Rare Germline DICER1 Variants in Pediatric Patients With Cushing's Disease: What Is Their Role?

abstract：:During the last decades, adipogenesis has become an emerging field of study in aquaculture due to the relevance of the adipose tissue in many physiological processes and its connection with the endocrine system. In this sense, recent studies have translated into the establishment of preadipocyte culture models from se...

journal_title：Frontiers in endocrinology

authors： Salmerón C,Riera-Heredia N,Gutiérrez J,Navarro I,Capilla E

更新日期：2016-08-22 00:00:00

abstract：:Biological steroids were traditionally thought to be synthesized exclusively by the adrenal glands and gonads. Recent decades have seen the discovery of neurosteroid production that acts locally within the central nervous system to affect physiology and behavior. These actions include, for example, regulation of aggre...

journal_title：Frontiers in endocrinology

authors： Wingfield JC,Wacker DW,Bentley GE,Tsutsui K

更新日期：2018-06-18 00:00:00

abstract：:Interferon gamma (IFNγ) is a Th1 cytokine that is critical for innate and adaptive immunity. Toll-like receptors (TLRs) signaling pathways are critical in early host defense against invading pathogens. miR-146a has been reported to participate in the regulation of host immunity. The known mechanisms of integrations be...

journal_title：Frontiers in endocrinology

authors： Peng W,Sun Y,Li GF,He LG,Li RZ,Liang YS,Ding X,Yu X,Zhang Y,Lin HR,Lu DQ

更新日期：2018-02-26 00:00:00

abstract：:Somatostatin is highly expressed in mammalian brain and is involved in many brain functions such as motor activity, sleep, sensory, and cognitive processes. Five somatostatin receptors have been described: sst(1), sst(2) (A and B), sst(3), sst(4), and sst(5), all belonging to the G-protein-coupled receptor family. Dur...

journal_title：Frontiers in endocrinology

authors： Martel G,Dutar P,Epelbaum J,Viollet C

更新日期：2012-12-06 00:00:00

abstract：:Classically, the modulation of brain function and behavior by steroid hormones was linked exclusively to secretion by peripheral endocrine glands. Subsequently, steroid actions within the brain were shown dependent upon either synthesis and secretion by peripheral organs or by production within the CNS itself using pe...

journal_title：Frontiers in endocrinology

authors： Remage-Healey L,Saldanha CJ,Schlinger BA

更新日期：2011-09-29 00:00:00

abstract：Background:Many studies suggest that the small ubiquitin-like modifier 4 (SUMO4) M55V gene polymorphism (rs237025) may be associated with an increased risk of type 2 diabetes mellitus (T2DM). However, due to other conflicting results, a clear consensus is lacking in the matter. Objective and methods:A meta-analysis co...

journal_title：Frontiers in endocrinology

authors： Li YY,Wang H,Yang XX,Geng HY,Gong G,Kim HJ,Zhou YH,Wu JJ

更新日期：2017-11-02 00:00:00

abstract：:Osteoporosis is a metabolic skeletal disorder in which bone mass is depleted and bone structure is destroyed to the degree that bone becomes fragile and prone to fractures. Emerging evidence suggests that N6-methyladenosine (m6A) modification, a novel epitranscriptomic marker, has a significant role in bone developmen...

journal_title：Frontiers in endocrinology

authors： Chen X,Hua W,Huang X,Chen Y,Zhang J,Li G

更新日期：2020-01-10 00:00:00

abstract：Objective:To analyze association between different perioperative glycemic control strategies and postoperative outcomes in patients with diabetes undergoing cardiac surgery. Methods:MEDLINE, Cochrane Library, Web of Science, EMBASE, Wanfang Data, China National Knowledge Infrastructure (CNKI) and China Biology Medicin...

journal_title：Frontiers in endocrinology

authors： Jin X,Wang J,Ma Y,Li X,An P,Wang J,Mao W,Mu Y,Chen Y,Chen K

更新日期：2020-12-17 00:00:00

abstract：:Human primordial germ cells (PGCs) have been described in the yolk sac wall around the beginning of the third week. From week 4 to 5, they migrate under control of SCF/c-KIT signaling pathway to the genital ridge, where they become gonocytes. PGCs and gonocytes express classic pluripotency markers, such as KIT, NANOG,...

journal_title：Frontiers in endocrinology

authors： Baroni T,Arato I,Mancuso F,Calafiore R,Luca G

更新日期：2019-06-06 00:00:00

abstract：:Reproductive function is regulated by the secretion of luteinizing hormone (LH) and follicle-stimulating hormone from the pituitary and the steroid hormones from the gonads. The dynamic changes in the levels of the reproductive hormones regulate secondary sex characteristics, gametogenesis, cellular function, and beha...

journal_title：Frontiers in endocrinology

authors： Radovick S,Levine JE,Wolfe A

更新日期：2012-04-09 00:00:00

abstract：:Background: Associations between vitiligo and thyroid disorders have been suggested, However, the prevalence of thyroid disorders in vitiligo vary widely. Purpose: To conduct a systematic review and meta-analysis assessing the prevalence of thyroid disorders in patients with vitiligo. Method: The PubMed, Cochrane Libr...

journal_title：Frontiers in endocrinology

authors： Yuan J,Sun C,Jiang S,Lu Y,Zhang Y,Gao XH,Wu Y,Chen HD

更新日期：2019-01-15 00:00:00

abstract：:It has been generally assumed that insulin circulates freely in blood. However it can also interact with plasma proteins. Insulin receptors are located in the membrane of target cells and consist of an alpha and beta subunits with a tyrosine kinase cytoplasmic domain. The ectodomain, called soluble insulin receptor (S...

journal_title：Frontiers in endocrinology

authors： Hiriart M,Sanchez-Soto C,Diaz-Garcia CM,Castanares DT,Avitia M,Velasco M,Mas-Oliva J,Macias-Silva M,González-Villalpando C,Delgado-Coello B,Sosa-Garrocho M,Vidaltamayo R,Fuentes-Silva D

更新日期：2014-06-19 00:00:00

abstract：:Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation of PCOS and 3- the r...

journal_title：Frontiers in endocrinology

authors： Dewailly D,Barbotin AL,Dumont A,Catteau-Jonard S,Robin G

更新日期：2020-09-09 00:00:00

abstract：:The placenta is the chief regulator of nutrient supply to the growing embryo during gestation. As such, adequate placental function is instrumental for developmental progression throughout intrauterine development. One of the most common complications during pregnancy is insufficient growth of the fetus, a problem ter...

journal_title：Frontiers in endocrinology

authors： Woods L,Perez-Garcia V,Hemberger M

更新日期：2018-09-27 00:00:00

abstract：:3-Iodothyronamine (3-T1AM) is an endogenous thyroid hormone metabolite. The profound pharmacological effects of 3-T1AM on energy metabolism and thermal homeostasis have raised interest to elucidate its signaling properties in tissues that pertain to metabolic regulation and thermogenesis. Previous studies identified G...

journal_title：Frontiers in endocrinology

authors： Bräunig J,Mergler S,Jyrch S,Hoefig CS,Rosowski M,Mittag J,Biebermann H,Khajavi N

更新日期：2018-09-11 00:00:00

abstract：:[This corrects the article on p. 162 in vol. 6, PMID: 26528241.]. ...

journal_title：Frontiers in endocrinology

authors： Frontiers Production Office.

更新日期：2015-11-16 00:00:00

abstract：:O-linked β-N-acetylglucosamine (O-GlcNAc) is an abundant and essential intracellular form of protein glycosylation in animals and plants. In humans, dysregulation of O-GlcNAcylation occurs in a wide range of diseases, including cancer, diabetes, and neurodegeneration. Since its discovery more than 30 years ago, great ...

journal_title：Frontiers in endocrinology

authors： Cox NJ,Luo PM,Smith TJ,Bisnett BJ,Soderblom EJ,Boyce M

更新日期：2018-10-15 00:00:00

abstract：Background:In adults, excess adiposity has been associated with low-grade, chronic inflammation and compromised bone health, but less is known about these linkages in children. The purpose of this study was to compare the circulating levels of inflammatory cytokines, adipokines, osteokines, and bone markers at rest and...

journal_title：Frontiers in endocrinology

authors： Kurgan N,McKee K,Calleja M,Josse AR,Klentrou P

更新日期：2020-12-11 00:00:00

abstract：:There is increasing evidence supporting the characterization of the pesticide DDT and its metabolite, DDE, as obesogens and metabolic disruptors. Elucidating the mechanism is critical to understanding whether the association of DDT and DDE with obesity and diabetes is in fact causal. One area of research investigating...

journal_title：Frontiers in endocrinology

authors： Elmore SE,La Merrill MA

更新日期：2019-03-12 00:00:00

abstract：:Obesity is associated with inflammation and type 2 diabetes. Innate immune system comprised of cellular and molecular components plays an important role in the inflammatory reactions. Immune cells like macrophages and their cell surface pattern-recognition receptors (PRRs) are representative for innate immunity promot...

journal_title：Frontiers in endocrinology

authors： Yamamoto Y,Yamamoto H

更新日期：2013-08-21 00:00:00

abstract：:The islet amyloid polypeptide (IAPP) or amylin maintains a key role in metabolism. This 37-residues-peptide could form pancreatic amyloids, which are a characteristic feature of diabetes mellitus type 2. However, some species do not form amyloid fibril structures. By employing a biomimetic approach, we generated an ex...

journal_title：Frontiers in endocrinology

authors： Pulido-Capiz A,Díaz-Molina R,Martínez-Navarro I,Guevara-Olaya LA,Casanueva-Pérez E,Mas-Oliva J,Rivero IA,García-González V

更新日期：2018-06-25 00:00:00

abstract：:Given that obesity and associated disorder type II diabetes mellitus have reached epidemic proportions worldwide, the development of efficient prevention and therapeutic interventions is a global public health interest. There is now a large body of evidence suggesting that the micro-organisms colonizing the human gut,...

journal_title：Frontiers in endocrinology

authors： Gérard C,Vidal H

更新日期：2019-01-30 00:00:00

abstract：:Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is a rare cause of Cushing syndrome. If routine imaging examinations cannot identify the source of ACTH production, long-term follow-up observation is necessary to determine the etiology. We present the case of a middle-aged male with gradual weight gain and a ...

journal_title：Frontiers in endocrinology

authors： Lu L,Meng Q,Xing X,Yuan T,Zhang H,Li N,Wang Y,Cheng Y,Bai C,Wang H,Cheng X,Xiao Y,Pan B,Li Y,Sun J,Liang Z,Zhu H,Wang R,Lu Z

更新日期：2019-10-22 00:00:00

abstract：:Vitamin D is important for bone health, but may also have extra-skeletal effects. Vitamin D and its binding protein DBP have immunological effects and may therefore be important in the development of type 1 diabetes (T1DM), and low serum levels of 25-hydroxyvitamin D (25(OH)D) are associated with later development of ...

journal_title：Frontiers in endocrinology

authors： Jorde R

更新日期：2019-02-19 00:00:00

abstract：:Background: Slow-wave activity (SWA) in non-rapid eye movement (NREM) sleep, obtained by spectral analysis of the electroencephalogram, is a marker of the depth or intensity of NREM sleep. Higher levels of SWA are associated with lower arousability during NREM sleep and protect against sleep fragmentation. Multiple st...

journal_title：Frontiers in endocrinology

authors： Morselli LL,Temple KA,Leproult R,Ehrmann DA,Van Cauter E,Mokhlesi B

更新日期：2018-07-12 00:00:00

abstract：:Activation of the hypothalamo-pituitary-adrenal (HPA) axis is a basic reaction of animals to environmental perturbations that threaten homeostasis. These responses are ultimately regulated by neurons residing within the paraventricular nucleus (PVN) of the hypothalamus. Within the PVN, corticotrophin-releasing hormone...

journal_title：Frontiers in endocrinology

authors： Handa RJ,Sharma D,Uht R

更新日期：2011-11-10 00:00:00

abstract：:Reproductive status is tightly coupled to metabolic state in females, and ovarian cycling in mammals is halted when energy output exceeds energy input, a metabolic condition known as negative energy balance. This inhibition of reproductive function during negative energy balance occurs due to suppression of gonadotrop...

journal_title：Frontiers in endocrinology

authors： True C,Grove KL,Smith MS

更新日期：2011-10-17 00:00:00

abstract：:Sex steroids play essential roles in the modulation of synaptic plasticity and neuroprotection in the hippocampus. Accumulating evidence shows that hippocampal neurons synthesize both estrogen and androgen. Recently, we also revealed the hippocampal synthesis of corticosteroids. The accurate concentrations of these hi...

journal_title：Frontiers in endocrinology

authors： Hojo Y,Higo S,Kawato S,Hatanaka Y,Ooishi Y,Murakami G,Ishii H,Komatsuzaki Y,Ogiue-Ikeda M,Mukai H,Kimoto T

更新日期：2011-10-10 00:00:00

abstract：:The orexigenic peptide hormone ghrelin is synthesized in the stomach and its receptor growth hormone secretagogue receptor (GHSR1a) is expressed mainly in the central nervous system (CNS). In this review, we confine our discussion to the physiological role of GHSR1a in the brain. Paradoxically, despite broad expressio...

journal_title：Frontiers in endocrinology

authors： Kern A,Grande C,Smith RG

更新日期：2014-08-18 00:00:00

abstract：Objective:Inflammation plays a central role in the pathogenesis of metabolic syndrome (MetS). Cyclophilin B (CypB) can be constitutively secreted in response to inflammatory stimuli and oxidative stress, participating in tissue or systemic inflammation. We investigated the relationship between CypB and MetS in both hum...

journal_title：Frontiers in endocrinology

authors： Zhang H,Fan Q,Xie H,Lu L,Tao R,Wang F,Xi R,Hu J,Chen Q,Shen W,Zhang R,Yan X

更新日期：2017-12-22 00:00:00