Follicle Stimulating Hormone Receptor (FSHR) Polymorphisms and Polycystic Ovary Syndrome (PCOS).


:Polycystic ovary syndrome (PCOS) is the commonest endocrine abnormality in women of reproductive age typically presenting with chronic oligo- or anovulation, clinical, or biochemical hyperandrogenism and polycystic ovarian morphology (PCOM). Restoring mono-ovulation is the ultimate goal of ovulation induction and most women do respond to ovulation inducing agents causing their Follicle-stimulating hormone (FSH) levels to rise. Familial clustering and the results from twin studies strongly support an underlying genetic basis for PCOS. Recent Genome wide association studies (GWAS) have identified several genetic variants being genome wide significantly associated with PCOS. Amongst those are variants in or near the Luteinizing hormone (LH) and FSH receptor genes as well as a variant in the FSH-β gene. The aim of this review is to summarize the available evidence as to whether single nucleotide polymorphisms are able to modify the PCOS phenotype or whether they constitute a risk factor for the syndrome. Data on the role of FSHR polymorphisms in PCOS are conflicting. It seems that in large Chinese studies FSHR polymorphisms are not associated with either PCOS risk or with PCOS treatment outcome. However, in large scale studies in Caucasians these polymorphisms seem to influence the risk of having PCOS. Moreover, these studies also showed that some polymorphisms might affect some clinical features of PCOS as well as treatment outcome. Although most research has focussed on the role of FSHR polymorphisms there seems to be also some evidence showing that single nucleotide polymorphisms (SNPs) in the LHCG-Receptor as well as those in FSH-β gene might also alter the phenotype of PCOS. In conclusion most studies confirm that FSHR polymorphisms do alter the phenotype of PCOS in that they either alter the response to exogenous FSH or hat they increase the risk of having PCOS.


Laven JSE




Has Abstract


2019-02-12 00:00:00








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    abstract::Background: Chronic inflammatory disorders and dyslipidemia in type 2 diabetes mellitus (T2DM) are essential contributors to the development of atherosclerotic cardiovascular disease. Monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is a novel and simple measure associated positively with the body ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Chen JW,Li C,Liu ZH,Shen Y,Ding FH,Shu XY,Zhang RY,Shen WF,Lu L,Wang XQ

    更新日期:2019-04-04 00:00:00

  • Mechanisms linking excess adiposity and carcinogenesis promotion.

    abstract::Obesity constitutes one of the most important metabolic diseases being associated to insulin resistance development and increased cardiovascular risk. Association between obesity and cancer has also been well established for several tumor types, such as breast cancer in post-menopausal women, colorectal, and prostate ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Pérez-Hernández AI,Catalán V,Gómez-Ambrosi J,Rodríguez A,Frühbeck G

    更新日期:2014-05-01 00:00:00

  • People Are Taller in Countries With Better Environmental Conditions.

    abstract::Background: Height is considered an indicator of health and well-being of an individual and population. Height variation results from a complex interaction of genetic, environmental, socioeconomic, and cultural influences. In order to understand the contribution of environmental stress associated with the child's grow...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: German A,Mesch G,Hochberg Z

    更新日期:2020-03-11 00:00:00

  • Opportunistic QCT Bone Mineral Density Measurements Predicting Osteoporotic Fractures: A Use Case in a Prospective Clinical Cohort.

    abstract:Purpose:To assess whether volumetric vertebral bone mineral density (BMD) measured with opportunistic quantitative computed tomography (QCT) (i.e., CT acquired for other reasons) can predict osteoporotic fracture occurrence in a prospective clinical cohort and how this performs in comparison to dual-energy X-ray absorp...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Leonhardt Y,May P,Gordijenko O,Koeppen-Ursic VA,Brandhorst H,Zimmer C,Makowski MR,Baum T,Kirschke JS,Gersing AS,Seifert-Klauss V,Schwaiger BJ

    更新日期:2020-11-09 00:00:00

  • Oxytocin reverses osteoporosis in a sex-dependent manner.

    abstract::The increase of life expectancy has led to the increase of age-related diseases such as osteoporosis. Osteoporosis is characterized by bone weakening promoting the occurrence of fractures with defective bone regeneration. Men aged over 50 have a prevalence for osteoporosis of 20%, which is related to a decline in sex ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Beranger GE,Djedaini M,Battaglia S,Roux CH,Scheideler M,Heymann D,Amri EZ,Pisani DF

    更新日期:2015-05-19 00:00:00

  • CCL2/Monocyte Chemoattractant Protein 1 and Parathyroid Hormone Action on Bone.

    abstract::Chemokines are small molecules that play a crucial role as chemoattractants for several cell types, and their components are associated with host immune responses and repair mechanisms. Chemokines selectively recruit monocytes, neutrophils, and lymphocytes and induce chemotaxis through the activation of G protein-coup...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Siddiqui JA,Partridge NC

    更新日期:2017-03-29 00:00:00

  • Association Between Perioperative Glycemic Control Strategy and Mortality in Patients With Diabetes Undergoing Cardiac Surgery: A Systematic Review and Meta-Analysis.

    abstract:Objective:To analyze association between different perioperative glycemic control strategies and postoperative outcomes in patients with diabetes undergoing cardiac surgery. Methods:MEDLINE, Cochrane Library, Web of Science, EMBASE, Wanfang Data, China National Knowledge Infrastructure (CNKI) and China Biology Medicin...

    journal_title:Frontiers in endocrinology



    authors: Jin X,Wang J,Ma Y,Li X,An P,Wang J,Mao W,Mu Y,Chen Y,Chen K

    更新日期:2020-12-17 00:00:00

  • What Is the Best Regimen for Ovarian Stimulation of Poor Responders in ART/IVF?

    abstract::The infertile patients with aging ovaries-also sometimes referred to as impending premature ovarian insufficiency (POI), impending premature ovarian failure (POF), or poor ovarian responders (POR), constitute a significant and increasing bulk of the patients appealing to IVF/ART. Different causes have been cited in th...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Blumenfeld Z

    更新日期:2020-04-17 00:00:00

  • The Potential Role of Platelet-Related microRNAs in the Development of Cardiovascular Events in High-Risk Populations, Including Diabetic Patients: A Review.

    abstract::Platelet activation plays a pivotal role in the development and progression of atherosclerosis, which often leads to potentially fatal ischemic events at later stages of the disease. Platelets and platelet microvesicles (PMVs) contain large amounts of microRNA (miRNA), which contributes largely to the pool of circulat...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Pordzik J,Pisarz K,De Rosa S,Jones AD,Eyileten C,Indolfi C,Malek L,Postula M

    更新日期:2018-03-20 00:00:00

  • Cardiovascular Autonomic Neuropathy and Glucose Variability in Patients With Type 1 Diabetes: Is There an Association?

    abstract:Introduction:The oxidative stress associated with glucose variability might be responsible for neuronal damage while autonomic neuropathy (AN) has a detrimental effect on metabolism. The aim of the study was to find relationship between AN and GV in type 1 diabetic patients and to identify further factors that affect G...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Nyiraty S,Pesei F,Orosz A,Coluzzi S,Vági OE,Lengyel C,Ábrahám G,Frontoni S,Kempler P,Várkonyi T

    更新日期:2018-04-19 00:00:00

  • Heat-Induced Limb Length Asymmetry Has Functional Impact on Weight Bearing in Mouse Hindlimbs.

    abstract::Limb length inequality results from many types of musculoskeletal disorders. Asymmetric weight bearing from a limb length discrepancy of less than 2% can have debilitating consequences such as back problems and early-onset osteoarthritis. Existing treatments include invasive surgeries and/or drug regimens that are oft...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Racine HL,Meadows CA,Ion G,Serrat MA

    更新日期:2018-06-04 00:00:00

  • Clinical Implications and Impact of Discovery of the Thyroid Hormone Receptor on Integrin αvβ3-A Review.

    abstract::Hypothyroidism has been reported to improve survival in cancer patients but only recently has the putative mechanism been identified as a receptor for thyroxine and tri-iodothyronine on integrin αvβ3. Recognition of divergence of action of the pro-oncogenic L-thyroxine (T4) from pro-metabolic 3,5,3'-triiodo-L-thyronin...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Hercbergs A

    更新日期:2019-08-23 00:00:00

  • Pharmacotherapy for the Treatment of Overweight and Obesity in Children, Adolescents, and Young Adults in a Large Health System in the US.

    abstract::Lifestyle modifications focused on diet, physical activity, and behavior have a modest impact on weight reduction in children, adolescents, and young adults (YA) with overweight and obesity. Several anti-obesity medications (AOMs) have been approved by the Food and Drug Administration (FDA) for use among adult patient...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Czepiel KS,Perez NP,Campoverde Reyes KJ,Sabharwal S,Stanford FC

    更新日期:2020-05-13 00:00:00

  • FSHR Trans-Activation and Oligomerization.

    abstract::Follicle stimulating hormone (FSH) plays a key role in human reproduction through, among others, induction of spermatogenesis in men and production of estrogen in women. The function FSH is performed upon binding to its cognate receptor-follicle-stimulating hormone receptor (FSHR) expressed on the surface of target ce...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Szymańska K,Kałafut J,Przybyszewska A,Paziewska B,Adamczuk G,Kiełbus M,Rivero-Müller A

    更新日期:2018-12-13 00:00:00

  • Cancer Stem Cells and Neuroblastoma: Characteristics and Therapeutic Targeting Options.

    abstract::The majority of embryonal tumors or childhood blastomas derive from pluripotent progenitors or fetal stem cells that acquire cancer stem cell (CSC) properties: multipotency, self-renewal ability, metastatic potential, chemoresistance, more pronounced levels of drug transporters, enhanced DNA-damage repair mechanisms, ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Veschi V,Verona F,Thiele CJ

    更新日期:2019-11-19 00:00:00

  • Behavioral Abnormalities in Knockout and Humanized Tau Mice.

    abstract::Microtubule-associated protein tau assists in stabilizing microtubules and has been particularly implicated in Alzheimer's disease (AD). Given the importance of tau to AD pathogenesis and therapies, it is important to understand non-classic physiological functions for this protein inside and outside the central nervou...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Gonçalves RA,Wijesekara N,Fraser PE,De Felice FG

    更新日期:2020-03-12 00:00:00

  • Vitiligo and Autoimmune Thyroid Disorders.

    abstract::Vitiligo represents the most common cause of acquired skin, hair, and oral depigmentation, affecting 0.5-1% of the population worldwide. It is clinically characterized by the appearance of disfiguring circumscribed skin macules following melanocyte destruction by autoreactive cytotoxic T lymphocytes. Patients affected...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Baldini E,Odorisio T,Sorrenti S,Catania A,Tartaglia F,Carbotta G,Pironi D,Rendina R,D'Armiento E,Persechino S,Ulisse S

    更新日期:2017-10-27 00:00:00

  • Three Therapeutic Strategies: Cinacalcet, Paricalcitol or Both in Secondary Hyperparathyroidism Treatment in Hemodialysed Patients During 1-Year Observational Study-A Comparison.

    abstract::Introduction: Secondary hyperparathyroidism (sHPT) is a common hormonal complication of chronic kidney disease. There are several therapeutic options for sHPT management aiming at calcium-phosphorus balance normalization and decrease of parathormone secretion. Objectives: The aim of this retrospective, observational s...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Zawierucha J,Malyszko J,Malyszko JS,Prystacki T,Marcinkowski WP,Dryl-Rydzynska T

    更新日期:2019-02-05 00:00:00

  • D2-Like Receptors Mediate Dopamine-Inhibited Insulin Secretion via Ion Channels in Rat Pancreatic β-Cells.

    abstract::Dopamine (DA) has a vital role in the central nervous system and also modulates lipid and glucose metabolism. The present study aimed to investigate the effect of dopamine on insulin secretion and the underlying mechanisms in rat pancreatic β-cells. Data from the radioimmunoassay indicated that dopamine inhibited insu...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Liu M,Ren L,Zhong X,Ding Y,Liu T,Liu Z,Yang X,Cui L,Yang L,Fan Y,Liu Y,Zhang Y

    更新日期:2020-04-07 00:00:00

  • Differentiated Thyroid Carcinoma in Pediatric Age: Genetic and Clinical Scenario.

    abstract::Introduction: Follicular-derived differentiated thyroid carcinoma (DTC) is the most common endocrine and epithelial malignancy in children. The differences in the clinical and pathological features of pediatric vs. adult DTC could relate to a different genetic profile. Few studies are currently available in this issue...

    journal_title:Frontiers in endocrinology

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    authors: Galuppini F,Vianello F,Censi S,Barollo S,Bertazza L,Carducci S,Colato C,Manso J,Rugge M,Iacobone M,Watutantrige Fernando S,Pennelli G,Mian C

    更新日期:2019-08-07 00:00:00

  • Coexistence of Myelolipoma and Primary Bilateral Macronodular Adrenal Hyperplasia With GIP-Dependent Cushing's Syndrome.

    abstract::Introduction: Adrenal myelolipomas are usually isolated benign adrenal lesions, but can be adjacent to steroid-secreting adrenocortical tumors. We studied the aberrant regulation of cortisol secretion in a 61 year-old woman with combined bilateral myelolipomas and primary bilateral macronodular adrenal hyperplasia (BM...

    journal_title:Frontiers in endocrinology



    authors: Larose S,Bondaz L,Mermejo LM,Latour M,Prosmanne O,Bourdeau I,Lacroix A

    更新日期:2019-09-11 00:00:00

  • Adiposity Criteria in Assessing Increased Cardiometabolic Risk in Prepubertal Children.

    abstract::Objective: Adiposity induces the clustering of cardiometabolic risk factors, and pediatric adiposity is a better indicator for adulthood cardiometabolic diseases than pediatric metabolic syndrome. However, the observed prevalence of pediatric adiposity depends on the methods and cut-points used. Therefore, we aimed to...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Tompuri TT,Jääskeläinen J,Lindi V,Laaksonen DE,Eloranta AM,Viitasalo A,Laitinen T,Lakka TA

    更新日期:2019-06-26 00:00:00

  • Therapeutic Irradiation: Consequences for Bone and Bone Marrow Adipose Tissue.

    abstract::Radiotherapy continues to be one of the most accepted medical treatments for cancer. Localized irradiation is the most common treatment for prostate, pancreatic, rectal, cervical and endometrial malignancies. Conventional localized fractions are total doses of 30-62Gy at 1.8-2Gy per fraction, with administration of ~6...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Costa S,Reagan MR

    更新日期:2019-08-29 00:00:00

  • Second Attempt of Cabergoline Withdrawal in Patients with Prolactinomas after a Failed First Attempt: Is it Worthwhile?

    abstract::Successful discontinuation of cabergoline (CAB) treatment has been reported in 31-75% of prolactinomas patients treated for at least 2 years. In contrast, it is not well established whether CAB therapy can be successfully withdrawn after a failed first attempt. This prospective open trial was designed to address this ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Vilar L,Albuquerque JL,Gadelha PS,Rangel Filho F,Siqueira AM,da Fonseca MM,Viana KF,Gomes BS,Lyra R

    更新日期:2015-02-04 00:00:00

  • Finite Element Analysis-Based Vertebral Bone Strength Prediction Using MDCT Data: How Low Can We Go?

    abstract::Objective: To study the impact of dose reduction in MDCT images through tube current reduction or sparse sampling on the vertebral bone strength prediction using finite element (FE) analysis for fracture risk assessment. Methods: Routine MDCT data covering lumbar vertebrae of 12 subjects (six male; six female; 74.70 ±...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Rayudu NM,Subburaj K,Mei K,Dieckmeyer M,Kirschke JS,Noël PB,Baum T

    更新日期:2020-07-28 00:00:00

  • Radiotherapy in Fibrodysplasia Ossificans Progressiva: A Case Report and Systematic Review of the Literature.

    abstract::Fibrodysplasia ossificans progressiva (FOP) is an autosomal dominant disease, characterized by the formation of heterotopic ossification (HO) in muscles, ligaments, and tendons. Flare-ups, an inflammatory process that often precedes the formation of HO, can occur spontaneously, but trauma is also a common trigger. It ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Botman E,Netelenbos JC,Rustemeyer T,Schoonmade LJ,Nieuwenhuijzen JA,Teunissen BP,Visser M,Raijmakers P,Lammertsma AA,Dahele M,Eekhoff M

    更新日期:2020-02-12 00:00:00

  • Effects of Neuroendocrine CB1 Activity on Adult Leydig Cells.

    abstract::Endocannabinoids control male reproduction acting at central and local level via cannabinoid receptors. The cannabinoid receptor CB1 has been characterized in the testis, in somatic and germ cells of mammalian and non-mammalian animal models, and its activity related to Leydig cell differentiation, steroidogenesis, sp...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Cobellis G,Meccariello R,Chianese R,Chioccarelli T,Fasano S,Pierantoni R

    更新日期:2016-06-03 00:00:00

  • Prevalence and Risk Factors of Left Ventricular Diastolic Dysfunction in Patients With Hyperthyroidism.

    abstract:Background:Left ventricular (LV) diastolic dysfunction has been demonstrated to be an independent predictor of the future heart failure. Heart failure is one of the severe complications caused by overt hyperthyroidism. However, the effects of overt hyperthyroidism on diastolic dysfunction are conflicting, and little is...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Li H,Zeng R,Liao Y,Fu M,Zhang H,Wang L,Li Y

    更新日期:2021-01-08 00:00:00

  • Sonographic and Elastographic Features of Extra- and Intrathyroidal Ectopic Thymus Mimicking Malignancy: Differential Diagnosis in Children.

    abstract::Thyroid nodules with ultrasound (US) cancer risk features and extra-thyroid lesions suggesting malignant lymph nodes, require prompt diagnosis, especially in children. The US pattern of intrathyroidal ectopic thymus (IET) can strongly suggest papillary thyroid carcinoma (PTC). The extra-thyroid ectopic thymic tissue (...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Stasiak M,Adamczewski Z,Stawerska R,Krawczyk T,Tomaszewska M,Lewiński A

    更新日期:2019-04-10 00:00:00

  • Two Distinct Interferon-γ in the Orange-Spotted Grouper (Epinephelus coioides): Molecular Cloning, Functional Characterization, and Regulation in Toll-Like Receptor Pathway by Induction of miR-146a.

    abstract::Interferon gamma (IFNγ) is a Th1 cytokine that is critical for innate and adaptive immunity. Toll-like receptors (TLRs) signaling pathways are critical in early host defense against invading pathogens. miR-146a has been reported to participate in the regulation of host immunity. The known mechanisms of integrations be...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Peng W,Sun Y,Li GF,He LG,Li RZ,Liang YS,Ding X,Yu X,Zhang Y,Lin HR,Lu DQ

    更新日期:2018-02-26 00:00:00