

journal_title：Frontiers in endocrinology

authors： Pizinger TM,Aggarwal B,St-Onge MP

更新日期：2018-07-18 00:00:00

abstract：:Graves' Orbitopathy (GO) is the most frequent extrathyroidal manifestation of Graves' disease (GD). Its ultimate cause remains unclear, but it is commonly considered an autoimmune disorder due to self recognition of autoantigens constitutively expressed by orbital fibroblasts (OFs), and thyroid epithelial cells. High ...

journal_title：Frontiers in endocrinology

authors： Lanzolla G,Vannucchi G,Ionni I,Campi I,Sileo F,Lazzaroni E,Marinò M

更新日期：2020-01-22 00:00:00

abstract：:The increase of life expectancy has led to the increase of age-related diseases such as osteoporosis. Osteoporosis is characterized by bone weakening promoting the occurrence of fractures with defective bone regeneration. Men aged over 50 have a prevalence for osteoporosis of 20%, which is related to a decline in sex ...

journal_title：Frontiers in endocrinology

authors： Beranger GE,Djedaini M,Battaglia S,Roux CH,Scheideler M,Heymann D,Amri EZ,Pisani DF

更新日期：2015-05-19 00:00:00

abstract：:Background: Gestational diabetes (GDM) is associated with adverse short- and long-term maternal and fetal outcomes. Observational data support a link between sleep-disordered breathing (SDB) during pregnancy and GDM. However, it is unknown whether treatment of SDB with continuous positive airway pressure (CPAP) improv...

journal_title：Frontiers in endocrinology

authors： Pamidi S,Meltzer SJ,Garfield N,Lavigne L,Olha A,Khalyfa A,Benedetti A,Tremblay G,Gagnon R,Rey E,Dasgupta K,Kimoff RJ

更新日期：2018-11-16 00:00:00

abstract：:The insulin-like growth factor (IGF) family plays key roles in growth and development. In the cornea, IGF family members have been implicated in proliferation, differentiation, and migration, critical events that maintain a smooth refracting surface that is essential for vision. The IGF family is composed of multiple ...

journal_title：Frontiers in endocrinology

authors： Stuard WL,Titone R,Robertson DM

更新日期：2020-03-03 00:00:00

abstract：Introduction:Vitamin D deficiency is an important public health problem worldwide. Vitamin D deficiency confers a significant risk for both skeletal and non-skeletal disorders and a number of lifelong negative health outcomes. The objectives of this evidence-based guidelines document are to provide health care professi...

journal_title：Frontiers in endocrinology

authors： Rusińska A,Płudowski P,Walczak M,Borszewska-Kornacka MK,Bossowski A,Chlebna-Sokół D,Czech-Kowalska J,Dobrzańska A,Franek E,Helwich E,Jackowska T,Kalina MA,Konstantynowicz J,Książyk J,Lewiński A,Łukaszkiewicz J,Marcinowska

更新日期：2018-05-31 00:00:00

abstract：:Obesity constitutes one of the most important metabolic diseases being associated to insulin resistance development and increased cardiovascular risk. Association between obesity and cancer has also been well established for several tumor types, such as breast cancer in post-menopausal women, colorectal, and prostate ...

journal_title：Frontiers in endocrinology

authors： Pérez-Hernández AI,Catalán V,Gómez-Ambrosi J,Rodríguez A,Frühbeck G

更新日期：2014-05-01 00:00:00

abstract：:Pheochromocytomas and paragangliomas (PHEO/PGL) are rare but occasionally life-threatening neoplasms, and are potentially malignant according to WHO classification in 2017. However, it is also well known that histopathological risk stratification to predict clinical outcome has not yet been established. The first hist...

journal_title：Frontiers in endocrinology

authors： Yamazaki Y,Gao X,Pecori A,Nakamura Y,Tezuka Y,Omata K,Ono Y,Morimoto R,Satoh F,Sasano H

更新日期：2020-10-27 00:00:00

abstract：:We sought to determine the efficacy of 12 weeks high-intensity interval training (HIIT), compared to moderate-intensity continuous training (MICT) on glucose control, cardiometabolic risk and microvascular complication markers in men living with type 2 diabetes (T2D). Both modalities were combined with resistance trai...

journal_title：Frontiers in endocrinology

authors： Wormgoor SG,Dalleck LC,Zinn C,Borotkanics R,Harris NK

更新日期：2018-08-28 00:00:00

abstract：:In the developed world, the hazards associated with obesity have largely outstripped the risk of starvation. Obesity remains a difficult public health issue to address, due in large part to the many disciplines involved. A full understanding requires knowledge in the fields of genetics, endocrinology, psychology, soci...

journal_title：Frontiers in endocrinology

authors： Neymotin F,Nemzer LR

更新日期：2014-10-07 00:00:00

abstract：:Background: Consistent evidence have demonstrated that patients with primary aldosteronism (PA) have higher risk of cardiovascular events to patients with essential hypertension (EH). Whether the long-term risk of mortality for PA patients is higher than EH patients is unclear. We aim to compare the long-term mortalit...

journal_title：Frontiers in endocrinology

authors： Meng Z,Dai Z,Huang K,Xu C,Zhang YG,Zheng H,Liu TZ

更新日期：2020-03-10 00:00:00

abstract：:Type 2 diabetes affects racial/ethnic minorities at an alarming rate in the US and in many countries around the world. The quality of health care provided to these groups is often suboptimal, resulting in worse patient-related outcomes when compared to those in mainstream populations. Understanding the complex biologi...

journal_title：Frontiers in endocrinology

authors： Caballero AE

更新日期：2018-08-28 00:00:00

abstract：:Background and Objectives: Clitoromegaly is an important parameter in the evaluation of ambiguous genitalia in neonates, but the normative data for clitoral size in newborns have racial/ethnic differences. The present study aimed to determine clitoral length (CL) and clitoral width (CW) values and establish cutoff mea...

journal_title：Frontiers in endocrinology

authors： Alaei M,Rohani F,Norouzi E,Hematian Boroujeni N,Tafreshi RI,Salehiniya H,Soheilipour F

更新日期：2020-06-03 00:00:00

abstract：:To identify if the absence of the vasoactive intestinal peptide (VIP) gene enhances susceptibility to death from metastatic bladder cancer, two strains of mice were injected with MB49 murine bladder cancer cells. The growth and spread of the cancer was measured over a period of 4 weeks in C57BL/6 mice and 5 weeks in V...

journal_title：Frontiers in endocrinology

authors： Mirsaidi N,Burns MP,McClain SA,Forsyth E,Li J,Dukes B,Lin D,Nahvi R,Giraldo J,Patton M,Wang P,Lin K,Miller E,Ratliff T,Hamidi S,Crist S,Takemaru KI,Szema A

更新日期：2017-08-07 00:00:00

abstract：:Somatostatin is highly expressed in mammalian brain and is involved in many brain functions such as motor activity, sleep, sensory, and cognitive processes. Five somatostatin receptors have been described: sst(1), sst(2) (A and B), sst(3), sst(4), and sst(5), all belonging to the G-protein-coupled receptor family. Dur...

journal_title：Frontiers in endocrinology

authors： Martel G,Dutar P,Epelbaum J,Viollet C

更新日期：2012-12-06 00:00:00

abstract：:[This corrects the article on p. 162 in vol. 6, PMID: 26528241.]. ...

journal_title：Frontiers in endocrinology

authors： Frontiers Production Office.

更新日期：2015-11-16 00:00:00

abstract：Background:Since hypothyroidism is a fairly common dysfunction, levothyroxine (L-T4) is one of the most prescribed medications. Approximately 70% of the administered L-T4 dose is absorbed. The absorption process takes place in the small intestine. Some disorders of the digestive system and some medicines, supplements, ...

journal_title：Frontiers in endocrinology

authors： Benvenga S,Capodicasa G,Perelli S,Ferrari SM,Fallahi P,Antonelli A

更新日期：2018-04-18 00:00:00