The IGF/Insulin-IGFBP Axis in Corneal Development, Wound Healing, and Disease.

abstract：Background:Repeated radioiodine (131I) treatment (RT) are commonly performed in patients with 131I-avid distant metastatic differentiated thyroid cancer (DM-DTC), but more precise indications remain indeterminate. This prospective study was conducted to explore predictors for biochemical response (BR) to next RT. Meth...

journal_title：Frontiers in endocrinology

authors： Sa R,Cheng L,Jin Y,Fu H,Shen Y,Chen L

更新日期：2020-11-16 00:00:00

abstract：Purpose:To assess whether volumetric vertebral bone mineral density (BMD) measured with opportunistic quantitative computed tomography (QCT) (i.e., CT acquired for other reasons) can predict osteoporotic fracture occurrence in a prospective clinical cohort and how this performs in comparison to dual-energy X-ray absorp...

journal_title：Frontiers in endocrinology

authors： Leonhardt Y,May P,Gordijenko O,Koeppen-Ursic VA,Brandhorst H,Zimmer C,Makowski MR,Baum T,Kirschke JS,Gersing AS,Seifert-Klauss V,Schwaiger BJ

更新日期：2020-11-09 00:00:00

abstract：:Background: Bologna criteria poor ovarian responders have a very low prognosis. Although, it has been proposed that LH supplementation could be beneficial in women with previous hypo-response to FSH. There are no studies comparing the cumulative live birth rates (LBRs) between corifollitropin alfa (CFA) and highly pur...

journal_title：Frontiers in endocrinology

authors： Errázuriz J,Romito A,Drakopoulos P,Frederix B,Racca A,De Munck N,Tournaye H,De Vos M,Blockeel C

更新日期：2019-03-22 00:00:00

abstract：:The infertile patients with aging ovaries-also sometimes referred to as impending premature ovarian insufficiency (POI), impending premature ovarian failure (POF), or poor ovarian responders (POR), constitute a significant and increasing bulk of the patients appealing to IVF/ART. Different causes have been cited in th...

journal_title：Frontiers in endocrinology

authors： Blumenfeld Z

更新日期：2020-04-17 00:00:00

abstract：:The brain orchestrates organ function and regulates whole body metabolism by the concerted action of neurons and glia cells in the central nervous system. To do so, the brain has tremendously high energy consumption and relies mainly on glucose utilization and mitochondrial function in order to exert its function. As ...

journal_title：Frontiers in endocrinology

authors： Castro JP,Wardelmann K,Grune T,Kleinridders A

更新日期：2018-04-26 00:00:00

abstract：:In a contribution to this Research Topic Erkki Somersalo and Daniela Calvetti carried out a mathematical analysis of neurotransmitter pathways in brain, modeling compartmental nitrogen flux among several major participants - ammonia, glutamine, glutamate, GABA, and selected amino acids. This analysis is important beca...

journal_title：Frontiers in endocrinology

authors： Cooper AJ

更新日期：2013-11-18 00:00:00

abstract：Background:Left ventricular (LV) diastolic dysfunction has been demonstrated to be an independent predictor of the future heart failure. Heart failure is one of the severe complications caused by overt hyperthyroidism. However, the effects of overt hyperthyroidism on diastolic dysfunction are conflicting, and little is...

journal_title：Frontiers in endocrinology

authors： Li H,Zeng R,Liao Y,Fu M,Zhang H,Wang L,Li Y

更新日期：2021-01-08 00:00:00

abstract：:In the developed world, the hazards associated with obesity have largely outstripped the risk of starvation. Obesity remains a difficult public health issue to address, due in large part to the many disciplines involved. A full understanding requires knowledge in the fields of genetics, endocrinology, psychology, soci...

journal_title：Frontiers in endocrinology

authors： Neymotin F,Nemzer LR

更新日期：2014-10-07 00:00:00

abstract：:Regenerative medicine is a multidisciplinary field that aims to determine different factors and develop various methods to regenerate impaired tissues, organs, and cells in the disease and impairment conditions. When treatment procedures are specified according to the individual's information, the leading role of pers...

journal_title：Frontiers in endocrinology

authors： Arjmand B,Tayanloo-Beik A,Foroughi Heravani N,Alaei S,Payab M,Alavi-Moghadam S,Goodarzi P,Gholami M,Larijani B

更新日期：2020-07-17 00:00:00

abstract：:Reproductive function is regulated by the secretion of luteinizing hormone (LH) and follicle-stimulating hormone from the pituitary and the steroid hormones from the gonads. The dynamic changes in the levels of the reproductive hormones regulate secondary sex characteristics, gametogenesis, cellular function, and beha...

journal_title：Frontiers in endocrinology

authors： Radovick S,Levine JE,Wolfe A

更新日期：2012-04-09 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a very common endocrine and metabolic disorder with the involvement of both genetic and environmental factors. Although much has been clarified on its pathogenesis, diagnosis, clinical manifestations, and therapy, there are still areas of uncertainty. To address fundamental concepts...

journal_title：Frontiers in endocrinology

authors： Aversa A,La Vignera S,Rago R,Gambineri A,Nappi RE,Calogero AE,Ferlin A

更新日期：2020-08-11 00:00:00

abstract：:Type 2 diabetes affects racial/ethnic minorities at an alarming rate in the US and in many countries around the world. The quality of health care provided to these groups is often suboptimal, resulting in worse patient-related outcomes when compared to those in mainstream populations. Understanding the complex biologi...

journal_title：Frontiers in endocrinology

authors： Caballero AE

更新日期：2018-08-28 00:00:00

abstract：:Calcium and bone homeostasis are intimately related. On the one hand, bone relies on a sufficient supply of calcium to maintain its structural and mechanical properties and thus largely depends on calcium absorption in the intestine and calcium reabsorption in the kidney. On the other hand, bone serves as a calcium re...

journal_title：Frontiers in endocrinology

authors： Lieben L,Carmeliet G

更新日期：2012-08-20 00:00:00

abstract：:Vitamin D is important for bone health, but may also have extra-skeletal effects. Vitamin D and its binding protein DBP have immunological effects and may therefore be important in the development of type 1 diabetes (T1DM), and low serum levels of 25-hydroxyvitamin D (25(OH)D) are associated with later development of ...

journal_title：Frontiers in endocrinology

authors： Jorde R

更新日期：2019-02-19 00:00:00

abstract：:Germline development in vivo is dependent on the environment formed by somatic cells and the differentiation cues they provide; hence, the impact of local factors is highly relevant to the production of sperm. Knowledge of how somatic and germline cells interact is central to achieving biomedical goals relating to res...

journal_title：Frontiers in endocrinology

authors： Loveland KL,Klein B,Pueschl D,Indumathy S,Bergmann M,Loveland BE,Hedger MP,Schuppe HC

更新日期：2017-11-20 00:00:00

abstract：:It has been generally assumed that insulin circulates freely in blood. However it can also interact with plasma proteins. Insulin receptors are located in the membrane of target cells and consist of an alpha and beta subunits with a tyrosine kinase cytoplasmic domain. The ectodomain, called soluble insulin receptor (S...

journal_title：Frontiers in endocrinology

authors： Hiriart M,Sanchez-Soto C,Diaz-Garcia CM,Castanares DT,Avitia M,Velasco M,Mas-Oliva J,Macias-Silva M,González-Villalpando C,Delgado-Coello B,Sosa-Garrocho M,Vidaltamayo R,Fuentes-Silva D

更新日期：2014-06-19 00:00:00

abstract：:To investigate the expression of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) in the aorta of subclinical hypothyroidism (SCH) rat model. The mechanisms underlying thyrotropin (TSH) affecting eNOS and PGRN expression in human umbilical vein endothelial cells (HUVECs) cultured in vitro were investigat...

journal_title：Frontiers in endocrinology

authors： Jiang F,Wang H,Bao S,Zhou H,Zhang Y,Yan Y,Lai Y,Teng W,Shan Z

更新日期：2018-07-05 00:00:00

abstract：:Evidence that adult humans have functional brown adipose tissue has stirred interest in the possibility that the impressive effectiveness of induction of brown adipocytes to reduce obesity in mice may be translated to the human condition. A major focus recently on the identification of signaling and transcription fact...

journal_title：Frontiers in endocrinology

authors： Kozak LP

更新日期：2011-10-31 00:00:00

abstract：:Sex pheromone production in most moths is initiated following pheromone biosynthesis activating neuropeptide receptor (PBANR) activation. PBANR was initially cloned from pheromone glands (PGs) of Helicoverpa zea and Bombyx mori. The B. mori PBANR is characterized by a relatively long C-terminus that is essential for l...

journal_title：Frontiers in endocrinology

authors： Lee JM,Hull JJ,Kawai T,Goto C,Kurihara M,Tanokura M,Nagata K,Nagasawa H,Matsumoto S

更新日期：2012-01-24 00:00:00

abstract：Background:Nonalcoholic steatohepatitis (NASH) is rapidly becoming a major chronic liver disease worldwide. However, little is known concerning the pathogenesis and progression mechanism of NASH. Our aim here is to identify key genes and elucidate their biological function in the progression from hepatic steatosis to N...

journal_title：Frontiers in endocrinology

authors： Ye J,Lin Y,Wang Q,Li Y,Zhao Y,Chen L,Wu Q,Xu C,Zhou C,Sun Y,Ye W,Bai F,Zhou T

更新日期：2020-11-26 00:00:00

abstract：:Spontaneous and oxytocin induced contractile activity was quantified in the bicornuate uteri of pregnant rabbits maintained in situ, using data from two- and uni- dimensional video spatiotemporal maps (VSTM) of linear and area strain rate and compared statistically. Spontaneous contractions occurred over a range of fr...

journal_title：Frontiers in endocrinology

authors： Hulls CM,Lentle RG,Chua WH,Suisted P,King QM,Chagas JAB,Chambers JP,Stewart L

更新日期：2019-11-21 00:00:00

abstract：:The origin of the coronavirus disease 2019 (COVID-19) pandemic is zoonotic. The circadian day-night is the rhythmic clue to organisms for their synchronized body functions. The "development for mankind" escalated the use of artificial light at night (ALAN). In this article, we tried to focus on the possible influence ...

journal_title：Frontiers in endocrinology

authors： Khan ZA,Yumnamcha T,Mondal G,Devi SD,Rajiv C,Labala RK,Sanjita Devi H,Chattoraj A

更新日期：2020-09-10 00:00:00

abstract：:Anti-Müllerian hormone reflects the continuum of the functional ovarian reserve, and as such can predict ovarian response to gonadotropin stimulation and be used to individualize treatment pathways to improve efficacy and safety. However, consistent with other biomarkers and age-based prediction models it has limited ...

journal_title：Frontiers in endocrinology

authors： Li HWR,Nelson SM

更新日期：2020-12-09 00:00:00

abstract：:Background: The long noncoding RNA (lncRNA) functions as a regulator of initiation, progression, and metastasis of thyroid carcinomas. lncRNA OTUD6B antisense RNA 1 (OTUD6B-AS1) is a tumor-suppressive noncoding RNA in clear cell renal cell carcinoma. The role of OTUD6B-AS1 in thyroid carcinomas has not been reported y...

journal_title：Frontiers in endocrinology

authors： Wang Z,Xia F,Feng T,Jiang B,Wang W,Li X

更新日期：2020-03-17 00:00:00

abstract：:Background: Insulin resistance (IR) is the hallmark of PCOS and it is known that exercise may decrease it. What is unknown is whether exercise may mechanistically alter the underlying IR, attenuating the dynamic lipid induced IR in insulin resistant subjects. Methods: 12 women with polycystic ovary syndrome (PCOS) and...

journal_title：Frontiers in endocrinology

authors： Aye MM,Butler AE,Kilpatrick ES,Kirk R,Vince R,Rigby AS,Sandeman D,Atkin SL

更新日期：2018-10-05 00:00:00

abstract：:Background: Non-alcoholic fatty liver disease (NAFLD) is a well-known cause of liver dysfunction and has become a common chronic liver disease in many countries. However, the intrinsic molecular mechanisms underlying the pathogenesis of NAFLD have not yet been fully elucidated. Methods: We obtained the gene expression...

journal_title：Frontiers in endocrinology

authors： Jia X,Zhai T

更新日期：2019-08-30 00:00:00

abstract：Objective:To evaluate whether endometrial thickness (EMT) change in response to progesterone has an effect on pregnancy outcomes in frozen-thawed embryo transfer (FET) cycles. Design:Retrospective observational study. Setting:Tertiary-care academic medical center. Participants:4465 infertile women undergoing their f...

journal_title：Frontiers in endocrinology

authors： Ye J,Zhang J,Gao H,Zhu Y,Wang Y,Cai R,Kuang Y

更新日期：2020-10-29 00:00:00

abstract：:In neuroendocrine cells, prohormones move from the endoplasmic reticulum to the Golgi complex (GC), where they are sorted and packed into secretory granules. The GC is considered the central station of the secretory pathway of proteins and lipids en route to their final destination. In most mammalian cells, it is form...

journal_title：Frontiers in endocrinology

authors： Martínez-Alonso E,Tomás M,Martínez-Menárguez JA

更新日期：2013-03-28 00:00:00

abstract：:Obesity is associated with inflammation and type 2 diabetes. Innate immune system comprised of cellular and molecular components plays an important role in the inflammatory reactions. Immune cells like macrophages and their cell surface pattern-recognition receptors (PRRs) are representative for innate immunity promot...

journal_title：Frontiers in endocrinology

authors： Yamamoto Y,Yamamoto H

更新日期：2013-08-21 00:00:00

abstract：:Introduction: An increase of serum dehydroepiandrosterone (DHEA) sulfate (DHEAS) is observed in premature adrenarche and congenital adrenal hyperplasia. Very high DHEAS levels are typical for adrenal tumors. Approximately 74% of DHEAS is hydrolyzed to DHEA by the steroid sulfatase (STS). The reverse reaction is DHEA s...

journal_title：Frontiers in endocrinology

authors： Iliev DI,Braun R,Sánchez-Guijo A,Hartmann M,Wudy SA,Heckmann D,Bruchelt G,Rösner A,Grosser G,Geyer J,Binder G

更新日期：2020-05-06 00:00:00