Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome.

Abstract:

:Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation of PCOS and 3- the role of AMH in the trans-generational transmission of PCOS. For each of those issues, the clinical and experimental evidences currently available are discussed and pathophysiological hypothesis are proposed.

authors

Dewailly D,Barbotin AL,Dumont A,Catteau-Jonard S,Robin G

doi

10.3389/fendo.2020.00641

subject

Has Abstract

pub_date

2020-09-09 00:00:00

pages

641

issn

1664-2392

journal_volume

11

pub_type

杂志文章,评审
  • Low Prevalence of Isolated Growth Hormone Deficiency in Patients After Brain Injury: Results From a Phase II Pilot Study.

    abstract::Growth hormone deficiency (GHD) results in an impaired health-related quality of life (HrQoL) and cognitive impairment in the attention and memory domain. GHD is assumed to be a frequent finding after brain injury due to traumatic brain injury (TBI), aneurysmal subarachnoid hemorrhage (SAH) or ischemic stroke. Hence, ...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2018.00723

    authors: Leonhardt M,Kopczak A,Schäpers B,Limbrock J,Sämann PG,Czisch M,von Steinbuechel N,Jordan M,Schneider HJ,Schneider M,Sievers C,Stalla GK

    更新日期:2018-12-17 00:00:00

  • Luteal Coasting and Individualization of Human Chorionic Gonadotropin Dose after Gonadotropin-Releasing Hormone Agonist Triggering for Final Oocyte Maturation-A Retrospective Proof-of-Concept Study.

    abstract::Ovarian stimulation in a gonadotropin-releasing hormone (GnRH) antagonist protocol with the use of GnRH agonist for final oocyte maturation is the state-of-the-art treatment in patients with an expected or known high response to avoid or at least reduce significantly the risk for development of ovarian hyperstimulatio...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00033

    authors: Lawrenz B,Samir S,Garrido N,Melado L,Engelmann N,Fatemi HM

    更新日期:2018-02-15 00:00:00

  • Plasma Prolactin and Progesterone Levels and the Risk of Gestational Diabetes: A Prospective and Longitudinal Study in a Multiracial Cohort.

    abstract::Objective: Prolactin and progesterone are implicated in glucose homeostasis in and outside of pregnancy. However, their associations with gestational diabetes (GDM) risk were not well-understood. This study investigates this question in a prospective and longitudinal cohort. Methods: This is a nested case-control stud...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00083

    authors: Li M,Song Y,Rawal S,Hinkle SN,Zhu Y,Tekola-Ayele F,Ferrara A,Tsai MY,Zhang C

    更新日期:2020-02-27 00:00:00

  • Plasma Levels of Amino Acids Related to Urea Cycle and Risk of Type 2 Diabetes Mellitus in Chinese Adults.

    abstract::Objective: This study aimed to test associations between type 2 diabetes mellitus (T2DM) and metabolites in urea cycle including arginine, citrulline and ornithine. Methods:This study used a hospital-based cross-sectional study design. We retrieved medical notes of 401 in-patients with onset of T2DM within 2 years and...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00050

    authors: Cao YF,Li J,Zhang Z,Liu J,Sun XY,Feng XF,Luo HH,Yang W,Li SN,Yang X,Fang ZZ

    更新日期:2019-02-18 00:00:00

  • Impact of Female Obesity on Cumulative Live Birth Rates in the First Complete Ovarian Stimulation Cycle.

    abstract::Background: Female overweight/obesity has been reported to be associated with compromised pregnancy outcomes in fresh embryo transfer cycles. It is unclear whether the cumulative live birth rate (CLBR) is adversely affected after all viable embryos are transferred from the first ovarian stimulation cycle. Objectives: ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00516

    authors: Ding W,Zhang FL,Liu XC,Hu LL,Dai SJ,Li G,Kong HJ,Guo YH

    更新日期:2019-08-02 00:00:00

  • Circulating MicroRNA-15a Associates With Retinal Damage in Patients With Early Stage Type 2 Diabetes.

    abstract::Circulating microRNAs are potential biomarkers of type 2 diabetes mellitus (T2DM) and related complications. Here, we investigated the association of microRNA-15a with early retinal damage in T2DM. A cohort of untreated subjects screened for intermediate/high risk of T2DM, according to a score assessment questionnaire...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00254

    authors: Sangalli E,Tagliabue E,Sala L,Prattichizzo F,Uccellatore A,Spada D,Lorino F,de Candia P,Lupini S,Cantone L,Favero C,Madeddu P,Bollati V,Genovese S,Spinetti G

    更新日期:2020-04-23 00:00:00

  • Future Perspectives of POSEIDON Stratification for Clinical Practice and Research.

    abstract::A total of 50% of patients undergoing IVF treatment has previously been estimated to fulfill the POSEIDON classification criteria; importantly, although the reproductive prognosis differs between patients, POSEIDON patients share the same characteristic of a low ovarian response to exogenous gonadotropin stimulation-i...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2019.00439

    authors: Humaidan P,La Marca A,Alviggi C,Esteves SC,Haahr T

    更新日期:2019-07-11 00:00:00

  • The Role of Peroxisome Proliferator-Activated Receptor Gamma (PPARG) in Adipogenesis: Applying Knowledge from the Fish Aquaculture Industry to Biomedical Research.

    abstract::The tropical freshwater zebrafish has recently emerged as a valuable model organism for the study of adipose tissue biology and obesity-related disease. The strengths of the zebrafish model system are its wealth of genetic mutants, transgenic tools, and amenability to high-resolution imaging of cell dynamics within li...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2017.00102

    authors: Wafer R,Tandon P,Minchin JEN

    更新日期:2017-05-22 00:00:00

  • Exploiting Nanobodies in the Detection and Quantification of Human Growth Hormone via Phage-Sandwich Enzyme-Linked Immunosorbent Assay.

    abstract:BACKGROUND:Monitoring blood levels of human growth hormone (hGH) in most children with short stature deficiencies is crucial for taking a decision of treatment with extended course of daily and expensive doses of recombinant hGH (rhGH or Somatropin®). Besides, misusing of rhGH by sportsmen is banned by the World Anti-D...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2017.00115

    authors: Murad H,Assaad JM,Al-Shemali R,Abbady AQ

    更新日期:2017-05-30 00:00:00

  • Anti-apoptotic Actions of Allopregnanolone and Ganaxolone Mediated Through Membrane Progesterone Receptors (PAQRs) in Neuronal Cells.

    abstract::The neurosteroids progesterone and allopregnanolone regulate numerous neuroprotective functions in neural tissues including inhibition of epileptic seizures and cell death. Many of progesterone's actions are mediated through the nuclear progesterone receptor (PR), while allopregnanolone is widely considered to be devo...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00417

    authors: Thomas P,Pang Y

    更新日期:2020-06-24 00:00:00

  • Exercise Training in Obese Rats Does Not Induce Browning at Thermoneutrality and Induces a Muscle-Like Signature in Brown Adipose Tissue.

    abstract::Aim: Exercise training elicits diverse effects on brown (BAT) and white adipose tissue (WAT) physiology in rodents housed below their thermoneutral zone (i.e., 28-32°C). In these conditions, BAT is chronically hyperactive and, unlike human residence, closer to thermoneutrality. Therefore, we set out to determine the e...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00097

    authors: Aldiss P,Lewis JE,Lupini I,Bloor I,Chavoshinejad R,Boocock DJ,Miles AK,Ebling FJP,Budge H,Symonds ME

    更新日期:2020-03-20 00:00:00

  • Opposite T3 Response of ACTG1-FOS Subnetwork Differentiate Tailfin Fate in Xenopus Tadpole and Post-hatching Axolotl.

    abstract::Amphibian post-embryonic development and Thyroid Hormones (TH) signaling are deeply and intimately connected. In anuran amphibians, TH induce the spectacular and complex process known as metamorphosis. In paedomorphic salamanders, at similar development time, raising levels of TH fail to induce proper metamorphosis, a...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00194

    authors: Kerdivel G,Blugeon C,Fund C,Rigolet M,Sachs LM,Buisine N

    更新日期:2019-04-02 00:00:00

  • Intracellular signal transduction and modification of the tumor microenvironment induced by RET/PTCs in papillary thyroid carcinoma.

    abstract::RET gene rearrangements (RET/PTCs) represent together with BRAF point mutations the two major groups of mutations involved in papillary thyroid carcinoma (PTC) initiation and progression. In this review, we will examine the mechanisms involved in RET/PTC-induced thyroid cell transformation. In detail, we will summariz...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2012.00067

    authors: Menicali E,Moretti S,Voce P,Romagnoli S,Avenia N,Puxeddu E

    更新日期:2012-05-22 00:00:00

  • Summary of Expert Opinion on the Management of Children With Chronic Kidney Disease and Growth Failure With Human Growth Hormone.

    abstract::Background: The management of children and adolescents with chronic kidney disease (CKD) and growth failure candidate for recombinant human growth hormone therapy (rhGH) is based on an appraisal of the literature established on a 2006 consensus statement and 2019 Clinical practice recommendations. The performance of t...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00587

    authors: Cappa M,Maghnie M,Carbone V,Chioma L,Errichiello C,Giavoli C,Giordano M,Guazzarotti L,Klain A,Montini G,Murer L,Parpagnoli M,Pecoraro C,Pesce S,Verrina E

    更新日期:2020-09-02 00:00:00

  • High Adiposity Is Associated With Higher Nocturnal and Diurnal Glycaemia, but Not With Glycemic Variability in Older Individuals Without Diabetes.

    abstract:Background:It is well known that adiposity is a risk factor for insulin resistance and type 2 diabetes mellitus. In the present study, we aimed to investigate the associations of measures of adiposity with indices of glycemia and of glycemic variability over a 72-h period in non-diabetic older adults. Methods:This cro...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00238

    authors: Noordam R,Huurman NC,Wijsman CA,Akintola AA,Jansen SWM,Stassen S,Beekman M,van de Rest O,Slagboom PE,Mooijaart SP,van Heemst D

    更新日期:2018-05-14 00:00:00

  • People Are Taller in Countries With Better Environmental Conditions.

    abstract::Background: Height is considered an indicator of health and well-being of an individual and population. Height variation results from a complex interaction of genetic, environmental, socioeconomic, and cultural influences. In order to understand the contribution of environmental stress associated with the child's grow...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00106

    authors: German A,Mesch G,Hochberg Z

    更新日期:2020-03-11 00:00:00

  • Cholecystokinin-From Local Gut Hormone to Ubiquitous Messenger.

    abstract::Cholecystokinin (CCK) was discovered in 1928 in jejunal extracts as a gallbladder contraction factor. It was later shown to be member of a peptide family, which are all ligands for the CCK1 and CCK2 receptors. CCK peptides are known to be synthetized in small intestinal endocrine I-cells and cerebral neurons. But in a...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2017.00047

    authors: Rehfeld JF

    更新日期:2017-04-13 00:00:00

  • Zebrafish: A Resourceful Vertebrate Model to Investigate Skeletal Disorders.

    abstract::Animal models are essential tools for addressing fundamental scientific questions about skeletal diseases and for the development of new therapeutic approaches. Traditionally, mice have been the most common model organism in biomedical research, but their use is hampered by several limitations including complex genera...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2020.00489

    authors: Tonelli F,Bek JW,Besio R,De Clercq A,Leoni L,Salmon P,Coucke PJ,Willaert A,Forlino A

    更新日期:2020-07-31 00:00:00

  • β-Arrestin 1 in Thyrotropin Receptor Signaling in Bone: Studies in Osteoblast-Like Cells.

    abstract::A direct action of thyrotropin (TSH, thyroid-stimulating hormone) on bone precursors in humans is controversial. Studies in rodent models have provided conflicting findings. We used cells derived from a moderately differentiated osteosarcoma stably overexpressing human TSH receptors (TSHRs) as a model of osteoblast pr...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2020.00312

    authors: Boutin A,Gershengorn MC,Neumann S

    更新日期:2020-05-20 00:00:00

  • Adipogenic Gene Expression in Gilthead Sea Bream Mesenchymal Stem Cells from Different Origin.

    abstract::During the last decades, adipogenesis has become an emerging field of study in aquaculture due to the relevance of the adipose tissue in many physiological processes and its connection with the endocrine system. In this sense, recent studies have translated into the establishment of preadipocyte culture models from se...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2016.00113

    authors: Salmerón C,Riera-Heredia N,Gutiérrez J,Navarro I,Capilla E

    更新日期:2016-08-22 00:00:00

  • The "A to Z" of Managing Type 2 Diabetes in Culturally Diverse Populations.

    abstract::Type 2 diabetes affects racial/ethnic minorities at an alarming rate in the US and in many countries around the world. The quality of health care provided to these groups is often suboptimal, resulting in worse patient-related outcomes when compared to those in mainstream populations. Understanding the complex biologi...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2018.00479

    authors: Caballero AE

    更新日期:2018-08-28 00:00:00

  • Testicular cancer and HPV semen infection.

    abstract::Testicular cancer represents the more frequent solid tumor affecting males aged 15-35 years. In the last decades, its incidence showed a progressive increased probably due to genetic and environmental factors. Despite exposure to some viruses such as HIV, HCV, EBV, and HPV is frequently related to cancer development, ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2012.00172

    authors: Garolla A,Pizzol D,Bertoldo A,Ghezzi M,Carraro U,Ferlin A,Foresta C

    更新日期:2012-12-21 00:00:00

  • Endocrine Disruption of Vasopressin Systems and Related Behaviors.

    abstract::Endocrine disrupting chemicals (EDCs) are chemicals that interfere with the organizational or activational effects of hormones. Although the vast majority of the EDC literature focuses on steroid hormone signaling related impacts, growing evidence from a myriad of species reveals that the nonapeptide hormones vasopres...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2017.00134

    authors: Patisaul HB

    更新日期:2017-06-19 00:00:00

  • Small Ubiquitin-Like Modifier 4 (SUMO4) Gene M55V Polymorphism and Type 2 Diabetes Mellitus: A Meta-analysis Including 6,823 Subjects.

    abstract:Background:Many studies suggest that the small ubiquitin-like modifier 4 (SUMO4) M55V gene polymorphism (rs237025) may be associated with an increased risk of type 2 diabetes mellitus (T2DM). However, due to other conflicting results, a clear consensus is lacking in the matter. Objective and methods:A meta-analysis co...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2017.00303

    authors: Li YY,Wang H,Yang XX,Geng HY,Gong G,Kim HJ,Zhou YH,Wu JJ

    更新日期:2017-11-02 00:00:00

  • The Impact of Bariatric Surgery on Type 2 Diabetes Mellitus and the Management of Hypoglycemic Events.

    abstract::Recent studies discussed the benefit of bariatric surgery on obese patients diagnosed with type 2 diabetes mellitus (T2DM). Several factors play an essential role in predicting the impact of bariatric surgery on T2DM, such as ABCD score (age, BMI, C-peptide, and duration of the disease), HbA1c, and fasting blood gluco...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2017.00037

    authors: Kassem MA,Durda MA,Stoicea N,Cavus O,Sahin L,Rogers B

    更新日期:2017-03-01 00:00:00

  • Distinguishing Patients With Distant Metastatic Differentiated Thyroid Cancer Who Biochemically Benefit From Next Radioiodine Treatment.

    abstract:Background:Repeated radioiodine (131I) treatment (RT) are commonly performed in patients with 131I-avid distant metastatic differentiated thyroid cancer (DM-DTC), but more precise indications remain indeterminate. This prospective study was conducted to explore predictors for biochemical response (BR) to next RT. Meth...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.587315

    authors: Sa R,Cheng L,Jin Y,Fu H,Shen Y,Chen L

    更新日期:2020-11-16 00:00:00

  • Long-Term Follow-Up of Significant Improvement After CAPTEM Treatment for Rare Adrenocorticotropin-Producing Cardiac Neuroendocrine Tumor.

    abstract::Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is a rare cause of Cushing syndrome. If routine imaging examinations cannot identify the source of ACTH production, long-term follow-up observation is necessary to determine the etiology. We present the case of a middle-aged male with gradual weight gain and a ...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2019.00713

    authors: Lu L,Meng Q,Xing X,Yuan T,Zhang H,Li N,Wang Y,Cheng Y,Bai C,Wang H,Cheng X,Xiao Y,Pan B,Li Y,Sun J,Liang Z,Zhu H,Wang R,Lu Z

    更新日期:2019-10-22 00:00:00

  • Adiponectin, Leptin and Visfatin in Hypoxia and its Effect for Weight Loss in Obesity.

    abstract::Rationale: Hypoxia induces leptin gene expression in human adipocytes via hypoxia-inducible factors (HIF-α/β). Under ambient moderate hypoxia, leptin in adipocytes is elevated for at least 14 days. Leptin is supposedly involved in the reduced food intake, increased utilization of fatty acids for energy production and ...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2018.00615

    authors: Rausch LK,Hofer M,Pramsohler S,Kaser S,Ebenbichler C,Haacke S,Gatterer H,Netzer NC

    更新日期:2018-10-18 00:00:00

  • Olfactory Receptors in Semen and in the Male Tract: From Proteome to Proteins.

    abstract::The estimated number of testicular olfactory receptors (ORs) in mammals range between 20 and 66. Previous data reported the role of hOR17-4 and mOR23 in sperm-oocyte chemiotaxis. Proteomic analysis was performed to understand which are the ORs expressed in seminal plasma. Seminal samples by four fertile men were analy...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2017.00379

    authors: Milardi D,Colussi C,Grande G,Vincenzoni F,Pierconti F,Mancini F,Baroni S,Castagnola M,Marana R,Pontecorvi A

    更新日期:2018-01-23 00:00:00

  • Corrigendum: The Gambian Bone and Muscle Ageing Study: Baseline Data From a Prospective Observational African Sub-Saharan Study.

    abstract::[This corrects the article on p. 219 in vol. 8, PMID: 28912754.]. ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,已发布勘误

    doi:10.3389/fendo.2018.00160

    authors: Zengin A,Fulford AJ,Sawo Y,Jarjou LM,Schoenmakers I,Goldberg G,Prentice A,Ward KA

    更新日期:2018-04-16 00:00:00