Oxytocin reverses osteoporosis in a sex-dependent manner.

abstract：:Aberrant activation of Wnt signaling is involved in the development of several epithelial tumors. Wnt signaling includes two major types of pathways: (i) the canonical or Wnt/β-catenin pathway; and (ii) the non-canonical pathways, which do not involve β-catenin stabilization. Among these pathways, the Wnt/β-catenin pa...

journal_title：Frontiers in endocrinology

authors： Sastre-Perona A,Santisteban P

更新日期：2012-02-29 00:00:00

abstract：:Sleep duration has become increasingly recognized as an important influencer of health. Epidemiologic and observational studies have shown associations between short sleep duration and increased risk for chronic cardiometabolic disorders, including obesity, type 2 diabetes, and cardiovascular disease. These associatio...

journal_title：Frontiers in endocrinology

authors： Pizinger TM,Aggarwal B,St-Onge MP

更新日期：2018-07-18 00:00:00

abstract：:Licorice has been used as a medicinal plant from 2.500 years. It shows a wide range of biological and pharmacological activities, including anti-inflammatory and immune regulatory actions. One of its most known effects is the induction of hypertension, and it can induce what appears to be pseudohyperaldosteronism, due...

journal_title：Frontiers in endocrinology

authors： Sabbadin C,Bordin L,Donà G,Manso J,Avruscio G,Armanini D

更新日期：2019-07-18 00:00:00

abstract：:The mammalian genome contains four genes encoding GABA transporters (GAT1, slc6a1; GAT2, slc6a13; GAT3, slc6a11; BGT1, slc6a12) and five glutamate transporter genes (EAAT1, slc1a3; EAAT2, slc1a2; EAAT3, slc1a1; EAAT4, slc1a6; EAAT5, slc1a7). These transporters keep the extracellular levels of GABA and excitatory amino...

journal_title：Frontiers in endocrinology

authors： Zhou Y,Danbolt NC

更新日期：2013-11-11 00:00:00

abstract：:This brief review describes some representative methodological approaches to the isolation of putative endogenous inhibitors of epithelial sodium transport - i.e., as ouabain-like factors (OLF) that inhibit the sodium transport enzyme Na-K-ATPase or inhibit the epithelial sodium channel (ENaC). Gel chromatography and ...

journal_title：Frontiers in endocrinology

authors： Kramer HJ

更新日期：2015-05-20 00:00:00

abstract：Background:The association between normal range thyroid function and offspring birth weight has been postulated, but evidence from observational studies is prone to be confounded. We conducted a two-sample Mendelian randomization (MR) study to explore the causal effects of maternal thyroid stimulating hormone (TSH) and...

journal_title：Frontiers in endocrinology

authors： Zhang X,Wu P,Chen Y,Zhang W,Xia K,Hu H,Zhou P

更新日期：2020-11-12 00:00:00

abstract：:To investigate the expression of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) in the aorta of subclinical hypothyroidism (SCH) rat model. The mechanisms underlying thyrotropin (TSH) affecting eNOS and PGRN expression in human umbilical vein endothelial cells (HUVECs) cultured in vitro were investigat...

journal_title：Frontiers in endocrinology

authors： Jiang F,Wang H,Bao S,Zhou H,Zhang Y,Yan Y,Lai Y,Teng W,Shan Z

更新日期：2018-07-05 00:00:00

abstract：:The past two decades have witnessed many advances in the prevention, treatment, and control of diabetes mellitus (DM) and its complications. Increased screening has led to a greater recognition of type 2 diabetes mellitus (type 2 DM) and prediabetes; however, Hispanics/Latinos, the largest minority group in the US, ha...

journal_title：Frontiers in endocrinology

authors： Avilés-Santa ML,Colón-Ramos U,Lindberg NM,Mattei J,Pasquel FJ,Pérez CM

更新日期：2017-11-10 00:00:00

abstract：Objective:To evaluate whether endometrial thickness (EMT) change in response to progesterone has an effect on pregnancy outcomes in frozen-thawed embryo transfer (FET) cycles. Design:Retrospective observational study. Setting:Tertiary-care academic medical center. Participants:4465 infertile women undergoing their f...

journal_title：Frontiers in endocrinology

authors： Ye J,Zhang J,Gao H,Zhu Y,Wang Y,Cai R,Kuang Y

更新日期：2020-10-29 00:00:00

abstract：:Multiple Endocrine Neoplasia type 1 (MEN1) is a rare autosomal dominant inherited condition, causing significant morbidity, and a reduction of life expectancy. A timely and accurate diagnosis of MEN1 is paramount to improve disease outcomes. This enables early identification of tumor manifestations allowing timely tre...

journal_title：Frontiers in endocrinology

authors： de Laat JM,van Leeuwaarde RS,Valk GD

更新日期：2018-09-11 00:00:00

abstract：:Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is a rare cause of Cushing syndrome. If routine imaging examinations cannot identify the source of ACTH production, long-term follow-up observation is necessary to determine the etiology. We present the case of a middle-aged male with gradual weight gain and a ...

journal_title：Frontiers in endocrinology

authors： Lu L,Meng Q,Xing X,Yuan T,Zhang H,Li N,Wang Y,Cheng Y,Bai C,Wang H,Cheng X,Xiao Y,Pan B,Li Y,Sun J,Liang Z,Zhu H,Wang R,Lu Z

更新日期：2019-10-22 00:00:00

abstract：:Congenital hyperinsulinism (CHI) is a heterogenous and complex disorder in which the unregulated insulin secretion from pancreatic beta-cells leads to hyperinsulinaemic hypoglycaemia. The severity of hypoglycaemia varies depending on the underlying molecular mechanism and genetic defects. The genetic and molecular cau...

journal_title：Frontiers in endocrinology

authors： Galcheva S,Demirbilek H,Al-Khawaga S,Hussain K

更新日期：2019-02-26 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fendo.2018.00031.]. ...

journal_title：Frontiers in endocrinology

authors： Beattie J,Al-Khafaji H,Noer PR,Alkharobi HE,Alhodhodi A,Meade J,El-Gendy R,Oxvig C

更新日期：2018-09-04 00:00:00

abstract：:Background: The health benefits of soy are widely reported but there are queries on the effect of soy isoflavones on thyroid function and the underlying mechanism of action. Materials and Methods: We examined the effect of soy isoflavones on reverse tri-iodothyronine (or 3,3',5'-tri-iodothyronine; rT3) in two studies ...

journal_title：Frontiers in endocrinology

authors： Sathyapalan T,Köhrle J,Rijntjes E,Rigby AS,Dargham SR,Kilpatrick ES,Atkin SL

更新日期：2018-11-22 00:00:00

abstract：Objective:To analyze association between different perioperative glycemic control strategies and postoperative outcomes in patients with diabetes undergoing cardiac surgery. Methods:MEDLINE, Cochrane Library, Web of Science, EMBASE, Wanfang Data, China National Knowledge Infrastructure (CNKI) and China Biology Medicin...

journal_title：Frontiers in endocrinology

authors： Jin X,Wang J,Ma Y,Li X,An P,Wang J,Mao W,Mu Y,Chen Y,Chen K

更新日期：2020-12-17 00:00:00

abstract：:Pulmonary fibrosis is a hallmark of diseases such as systemic sclerosis (SSc, scleroderma) and idiopathic pulmonary fibrosis (IPF). To date, the therapeutic options for patients with pulmonary fibrosis are limited, and organ transplantation remains the most effective option. Insulin-like growth factor-binding protein ...

journal_title：Frontiers in endocrinology

authors： Nguyen XX,Muhammad L,Nietert PJ,Feghali-Bostwick C

更新日期：2018-10-15 00:00:00

abstract：:Background: The long noncoding RNA (lncRNA) functions as a regulator of initiation, progression, and metastasis of thyroid carcinomas. lncRNA OTUD6B antisense RNA 1 (OTUD6B-AS1) is a tumor-suppressive noncoding RNA in clear cell renal cell carcinoma. The role of OTUD6B-AS1 in thyroid carcinomas has not been reported y...

journal_title：Frontiers in endocrinology

authors： Wang Z,Xia F,Feng T,Jiang B,Wang W,Li X

更新日期：2020-03-17 00:00:00

abstract：:Dopamine (DA) has a vital role in the central nervous system and also modulates lipid and glucose metabolism. The present study aimed to investigate the effect of dopamine on insulin secretion and the underlying mechanisms in rat pancreatic β-cells. Data from the radioimmunoassay indicated that dopamine inhibited insu...

journal_title：Frontiers in endocrinology

authors： Liu M,Ren L,Zhong X,Ding Y,Liu T,Liu Z,Yang X,Cui L,Yang L,Fan Y,Liu Y,Zhang Y

更新日期：2020-04-07 00:00:00

abstract：:Endocannabinoids control male reproduction acting at central and local level via cannabinoid receptors. The cannabinoid receptor CB1 has been characterized in the testis, in somatic and germ cells of mammalian and non-mammalian animal models, and its activity related to Leydig cell differentiation, steroidogenesis, sp...

journal_title：Frontiers in endocrinology

authors： Cobellis G,Meccariello R,Chianese R,Chioccarelli T,Fasano S,Pierantoni R

更新日期：2016-06-03 00:00:00

abstract：:Parathyroid (PTH) exploration surgery carries the risk of developing post-operative thyroiditis due to vigorous manual manipulation of the thyroid gland during surgery. Post-operative thyroiditis has a wide spectrum of clinical manifestations. However, it remains underreported. Here, we describe a case of post-operati...

journal_title：Frontiers in endocrinology

authors： Hakami YA

更新日期：2015-08-18 00:00:00

abstract：Background:For detecting tumor recurrence of medullary thyroid carcinoma (MTC) in the neck, an appropriate frequency and interval of postoperative ultrasonography (US) surveillance remains unclear. This study aimed to assess an appropriate interval and frequency of postoperative neck US surveillance for detecting tumor...

journal_title：Frontiers in endocrinology

authors： Ahn HS,Kim DW,Lee YJ,Lee CY,Kim JH,Choi YJ,Lee S,Ryoo I,Huh JY,Sung JY,Kwak JY,Baek HJ

更新日期：2018-03-15 00:00:00

abstract：Background:Vandetanib is the most largely used tyrosine kinase inhibitor (TKI) in patients with locally advanced and/or metastatic medullary thyroid cancer (MTC). Here, we conducted a systematic review on its efficacy and attempted to perform a meta-analysis adopting standardized RECIST criteria as end-points. Methods...

journal_title：Frontiers in endocrinology

authors： Trimboli P,Castellana M,Virili C,Giorgino F,Giovanella L

更新日期：2018-05-03 00:00:00

abstract：:Hypertrehalosemic hormone (HTH) is a peptide hormone that belongs to the adipokinetic hormone/red pigment concentrating hormone (AKH/RPCH) family, which exerts pleiotropic actions related to catabolic reaction and stress response. AKH peptides have been demonstrated to participate in stress response including oxidativ...

journal_title：Frontiers in endocrinology

authors： Huang JH,Bellés X,Lee HJ

更新日期：2012-01-09 00:00:00

abstract：:Background: Non-alcoholic fatty liver disease (NAFLD) is a well-known cause of liver dysfunction and has become a common chronic liver disease in many countries. However, the intrinsic molecular mechanisms underlying the pathogenesis of NAFLD have not yet been fully elucidated. Methods: We obtained the gene expression...

journal_title：Frontiers in endocrinology

authors： Jia X,Zhai T

更新日期：2019-08-30 00:00:00

abstract：:Osteocytes are the most abundant (~95%) cells in bone with the longest half-life (~25 years) in humans. In the past osteocytes have been regarded as vestigial cells in bone, since they are buried inside the tough bone matrix. However, during the last 30 years it has become clear that osteocytes are as important as bon...

journal_title：Frontiers in endocrinology

authors： Pathak JL,Bravenboer N,Klein-Nulend J

更新日期：2020-07-08 00:00:00

abstract：:Accumulating evidence shows that H2S has physiological functions in various tissues and organs. It includes regulation of neuronal activity, vascular tension, a release of insulin, and protection of the heart, kidney, and brain from ischemic insult. H2S is produced by enzymes from l-cysteine; cystathionine β-synthase,...

journal_title：Frontiers in endocrinology

authors： Shibuya N,Kimura H

更新日期：2013-07-16 00:00:00

abstract：:Objective: Quantitative investigations of facial changes in acromegaly are rare. A new imaging technique, three-dimensional (3D) stereophotography, can accurately quantify whole facial changes. We aimed to measure facial characteristics in acromegaly patients using 3D stereophotography, analyze gender-specific feature...

journal_title：Frontiers in endocrinology

authors： Guo X,Meng T,Huang J,Wang X,Lian W,Deng K,Gao L,Wang Z,Xing B,Long X

更新日期：2018-11-29 00:00:00

abstract：:Lifestyle modifications focused on diet, physical activity, and behavior have a modest impact on weight reduction in children, adolescents, and young adults (YA) with overweight and obesity. Several anti-obesity medications (AOMs) have been approved by the Food and Drug Administration (FDA) for use among adult patient...

journal_title：Frontiers in endocrinology

authors： Czepiel KS,Perez NP,Campoverde Reyes KJ,Sabharwal S,Stanford FC

更新日期：2020-05-13 00:00:00

abstract：:A substantial body of evidence supports that the gut microbiota plays a pivotal role in the regulation of metabolic, endocrine and immune functions. In recent years, there has been growing recognition of the involvement of the gut microbiota in the modulation of multiple neurochemical pathways through the highly inter...

journal_title：Frontiers in endocrinology

authors： Silva YP,Bernardi A,Frozza RL

更新日期：2020-01-31 00:00:00

abstract：:Growth hormone deficiency (GHD) results in an impaired health-related quality of life (HrQoL) and cognitive impairment in the attention and memory domain. GHD is assumed to be a frequent finding after brain injury due to traumatic brain injury (TBI), aneurysmal subarachnoid hemorrhage (SAH) or ischemic stroke. Hence, ...

journal_title：Frontiers in endocrinology

authors： Leonhardt M,Kopczak A,Schäpers B,Limbrock J,Sämann PG,Czisch M,von Steinbuechel N,Jordan M,Schneider HJ,Schneider M,Sievers C,Stalla GK

更新日期：2018-12-17 00:00:00