Early Diagnosis of Low-Risk Papillary Thyroid Cancer Results Rather in Overtreatment Than a Better Survival.

abstract：:The tropical freshwater zebrafish has recently emerged as a valuable model organism for the study of adipose tissue biology and obesity-related disease. The strengths of the zebrafish model system are its wealth of genetic mutants, transgenic tools, and amenability to high-resolution imaging of cell dynamics within li...

journal_title：Frontiers in endocrinology

authors： Wafer R,Tandon P,Minchin JEN

更新日期：2017-05-22 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) is a pleotropic metabolic regulator, expression of which is elevated during fasting. To this end, the precise role played by FGF21 in the biology of fasting has been the subject of several recent studies, which have demonstrated contributions to the regulation of both lipid and carb...

journal_title：Frontiers in endocrinology

authors： Antonellis PJ,Hayes MP,Adams AC

更新日期：2016-06-30 00:00:00

abstract：:Polybrominated diphenyl ethers (PBDEs) were used as flame-retardant additives starting 1965 and were recently withdrawn from commerce in North America and Europe. Approximately 1/5 of the total U.S. population were born when environmental concentrations of PBDE plateaued at their maximum. Accumulating evidence suggest...

journal_title：Frontiers in endocrinology

authors： Khalil A,Cevik SE,Hung S,Kolla S,Roy MA,Suvorov A

更新日期：2018-09-20 00:00:00

abstract：:Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory cytokines, myokines, and osteokines, contribute substantially to the development of abnormal glucose and lipid metabolism. Some cytokines play a positive role in metabolism action, while others have a negative metabolic role l...

journal_title：Frontiers in endocrinology

authors： Shi J,Fan J,Su Q,Yang Z

更新日期：2019-10-30 00:00:00

abstract：:Aging represents one of the most complicated and highly integrated somatic processes. Healthy aging is suggested to rely upon the coherent regulation of hormonal and neuronal communication between the central nervous system and peripheral tissues. The hypothalamus is one of the main structures in the body responsible ...

journal_title：Frontiers in endocrinology

authors： Martin B,Chadwick W,Janssens J,Premont RT,Schmalzigaug R,Becker KG,Lehrmann E,Wood WH,Zhang Y,Siddiqui S,Park SS,Cong WN,Daimon CM,Maudsley S

更新日期：2016-01-18 00:00:00

abstract：:Gonadotropin-inhibitory hormone (GnIH) was first identified in the Japanese quail as a hypothalamic neuropeptide inhibitor of gonadotropin secretion. Subsequent studies have shown that GnIH is present in the brains of birds including songbirds, and mammals including humans. The identified avian and mammalian GnIH pept...

journal_title：Frontiers in endocrinology

authors： Ubuka T,Son YL,Tobari Y,Tsutsui K

更新日期：2012-11-28 00:00:00

abstract：:Classically, the modulation of brain function and behavior by steroid hormones was linked exclusively to secretion by peripheral endocrine glands. Subsequently, steroid actions within the brain were shown dependent upon either synthesis and secretion by peripheral organs or by production within the CNS itself using pe...

journal_title：Frontiers in endocrinology

authors： Remage-Healey L,Saldanha CJ,Schlinger BA

更新日期：2011-09-29 00:00:00

abstract：BACKGROUND:Monitoring blood levels of human growth hormone (hGH) in most children with short stature deficiencies is crucial for taking a decision of treatment with extended course of daily and expensive doses of recombinant hGH (rhGH or Somatropin®). Besides, misusing of rhGH by sportsmen is banned by the World Anti-D...

journal_title：Frontiers in endocrinology

authors： Murad H,Assaad JM,Al-Shemali R,Abbady AQ

更新日期：2017-05-30 00:00:00

abstract：:Dysnatremia is associated with increased mortality in patients with community-acquired pneumonia. SARS-COV2 (Severe-acute-respiratory syndrome caused by Coronavirus-type 2) pneumonia can be fatal. The aim of this study was to ascertain whether admittance dysnatremia is associated with mortality, sepsis, or intensive t...

journal_title：Frontiers in endocrinology

authors： Ruiz-Sánchez JG,Núñez-Gil IJ,Cuesta M,Rubio MA,Maroun-Eid C,Arroyo-Espliguero R,Romero R,Becerra-Muñoz VM,Uribarri A,Feltes G,Trabattoni D,Molina M,García Aguado M,Pepe M,Cerrato E,Alfonso E,Castro Mejía AF,Roubin SR,

更新日期：2020-11-30 00:00:00

abstract：:Last two decades of structure-function studies performed in numerous laboratories provided substantial progress in understanding basic science, physiological, pathophysiological, pharmacological, and comparative aspects of glycoprotein hormones (GPHs) and their cognate receptors. Multiple concepts and models developed...

journal_title：Frontiers in endocrinology

authors： Szkudlinski MW

更新日期：2015-10-19 00:00:00

abstract：:O-linked β-N-acetylglucosamine (O-GlcNAc) is an abundant and essential intracellular form of protein glycosylation in animals and plants. In humans, dysregulation of O-GlcNAcylation occurs in a wide range of diseases, including cancer, diabetes, and neurodegeneration. Since its discovery more than 30 years ago, great ...

journal_title：Frontiers in endocrinology

authors： Cox NJ,Luo PM,Smith TJ,Bisnett BJ,Soderblom EJ,Boyce M

更新日期：2018-10-15 00:00:00

abstract：:Background: POU1F1 is an essential transcription factor for the differentiation, proliferation and survival of somatotrophs, lactotrophs, and thyrotrophs. Mutations in the POU1F1 gene are characterized by growth hormone (GH), thyrotropin, and prolactin deficiencies, commonly presenting with growth retardation and cent...

journal_title：Frontiers in endocrinology

authors： Majdoub H,Amselem S,Legendre M,Rath S,Bercovich D,Tenenbaum-Rakover Y

更新日期：2019-06-27 00:00:00

abstract：:Remodeling of the cellular distribution of gap junctions formed mainly by connexin-43 (Cx43) can be related to the increased incidence of cardiac arrhythmias. It has been shown that adaptation to chronic intermittent hypobaric hypoxia (IHH) attenuates the incidence and severity of ischemic and reperfusion ventricular ...

journal_title：Frontiers in endocrinology

authors： Kohutova J,Elsnicova B,Holzerova K,Neckar J,Sebesta O,Jezkova J,Vecka M,Vebr P,Hornikova D,Szeiffova Bacova B,Egan Benova T,Hlavackova M,Tribulova N,Kolar F,Novakova O,Zurmanova JM

更新日期：2019-01-25 00:00:00

abstract：:Initially identified as monomers, G protein-coupled receptors (GPCRs) can also form functional homo- and heterodimers that act as distinct signaling hubs for cellular signal integration. We previously found that the angiotensin II (Ang II) type 1 receptor (AT1R) and the prostaglandin F2α (PGF2α) receptor (FP), both im...

journal_title：Frontiers in endocrinology

authors： Fillion D,Devost D,Sleno R,Inoue A,Hébert TE

更新日期：2019-03-18 00:00:00

abstract：:In a contribution to this Research Topic Erkki Somersalo and Daniela Calvetti carried out a mathematical analysis of neurotransmitter pathways in brain, modeling compartmental nitrogen flux among several major participants - ammonia, glutamine, glutamate, GABA, and selected amino acids. This analysis is important beca...

journal_title：Frontiers in endocrinology

authors： Cooper AJ

更新日期：2013-11-18 00:00:00

abstract：:Objective: To clarify the role and mechanism of miR-17-92 cluster in islet beta-cell repair after streptozotocin intervention. Methods: Genetically engineered mice (miR-17-92βKO) and control RIP-Cre mice were intraperitoneally injected with multiple low dose streptozotocin. Body weight, random blood glucose (RBG), fas...

journal_title：Frontiers in endocrinology

authors： Wan S,Zhang J,Chen X,Lang J,Li L,Chen F,Tian L,Meng Y,Yu X

更新日期：2020-01-23 00:00:00

abstract：:The estimated number of testicular olfactory receptors (ORs) in mammals range between 20 and 66. Previous data reported the role of hOR17-4 and mOR23 in sperm-oocyte chemiotaxis. Proteomic analysis was performed to understand which are the ORs expressed in seminal plasma. Seminal samples by four fertile men were analy...

journal_title：Frontiers in endocrinology

authors： Milardi D,Colussi C,Grande G,Vincenzoni F,Pierconti F,Mancini F,Baroni S,Castagnola M,Marana R,Pontecorvi A

更新日期：2018-01-23 00:00:00

abstract：:The placenta is the chief regulator of nutrient supply to the growing embryo during gestation. As such, adequate placental function is instrumental for developmental progression throughout intrauterine development. One of the most common complications during pregnancy is insufficient growth of the fetus, a problem ter...

journal_title：Frontiers in endocrinology

authors： Woods L,Perez-Garcia V,Hemberger M

更新日期：2018-09-27 00:00:00

abstract：:The Twist proteins (Twist-1 and -2) are highly conserved developmental proteins with key roles for the transcriptional regulation in mesenchymal cell lineages. They belong to the super-family of bHLH proteins and exhibit bi-functional roles as both activators and repressors of gene transcription. The Twist proteins ar...

journal_title：Frontiers in endocrinology

authors： Dobrian AD

更新日期：2012-08-30 00:00:00

abstract：:Background: The number of subjects with gender dysphoria has been increasing. In general, male-to-female transsexual subjects are treated with estradiol valerate therapy. In this report, we showed the time course of ACTH and cortisol levels after estradiol valerate injection in a male subject with gender dysphoria. It...

journal_title：Frontiers in endocrinology

authors： Anno T,Kawasaki F,Shigemoto R,Irie S,Mune T,Kaku K,Kaneto H

更新日期：2019-11-05 00:00:00

abstract：:Testosterone is responsible for several changes in the brain, including behavioral and emotional responses, memory, and cognition. Given this, we investigated changes in the brain wave profile caused by supplementation with exogenous testosterone in both castrated and non-castrated rats. We also investigated the serum...

journal_title：Frontiers in endocrinology

authors： Estumano DP,Ferreira LO,Bezerra PAL,da Silva MCP,Jardim GC,Santos GFS,Gustavo KS,Mattos BG,Ramos JAB,Jóia de Mello V,da Costa ET,Lopes DCF,Hamoy M

更新日期：2019-09-24 00:00:00

abstract：:Rationale: Hypoxia induces leptin gene expression in human adipocytes via hypoxia-inducible factors (HIF-α/β). Under ambient moderate hypoxia, leptin in adipocytes is elevated for at least 14 days. Leptin is supposedly involved in the reduced food intake, increased utilization of fatty acids for energy production and ...

journal_title：Frontiers in endocrinology

authors： Rausch LK,Hofer M,Pramsohler S,Kaser S,Ebenbichler C,Haacke S,Gatterer H,Netzer NC

更新日期：2018-10-18 00:00:00

abstract：:Although the pathogenesis of Polycystic Ovary Syndrome (PCOS) is still unclear, the disturbance of hypothalamic-pituitary-gonadal (HPG) axis is suspected to be the main culprit in the development of PCOS. Kisspeptin, a hypothalamic peptide encoded by the KISS1 gene, is widely reported as a key factor in the regulation...

journal_title：Frontiers in endocrinology

authors： Tang R,Ding X,Zhu J

更新日期：2019-05-10 00:00:00

abstract：:Osteoporosis is a metabolic skeletal disorder in which bone mass is depleted and bone structure is destroyed to the degree that bone becomes fragile and prone to fractures. Emerging evidence suggests that N6-methyladenosine (m6A) modification, a novel epitranscriptomic marker, has a significant role in bone developmen...

journal_title：Frontiers in endocrinology

authors： Chen X,Hua W,Huang X,Chen Y,Zhang J,Li G

更新日期：2020-01-10 00:00:00

abstract：:Co-heritability of hypertension and insulin resistance (IR) within families not only implies genetic susceptibility may be responsible for these complex traits but also suggests a rational that biological candidate genes for hypertension may serve as markers for features of the metabolic syndrome (MetS). Thus we deter...

journal_title：Frontiers in endocrinology

authors： Ho LT,Hsu YP,Hsiao CF,Ting CT,Shih KC,Chuang LM,Masaki K,Grove J,Quertermous T,Juan CC,Lin MW,Chiang SC,Chen YD

更新日期：2013-11-28 00:00:00

abstract：:After decades of primarily morphological study, positional cloning of the NPHS1 gene was the landmark event that established aberrant podocyte genetics as a pivotal cause of malfunction of the glomerular filter. This ended any uncertainty whether genetic mutation plays a significant role in hereditary nephrotic syndro...

journal_title：Frontiers in endocrinology

authors： Bierzynska A,Soderquest K,Koziell A

更新日期：2015-01-23 00:00:00

abstract：:Microtubule-associated protein tau assists in stabilizing microtubules and has been particularly implicated in Alzheimer's disease (AD). Given the importance of tau to AD pathogenesis and therapies, it is important to understand non-classic physiological functions for this protein inside and outside the central nervou...

journal_title：Frontiers in endocrinology

authors： Gonçalves RA,Wijesekara N,Fraser PE,De Felice FG

更新日期：2020-03-12 00:00:00

abstract：:Catecholamine (CA) secretion from the adrenal medullary tissue is a key step of the adaptive response triggered by an organism to cope with stress. Whereas molecular and cellular secretory processes have been extensively studied at the single chromaffin cell level, data available for the whole gland level are much sca...

journal_title：Frontiers in endocrinology

authors： De Nardi F,Lefort C,Bréard D,Richomme P,Legros C,Guérineau NC

更新日期：2017-09-25 00:00:00

abstract：:Background: Early metabolic responses following bariatric surgery appear greater than expected given the initial weight loss and coincide with improvement in diabetes. We hypothesized that small non-coding microRNA changes might contribute to regulating mechanisms for metabolic changes and weight loss in patients with...

journal_title：Frontiers in endocrinology

authors： Atkin SL,Ramachandran V,Yousri NA,Benurwar M,Simper SC,McKinlay R,Adams TD,Najafi-Shoushtari SH,Hunt SC

更新日期：2019-01-04 00:00:00

abstract：Introduction:Obesity is associated with a higher risk of abortion in women undergoing in vitro fertilization (IVF). Whether thrombophilia amplifies this risk is currently unclear. The aim of this study was to evaluate the effects of thrombophilia on the risk of abortion in obese women treated with IVF. Methods:Patient...

journal_title：Frontiers in endocrinology

authors： Candeloro M,Di Nisio M,Ponzano A,Tiboni GM,Potere N,Tana M,Rutjes AWS,Porreca E

更新日期：2020-12-23 00:00:00