Therapeutic prospects of metabolically active brown adipose tissue in humans.

abstract：:Both males and females of heliothine moths utilize sex-pheromones during the mating process. Females produce and release a sex pheromone for the long-range attraction of males for mating. Production of sex pheromone in females is controlled by the peptide hormone (pheromone biosynthesis activating neuropeptide, PBAN)....

journal_title：Frontiers in endocrinology

authors： Jurenka R,Rafaeli A

更新日期：2011-10-10 00:00:00

abstract：Background:Levothyroxine sodium (LT4) is the therapy of choice for hypothyroidism. In the last decade, new LT4 formulations, such as liquid and softgel capsules, became available. Even if some evidence has been reached in the efficacy of liquid LT4 in patients with suboptimal TSH on tablet LT4, the usefulness of softge...

journal_title：Frontiers in endocrinology

authors： Trimboli P,Virili C,Centanni M,Giovanella L

更新日期：2018-03-21 00:00:00

abstract：:Gonadotropin-inhibitory hormone (GnIH) was first identified in the Japanese quail as a hypothalamic neuropeptide inhibitor of gonadotropin secretion. Subsequent studies have shown that GnIH is present in the brains of birds including songbirds, and mammals including humans. The identified avian and mammalian GnIH pept...

journal_title：Frontiers in endocrinology

authors： Ubuka T,Son YL,Tobari Y,Tsutsui K

更新日期：2012-11-28 00:00:00

abstract：Objectives:Based on data from the China National Health Survey, we aimed to examine the association between body height and cardiometabolic disease (CMD) in a large adult population from Shaanxi province, and further to test whether this association was hinged upon other population characteristics. Methods:This popula...

journal_title：Frontiers in endocrinology

authors： Yuan Y,Zhou B,Wang S,Ma J,Dong F,Yang M,Zhang Z,Niu W

更新日期：2020-12-21 00:00:00

abstract：:Breast cancer remains a significant female mortality cause. It constitutes a multifactorial disease for which research on environmental factors offers little help in predicting onset or progression. The pursuit for its foundations by analyzing hormonal changes as a motive for disease development, indicates that increa...

journal_title：Frontiers in endocrinology

authors： Liarte S,Alonso-Romero JL,Nicolás FJ

更新日期：2018-09-27 00:00:00

abstract：:Background: Several preclinical and clinical studies have suggested that BRCA-mutation carriers may have decreased ovarian reserve. However, data in this area are limited and inconsistent, especially in young breast cancer patients. Objective: This study evaluated the association between BRCA mutation status and serum...

journal_title：Frontiers in endocrinology

authors： Son KA,Lee DY,Choi D

更新日期：2019-04-11 00:00:00

abstract：:Maternal over-nutrition can lead to metabolic disorders in offspring, whereas maternal dietary genistein may have beneficial effects on the metabolic health of offspring. Our objective was to determine whether maternal dietary genistein could attenuate the detrimental effects of a maternal high-fat diet on their offsp...

journal_title：Frontiers in endocrinology

authors： Zhou L,Xiao X,Zhang Q,Zheng J,Li M,Yu M,Wang X,Deng M,Zhai X,Li R

更新日期：2018-09-04 00:00:00

abstract：:Atherosclerosis results from endothelial cell dysfunction and inflammatory processes affecting both macro- and microvasculature which are involved in vascular diabetic complications. Glucagon-like peptide-1 (GLP-1) is an incretin hormone responsible for amplification of insulin secretion when nutrients are given orall...

journal_title：Frontiers in endocrinology

authors： Alonso N,Julián MT,Puig-Domingo M,Vives-Pi M

更新日期：2012-09-07 00:00:00

abstract：:The paper reviews the early stages of the research on natriuretic hormone. The described experimental work was designed and accomplished in several internationally recognized laboratories where the author was invited to extend his projects. The cross-circulation experiments in animals with acutely increased extracellu...

journal_title：Frontiers in endocrinology

authors： Lichardus B

更新日期：2014-11-11 00:00:00

abstract：:Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is a rare cause of Cushing syndrome. If routine imaging examinations cannot identify the source of ACTH production, long-term follow-up observation is necessary to determine the etiology. We present the case of a middle-aged male with gradual weight gain and a ...

journal_title：Frontiers in endocrinology

authors： Lu L,Meng Q,Xing X,Yuan T,Zhang H,Li N,Wang Y,Cheng Y,Bai C,Wang H,Cheng X,Xiao Y,Pan B,Li Y,Sun J,Liang Z,Zhu H,Wang R,Lu Z

更新日期：2019-10-22 00:00:00

abstract：:Obstructive sleep apnea-hypopnea syndrome (OSAHS) is frequently present in patients with severe obesity, but its prevalence especially in women is not well defined. OSAHS and non-alcoholic fatty liver disease are common conditions, frequently associated in patients with central obesity and metabolic syndrome and are b...

journal_title：Frontiers in endocrinology

authors： Scartabelli G,Querci G,Marconi L,Ceccarini G,Piaggi P,Fierabracci P,Salvetti G,Cizza G,Mazzeo S,Vitti J,Berger S,Palla A,Santini F

更新日期：2018-06-06 00:00:00

abstract：:Testosterone is responsible for several changes in the brain, including behavioral and emotional responses, memory, and cognition. Given this, we investigated changes in the brain wave profile caused by supplementation with exogenous testosterone in both castrated and non-castrated rats. We also investigated the serum...

journal_title：Frontiers in endocrinology

authors： Estumano DP,Ferreira LO,Bezerra PAL,da Silva MCP,Jardim GC,Santos GFS,Gustavo KS,Mattos BG,Ramos JAB,Jóia de Mello V,da Costa ET,Lopes DCF,Hamoy M

更新日期：2019-09-24 00:00:00

abstract：:Objective: Circulating free DNA (cfDNA) in general and circulating tumor DNA (ctDNA) in particular is becoming an increasingly used form of liquid biopsy biomarkers. In this study, we are investigating the ability to detect ctDNA from the plasma of pituitary adenoma (PA) patients. Design: Tumor tissue samples were obt...

journal_title：Frontiers in endocrinology

authors： Megnis K,Peculis R,Rovite V,Laksa P,Niedra H,Balcere I,Caune O,Breiksa A,Nazarovs J,Stukens J,Konrade I,Pirags V,Klovins J

更新日期：2019-09-18 00:00:00

abstract：:During mammalian pregnancy, highly specialized mechanisms of immune tolerance are triggered in order to allow the semi-allogeneic fetus to grow within the maternal uterus in harmony with the maternal immune system. Among other mechanisms, changes in the endocrine status have been proposed to be at least part of the ma...

journal_title：Frontiers in endocrinology

authors： Muzzio D,Zygmunt M,Jensen F

更新日期：2014-04-01 00:00:00

abstract：:Background: Height is considered an indicator of health and well-being of an individual and population. Height variation results from a complex interaction of genetic, environmental, socioeconomic, and cultural influences. In order to understand the contribution of environmental stress associated with the child's grow...

journal_title：Frontiers in endocrinology

authors： German A,Mesch G,Hochberg Z

更新日期：2020-03-11 00:00:00

abstract：:Objective: To clarify the role and mechanism of miR-17-92 cluster in islet beta-cell repair after streptozotocin intervention. Methods: Genetically engineered mice (miR-17-92βKO) and control RIP-Cre mice were intraperitoneally injected with multiple low dose streptozotocin. Body weight, random blood glucose (RBG), fas...

journal_title：Frontiers in endocrinology

authors： Wan S,Zhang J,Chen X,Lang J,Li L,Chen F,Tian L,Meng Y,Yu X

更新日期：2020-01-23 00:00:00

abstract：:Osteoporosis is metabolic bone disease caused by an altered balance between bone anabolism and catabolism. This dysregulated balance is responsible for fragile bones that fracture easily after minor falls. With an aging population, the incidence is rising and as yet pharmaceutical options to restore this imbalance is ...

journal_title：Frontiers in endocrinology

authors： Bergen DJM,Kague E,Hammond CL

更新日期：2019-01-29 00:00:00

abstract：:The present study aimed to compare effects of increasing chronic stress load on the stress response of European seabass (Dicentrarchus labrax) and gilthead seabream (Sparus aurata) to identify neuroendocrine functions that regulate this response. Fish were left undisturbed (controls) or exposed to three levels of chro...

journal_title：Frontiers in endocrinology

authors： Samaras A,Espírito Santo C,Papandroulakis N,Mitrizakis N,Pavlidis M,Höglund E,Pelgrim TNM,Zethof J,Spanings FAT,Vindas MA,Ebbesson LOE,Flik G,Gorissen M

更新日期：2018-08-13 00:00:00

abstract：:The islet amyloid polypeptide (IAPP) or amylin maintains a key role in metabolism. This 37-residues-peptide could form pancreatic amyloids, which are a characteristic feature of diabetes mellitus type 2. However, some species do not form amyloid fibril structures. By employing a biomimetic approach, we generated an ex...

journal_title：Frontiers in endocrinology

authors： Pulido-Capiz A,Díaz-Molina R,Martínez-Navarro I,Guevara-Olaya LA,Casanueva-Pérez E,Mas-Oliva J,Rivero IA,García-González V

更新日期：2018-06-25 00:00:00

abstract：:Radiotherapy continues to be one of the most accepted medical treatments for cancer. Localized irradiation is the most common treatment for prostate, pancreatic, rectal, cervical and endometrial malignancies. Conventional localized fractions are total doses of 30-62Gy at 1.8-2Gy per fraction, with administration of ~6...

journal_title：Frontiers in endocrinology

authors： Costa S,Reagan MR

更新日期：2019-08-29 00:00:00

abstract：:Circulating microRNAs are potential biomarkers of type 2 diabetes mellitus (T2DM) and related complications. Here, we investigated the association of microRNA-15a with early retinal damage in T2DM. A cohort of untreated subjects screened for intermediate/high risk of T2DM, according to a score assessment questionnaire...

journal_title：Frontiers in endocrinology

authors： Sangalli E,Tagliabue E,Sala L,Prattichizzo F,Uccellatore A,Spada D,Lorino F,de Candia P,Lupini S,Cantone L,Favero C,Madeddu P,Bollati V,Genovese S,Spinetti G

更新日期：2020-04-23 00:00:00

abstract：:The orexigenic peptide hormone ghrelin is synthesized in the stomach and its receptor growth hormone secretagogue receptor (GHSR1a) is expressed mainly in the central nervous system (CNS). In this review, we confine our discussion to the physiological role of GHSR1a in the brain. Paradoxically, despite broad expressio...

journal_title：Frontiers in endocrinology

authors： Kern A,Grande C,Smith RG

更新日期：2014-08-18 00:00:00

abstract：:Osteoporosis is a metabolic skeletal disorder in which bone mass is depleted and bone structure is destroyed to the degree that bone becomes fragile and prone to fractures. Emerging evidence suggests that N6-methyladenosine (m6A) modification, a novel epitranscriptomic marker, has a significant role in bone developmen...

journal_title：Frontiers in endocrinology

authors： Chen X,Hua W,Huang X,Chen Y,Zhang J,Li G

更新日期：2020-01-10 00:00:00

abstract：INTRODUCTION:Risk of testicular germ cell tumors (TGCT) is consistently associated with a history of cryptorchidism (CO) in epidemiologic studies. Factors modifying the association may provide insights regarding etiology of TGCT and suggest a basis for individualized care of CO. To identify modifiers of the CO-TGCT ass...

journal_title：Frontiers in endocrinology

authors： Banks K,Tuazon E,Berhane K,Koh CJ,De Filippo RE,Chang A,Kim SS,Daneshmand S,Davis-Dao C,Lewinger JP,Bernstein L,Cortessis VK

更新日期：2013-02-18 00:00:00

abstract：:Background: The health benefits of soy are widely reported but there are queries on the effect of soy isoflavones on thyroid function and the underlying mechanism of action. Materials and Methods: We examined the effect of soy isoflavones on reverse tri-iodothyronine (or 3,3',5'-tri-iodothyronine; rT3) in two studies ...

journal_title：Frontiers in endocrinology

authors： Sathyapalan T,Köhrle J,Rijntjes E,Rigby AS,Dargham SR,Kilpatrick ES,Atkin SL

更新日期：2018-11-22 00:00:00

abstract：:Cushing's disease recurrence following successful pituitary surgery is common and merits prompt and careful diagnosis, as untreated hypercortisolism leads to increased morbidity and mortality. However, an established recurrence definition has not been forthcoming. This poses a diagnostic challenge especially early in ...

journal_title：Frontiers in endocrinology

authors： Hinojosa-Amaya JM,Varlamov EV,McCartney S,Fleseriu M

更新日期：2019-11-08 00:00:00

abstract：:Introduction: An increase of serum dehydroepiandrosterone (DHEA) sulfate (DHEAS) is observed in premature adrenarche and congenital adrenal hyperplasia. Very high DHEAS levels are typical for adrenal tumors. Approximately 74% of DHEAS is hydrolyzed to DHEA by the steroid sulfatase (STS). The reverse reaction is DHEA s...

journal_title：Frontiers in endocrinology

authors： Iliev DI,Braun R,Sánchez-Guijo A,Hartmann M,Wudy SA,Heckmann D,Bruchelt G,Rösner A,Grosser G,Geyer J,Binder G

更新日期：2020-05-06 00:00:00

abstract：Objective:Inflammation plays a central role in the pathogenesis of metabolic syndrome (MetS). Cyclophilin B (CypB) can be constitutively secreted in response to inflammatory stimuli and oxidative stress, participating in tissue or systemic inflammation. We investigated the relationship between CypB and MetS in both hum...

journal_title：Frontiers in endocrinology

authors： Zhang H,Fan Q,Xie H,Lu L,Tao R,Wang F,Xi R,Hu J,Chen Q,Shen W,Zhang R,Yan X

更新日期：2017-12-22 00:00:00

abstract：:Autophagy requires the conjugation of autophagy-related protein 12 (ATG12) to autophagy-related protein 5 (ATG5) through covalent attachment. However, the signals regulating ATG12-ATG5 conjugation are unclear. The larval midgut of lepidopteran insects performs autophagy and apoptosis sequentially during the transition...

journal_title：Frontiers in endocrinology

authors： Li YB,Yang T,Wang JX,Zhao XF

更新日期：2018-02-07 00:00:00

abstract：:The insulin/IGF system plays an important role in cancer progression. Accordingly, elevated levels of circulating insulin have been associated with an increased cancer risk as well as with aggressive and metastatic cancer phenotypes. Numerous studies have documented that estrogens cooperate with the insulin/IGF system...

journal_title：Frontiers in endocrinology

authors： De Marco P,Cirillo F,Vivacqua A,Malaguarnera R,Belfiore A,Maggiolini M

更新日期：2015-03-06 00:00:00