Efficacy of Vandetanib in Treating Locally Advanced or Metastatic Medullary Thyroid Carcinoma According to RECIST Criteria: A Systematic Review and Meta-Analysis.

abstract：:Background: Insulin resistance (IR) is the hallmark of PCOS and it is known that exercise may decrease it. What is unknown is whether exercise may mechanistically alter the underlying IR, attenuating the dynamic lipid induced IR in insulin resistant subjects. Methods: 12 women with polycystic ovary syndrome (PCOS) and...

journal_title：Frontiers in endocrinology

authors： Aye MM,Butler AE,Kilpatrick ES,Kirk R,Vince R,Rigby AS,Sandeman D,Atkin SL

更新日期：2018-10-05 00:00:00

abstract：:Animal models are essential tools for addressing fundamental scientific questions about skeletal diseases and for the development of new therapeutic approaches. Traditionally, mice have been the most common model organism in biomedical research, but their use is hampered by several limitations including complex genera...

journal_title：Frontiers in endocrinology

authors： Tonelli F,Bek JW,Besio R,De Clercq A,Leoni L,Salmon P,Coucke PJ,Willaert A,Forlino A

更新日期：2020-07-31 00:00:00

abstract：:The post-translational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) is regulated by a unique couple of enzymes. O-GlcNAc transferase (OGT) transfers the GlcNAc residue from UDP-GlcNAc, the final product of the hexosamine biosynthetic pathway (HBP), whereas O-GlcNAcase (OGA) removes it. This st...

journal_title：Frontiers in endocrinology

authors： Steenackers A,Olivier-Van Stichelen S,Baldini SF,Dehennaut V,Toillon RA,Le Bourhis X,El Yazidi-Belkoura I,Lefebvre T

更新日期：2016-05-25 00:00:00

abstract：:Classically, the modulation of brain function and behavior by steroid hormones was linked exclusively to secretion by peripheral endocrine glands. Subsequently, steroid actions within the brain were shown dependent upon either synthesis and secretion by peripheral organs or by production within the CNS itself using pe...

journal_title：Frontiers in endocrinology

authors： Remage-Healey L,Saldanha CJ,Schlinger BA

更新日期：2011-09-29 00:00:00

abstract：:Pregnancy-associated plasma protein-A (PAPP-A) and its homolog PAPP-A2 are enzymes that modulate the availability and mitogenic activity of insulin-like growth factor-I (IGF-I). PAPP-A has been implicated in numerous cancers but reports on PAPP-A2 in malignancy are non-existent. In a prospective observational study of...

journal_title：Frontiers in endocrinology

authors： Hjortebjerg R,Espelund U,Rasmussen TR,Folkersen B,Steiniche T,Georgsen JB,Oxvig C,Frystyk J

更新日期：2020-09-02 00:00:00

abstract：:Giant pandas represent one of the most endangered species worldwide, and their reproductive capacity is extremely low. They have a relatively long gestational period, mainly because embryo implantation is delayed. Giant panda cubs comprise only a small proportion of the mother's body weight, making it difficult to det...

journal_title：Frontiers in endocrinology

authors： Cao M,Li C,Liu Y,Cai K,Chen L,Yuan C,Zhao Z,Zhang B,Hou R,Zhou X

更新日期：2020-04-16 00:00:00

abstract：Objective:To analyze association between different perioperative glycemic control strategies and postoperative outcomes in patients with diabetes undergoing cardiac surgery. Methods:MEDLINE, Cochrane Library, Web of Science, EMBASE, Wanfang Data, China National Knowledge Infrastructure (CNKI) and China Biology Medicin...

journal_title：Frontiers in endocrinology

authors： Jin X,Wang J,Ma Y,Li X,An P,Wang J,Mao W,Mu Y,Chen Y,Chen K

更新日期：2020-12-17 00:00:00

abstract：:Prostate cancer (PCa) is the major cause of cancer-related death among the male population of Western society, and androgen-deprivation therapy (ADT) represents the first line in PCa treatment. However, although androgen receptor (AR) expression is maintained throughout the various stages of PCa, ADT frequently fails....

journal_title：Frontiers in endocrinology

authors： Di Donato M,Giovannelli P,Cernera G,Di Santi A,Marino I,Bilancio A,Galasso G,Auricchio F,Migliaccio A,Castoria G

更新日期：2015-01-19 00:00:00

abstract：:The mammalian genome contains four genes encoding GABA transporters (GAT1, slc6a1; GAT2, slc6a13; GAT3, slc6a11; BGT1, slc6a12) and five glutamate transporter genes (EAAT1, slc1a3; EAAT2, slc1a2; EAAT3, slc1a1; EAAT4, slc1a6; EAAT5, slc1a7). These transporters keep the extracellular levels of GABA and excitatory amino...

journal_title：Frontiers in endocrinology

authors： Zhou Y,Danbolt NC

更新日期：2013-11-11 00:00:00

abstract：:Background: About 85-90% of children born small for gestational age (SGA) experience a catch-up growth that occurs mostly during the first year of life and results in a full stature recovery by the age of 2. Objective: To investigate the relation between bone maturation (BM) and catch-up growth during the first year o...

journal_title：Frontiers in endocrinology

authors： Pepe G,Calafiore M,Valenzise M,Corica D,Morabito L,Pajno GB,Aversa T,Wasniewska M

更新日期：2020-03-24 00:00:00

abstract：:This review focuses on the biologic importance of the vitamin D binding protein (DBP) with emphasis on its regulation of total and free vitamin D metabolite levels in various clinical conditions. Nearly all DBP is produced in the liver, where its regulation is influenced by estrogen, glucocorticoids and inflammatory c...

journal_title：Frontiers in endocrinology

authors： Bikle DD,Schwartz J

更新日期：2019-05-28 00:00:00

abstract：:RET gene rearrangements (RET/PTCs) represent together with BRAF point mutations the two major groups of mutations involved in papillary thyroid carcinoma (PTC) initiation and progression. In this review, we will examine the mechanisms involved in RET/PTC-induced thyroid cell transformation. In detail, we will summariz...

journal_title：Frontiers in endocrinology

authors： Menicali E,Moretti S,Voce P,Romagnoli S,Avenia N,Puxeddu E

更新日期：2012-05-22 00:00:00

abstract：:The estrogen receptor and glucocorticoid receptor are members of the nuclear receptor superfamily that can signal using both non-genomic and genomic transcriptional modes. Though genomic modes of signaling have been well characterized and several behaviors attributed to this signaling mechanism, the physiological sign...

journal_title：Frontiers in endocrinology

authors： Rainville J,Pollard K,Vasudevan N

更新日期：2015-02-16 00:00:00

abstract：:Graves' disease (GD) is an organ-specific autoimmune disease, and thyrotropin (TSH) receptor (TSHR) is a major autoantigen in this condition. Since the extracellular domain of human TSHR (TSHR-ECD) is shed into the circulation, TSHR-ECD is a preferentially immunogenic portion of TSHR. Both genetic factors and environm...

journal_title：Frontiers in endocrinology

authors： Inaba H,De Groot LJ,Akamizu T

更新日期：2016-08-23 00:00:00

abstract：:To investigate the expression of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) in the aorta of subclinical hypothyroidism (SCH) rat model. The mechanisms underlying thyrotropin (TSH) affecting eNOS and PGRN expression in human umbilical vein endothelial cells (HUVECs) cultured in vitro were investigat...

journal_title：Frontiers in endocrinology

authors： Jiang F,Wang H,Bao S,Zhou H,Zhang Y,Yan Y,Lai Y,Teng W,Shan Z

更新日期：2018-07-05 00:00:00

abstract：:Despite the long-held belief that growth hormone supplementation provides psychosocial benefits to patients with Turner syndrome (TS), this assumption has never been rigorously tested in a randomized control trial. As a sub-study of the Canadian growth-hormone trial, parent-, and patient-completed standardized questio...

journal_title：Frontiers in endocrinology

authors： Rovet JF,Van Vliet G

更新日期：2019-03-13 00:00:00

abstract：Objective:Two missense mutations in KCNQ1, an imprinted gene that encodes the alpha subunit of the voltage-gated potassium channel Kv7.1, cause autosomal dominant growth hormone deficiency and maternally inherited gingival fibromatosis. We evaluated endocrine features, birth size, and subsequent somatic growth of patie...

journal_title：Frontiers in endocrinology

authors： Huttunen H,Hero M,Lääperi M,Känsäkoski J,Swan H,Hirsch JA,Miettinen PJ,Raivio T

更新日期：2018-04-24 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is the commonest endocrine abnormality in women of reproductive age typically presenting with chronic oligo- or anovulation, clinical, or biochemical hyperandrogenism and polycystic ovarian morphology (PCOM). Restoring mono-ovulation is the ultimate goal of ovulation induction and most...

journal_title：Frontiers in endocrinology

authors： Laven JSE

更新日期：2019-02-12 00:00:00

abstract：:Context: The DICER1 syndrome is a multiple neoplasia disorder caused by germline mutations in the DICER1 gene. In DICER1 patients, aggressive congenital pituitary tumors lead to neonatal Cushing's disease (CD). The role of DICER1 in other corticotropinomas, however, remains unknown. Objective: To perform a comprehensi...

journal_title：Frontiers in endocrinology

authors： Martínez de LaPiscina I,Hernández-Ramírez LC,Portillo N,Gómez-Gila AL,Urrutia I,Martínez-Salazar R,García-Castaño A,Aguayo A,Rica I,Gaztambide S,Faucz FR,Keil MF,Lodish MB,Quezado M,Pankratz N,Chittiboina P,Lane J,Kay D

更新日期：2020-07-03 00:00:00

abstract：:Atherosclerosis results from endothelial cell dysfunction and inflammatory processes affecting both macro- and microvasculature which are involved in vascular diabetic complications. Glucagon-like peptide-1 (GLP-1) is an incretin hormone responsible for amplification of insulin secretion when nutrients are given orall...

journal_title：Frontiers in endocrinology

authors： Alonso N,Julián MT,Puig-Domingo M,Vives-Pi M

更新日期：2012-09-07 00:00:00

abstract：:Background: Intracystic hemorrhage can present occasionally during ultrasound-guided percutaneous microwave ablation (PMWA) for cystic thyroid nodules. It can affect treatment outcome, can lead to ablation failure, and even conversion to open surgery. We aim to avoid such cases in the future by exploring their causes ...

journal_title：Frontiers in endocrinology

authors： Dong S,Sun L,Xu J,Han Z,Liu J

更新日期：2020-09-08 00:00:00

abstract：:The rapid increase of obesity rates worldwide is associated with chronic liver injury due to non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Chronic liver inflammation drives hepatic fibrosis, which is a highly conserved and coordinated protective response to tissue injury, and is a reversible pro...

journal_title：Frontiers in endocrinology

authors： Cho EH

更新日期：2018-08-21 00:00:00

abstract：:Human primordial germ cells (PGCs) have been described in the yolk sac wall around the beginning of the third week. From week 4 to 5, they migrate under control of SCF/c-KIT signaling pathway to the genital ridge, where they become gonocytes. PGCs and gonocytes express classic pluripotency markers, such as KIT, NANOG,...

journal_title：Frontiers in endocrinology

authors： Baroni T,Arato I,Mancuso F,Calafiore R,Luca G

更新日期：2019-06-06 00:00:00

abstract：Objective:Both vitamin D and K2 are involved in a number of metabolic processes, including bone metabolism; however, associations between the vitamins are not fully understood. The aim of the study was to evaluate serum concentrations of 25-hydroxyvitamin D [25(OH)D] in adult patients receiving long-term acenocoumarol ...

journal_title：Frontiers in endocrinology

authors： Sawicka-Powierza J,Konstantynowicz J,Jablonska E,Zelazowska-Rutkowska B,Jelski W,Abramowicz P,Sasinowski C,Chlabicz S

更新日期：2018-05-04 00:00:00

abstract：:Over the last decades, thyroid hormone metabolites (THMs) received marked attention as it has been demonstrated that they are bioactive compounds. Their concentrations were determined by immunoassay or mass-spectrometry methods. Among those metabolites, 3,5-diiodothyronine (3,5-T2), occurs at low nanomolar concentrati...

journal_title：Frontiers in endocrinology

authors： Köhrle J,Lehmphul I,Pietzner M,Renko K,Rijntjes E,Richards K,Anselmo J,Danielsen M,Jonklaas J

更新日期：2020-01-08 00:00:00

abstract：BACKGROUND:Monitoring blood levels of human growth hormone (hGH) in most children with short stature deficiencies is crucial for taking a decision of treatment with extended course of daily and expensive doses of recombinant hGH (rhGH or Somatropin®). Besides, misusing of rhGH by sportsmen is banned by the World Anti-D...

journal_title：Frontiers in endocrinology

authors： Murad H,Assaad JM,Al-Shemali R,Abbady AQ

更新日期：2017-05-30 00:00:00

abstract：:[This corrects the article on p. 162 in vol. 6, PMID: 26528241.]. ...

journal_title：Frontiers in endocrinology

authors： Frontiers Production Office.

更新日期：2015-11-16 00:00:00

abstract：Introduction:The oxidative stress associated with glucose variability might be responsible for neuronal damage while autonomic neuropathy (AN) has a detrimental effect on metabolism. The aim of the study was to find relationship between AN and GV in type 1 diabetic patients and to identify further factors that affect G...

journal_title：Frontiers in endocrinology

authors： Nyiraty S,Pesei F,Orosz A,Coluzzi S,Vági OE,Lengyel C,Ábrahám G,Frontoni S,Kempler P,Várkonyi T

更新日期：2018-04-19 00:00:00

abstract：:Vertebrate eyes are known to contain circadian clocks, but their regulatory mechanisms remain largely unknown. To address this, we used a cell line from human retinal pigment epithelium (hRPE-YC) with stable coexpression of reporters for molecular clock oscillations (Bmal1-luciferase) and intracellular Ca2+ concentrat...

journal_title：Frontiers in endocrinology

authors： Morioka E,Kanda Y,Koizumi H,Miyamoto T,Ikeda M

更新日期：2018-03-19 00:00:00

abstract：:RFamide-related peptide-3 (RFRP-3) [mammalian ortholog to gonadotropin-inhibiting hormone (GnIH)] potently inhibits gonadotropin secretion in mammals. Studies of RFRP-3 immunoreactivity and Rfrp expression (the gene encoding RFRP-3) in mammalian brains have uncovered several possible pathways regulating RFRP-3 neurons...

journal_title：Frontiers in endocrinology

authors： Poling MC,Kauffman AS

更新日期：2015-09-24 00:00:00