Impact of Gut Microbiota on Host Glycemic Control.


:Given that obesity and associated disorder type II diabetes mellitus have reached epidemic proportions worldwide, the development of efficient prevention and therapeutic interventions is a global public health interest. There is now a large body of evidence suggesting that the micro-organisms colonizing the human gut, known as gut microbiota, play a central role in human physiology and metabolism. Understanding how gut microbiota affects and regulates key metabolic functions such as glucose regulation and insulin resistance is an important health issue. The present review summarizes recent advances in our understanding of how gut bacterial species interfere with host metabolic phenotype. We will examine key biological molecular mechanisms underlying the impact of gut microbiota on host glycemic control including: incretin secretion, short-chain fatty acid production, bile acid metabolism, and adipose tissue regulation. We will highlight how prebiotic/probiotic interventions affect these bacterial processes and are now considered as promising approaches to treat obese and diabetic patients.


Gérard C,Vidal H




Has Abstract


2019-01-30 00:00:00








  • Differential Function of Melatonin MT1 and MT2 Receptors in REM and NREM Sleep.

    abstract::The pathophysiological function of the G-protein coupled melatonin MT1 and MT2 receptors has not yet been well-clarified. Recent advancements using selective MT1/ MT2 receptor ligands and MT1/MT2 receptor knockout mice have suggested that the activation of the MT1 receptors are mainly implicated in the regulation of r...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Gobbi G,Comai S

    更新日期:2019-03-01 00:00:00

  • Dietary Protein Intake, Meat Consumption, and Dairy Consumption in the Year Preceding Pregnancy and During Pregnancy and Their Associations With the Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study in Southwest China.

    abstract::Background: Gestational diabetes mellitus (GDM) has become a public health problem in China. Objective: To examine the association of dietary protein intake before and during pregnancy with the risk of GDM. Design: Dietary intake before pregnancy and during the first and second trimesters of pregnancy was assessed usi...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Liang Y,Gong Y,Zhang X,Yang D,Zhao D,Quan L,Zhou R,Bao W,Cheng G

    更新日期:2018-10-11 00:00:00

  • Transient Thyroiditis after Surgery for Tertiary Hyperparathyroidism: A Case Report.

    abstract::Parathyroid (PTH) exploration surgery carries the risk of developing post-operative thyroiditis due to vigorous manual manipulation of the thyroid gland during surgery. Post-operative thyroiditis has a wide spectrum of clinical manifestations. However, it remains underreported. Here, we describe a case of post-operati...

    journal_title:Frontiers in endocrinology



    authors: Hakami YA

    更新日期:2015-08-18 00:00:00

  • Two Distinct Interferon-γ in the Orange-Spotted Grouper (Epinephelus coioides): Molecular Cloning, Functional Characterization, and Regulation in Toll-Like Receptor Pathway by Induction of miR-146a.

    abstract::Interferon gamma (IFNγ) is a Th1 cytokine that is critical for innate and adaptive immunity. Toll-like receptors (TLRs) signaling pathways are critical in early host defense against invading pathogens. miR-146a has been reported to participate in the regulation of host immunity. The known mechanisms of integrations be...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Peng W,Sun Y,Li GF,He LG,Li RZ,Liang YS,Ding X,Yu X,Zhang Y,Lin HR,Lu DQ

    更新日期:2018-02-26 00:00:00

  • Variations in CD14 Gene Are Associated With Autoimmune Thyroid Diseases in the Chinese Population.

    abstract::Autoimmune thyroid diseases (AITDs) are chronic organ-specific autoimmune diseases and mainly include Graves' disease (GD) and Hashimoto's thyroiditis (HT). CD14 is an important component of the immune system as a receptor for gram-negative lipopolysaccharide (LPS). The genetic polymorphisms of CD14 have been confirme...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Jia X,Wang B,Yao Q,Li Q,Zhang J

    更新日期:2019-01-16 00:00:00

  • Mitochondrial Chaperones in the Brain: Safeguarding Brain Health and Metabolism?

    abstract::The brain orchestrates organ function and regulates whole body metabolism by the concerted action of neurons and glia cells in the central nervous system. To do so, the brain has tremendously high energy consumption and relies mainly on glucose utilization and mitochondrial function in order to exert its function. As ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Castro JP,Wardelmann K,Grune T,Kleinridders A

    更新日期:2018-04-26 00:00:00

  • Effects of Chronic Social Stress and Maternal Intranasal Oxytocin and Vasopressin on Offspring Interferon-γ and Behavior.

    abstract::Recent studies support the hypothesis that the adverse effects of early-life adversity and transgenerational stress on neural plasticity and behavior are mediated by inflammation. The objective of the present study was to investigate the immune and behavioral programing effects of intranasal (IN) vasopressin (AVP) and...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Murgatroyd CA,Hicks-Nelson A,Fink A,Beamer G,Gurel K,Elnady F,Pittet F,Nephew BC

    更新日期:2016-12-14 00:00:00

  • Sonographic and Elastographic Features of Extra- and Intrathyroidal Ectopic Thymus Mimicking Malignancy: Differential Diagnosis in Children.

    abstract::Thyroid nodules with ultrasound (US) cancer risk features and extra-thyroid lesions suggesting malignant lymph nodes, require prompt diagnosis, especially in children. The US pattern of intrathyroidal ectopic thymus (IET) can strongly suggest papillary thyroid carcinoma (PTC). The extra-thyroid ectopic thymic tissue (...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Stasiak M,Adamczewski Z,Stawerska R,Krawczyk T,Tomaszewska M,Lewiński A

    更新日期:2019-04-10 00:00:00

  • 3-Iodothyronamine Activates a Set of Membrane Proteins in Murine Hypothalamic Cell Lines.

    abstract::3-Iodothyronamine (3-T1AM) is an endogenous thyroid hormone metabolite. The profound pharmacological effects of 3-T1AM on energy metabolism and thermal homeostasis have raised interest to elucidate its signaling properties in tissues that pertain to metabolic regulation and thermogenesis. Previous studies identified G...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Bräunig J,Mergler S,Jyrch S,Hoefig CS,Rosowski M,Mittag J,Biebermann H,Khajavi N

    更新日期:2018-09-11 00:00:00

  • Insulin Resistance in Children.

    abstract::Insulin resistance (IR) is a pathological condition strongly associated with obesity. However, corticosteroids or growth hormone therapy and genetic diseases may affect insulin sensitivity lifelong. In obese children and adolescents of any age there is an evident association between IR and an increased prevalence of t...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Tagi VM,Giannini C,Chiarelli F

    更新日期:2019-06-04 00:00:00

  • A Rare Case of Pituitary Melanoma Metastasis: A Dramatic and Prolonged Response to Dabrafenib-Trametinib Therapy.

    abstract::Introduction: Pituitary metastases (PM) are rare events and to date only very few cases of melanoma PM have been described in literature up to now. Case Presentation: We describe the clinical history of a 33-year-old male patient who underwent surgical excision of an inter-scapular melanoma in 2008. The subsequent fol...

    journal_title:Frontiers in endocrinology



    authors: Mormando M,Puliani G,Barnabei A,Lauretta R,Bianchini M,Chiefari A,Russillo M,Cognetti F,Romano L,Appetecchia M

    更新日期:2020-07-23 00:00:00

  • Exercise Training in Obese Rats Does Not Induce Browning at Thermoneutrality and Induces a Muscle-Like Signature in Brown Adipose Tissue.

    abstract::Aim: Exercise training elicits diverse effects on brown (BAT) and white adipose tissue (WAT) physiology in rodents housed below their thermoneutral zone (i.e., 28-32°C). In these conditions, BAT is chronically hyperactive and, unlike human residence, closer to thermoneutrality. Therefore, we set out to determine the e...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Aldiss P,Lewis JE,Lupini I,Bloor I,Chavoshinejad R,Boocock DJ,Miles AK,Ebling FJP,Budge H,Symonds ME

    更新日期:2020-03-20 00:00:00

  • Gonadotropin-inhibitory hormone action in the brain and pituitary.

    abstract::Gonadotropin-inhibitory hormone (GnIH) was first identified in the Japanese quail as a hypothalamic neuropeptide inhibitor of gonadotropin secretion. Subsequent studies have shown that GnIH is present in the brains of birds including songbirds, and mammals including humans. The identified avian and mammalian GnIH pept...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Ubuka T,Son YL,Tobari Y,Tsutsui K

    更新日期:2012-11-28 00:00:00

  • Pineal Gland Metastasis From Poorly Differentiated Carcinoma of Unknown Primary Origin.

    abstract::Pineal metastasis is an exceedingly rare finding in patients with systemic malignancies. Such lesions are typically the manifestation of a primary lung cancer; nonetheless, a variety of malignancies have been reported to disseminate to the pineal gland including gastrointestinal, endocrine, and skin cancers, among oth...

    journal_title:Frontiers in endocrinology



    authors: Cuoco JA,Kortz MW,Benko MJ,Jarrett RW,Rogers CM,Witcher MR,Marvin EA

    更新日期:2020-10-23 00:00:00

  • Podocytes … What's Under Yours? (Podocytes and Foot Processes and How They Change in Nephropathy).

    abstract::Most of the described structures of podocytes in health and disease have been inferred from light and electron microscopic studies of rodent models. The variation in filtration barrier features is measured on micrographs, the aim being statistical significance. This is the technical campaign waged against kidney disea...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Neal CR

    更新日期:2015-02-23 00:00:00

  • Importance of Illness Acceptance Among Other Factors Affecting Quality of Life in Acromegaly.

    abstract::Introduction: The aim of this study was to analyze psychological factors of patients with acromegaly and assessment of their relationship with the quality of life (QoL) in the context of the control of the disease. Materials and methods: A total sample of 50 patients (62% of females; mean age = 51.66 ± 14.5) with acro...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Jawiarczyk-Przybyłowska A,Szcześniak D,Ciułkowicz M,Bolanowski M,Rymaszewska J

    更新日期:2020-01-14 00:00:00

  • Diabetes and change in bone mineral density at the hip, calcaneus, spine, and radius in older women.

    abstract::Older women with type 2 diabetes mellitus (DM) have higher bone mineral density (BMD) but also have higher rates of fracture compared to those without DM. Limited evidence suggests that DM may also be associated with more rapid bone loss. To determine if bone loss rates differ by DM status in older women, we analyzed ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Schwartz AV,Ewing SK,Porzig AM,McCulloch CE,Resnick HE,Hillier TA,Ensrud KE,Black DM,Nevitt MC,Cummings SR,Sellmeyer DE

    更新日期:2013-05-30 00:00:00

  • Circulating MicroRNA-15a Associates With Retinal Damage in Patients With Early Stage Type 2 Diabetes.

    abstract::Circulating microRNAs are potential biomarkers of type 2 diabetes mellitus (T2DM) and related complications. Here, we investigated the association of microRNA-15a with early retinal damage in T2DM. A cohort of untreated subjects screened for intermediate/high risk of T2DM, according to a score assessment questionnaire...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Sangalli E,Tagliabue E,Sala L,Prattichizzo F,Uccellatore A,Spada D,Lorino F,de Candia P,Lupini S,Cantone L,Favero C,Madeddu P,Bollati V,Genovese S,Spinetti G

    更新日期:2020-04-23 00:00:00

  • Small Ubiquitin-Like Modifier 4 (SUMO4) Gene M55V Polymorphism and Type 2 Diabetes Mellitus: A Meta-analysis Including 6,823 Subjects.

    abstract:Background:Many studies suggest that the small ubiquitin-like modifier 4 (SUMO4) M55V gene polymorphism (rs237025) may be associated with an increased risk of type 2 diabetes mellitus (T2DM). However, due to other conflicting results, a clear consensus is lacking in the matter. Objective and methods:A meta-analysis co...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Li YY,Wang H,Yang XX,Geng HY,Gong G,Kim HJ,Zhou YH,Wu JJ

    更新日期:2017-11-02 00:00:00

  • Opportunistic QCT Bone Mineral Density Measurements Predicting Osteoporotic Fractures: A Use Case in a Prospective Clinical Cohort.

    abstract:Purpose:To assess whether volumetric vertebral bone mineral density (BMD) measured with opportunistic quantitative computed tomography (QCT) (i.e., CT acquired for other reasons) can predict osteoporotic fracture occurrence in a prospective clinical cohort and how this performs in comparison to dual-energy X-ray absorp...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Leonhardt Y,May P,Gordijenko O,Koeppen-Ursic VA,Brandhorst H,Zimmer C,Makowski MR,Baum T,Kirschke JS,Gersing AS,Seifert-Klauss V,Schwaiger BJ

    更新日期:2020-11-09 00:00:00

  • Reduced Expression of PLCXD3 Associates With Disruption of Glucose Sensing and Insulin Signaling in Pancreatic β-Cells.

    abstract::Previous work has shown that reduced expression of PLCXD3, a member of the phosphoinositide-specific phospholipases (PI-PLC) family, impaired insulin secretion with an unclear mechanism. In the current study, we aim to investigate the mechanism underlying this effect using human islets and rat INS-1 (832/13) cells. Mi...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Aljaibeji H,Mukhopadhyay D,Mohammed AK,Dhaiban S,Hachim MY,Elemam NM,Sulaiman N,Salehi A,Taneera J

    更新日期:2019-11-06 00:00:00

  • Role of the wnt pathway in thyroid cancer.

    abstract::Aberrant activation of Wnt signaling is involved in the development of several epithelial tumors. Wnt signaling includes two major types of pathways: (i) the canonical or Wnt/β-catenin pathway; and (ii) the non-canonical pathways, which do not involve β-catenin stabilization. Among these pathways, the Wnt/β-catenin pa...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Sastre-Perona A,Santisteban P

    更新日期:2012-02-29 00:00:00

  • Summary of Expert Opinion on the Management of Children With Chronic Kidney Disease and Growth Failure With Human Growth Hormone.

    abstract::Background: The management of children and adolescents with chronic kidney disease (CKD) and growth failure candidate for recombinant human growth hormone therapy (rhGH) is based on an appraisal of the literature established on a 2006 consensus statement and 2019 Clinical practice recommendations. The performance of t...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Cappa M,Maghnie M,Carbone V,Chioma L,Errichiello C,Giavoli C,Giordano M,Guazzarotti L,Klain A,Montini G,Murer L,Parpagnoli M,Pecoraro C,Pesce S,Verrina E

    更新日期:2020-09-02 00:00:00

  • Production of hydrogen sulfide from d-cysteine and its therapeutic potential.

    abstract::Accumulating evidence shows that H2S has physiological functions in various tissues and organs. It includes regulation of neuronal activity, vascular tension, a release of insulin, and protection of the heart, kidney, and brain from ischemic insult. H2S is produced by enzymes from l-cysteine; cystathionine β-synthase,...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Shibuya N,Kimura H

    更新日期:2013-07-16 00:00:00

  • Expanding the Clinical Spectrum of Osteogenesis Imperfecta Type V: 13 Additional Patients and Review.

    abstract::Osteogenesis imperfecta (OI) is an inherited connective tissue disorder characterized by bone fragility and is characterized by clinical and genetic heterogeneity. Previous studies showed that the same mutation (c.-14C> T) of the IFITM5 gene is responsible for autosomal dominant OI type V. However, the mutation has a ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Cao YJ,Wei Z,Zhang H,Zhang ZL

    更新日期:2019-06-12 00:00:00

  • Endocrine Disruption of Vasopressin Systems and Related Behaviors.

    abstract::Endocrine disrupting chemicals (EDCs) are chemicals that interfere with the organizational or activational effects of hormones. Although the vast majority of the EDC literature focuses on steroid hormone signaling related impacts, growing evidence from a myriad of species reveals that the nonapeptide hormones vasopres...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Patisaul HB

    更新日期:2017-06-19 00:00:00

  • Developmental Exposure to 2,2',4,4'-Tetrabromodiphenyl Ether Permanently Alters Blood-Liver Balance of Lipids in Male Mice.

    abstract::Polybrominated diphenyl ethers (PBDEs) were used as flame-retardant additives starting 1965 and were recently withdrawn from commerce in North America and Europe. Approximately 1/5 of the total U.S. population were born when environmental concentrations of PBDE plateaued at their maximum. Accumulating evidence suggest...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Khalil A,Cevik SE,Hung S,Kolla S,Roy MA,Suvorov A

    更新日期:2018-09-20 00:00:00

  • Congenital Hypogonadotrophic Hypogonadism: Minipuberty and the Case for Neonatal Diagnosis.

    abstract::Congenital hypogonadotrophic hypogonadism (CHH) is a rare but important etiology of pubertal failure and infertility, resulting from impaired gonadotrophin-releasing hormone secretion or action. Despite the availability of effective hormonal therapies, the majority of men with CHH experience unsatisfactory outcomes, i...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Swee DS,Quinton R

    更新日期:2019-02-21 00:00:00

  • Regulatory Role of RNA N6-Methyladenosine Modification in Bone Biology and Osteoporosis.

    abstract::Osteoporosis is a metabolic skeletal disorder in which bone mass is depleted and bone structure is destroyed to the degree that bone becomes fragile and prone to fractures. Emerging evidence suggests that N6-methyladenosine (m6A) modification, a novel epitranscriptomic marker, has a significant role in bone developmen...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Chen X,Hua W,Huang X,Chen Y,Zhang J,Li G

    更新日期:2020-01-10 00:00:00

  • Regulation of Placental Development and Its Impact on Fetal Growth-New Insights From Mouse Models.

    abstract::The placenta is the chief regulator of nutrient supply to the growing embryo during gestation. As such, adequate placental function is instrumental for developmental progression throughout intrauterine development. One of the most common complications during pregnancy is insufficient growth of the fetus, a problem ter...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Woods L,Perez-Garcia V,Hemberger M

    更新日期:2018-09-27 00:00:00