Long-Term Follow-Up of Significant Improvement After CAPTEM Treatment for Rare Adrenocorticotropin-Producing Cardiac Neuroendocrine Tumor.

abstract：:Pregnancy-associated plasma protein-A (PAPP-A) and its homolog PAPP-A2 are enzymes that modulate the availability and mitogenic activity of insulin-like growth factor-I (IGF-I). PAPP-A has been implicated in numerous cancers but reports on PAPP-A2 in malignancy are non-existent. In a prospective observational study of...

journal_title：Frontiers in endocrinology

authors： Hjortebjerg R,Espelund U,Rasmussen TR,Folkersen B,Steiniche T,Georgsen JB,Oxvig C,Frystyk J

更新日期：2020-09-02 00:00:00

abstract：:Obstructive sleep apnea-hypopnea syndrome (OSAHS) is frequently present in patients with severe obesity, but its prevalence especially in women is not well defined. OSAHS and non-alcoholic fatty liver disease are common conditions, frequently associated in patients with central obesity and metabolic syndrome and are b...

journal_title：Frontiers in endocrinology

authors： Scartabelli G,Querci G,Marconi L,Ceccarini G,Piaggi P,Fierabracci P,Salvetti G,Cizza G,Mazzeo S,Vitti J,Berger S,Palla A,Santini F

更新日期：2018-06-06 00:00:00

abstract：:Objective: Circulating free DNA (cfDNA) in general and circulating tumor DNA (ctDNA) in particular is becoming an increasingly used form of liquid biopsy biomarkers. In this study, we are investigating the ability to detect ctDNA from the plasma of pituitary adenoma (PA) patients. Design: Tumor tissue samples were obt...

journal_title：Frontiers in endocrinology

authors： Megnis K,Peculis R,Rovite V,Laksa P,Niedra H,Balcere I,Caune O,Breiksa A,Nazarovs J,Stukens J,Konrade I,Pirags V,Klovins J

更新日期：2019-09-18 00:00:00

abstract：:Cushing's disease recurrence following successful pituitary surgery is common and merits prompt and careful diagnosis, as untreated hypercortisolism leads to increased morbidity and mortality. However, an established recurrence definition has not been forthcoming. This poses a diagnostic challenge especially early in ...

journal_title：Frontiers in endocrinology

authors： Hinojosa-Amaya JM,Varlamov EV,McCartney S,Fleseriu M

更新日期：2019-11-08 00:00:00

abstract：:Kisspeptin, encoded by the Kiss1 gene, is required for reproduction. Humans and mice lacking kisspeptin or its receptor, Kiss1r, have impairments in reproductive physiology and fertility. In addition to being located in the hypothalamus in the anteroventral periventricular and arcuate nuclei, kisspeptin neurons are al...

journal_title：Frontiers in endocrinology

authors： Stephens SBZ,Kauffman AS

更新日期：2017-08-07 00:00:00

abstract：:The world-wide obesity epidemic constitutes a severe threat to human health and wellbeing and poses a major challenge to health-care systems. Current therapeutic approaches, relying mainly on reduced energy intake and/or increased exercise energy expenditure, are generally of limited effectiveness. Previously believed...

journal_title：Frontiers in endocrinology

authors： Betz MJ,Enerbäck S

更新日期：2011-11-29 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) is a pleotropic metabolic regulator, expression of which is elevated during fasting. To this end, the precise role played by FGF21 in the biology of fasting has been the subject of several recent studies, which have demonstrated contributions to the regulation of both lipid and carb...

journal_title：Frontiers in endocrinology

authors： Antonellis PJ,Hayes MP,Adams AC

更新日期：2016-06-30 00:00:00

abstract：:[This corrects the article on p. 26 in vol. 9, PMID: 29487564.]. ...

journal_title：Frontiers in endocrinology

authors： Konya J,Spurgeon BEJ,Al Qaissi A,Sathyapalan T,Ajjan R,Madden L,Naseem KM,Garrett AT,Kilpatrick E,Atkin SL

更新日期：2018-06-07 00:00:00

abstract：:Some newly described steroid-related compounds, also found in the rest of the body, are formed and active in the central nervous system, particularly in the brain. Some are of pharmacological and physiopathological interest. We specifically report on two compounds, "MAP4343," a new neurosteroid very efficient antidepr...

journal_title：Frontiers in endocrinology

authors： Baulieu EE

更新日期：2018-06-15 00:00:00

abstract：:Sex steroids play essential roles in the modulation of synaptic plasticity and neuroprotection in the hippocampus. Accumulating evidence shows that hippocampal neurons synthesize both estrogen and androgen. Recently, we also revealed the hippocampal synthesis of corticosteroids. The accurate concentrations of these hi...

journal_title：Frontiers in endocrinology

authors： Hojo Y,Higo S,Kawato S,Hatanaka Y,Ooishi Y,Murakami G,Ishii H,Komatsuzaki Y,Ogiue-Ikeda M,Mukai H,Kimoto T

更新日期：2011-10-10 00:00:00

abstract：:The 3D arrangement of porous granular biomaterials usable to fill bone defects has received little study. Granular biomaterials occupy 3D space when packed together in a manner that creates a porosity suitable for the invasion of vascular and bone cells. Granules of beta-tricalcium phosphate (β-TCP) were prepared with...

journal_title：Frontiers in endocrinology

authors： Chappard D,Terranova L,Mallet R,Mercier P

更新日期：2015-10-12 00:00:00

abstract：:Chemokines are small molecules that play a crucial role as chemoattractants for several cell types, and their components are associated with host immune responses and repair mechanisms. Chemokines selectively recruit monocytes, neutrophils, and lymphocytes and induce chemotaxis through the activation of G protein-coup...

journal_title：Frontiers in endocrinology

authors： Siddiqui JA,Partridge NC

更新日期：2017-03-29 00:00:00

abstract：:Successful discontinuation of cabergoline (CAB) treatment has been reported in 31-75% of prolactinomas patients treated for at least 2 years. In contrast, it is not well established whether CAB therapy can be successfully withdrawn after a failed first attempt. This prospective open trial was designed to address this ...

journal_title：Frontiers in endocrinology

authors： Vilar L,Albuquerque JL,Gadelha PS,Rangel Filho F,Siqueira AM,da Fonseca MM,Viana KF,Gomes BS,Lyra R

更新日期：2015-02-04 00:00:00

abstract：:Osteoporosis is a metabolic skeletal disorder in which bone mass is depleted and bone structure is destroyed to the degree that bone becomes fragile and prone to fractures. Emerging evidence suggests that N6-methyladenosine (m6A) modification, a novel epitranscriptomic marker, has a significant role in bone developmen...

journal_title：Frontiers in endocrinology

authors： Chen X,Hua W,Huang X,Chen Y,Zhang J,Li G

更新日期：2020-01-10 00:00:00

abstract：:Hard tissue regeneration represents a challenge for the Regenerative Medicine and Mesenchymal stem cells (MSCs) could be a successful therapeutic strategy. T-LysYal® (T-Lys), a new derivative of Hyaluronic Acid (HA) possessing a superior stability, has already been proved efficient in repairing corneal epithelial cell...

journal_title：Frontiers in endocrinology

authors： Di Benedetto A,Posa F,Marazzi M,Kalemaj Z,Grassi R,Lo Muzio L,Comite MD,Cavalcanti-Adam EA,Grassi FR,Mori G

更新日期：2020-05-05 00:00:00

abstract：:Catecholamine (CA) secretion from the adrenal medullary tissue is a key step of the adaptive response triggered by an organism to cope with stress. Whereas molecular and cellular secretory processes have been extensively studied at the single chromaffin cell level, data available for the whole gland level are much sca...

journal_title：Frontiers in endocrinology

authors： De Nardi F,Lefort C,Bréard D,Richomme P,Legros C,Guérineau NC

更新日期：2017-09-25 00:00:00

abstract：:The brain is composed of neurons and non-neuronal cells, with the latter encompassing glial, ependymal and endothelial cells, as well as pericytes and progenitor cells. Studies aimed at understanding how the brain operates have traditionally focused on neurons, but the importance of non-neuronal cells has become incre...

journal_title：Frontiers in endocrinology

authors： Argente-Arizón P,Freire-Regatillo A,Argente J,Chowen JA

更新日期：2015-03-26 00:00:00

abstract：:In some organisms and cells, oxygen availability influences oxygen consumption. In this review, we examine this phenomenon of hypoxic hypometabolism (HH), discussing its features, mechanisms, and implications. Small mammals and other vertebrate species exhibit "oxyconformism," a downregulation of metabolic rate and bo...

journal_title：Frontiers in endocrinology

authors： Gu C,Jun JC

更新日期：2018-11-13 00:00:00

abstract：:Growth hormone (GH) has been used as an adjunct in the field of female infertility treatment for more than 25 years, although, apart from treating women with GH deficiency its role has not yet been clarified. Contributing to this lack of clarity is that several underpowered studies have been performed on women undergo...

journal_title：Frontiers in endocrinology

authors： Hart RJ

更新日期：2019-07-24 00:00:00

abstract：:Thyroid nodules with ultrasound (US) cancer risk features and extra-thyroid lesions suggesting malignant lymph nodes, require prompt diagnosis, especially in children. The US pattern of intrathyroidal ectopic thymus (IET) can strongly suggest papillary thyroid carcinoma (PTC). The extra-thyroid ectopic thymic tissue (...

journal_title：Frontiers in endocrinology

authors： Stasiak M,Adamczewski Z,Stawerska R,Krawczyk T,Tomaszewska M,Lewiński A

更新日期：2019-04-10 00:00:00

abstract：:Background: About 85-90% of children born small for gestational age (SGA) experience a catch-up growth that occurs mostly during the first year of life and results in a full stature recovery by the age of 2. Objective: To investigate the relation between bone maturation (BM) and catch-up growth during the first year o...

journal_title：Frontiers in endocrinology

authors： Pepe G,Calafiore M,Valenzise M,Corica D,Morabito L,Pajno GB,Aversa T,Wasniewska M

更新日期：2020-03-24 00:00:00

abstract：:Activation of the hypothalamo-pituitary-adrenal (HPA) axis is a basic reaction of animals to environmental perturbations that threaten homeostasis. These responses are ultimately regulated by neurons residing within the paraventricular nucleus (PVN) of the hypothalamus. Within the PVN, corticotrophin-releasing hormone...

journal_title：Frontiers in endocrinology

authors： Handa RJ,Sharma D,Uht R

更新日期：2011-11-10 00:00:00

abstract：:Anti-Müllerian hormone reflects the continuum of the functional ovarian reserve, and as such can predict ovarian response to gonadotropin stimulation and be used to individualize treatment pathways to improve efficacy and safety. However, consistent with other biomarkers and age-based prediction models it has limited ...

journal_title：Frontiers in endocrinology

authors： Li HWR,Nelson SM

更新日期：2020-12-09 00:00:00

abstract：:Introduction: Adrenal myelolipomas are usually isolated benign adrenal lesions, but can be adjacent to steroid-secreting adrenocortical tumors. We studied the aberrant regulation of cortisol secretion in a 61 year-old woman with combined bilateral myelolipomas and primary bilateral macronodular adrenal hyperplasia (BM...

journal_title：Frontiers in endocrinology

authors： Larose S,Bondaz L,Mermejo LM,Latour M,Prosmanne O,Bourdeau I,Lacroix A

更新日期：2019-09-11 00:00:00

abstract：:As one of the most serious complications of diabetes, diabetic cardiomyopathy (DCM) imposes a huge burden on individuals and society, and represents a major public health problem. It has long been recognized that physical exercise has important health benefits for patients with type 2 diabetes, and regular physical ex...

journal_title：Frontiers in endocrinology

authors： Zheng J,Cheng J,Zheng S,Zhang L,Guo X,Zhang J,Xiao X

更新日期：2018-12-03 00:00:00

abstract：:Background: Disturbance of immunometabolic signaling is a key process involved in the progression of obesity. Microglia-the resident immune cells in the brain, initiate local immune responses. It is known that hypercaloric diets lead to microglial activation. Previously, we observed that hypothalamic microglial cells ...

journal_title：Frontiers in endocrinology

authors： Milanova IV,Kalsbeek MJT,Wang XL,Korpel NL,Stenvers DJ,Wolff SEC,de Goede P,Heijboer AC,Fliers E,la Fleur SE,Kalsbeek A,Yi CX

更新日期：2019-06-26 00:00:00

abstract：Background:In adults, excess adiposity has been associated with low-grade, chronic inflammation and compromised bone health, but less is known about these linkages in children. The purpose of this study was to compare the circulating levels of inflammatory cytokines, adipokines, osteokines, and bone markers at rest and...

journal_title：Frontiers in endocrinology

authors： Kurgan N,McKee K,Calleja M,Josse AR,Klentrou P

更新日期：2020-12-11 00:00:00

abstract：:Platelet activation plays a pivotal role in the development and progression of atherosclerosis, which often leads to potentially fatal ischemic events at later stages of the disease. Platelets and platelet microvesicles (PMVs) contain large amounts of microRNA (miRNA), which contributes largely to the pool of circulat...

journal_title：Frontiers in endocrinology

authors： Pordzik J,Pisarz K,De Rosa S,Jones AD,Eyileten C,Indolfi C,Malek L,Postula M

更新日期：2018-03-20 00:00:00

abstract：:At least 57 independent loci within the human genome confer varying degrees of risk for the development of type 1 diabetes (T1D). The majority of these variants are thought to contribute to overall genetic risk by modulating host innate and adaptive immune responses, ultimately resulting in a loss of immunological tol...

journal_title：Frontiers in endocrinology

authors： Wallet MA,Santostefano KE,Terada N,Brusko TM

更新日期：2017-10-18 00:00:00

abstract：:Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, which then modulates the degree of adaptation and response to a later stressor. It is known that early-life stress can impact on later health but less is known about how early-life stress impairs HPA axis activity, contributing to maladaptation of the str...

journal_title：Frontiers in endocrinology

authors： Maniam J,Antoniadis C,Morris MJ

更新日期：2014-05-13 00:00:00