The Nomogram of Clitoral Length and Width in Iranian Term and Preterm Neonates.

abstract：:This review focuses on the biologic importance of the vitamin D binding protein (DBP) with emphasis on its regulation of total and free vitamin D metabolite levels in various clinical conditions. Nearly all DBP is produced in the liver, where its regulation is influenced by estrogen, glucocorticoids and inflammatory c...

journal_title：Frontiers in endocrinology

authors： Bikle DD,Schwartz J

更新日期：2019-05-28 00:00:00

abstract：:Calcium and bone homeostasis are intimately related. On the one hand, bone relies on a sufficient supply of calcium to maintain its structural and mechanical properties and thus largely depends on calcium absorption in the intestine and calcium reabsorption in the kidney. On the other hand, bone serves as a calcium re...

journal_title：Frontiers in endocrinology

authors： Lieben L,Carmeliet G

更新日期：2012-08-20 00:00:00

abstract：:Platelet activation plays a pivotal role in the development and progression of atherosclerosis, which often leads to potentially fatal ischemic events at later stages of the disease. Platelets and platelet microvesicles (PMVs) contain large amounts of microRNA (miRNA), which contributes largely to the pool of circulat...

journal_title：Frontiers in endocrinology

authors： Pordzik J,Pisarz K,De Rosa S,Jones AD,Eyileten C,Indolfi C,Malek L,Postula M

更新日期：2018-03-20 00:00:00

abstract：:Aims: This study aimed to investigate the clinical courses and outcomes of diabetes mellitus patients with coronavirus disease 2019 (COVID-19) in Wuhan. Methods: This study enrolled 1,880 consecutive patients with confirmed COVID-19 in Leishenshan Hospital. We collected and analyzed their data, including demographic d...

journal_title：Frontiers in endocrinology

authors： Liu Z,Li J,Huang J,Guo L,Gao R,Luo K,Zeng G,Zhang T,Yi M,Huang Y,Chen J,Yang Y,Wu X

更新日期：2020-07-14 00:00:00

abstract：:Testosterone is responsible for several changes in the brain, including behavioral and emotional responses, memory, and cognition. Given this, we investigated changes in the brain wave profile caused by supplementation with exogenous testosterone in both castrated and non-castrated rats. We also investigated the serum...

journal_title：Frontiers in endocrinology

authors： Estumano DP,Ferreira LO,Bezerra PAL,da Silva MCP,Jardim GC,Santos GFS,Gustavo KS,Mattos BG,Ramos JAB,Jóia de Mello V,da Costa ET,Lopes DCF,Hamoy M

更新日期：2019-09-24 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of a nuclear receptor superfamily and acts as a ligand-dependent transcription factor, playing key roles in maintenance of adipose tissue and in regulation of glucose and lipid homeostasis. This receptor is the target of thiazolidinediones, a class o...

journal_title：Frontiers in endocrinology

authors： Ribeiro Filho HV,Bernardi Videira N,Bridi AV,Tittanegro TH,Helena Batista FA,de Carvalho Pereira JG,de Oliveira PSL,Bajgelman MC,Le Maire A,Figueira ACM

更新日期：2018-02-01 00:00:00

abstract：:Fibrodysplasia ossificans progressiva (FOP) is an autosomal dominant disease, characterized by the formation of heterotopic ossification (HO) in muscles, ligaments, and tendons. Flare-ups, an inflammatory process that often precedes the formation of HO, can occur spontaneously, but trauma is also a common trigger. It ...

journal_title：Frontiers in endocrinology

authors： Botman E,Netelenbos JC,Rustemeyer T,Schoonmade LJ,Nieuwenhuijzen JA,Teunissen BP,Visser M,Raijmakers P,Lammertsma AA,Dahele M,Eekhoff M

更新日期：2020-02-12 00:00:00

abstract：:Circulating microRNAs are potential biomarkers of type 2 diabetes mellitus (T2DM) and related complications. Here, we investigated the association of microRNA-15a with early retinal damage in T2DM. A cohort of untreated subjects screened for intermediate/high risk of T2DM, according to a score assessment questionnaire...

journal_title：Frontiers in endocrinology

authors： Sangalli E,Tagliabue E,Sala L,Prattichizzo F,Uccellatore A,Spada D,Lorino F,de Candia P,Lupini S,Cantone L,Favero C,Madeddu P,Bollati V,Genovese S,Spinetti G

更新日期：2020-04-23 00:00:00

abstract：:Osteocytes are the most abundant (~95%) cells in bone with the longest half-life (~25 years) in humans. In the past osteocytes have been regarded as vestigial cells in bone, since they are buried inside the tough bone matrix. However, during the last 30 years it has become clear that osteocytes are as important as bon...

journal_title：Frontiers in endocrinology

authors： Pathak JL,Bravenboer N,Klein-Nulend J

更新日期：2020-07-08 00:00:00

abstract：:Exercise training triggers numerous positive adaptations through the regulation of genes controlling muscle structure and function. Epigenetic modifications, including DNA methylation, participate in transcriptional activation by allowing the recruitment of the transcription machinery to gene promoters. Exercise induc...

journal_title：Frontiers in endocrinology

authors： Pattamaprapanont P,Garde C,Fabre O,Barrès R

更新日期：2016-12-23 00:00:00

abstract：:Lifestyle modifications focused on diet, physical activity, and behavior have a modest impact on weight reduction in children, adolescents, and young adults (YA) with overweight and obesity. Several anti-obesity medications (AOMs) have been approved by the Food and Drug Administration (FDA) for use among adult patient...

journal_title：Frontiers in endocrinology

authors： Czepiel KS,Perez NP,Campoverde Reyes KJ,Sabharwal S,Stanford FC

更新日期：2020-05-13 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fendo.2019.00276.]. ...

journal_title：Frontiers in endocrinology

authors： Thambirajah AA,Koide EM,Imbery JJ,Helbing CC

更新日期：2019-06-26 00:00:00

abstract：:Objective: Prolactin and progesterone are implicated in glucose homeostasis in and outside of pregnancy. However, their associations with gestational diabetes (GDM) risk were not well-understood. This study investigates this question in a prospective and longitudinal cohort. Methods: This is a nested case-control stud...

journal_title：Frontiers in endocrinology

authors： Li M,Song Y,Rawal S,Hinkle SN,Zhu Y,Tekola-Ayele F,Ferrara A,Tsai MY,Zhang C

更新日期：2020-02-27 00:00:00

abstract：:After decades of primarily morphological study, positional cloning of the NPHS1 gene was the landmark event that established aberrant podocyte genetics as a pivotal cause of malfunction of the glomerular filter. This ended any uncertainty whether genetic mutation plays a significant role in hereditary nephrotic syndro...

journal_title：Frontiers in endocrinology

authors： Bierzynska A,Soderquest K,Koziell A

更新日期：2015-01-23 00:00:00

abstract：:Vitiligo represents the most common cause of acquired skin, hair, and oral depigmentation, affecting 0.5-1% of the population worldwide. It is clinically characterized by the appearance of disfiguring circumscribed skin macules following melanocyte destruction by autoreactive cytotoxic T lymphocytes. Patients affected...

journal_title：Frontiers in endocrinology

authors： Baldini E,Odorisio T,Sorrenti S,Catania A,Tartaglia F,Carbotta G,Pironi D,Rendina R,D'Armiento E,Persechino S,Ulisse S

更新日期：2017-10-27 00:00:00

abstract：:The placenta is the chief regulator of nutrient supply to the growing embryo during gestation. As such, adequate placental function is instrumental for developmental progression throughout intrauterine development. One of the most common complications during pregnancy is insufficient growth of the fetus, a problem ter...

journal_title：Frontiers in endocrinology

authors： Woods L,Perez-Garcia V,Hemberger M

更新日期：2018-09-27 00:00:00

abstract：:The world-wide obesity epidemic constitutes a severe threat to human health and wellbeing and poses a major challenge to health-care systems. Current therapeutic approaches, relying mainly on reduced energy intake and/or increased exercise energy expenditure, are generally of limited effectiveness. Previously believed...

journal_title：Frontiers in endocrinology

authors： Betz MJ,Enerbäck S

更新日期：2011-11-29 00:00:00

abstract：:Human primordial germ cells (PGCs) have been described in the yolk sac wall around the beginning of the third week. From week 4 to 5, they migrate under control of SCF/c-KIT signaling pathway to the genital ridge, where they become gonocytes. PGCs and gonocytes express classic pluripotency markers, such as KIT, NANOG,...

journal_title：Frontiers in endocrinology

authors： Baroni T,Arato I,Mancuso F,Calafiore R,Luca G

更新日期：2019-06-06 00:00:00

abstract：:Osteoporosis is a metabolic skeletal disorder in which bone mass is depleted and bone structure is destroyed to the degree that bone becomes fragile and prone to fractures. Emerging evidence suggests that N6-methyladenosine (m6A) modification, a novel epitranscriptomic marker, has a significant role in bone developmen...

journal_title：Frontiers in endocrinology

authors： Chen X,Hua W,Huang X,Chen Y,Zhang J,Li G

更新日期：2020-01-10 00:00:00

abstract：:Context: The DICER1 syndrome is a multiple neoplasia disorder caused by germline mutations in the DICER1 gene. In DICER1 patients, aggressive congenital pituitary tumors lead to neonatal Cushing's disease (CD). The role of DICER1 in other corticotropinomas, however, remains unknown. Objective: To perform a comprehensi...

journal_title：Frontiers in endocrinology

authors： Martínez de LaPiscina I,Hernández-Ramírez LC,Portillo N,Gómez-Gila AL,Urrutia I,Martínez-Salazar R,García-Castaño A,Aguayo A,Rica I,Gaztambide S,Faucz FR,Keil MF,Lodish MB,Quezado M,Pankratz N,Chittiboina P,Lane J,Kay D

更新日期：2020-07-03 00:00:00

abstract：:Background: Chronic inflammatory disorders and dyslipidemia in type 2 diabetes mellitus (T2DM) are essential contributors to the development of atherosclerotic cardiovascular disease. Monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is a novel and simple measure associated positively with the body ...

journal_title：Frontiers in endocrinology

authors： Chen JW,Li C,Liu ZH,Shen Y,Ding FH,Shu XY,Zhang RY,Shen WF,Lu L,Wang XQ

更新日期：2019-04-04 00:00:00

abstract：:Gonadotropin-releasing hormone (GnRH) is the ultimate output signal of an intricate network of neuroendocrine factors that, acting on the pituitary, trigger gonadotropin release. In turn, gonadotropins exert their trophic action on the gonads to stimulate the synthesis of sex steroids thus completing the gonadotropic ...

journal_title：Frontiers in endocrinology

authors： Navarro VM

更新日期：2012-04-02 00:00:00

abstract：:Progression and severity of type 1 diabetes is dependent upon inflammatory induction of nitric oxide production and consequent pancreatic β-cell damage. Glucocorticoids (GCs) are highly effective anti-inflammatory agents but have been precluded in type 1 diabetes and in islet transplantation protocols because they exa...

journal_title：Frontiers in endocrinology

authors： Liu X,Turban S,Carter RN,Ahmad S,Ramage L,Webster SP,Walker BR,Seckl JR,Morton NM

更新日期：2014-10-14 00:00:00

abstract：:The infertile patients with aging ovaries-also sometimes referred to as impending premature ovarian insufficiency (POI), impending premature ovarian failure (POF), or poor ovarian responders (POR), constitute a significant and increasing bulk of the patients appealing to IVF/ART. Different causes have been cited in th...

journal_title：Frontiers in endocrinology

authors： Blumenfeld Z

更新日期：2020-04-17 00:00:00

abstract：:Thyroid hormone concentrations only become sufficient to maintain a euthyroid state through appropriate stimulation by pituitary thyroid-stimulating hormone (TSH). In such a dynamic system under constant high pressure, guarding against overstimulation becomes vital. Therefore, several defensive mechanisms protect agai...

journal_title：Frontiers in endocrinology

authors： Hoermann R,Midgley JE,Larisch R,Dietrich JW

更新日期：2016-11-07 00:00:00

abstract：:Ghrelin is a peptide hormone that is acylated with a fatty acid, usually n-octanoic acid, at the third amino acid (aa) residue (usually a serine or threonine), and this acylation is known to be essential for ghrelin activity not only in mammals but also in non-mammals, such as fish. However, the modification mechanism...

journal_title：Frontiers in endocrinology

authors： Kaiya H,Andoh T,Ichikawa T,Amiya N,Matsuda K,Kangawa K,Miyazato M

更新日期：2013-09-03 00:00:00

abstract：:Cushing's disease recurrence following successful pituitary surgery is common and merits prompt and careful diagnosis, as untreated hypercortisolism leads to increased morbidity and mortality. However, an established recurrence definition has not been forthcoming. This poses a diagnostic challenge especially early in ...

journal_title：Frontiers in endocrinology

authors： Hinojosa-Amaya JM,Varlamov EV,McCartney S,Fleseriu M

更新日期：2019-11-08 00:00:00

abstract：:Fibroblast growth factor 1 (FGF1) is reported to be expressed in the testis. How FGF1 affects stem Leydig cell development remains unclear. Here, we report the effects of FGF1 on rat stem Leydig cell development in an ethane dimethane sulfonate (EDS)-treated model. FGF1 (100 ng/testis) significantly increased serum te...

journal_title：Frontiers in endocrinology

authors： Chen L,Li X,Wang Y,Song T,Li H,Xie L,Li L,Chen X,Ma L,Chen Y,Lv Y,Li X,Ge RS

更新日期：2019-03-08 00:00:00

abstract：:Kisspeptin, a novel neuropeptide product of the Kiss1 gene, activates the G protein-coupled membrane receptor G protein-coupled receptor 54 (now termed Kiss1r). Over the last 15 years, the importance of the kisspeptin system has been the subject of much debate in the mammalian research field. At the heart of the debat...

journal_title：Frontiers in endocrinology

authors： Ohga H,Selvaraj S,Matsuyama M

更新日期：2018-04-04 00:00:00

abstract：:SIRT7 is one of seven mammalian sirtuins that functions as an NAD+-dependent histone/protein deacetylase. SIRT7 is the least well-known member of the sirtuin family, but recent efforts have identified its involvement in various cellular processes, such as ribosome biogenesis, gene expression, cellular metabolism and c...

journal_title：Frontiers in endocrinology

authors： Wu D,Li Y,Zhu KS,Wang H,Zhu WG

更新日期：2018-11-19 00:00:00