Effects of Neuroendocrine CB1 Activity on Adult Leydig Cells.

Abstract:

:Endocannabinoids control male reproduction acting at central and local level via cannabinoid receptors. The cannabinoid receptor CB1 has been characterized in the testis, in somatic and germ cells of mammalian and non-mammalian animal models, and its activity related to Leydig cell differentiation, steroidogenesis, spermiogenesis, sperm quality, and maturation. In this short review, we provide a summary of the insights concerning neuroendocrine CB1 activity in male reproduction focusing on adult Leydig cell ontogenesis and steroid biosynthesis.

authors

Cobellis G,Meccariello R,Chianese R,Chioccarelli T,Fasano S,Pierantoni R

doi

10.3389/fendo.2016.00047

subject

Has Abstract

pub_date

2016-06-03 00:00:00

pages

47

issn

1664-2392

journal_volume

7

pub_type

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