Monitoring the Secretory Behavior of the Rat Adrenal Medulla by High-Performance Liquid Chromatography-Based Catecholamine Assay from Slice Supernatants.

abstract：AIM:The leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (DM) is coronary artery disease (CAD), a condition often asymptomatic but severe in these patients. Although glucose metabolism impairment and oxidative stress are known actors in the endothelial dysfunction/remodeling that occur...

journal_title：Frontiers in endocrinology

authors： Infante T,Forte E,Aiello M,Salvatore M,Cavaliere C

更新日期：2017-08-21 00:00:00

abstract：:The p53-related gene p63 is required for epithelial cell establishment and its expression is often altered in tumor cells. Great strides have been made in understanding the pathways and mechanisms that regulate p63 levels, such as the Wnt, Hedgehog, Notch, and EGFR pathways. We discuss here the multiple signaling path...

journal_title：Frontiers in endocrinology

authors： Yoh K,Prywes R

更新日期：2015-04-28 00:00:00

abstract：:3-Iodothyronamine (3-T1AM) is an endogenous thyroid hormone metabolite. The profound pharmacological effects of 3-T1AM on energy metabolism and thermal homeostasis have raised interest to elucidate its signaling properties in tissues that pertain to metabolic regulation and thermogenesis. Previous studies identified G...

journal_title：Frontiers in endocrinology

authors： Bräunig J,Mergler S,Jyrch S,Hoefig CS,Rosowski M,Mittag J,Biebermann H,Khajavi N

更新日期：2018-09-11 00:00:00

abstract：:Some newly described steroid-related compounds, also found in the rest of the body, are formed and active in the central nervous system, particularly in the brain. Some are of pharmacological and physiopathological interest. We specifically report on two compounds, "MAP4343," a new neurosteroid very efficient antidepr...

journal_title：Frontiers in endocrinology

authors： Baulieu EE

更新日期：2018-06-15 00:00:00

abstract：:Background: Congenital Hyperinsulinism (CHI) is an important cause of severe and persistent hypoglycaemia in infancy and childhood. The focal form (CHI-F) of CHI can be potentially cured by pancreatic lesionectomy. While diagnostic characteristics of CHI-F pancreatic histopathology are well-recognized, correlation wit...

journal_title：Frontiers in endocrinology

authors： Craigie RJ,Salomon-Estebanez M,Yau D,Han B,Mal W,Newbould M,Cheesman E,Bitetti S,Mohamed Z,Sajjan R,Padidela R,Skae M,Flanagan S,Ellard S,Cosgrove KE,Banerjee I,Dunne MJ

更新日期：2018-10-17 00:00:00

abstract：:Fibroblast growth factor 1 (FGF1) is reported to be expressed in the testis. How FGF1 affects stem Leydig cell development remains unclear. Here, we report the effects of FGF1 on rat stem Leydig cell development in an ethane dimethane sulfonate (EDS)-treated model. FGF1 (100 ng/testis) significantly increased serum te...

journal_title：Frontiers in endocrinology

authors： Chen L,Li X,Wang Y,Song T,Li H,Xie L,Li L,Chen X,Ma L,Chen Y,Lv Y,Li X,Ge RS

更新日期：2019-03-08 00:00:00

abstract：:Several reports in humans as well as transgenic mouse models have shown that estrogens play an important role in male reproduction and fertility. Estrogen receptor alpha (ERα) and beta (ERβ) are expressed in different male tissues including the brain. The estradiol-binding protein GPER1 also mediates estrogen action i...

journal_title：Frontiers in endocrinology

authors： Guercio G,Saraco N,Costanzo M,Marino R,Ramirez P,Berensztein E,Rivarola MA,Belgorosky A

更新日期：2020-02-25 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fendo.2017.00018.]. ...

journal_title：Frontiers in endocrinology

authors： Sekar R,Wang L,Chow BKC

更新日期：2018-07-18 00:00:00

abstract：:11-ketotestosterone (11-KT) is a non-aromatizable and the most potent androgen in a few teleost. It has been reported that 11-KT in serum had a high concentration and increased sharply before the period of yolk deposition in females of few fishes. The aim of this study was to analyze the role of 11-KT both in vivo and...

journal_title：Frontiers in endocrinology

authors： Wang W,Zhu H,Tian Z,Sun A,Dong Y,Dong T,Hu H

更新日期：2020-03-25 00:00:00

abstract：:The pathophysiological function of the G-protein coupled melatonin MT1 and MT2 receptors has not yet been well-clarified. Recent advancements using selective MT1/ MT2 receptor ligands and MT1/MT2 receptor knockout mice have suggested that the activation of the MT1 receptors are mainly implicated in the regulation of r...

journal_title：Frontiers in endocrinology

authors： Gobbi G,Comai S

更新日期：2019-03-01 00:00:00

abstract：Background:For detecting tumor recurrence of medullary thyroid carcinoma (MTC) in the neck, an appropriate frequency and interval of postoperative ultrasonography (US) surveillance remains unclear. This study aimed to assess an appropriate interval and frequency of postoperative neck US surveillance for detecting tumor...

journal_title：Frontiers in endocrinology

authors： Ahn HS,Kim DW,Lee YJ,Lee CY,Kim JH,Choi YJ,Lee S,Ryoo I,Huh JY,Sung JY,Kwak JY,Baek HJ

更新日期：2018-03-15 00:00:00

abstract：:The extracellular signal-regulated kinases (ERKs) are key components of multiple important cell signaling pathways regulating diverse biological responses. This signaling is characterized by phosphorylation cascades leading to ERK1/2 activation and promoted by various cell surface receptors including G protein-coupled...

journal_title：Frontiers in endocrinology

authors： Ayoub MA,Trebaux J,Vallaghe J,Charrier-Savournin F,Al-Hosaini K,Gonzalez Moya A,Pin JP,Pfleger KD,Trinquet E

更新日期：2014-06-23 00:00:00

abstract：:Introduction: Pituitary metastases (PM) are rare events and to date only very few cases of melanoma PM have been described in literature up to now. Case Presentation: We describe the clinical history of a 33-year-old male patient who underwent surgical excision of an inter-scapular melanoma in 2008. The subsequent fol...

journal_title：Frontiers in endocrinology

authors： Mormando M,Puliani G,Barnabei A,Lauretta R,Bianchini M,Chiefari A,Russillo M,Cognetti F,Romano L,Appetecchia M

更新日期：2020-07-23 00:00:00

abstract：:Pituitary adenomas, accounting for 15% of diagnosed intracranial neoplasms, are usually benign and pharmacologically and surgically treatable; however, the critical location, mass effects and hormone hypersecretion sustain their significant morbidity. Approximately 35% of pituitary tumors show a less benign course sin...

journal_title：Frontiers in endocrinology

authors： Würth R,Thellung S,Corsaro A,Barbieri F,Florio T

更新日期：2020-02-20 00:00:00

abstract：:Interferon gamma (IFNγ) is a Th1 cytokine that is critical for innate and adaptive immunity. Toll-like receptors (TLRs) signaling pathways are critical in early host defense against invading pathogens. miR-146a has been reported to participate in the regulation of host immunity. The known mechanisms of integrations be...

journal_title：Frontiers in endocrinology

authors： Peng W,Sun Y,Li GF,He LG,Li RZ,Liang YS,Ding X,Yu X,Zhang Y,Lin HR,Lu DQ

更新日期：2018-02-26 00:00:00

abstract：:Congenital hyperinsulinism (CHI) is a heterogenous and complex disorder in which the unregulated insulin secretion from pancreatic beta-cells leads to hyperinsulinaemic hypoglycaemia. The severity of hypoglycaemia varies depending on the underlying molecular mechanism and genetic defects. The genetic and molecular cau...

journal_title：Frontiers in endocrinology

authors： Galcheva S,Demirbilek H,Al-Khawaga S,Hussain K

更新日期：2019-02-26 00:00:00

abstract：:Background: The long noncoding RNA (lncRNA) functions as a regulator of initiation, progression, and metastasis of thyroid carcinomas. lncRNA OTUD6B antisense RNA 1 (OTUD6B-AS1) is a tumor-suppressive noncoding RNA in clear cell renal cell carcinoma. The role of OTUD6B-AS1 in thyroid carcinomas has not been reported y...

journal_title：Frontiers in endocrinology

authors： Wang Z,Xia F,Feng T,Jiang B,Wang W,Li X

更新日期：2020-03-17 00:00:00

abstract：:The paper reviews the early stages of the research on natriuretic hormone. The described experimental work was designed and accomplished in several internationally recognized laboratories where the author was invited to extend his projects. The cross-circulation experiments in animals with acutely increased extracellu...

journal_title：Frontiers in endocrinology

authors： Lichardus B

更新日期：2014-11-11 00:00:00

abstract：:RFamide-related peptide-3 (RFRP-3) [mammalian ortholog to gonadotropin-inhibiting hormone (GnIH)] potently inhibits gonadotropin secretion in mammals. Studies of RFRP-3 immunoreactivity and Rfrp expression (the gene encoding RFRP-3) in mammalian brains have uncovered several possible pathways regulating RFRP-3 neurons...

journal_title：Frontiers in endocrinology

authors： Poling MC,Kauffman AS

更新日期：2015-09-24 00:00:00

abstract：:A direct action of thyrotropin (TSH, thyroid-stimulating hormone) on bone precursors in humans is controversial. Studies in rodent models have provided conflicting findings. We used cells derived from a moderately differentiated osteosarcoma stably overexpressing human TSH receptors (TSHRs) as a model of osteoblast pr...

journal_title：Frontiers in endocrinology

authors： Boutin A,Gershengorn MC,Neumann S

更新日期：2020-05-20 00:00:00

abstract：:O-linked β-N-acetylglucosamine (O-GlcNAc) is an abundant and essential intracellular form of protein glycosylation in animals and plants. In humans, dysregulation of O-GlcNAcylation occurs in a wide range of diseases, including cancer, diabetes, and neurodegeneration. Since its discovery more than 30 years ago, great ...

journal_title：Frontiers in endocrinology

authors： Cox NJ,Luo PM,Smith TJ,Bisnett BJ,Soderblom EJ,Boyce M

更新日期：2018-10-15 00:00:00

abstract：:The insulin-like growth factor (IGF) family plays key roles in growth and development. In the cornea, IGF family members have been implicated in proliferation, differentiation, and migration, critical events that maintain a smooth refracting surface that is essential for vision. The IGF family is composed of multiple ...

journal_title：Frontiers in endocrinology

authors： Stuard WL,Titone R,Robertson DM

更新日期：2020-03-03 00:00:00

abstract：:The tropical freshwater zebrafish has recently emerged as a valuable model organism for the study of adipose tissue biology and obesity-related disease. The strengths of the zebrafish model system are its wealth of genetic mutants, transgenic tools, and amenability to high-resolution imaging of cell dynamics within li...

journal_title：Frontiers in endocrinology

authors： Wafer R,Tandon P,Minchin JEN

更新日期：2017-05-22 00:00:00

abstract：:Molecular mechanisms responsible for gonadotrophic control of ovarian follicle development and ovulation have not been fully delineated. In this study, prepubertal female rabbits were subjected to a combined PMSG/hCG treatment for the induction of follicle maturation and ovulation. Ovaries of 6 does at different time ...

journal_title：Frontiers in endocrinology

authors： Hu S,Liang X,Ren X,Shi Y,Su H,Li Y,Du K,Wang J,Jia X,Chen S,Lai S

更新日期：2019-10-29 00:00:00

abstract：:Women with impaired ovarian reserve or poor ovarian response (POR) to exogenous gonadotropin stimulation present a challenge for reproductive specialists. The primary reasons relate to the still limited knowledge about the POR pathophysiology and the lack of practical solutions for the management of these conditions. ...

journal_title：Frontiers in endocrinology

authors： Esteves SC,Roque M,Bedoschi GM,Conforti A,Humaidan P,Alviggi C

更新日期：2018-08-17 00:00:00

abstract：:Vitiligo represents the most common cause of acquired skin, hair, and oral depigmentation, affecting 0.5-1% of the population worldwide. It is clinically characterized by the appearance of disfiguring circumscribed skin macules following melanocyte destruction by autoreactive cytotoxic T lymphocytes. Patients affected...

journal_title：Frontiers in endocrinology

authors： Baldini E,Odorisio T,Sorrenti S,Catania A,Tartaglia F,Carbotta G,Pironi D,Rendina R,D'Armiento E,Persechino S,Ulisse S

更新日期：2017-10-27 00:00:00

abstract：:Bone marrow adipose tissue (MAT) is distinct from white adipose tissue (WAT) or brown adipose tissue (BAT) for its location, feature and function. As a largely ignored adipose depot, it is situated in bone marrow space and resided with bone tissue side-by-side. MAT is considered not only as a regulator of bone metabol...

journal_title：Frontiers in endocrinology

authors： Li Y,Meng Y,Yu X

更新日期：2019-02-08 00:00:00

abstract：:Early studies recognizing the importance of the decapod eyestalk in the endocrine regulation of crustacean physiology-molting, metabolism, reproduction, osmotic balance, etc.-helped found the field of crustacean endocrinology. Characterization of putative factors in the eyestalk using distinct functional bioassays ult...

journal_title：Frontiers in endocrinology

authors： Chen HY,Toullec JY,Lee CY

更新日期：2020-10-01 00:00:00

abstract：:The brain is composed of neurons and non-neuronal cells, with the latter encompassing glial, ependymal and endothelial cells, as well as pericytes and progenitor cells. Studies aimed at understanding how the brain operates have traditionally focused on neurons, but the importance of non-neuronal cells has become incre...

journal_title：Frontiers in endocrinology

authors： Argente-Arizón P,Freire-Regatillo A,Argente J,Chowen JA

更新日期：2015-03-26 00:00:00

abstract：:The neurosteroids progesterone and allopregnanolone regulate numerous neuroprotective functions in neural tissues including inhibition of epileptic seizures and cell death. Many of progesterone's actions are mediated through the nuclear progesterone receptor (PR), while allopregnanolone is widely considered to be devo...

journal_title：Frontiers in endocrinology

authors： Thomas P,Pang Y

更新日期：2020-06-24 00:00:00