Plasma Prolactin and Progesterone Levels and the Risk of Gestational Diabetes: A Prospective and Longitudinal Study in a Multiracial Cohort.

Abstract:

:Objective: Prolactin and progesterone are implicated in glucose homeostasis in and outside of pregnancy. However, their associations with gestational diabetes (GDM) risk were not well-understood. This study investigates this question in a prospective and longitudinal cohort. Methods: This is a nested case-control study of 107 incident GDM cases and 214 matched non-GDM controls within the NICHD Fetal Growth Studies-Singleton Cohort. Blood samples were collected at gestational weeks 10-14, 15-26, 23-31, and 33-39. The odds ratios (OR) of GDM were estimated using conditional logistic regression. The longitudinal changes in prolactin and progesterone were estimated using linear mixed-effects models. Results: Compared to controls, cases have significantly higher prolactin levels at weeks 10-14 (median: 50.4 vs. 42.1 ng/mL), and significantly lower progesterone levels at weeks 10-14 (median: 109.4 vs. 126.5 nmol/L). Prolactin levels at weeks 10-14 were significantly and positively associated with GDM risk; the adjusted ORs across increasing quartiles were 1.00, 1.13, 1.80, 2.33 (p-trend = 0.02). A similar but slightly attenuated association was observed at weeks 15-26 (p-trend = 0.05). Progesterone was not associated with GDM risk at either time points. Longitudinal changes in prolactin and progesterone between the first two visits were not associated with GDM risk. In addition, prolactin was significantly and positively associated with insulin and C-peptide levels at weeks 10-14, and significantly and inversely associated with C-peptide levels at weeks 15-26; progesterone was significantly and inversely associated with glucose and insulin levels. Conclusions: This study provided the first prospective evidence of a positive association between prolactin levels in early pregnancy and GDM risk.

authors

Li M,Song Y,Rawal S,Hinkle SN,Zhu Y,Tekola-Ayele F,Ferrara A,Tsai MY,Zhang C

doi

10.3389/fendo.2020.00083

subject

Has Abstract

pub_date

2020-02-27 00:00:00

pages

83

issn

1664-2392

journal_volume

11

pub_type

杂志文章
  • All-Atom Structural Models of the Transmembrane Domains of Insulin and Type 1 Insulin-Like Growth Factor Receptors.

    abstract::The receptor tyrosine kinase superfamily comprises many cell-surface receptors including the insulin receptor (IR) and type 1 insulin-like growth factor receptor (IGF1R) that are constitutively homodimeric transmembrane glycoproteins. Therefore, these receptors require ligand-triggered domain rearrangements rather tha...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2016.00068

    authors: Mohammadiarani H,Vashisth H

    更新日期:2016-06-20 00:00:00

  • RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer.

    abstract::The relaxin-like RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/tumor necrosis factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor, RXFP1, with functions in brain cancer....

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2015.00127

    authors: Thanasupawat T,Glogowska A,Burg M,Wong GW,Hoang-Vu C,Hombach-Klonisch S,Klonisch T

    更新日期:2015-08-13 00:00:00

  • Early Diagnosis of Low-Risk Papillary Thyroid Cancer Results Rather in Overtreatment Than a Better Survival.

    abstract::We are witnessing a rapid worldwide increase in the incidence of papillary thyroid carcinoma (PTC) in the last thirty years. Extensive implementation of cancer screening and wide availability of neck ultrasound or other imaging studies is the main reason responsible for this phenomenon. It resulted in a detection of a...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2020.571421

    authors: Krajewska J,Kukulska A,Oczko-Wojciechowska M,Kotecka-Blicharz A,Drosik-Rutowicz K,Haras-Gil M,Jarzab B,Handkiewicz-Junak D

    更新日期:2020-10-06 00:00:00

  • Expression and Role of Gonadotropin-Releasing Hormone 2 and Its Receptor in Mammals.

    abstract::Gonadotropin-releasing hormone 1 (GnRH1) and its receptor (GnRHR1) drive mammalian reproduction via regulation of the gonadotropins. Yet, a second form of GnRH (GnRH2) and its receptor (GnRHR2) also exist in mammals. GnRH2 has been completely conserved throughout 500 million years of evolution, signifying high selecti...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2017.00269

    authors: Desaulniers AT,Cederberg RA,Lents CA,White BR

    更新日期:2017-12-11 00:00:00

  • Morpho-functional architecture of the Golgi complex of neuroendocrine cells.

    abstract::In neuroendocrine cells, prohormones move from the endoplasmic reticulum to the Golgi complex (GC), where they are sorted and packed into secretory granules. The GC is considered the central station of the secretory pathway of proteins and lipids en route to their final destination. In most mammalian cells, it is form...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2013.00041

    authors: Martínez-Alonso E,Tomás M,Martínez-Menárguez JA

    更新日期:2013-03-28 00:00:00

  • Differential Function of Melatonin MT1 and MT2 Receptors in REM and NREM Sleep.

    abstract::The pathophysiological function of the G-protein coupled melatonin MT1 and MT2 receptors has not yet been well-clarified. Recent advancements using selective MT1/ MT2 receptor ligands and MT1/MT2 receptor knockout mice have suggested that the activation of the MT1 receptors are mainly implicated in the regulation of r...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2019.00087

    authors: Gobbi G,Comai S

    更新日期:2019-03-01 00:00:00

  • The Potential Role of Platelet-Related microRNAs in the Development of Cardiovascular Events in High-Risk Populations, Including Diabetic Patients: A Review.

    abstract::Platelet activation plays a pivotal role in the development and progression of atherosclerosis, which often leads to potentially fatal ischemic events at later stages of the disease. Platelets and platelet microvesicles (PMVs) contain large amounts of microRNA (miRNA), which contributes largely to the pool of circulat...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2018.00074

    authors: Pordzik J,Pisarz K,De Rosa S,Jones AD,Eyileten C,Indolfi C,Malek L,Postula M

    更新日期:2018-03-20 00:00:00

  • The Prevalence of Thyroid Disorders in Patients With Vitiligo: A Systematic Review and Meta-Analysis.

    abstract::Background: Associations between vitiligo and thyroid disorders have been suggested, However, the prevalence of thyroid disorders in vitiligo vary widely. Purpose: To conduct a systematic review and meta-analysis assessing the prevalence of thyroid disorders in patients with vitiligo. Method: The PubMed, Cochrane Libr...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00803

    authors: Yuan J,Sun C,Jiang S,Lu Y,Zhang Y,Gao XH,Wu Y,Chen HD

    更新日期:2019-01-15 00:00:00

  • Cytokines and Abnormal Glucose and Lipid Metabolism.

    abstract::Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory cytokines, myokines, and osteokines, contribute substantially to the development of abnormal glucose and lipid metabolism. Some cytokines play a positive role in metabolism action, while others have a negative metabolic role l...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2019.00703

    authors: Shi J,Fan J,Su Q,Yang Z

    更新日期:2019-10-30 00:00:00

  • Cytokines in Male Fertility and Reproductive Pathologies: Immunoregulation and Beyond.

    abstract::Germline development in vivo is dependent on the environment formed by somatic cells and the differentiation cues they provide; hence, the impact of local factors is highly relevant to the production of sperm. Knowledge of how somatic and germline cells interact is central to achieving biomedical goals relating to res...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2017.00307

    authors: Loveland KL,Klein B,Pueschl D,Indumathy S,Bergmann M,Loveland BE,Hedger MP,Schuppe HC

    更新日期:2017-11-20 00:00:00

  • Adult Body Height and Cardiometabolic Disease Risk: The China National Health Survey in Shaanxi.

    abstract:Objectives:Based on data from the China National Health Survey, we aimed to examine the association between body height and cardiometabolic disease (CMD) in a large adult population from Shaanxi province, and further to test whether this association was hinged upon other population characteristics. Methods:This popula...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.587616

    authors: Yuan Y,Zhou B,Wang S,Ma J,Dong F,Yang M,Zhang Z,Niu W

    更新日期:2020-12-21 00:00:00

  • A Pilot Randomized-Controlled Trial on the Effect of CPAP Treatment on Glycemic Control in Gestational Diabetes: Study Design and Methods.

    abstract::Background: Gestational diabetes (GDM) is associated with adverse short- and long-term maternal and fetal outcomes. Observational data support a link between sleep-disordered breathing (SDB) during pregnancy and GDM. However, it is unknown whether treatment of SDB with continuous positive airway pressure (CPAP) improv...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2018.00659

    authors: Pamidi S,Meltzer SJ,Garfield N,Lavigne L,Olha A,Khalyfa A,Benedetti A,Tremblay G,Gagnon R,Rey E,Dasgupta K,Kimoff RJ

    更新日期:2018-11-16 00:00:00

  • O-GlcNAcylation: A New Cancer Hallmark?

    abstract::O-linked N-acetylglucosaminylation (O-GlcNAcylation) is a reversible post-translational modification consisting in the addition of a sugar moiety to serine/threonine residues of cytosolic or nuclear proteins. Catalyzed by O-GlcNAc-transferase (OGT) and removed by O-GlcNAcase, this dynamic modification is dependent on ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2013.00099

    authors: Fardini Y,Dehennaut V,Lefebvre T,Issad T

    更新日期:2013-08-12 00:00:00

  • Differences in Signal Activation by LH and hCG are Mediated by the LH/CG Receptor's Extracellular Hinge Region.

    abstract::The human lutropin (hLH)/choriogonadotropin (hCG) receptor (LHCGR) can be activated by binding two slightly different gonadotropic glycoprotein hormones, choriogonadotropin (CG) - secreted by the placenta, and lutropin (LH) - produced by the pituitary. They induce different signaling profiles at the LHCGR. This cannot...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2015.00140

    authors: Grzesik P,Kreuchwig A,Rutz C,Furkert J,Wiesner B,Schuelein R,Kleinau G,Gromoll J,Krause G

    更新日期:2015-09-22 00:00:00

  • Evaluation of the Possibility to Detect Circulating Tumor DNA From Pituitary Adenoma.

    abstract::Objective: Circulating free DNA (cfDNA) in general and circulating tumor DNA (ctDNA) in particular is becoming an increasingly used form of liquid biopsy biomarkers. In this study, we are investigating the ability to detect ctDNA from the plasma of pituitary adenoma (PA) patients. Design: Tumor tissue samples were obt...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00615

    authors: Megnis K,Peculis R,Rovite V,Laksa P,Niedra H,Balcere I,Caune O,Breiksa A,Nazarovs J,Stukens J,Konrade I,Pirags V,Klovins J

    更新日期:2019-09-18 00:00:00

  • Peculiarities of Precocious Puberty in Boys and Girls With McCune-Albright Syndrome.

    abstract::McCune-Albright Syndrome (MAS; OMIM # 174800) is a rare, sporadic disease caused by a post-zygotic, activating mutation in the guanine-nucleotide binding protein α-subunit (GNAS1) gene. MAS is characterized by the clinical triad of polyostotic fibrous dysplasia of bone, café-au-lait skin pigmentation and peripheral pr...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2018.00337

    authors: Corica D,Aversa T,Pepe G,De Luca F,Wasniewska M

    更新日期:2018-06-22 00:00:00

  • Does Hypoxia Decrease the Metabolic Rate?

    abstract::In some organisms and cells, oxygen availability influences oxygen consumption. In this review, we examine this phenomenon of hypoxic hypometabolism (HH), discussing its features, mechanisms, and implications. Small mammals and other vertebrate species exhibit "oxyconformism," a downregulation of metabolic rate and bo...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2018.00668

    authors: Gu C,Jun JC

    更新日期:2018-11-13 00:00:00

  • Obstetric and Neonatal Outcome of Pregnancy in Carney Complex: A Case Report.

    abstract::Background: Carney complex (CNC) is a rare multiple endocrine neoplasia syndrome with autosomal dominant inheritance. Affected individuals present with mucocutaneous lentigines/blue nevi, cardiac and noncardiac myxomatous tumors, and multiple endocrine tumors. Mutations in PRKAR1A have been identified as genetic cause...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2020.00296

    authors: Ralser DJ,Strizek B,Kupczyk P,Stoffel-Wagner B,Altengarten J,Müller A,Woelfle J,Gembruch U,Klingmueller D,Merz WM,Paschkowiak-Christes A

    更新日期:2020-05-08 00:00:00

  • CCL2/Monocyte Chemoattractant Protein 1 and Parathyroid Hormone Action on Bone.

    abstract::Chemokines are small molecules that play a crucial role as chemoattractants for several cell types, and their components are associated with host immune responses and repair mechanisms. Chemokines selectively recruit monocytes, neutrophils, and lymphocytes and induce chemotaxis through the activation of G protein-coup...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2017.00049

    authors: Siddiqui JA,Partridge NC

    更新日期:2017-03-29 00:00:00

  • From Sea to Shining Sea and the Great Plains to Patagonia: A Review on Current Knowledge of Diabetes Mellitus in Hispanics/Latinos in the US and Latin America.

    abstract::The past two decades have witnessed many advances in the prevention, treatment, and control of diabetes mellitus (DM) and its complications. Increased screening has led to a greater recognition of type 2 diabetes mellitus (type 2 DM) and prediabetes; however, Hispanics/Latinos, the largest minority group in the US, ha...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2017.00298

    authors: Avilés-Santa ML,Colón-Ramos U,Lindberg NM,Mattei J,Pasquel FJ,Pérez CM

    更新日期:2017-11-10 00:00:00

  • Podocytes … What's Under Yours? (Podocytes and Foot Processes and How They Change in Nephropathy).

    abstract::Most of the described structures of podocytes in health and disease have been inferred from light and electron microscopic studies of rodent models. The variation in filtration barrier features is measured on micrographs, the aim being statistical significance. This is the technical campaign waged against kidney disea...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2015.00009

    authors: Neal CR

    更新日期:2015-02-23 00:00:00

  • Three Therapeutic Strategies: Cinacalcet, Paricalcitol or Both in Secondary Hyperparathyroidism Treatment in Hemodialysed Patients During 1-Year Observational Study-A Comparison.

    abstract::Introduction: Secondary hyperparathyroidism (sHPT) is a common hormonal complication of chronic kidney disease. There are several therapeutic options for sHPT management aiming at calcium-phosphorus balance normalization and decrease of parathormone secretion. Objectives: The aim of this retrospective, observational s...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00040

    authors: Zawierucha J,Malyszko J,Malyszko JS,Prystacki T,Marcinkowski WP,Dryl-Rydzynska T

    更新日期:2019-02-05 00:00:00

  • Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions.

    abstract::This review focuses on the biologic importance of the vitamin D binding protein (DBP) with emphasis on its regulation of total and free vitamin D metabolite levels in various clinical conditions. Nearly all DBP is produced in the liver, where its regulation is influenced by estrogen, glucocorticoids and inflammatory c...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2019.00317

    authors: Bikle DD,Schwartz J

    更新日期:2019-05-28 00:00:00

  • GABA and Glutamate Transporters in Brain.

    abstract::The mammalian genome contains four genes encoding GABA transporters (GAT1, slc6a1; GAT2, slc6a13; GAT3, slc6a11; BGT1, slc6a12) and five glutamate transporter genes (EAAT1, slc1a3; EAAT2, slc1a2; EAAT3, slc1a1; EAAT4, slc1a6; EAAT5, slc1a7). These transporters keep the extracellular levels of GABA and excitatory amino...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2013.00165

    authors: Zhou Y,Danbolt NC

    更新日期:2013-11-11 00:00:00

  • Postoperative Neck Ultrasonography Surveillance After Thyroidectomy in Patients With Medullary Thyroid Carcinoma: A Multicenter Study.

    abstract:Background:For detecting tumor recurrence of medullary thyroid carcinoma (MTC) in the neck, an appropriate frequency and interval of postoperative ultrasonography (US) surveillance remains unclear. This study aimed to assess an appropriate interval and frequency of postoperative neck US surveillance for detecting tumor...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00102

    authors: Ahn HS,Kim DW,Lee YJ,Lee CY,Kim JH,Choi YJ,Lee S,Ryoo I,Huh JY,Sung JY,Kwak JY,Baek HJ

    更新日期:2018-03-15 00:00:00

  • Hypothyroidism and Adverse Endpoints in Diabetic Patients: A Systematic Review and Meta-Analysis.

    abstract::Background: This study investigated the relationship strength between hypothyroidism and cardiovascular and renal outcomes in diabetic patients. Methods: The electronic databases PubMed, EmBase, and Cochrane library were screened for relevant studies published before November 2018. The outcomes included major cardiova...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2019.00889

    authors: Zhang S,Feng G,Kang F,Guo Y,Ti H,Hao L,Gao P,Gao J

    更新日期:2020-01-10 00:00:00

  • The Involvement of TRP Channels in Bone Homeostasis.

    abstract::Calcium and bone homeostasis are intimately related. On the one hand, bone relies on a sufficient supply of calcium to maintain its structural and mechanical properties and thus largely depends on calcium absorption in the intestine and calcium reabsorption in the kidney. On the other hand, bone serves as a calcium re...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2012.00099

    authors: Lieben L,Carmeliet G

    更新日期:2012-08-20 00:00:00

  • Corrigendum: Insulin- like Growth Factor-Binding Protein Action in Bone Tissue: A Key Role for Pregnancy- Associated Plasma Protein-A.

    abstract::[This corrects the article DOI: 10.3389/fendo.2018.00031.]. ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,已发布勘误

    doi:10.3389/fendo.2018.00510

    authors: Beattie J,Al-Khafaji H,Noer PR,Alkharobi HE,Alhodhodi A,Meade J,El-Gendy R,Oxvig C

    更新日期:2018-09-04 00:00:00

  • Corrigendum: Role of Hippocampal Lipocalin-2 in Experimental Diabetic Encephalopathy.

    abstract::[This corrects the article DOI: 10.3389/fendo.2019.00025.]. ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,已发布勘误

    doi:10.3389/fendo.2019.00239

    authors: Bhusal A,Rahman MH,Lee IK,Suk K

    更新日期:2019-04-09 00:00:00

  • Effects of Chronic Social Stress and Maternal Intranasal Oxytocin and Vasopressin on Offspring Interferon-γ and Behavior.

    abstract::Recent studies support the hypothesis that the adverse effects of early-life adversity and transgenerational stress on neural plasticity and behavior are mediated by inflammation. The objective of the present study was to investigate the immune and behavioral programing effects of intranasal (IN) vasopressin (AVP) and...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2016.00155

    authors: Murgatroyd CA,Hicks-Nelson A,Fink A,Beamer G,Gurel K,Elnady F,Pittet F,Nephew BC

    更新日期:2016-12-14 00:00:00