Alteration of Testosterone Levels Changes Brain Wave Activity Patterns and Induces Aggressive Behavior in Rats.

abstract：:Cushing's disease recurrence following successful pituitary surgery is common and merits prompt and careful diagnosis, as untreated hypercortisolism leads to increased morbidity and mortality. However, an established recurrence definition has not been forthcoming. This poses a diagnostic challenge especially early in ...

journal_title：Frontiers in endocrinology

authors： Hinojosa-Amaya JM,Varlamov EV,McCartney S,Fleseriu M

更新日期：2019-11-08 00:00:00

abstract：:Accumulating evidence shows that H2S has physiological functions in various tissues and organs. It includes regulation of neuronal activity, vascular tension, a release of insulin, and protection of the heart, kidney, and brain from ischemic insult. H2S is produced by enzymes from l-cysteine; cystathionine β-synthase,...

journal_title：Frontiers in endocrinology

authors： Shibuya N,Kimura H

更新日期：2013-07-16 00:00:00

abstract：:Anti-Müllerian hormone reflects the continuum of the functional ovarian reserve, and as such can predict ovarian response to gonadotropin stimulation and be used to individualize treatment pathways to improve efficacy and safety. However, consistent with other biomarkers and age-based prediction models it has limited ...

journal_title：Frontiers in endocrinology

authors： Li HWR,Nelson SM

更新日期：2020-12-09 00:00:00

abstract：:Cholecystokinin (CCK) was discovered in 1928 in jejunal extracts as a gallbladder contraction factor. It was later shown to be member of a peptide family, which are all ligands for the CCK1 and CCK2 receptors. CCK peptides are known to be synthetized in small intestinal endocrine I-cells and cerebral neurons. But in a...

journal_title：Frontiers in endocrinology

authors： Rehfeld JF

更新日期：2017-04-13 00:00:00

abstract：:Background: The management of children and adolescents with chronic kidney disease (CKD) and growth failure candidate for recombinant human growth hormone therapy (rhGH) is based on an appraisal of the literature established on a 2006 consensus statement and 2019 Clinical practice recommendations. The performance of t...

journal_title：Frontiers in endocrinology

authors： Cappa M,Maghnie M,Carbone V,Chioma L,Errichiello C,Giavoli C,Giordano M,Guazzarotti L,Klain A,Montini G,Murer L,Parpagnoli M,Pecoraro C,Pesce S,Verrina E

更新日期：2020-09-02 00:00:00

abstract：:[This corrects the article on p. 26 in vol. 9, PMID: 29487564.]. ...

journal_title：Frontiers in endocrinology

authors： Konya J,Spurgeon BEJ,Al Qaissi A,Sathyapalan T,Ajjan R,Madden L,Naseem KM,Garrett AT,Kilpatrick E,Atkin SL

更新日期：2018-06-07 00:00:00

abstract：:Fibrodysplasia ossificans progressiva (FOP) is an autosomal dominant disease, characterized by the formation of heterotopic ossification (HO) in muscles, ligaments, and tendons. Flare-ups, an inflammatory process that often precedes the formation of HO, can occur spontaneously, but trauma is also a common trigger. It ...

journal_title：Frontiers in endocrinology

authors： Botman E,Netelenbos JC,Rustemeyer T,Schoonmade LJ,Nieuwenhuijzen JA,Teunissen BP,Visser M,Raijmakers P,Lammertsma AA,Dahele M,Eekhoff M

更新日期：2020-02-12 00:00:00

abstract：:Dysnatremia is associated with increased mortality in patients with community-acquired pneumonia. SARS-COV2 (Severe-acute-respiratory syndrome caused by Coronavirus-type 2) pneumonia can be fatal. The aim of this study was to ascertain whether admittance dysnatremia is associated with mortality, sepsis, or intensive t...

journal_title：Frontiers in endocrinology

authors： Ruiz-Sánchez JG,Núñez-Gil IJ,Cuesta M,Rubio MA,Maroun-Eid C,Arroyo-Espliguero R,Romero R,Becerra-Muñoz VM,Uribarri A,Feltes G,Trabattoni D,Molina M,García Aguado M,Pepe M,Cerrato E,Alfonso E,Castro Mejía AF,Roubin SR,

更新日期：2020-11-30 00:00:00

abstract：:Sleep duration has become increasingly recognized as an important influencer of health. Epidemiologic and observational studies have shown associations between short sleep duration and increased risk for chronic cardiometabolic disorders, including obesity, type 2 diabetes, and cardiovascular disease. These associatio...

journal_title：Frontiers in endocrinology

authors： Pizinger TM,Aggarwal B,St-Onge MP

更新日期：2018-07-18 00:00:00

abstract：:Background: The effect of testosterone supplementation in patients with chronic heart failure (CHF) remains uncertain. Methods: A meta-analysis of randomized controlled trials (RCTs) was performed. RCTs that evaluate the chronic effect of testosterone supplementation on exercise capacity and cardiac function in CHF we...

journal_title：Frontiers in endocrinology

authors： Tao J,Liu X,Bai W

更新日期：2020-03-13 00:00:00

abstract：:Follicle stimulating hormone (FSH) plays a key role in human reproduction through, among others, induction of spermatogenesis in men and production of estrogen in women. The function FSH is performed upon binding to its cognate receptor-follicle-stimulating hormone receptor (FSHR) expressed on the surface of target ce...

journal_title：Frontiers in endocrinology

authors： Szymańska K,Kałafut J,Przybyszewska A,Paziewska B,Adamczuk G,Kiełbus M,Rivero-Müller A

更新日期：2018-12-13 00:00:00

abstract：:Background: Gestational diabetes (GDM) is associated with adverse short- and long-term maternal and fetal outcomes. Observational data support a link between sleep-disordered breathing (SDB) during pregnancy and GDM. However, it is unknown whether treatment of SDB with continuous positive airway pressure (CPAP) improv...

journal_title：Frontiers in endocrinology

authors： Pamidi S,Meltzer SJ,Garfield N,Lavigne L,Olha A,Khalyfa A,Benedetti A,Tremblay G,Gagnon R,Rey E,Dasgupta K,Kimoff RJ

更新日期：2018-11-16 00:00:00

abstract：:Phthalates are ubiquitous environmental endocrine-disrupting chemicals suspected to interfere with developmental androgen action leading to adverse effects on male reproductive function. Prenatal exposure studies in rodents show cryptorchidism, hypospadias and reduced testicular volume (TV), testosterone and anogenita...

journal_title：Frontiers in endocrinology

authors： Hart RJ,Frederiksen H,Doherty DA,Keelan JA,Skakkebaek NE,Minaee NS,McLachlan R,Newnham JP,Dickinson JE,Pennell CE,Norman RJ,Main KM

更新日期：2018-06-04 00:00:00

abstract：:A direct action of thyrotropin (TSH, thyroid-stimulating hormone) on bone precursors in humans is controversial. Studies in rodent models have provided conflicting findings. We used cells derived from a moderately differentiated osteosarcoma stably overexpressing human TSH receptors (TSHRs) as a model of osteoblast pr...

journal_title：Frontiers in endocrinology

authors： Boutin A,Gershengorn MC,Neumann S

更新日期：2020-05-20 00:00:00

abstract：:Leptin affects food intake regulation and energy homeostasis in mammals, as opposed to mammals who have a single leptin gene, fish have duplicated leptin gene paralogues. Until now, most functional studies on fish focused on the first reported paralogue without much explanation on specific gene paralogue. This study s...

journal_title：Frontiers in endocrinology

authors： Yuan XC,Liang XF,Cai WJ,Li AX,Huang D,He S

更新日期：2020-08-14 00:00:00

abstract：:Classically, the modulation of brain function and behavior by steroid hormones was linked exclusively to secretion by peripheral endocrine glands. Subsequently, steroid actions within the brain were shown dependent upon either synthesis and secretion by peripheral organs or by production within the CNS itself using pe...

journal_title：Frontiers in endocrinology

authors： Remage-Healey L,Saldanha CJ,Schlinger BA

更新日期：2011-09-29 00:00:00

abstract：:Natriuretic hormones (NH) include three groups of compounds: the natriuretic peptides (ANP, BNP and CNP), the gastrointestinal peptides (guanylin and uroguanylin), and endogenous cardiac steroids. These substances induce the kidney to excrete sodium and therefore participate in the regulation of sodium and water homeo...

journal_title：Frontiers in endocrinology

authors： Hodes A,Lichtstein D

更新日期：2014-11-28 00:00:00

abstract：:Graves' disease (GD) is an organ-specific autoimmune disease, and thyrotropin (TSH) receptor (TSHR) is a major autoantigen in this condition. Since the extracellular domain of human TSHR (TSHR-ECD) is shed into the circulation, TSHR-ECD is a preferentially immunogenic portion of TSHR. Both genetic factors and environm...

journal_title：Frontiers in endocrinology

authors： Inaba H,De Groot LJ,Akamizu T

更新日期：2016-08-23 00:00:00

abstract：:The G-protein coupled parathyroid hormone 2 receptor (PTH2R) is concentrated in endocrine and limbic regions in the forebrain. Its endogenous ligand, tuberoinfundibular peptide of 39 residues (TIP39), is synthesized in only two brain regions, within the posterior thalamus and the lateral pons. TIP39-expressing neurons...

journal_title：Frontiers in endocrinology

authors： Dobolyi A,Dimitrov E,Palkovits M,Usdin TB

更新日期：2012-10-08 00:00:00

abstract：:Intrauterine growth restriction (IUGR) is a complex global healthcare issue. Concerted research and clinical efforts have improved our knowledge of the neurodevelopmental sequelae of IUGR which has raised the profile of this complex problem. Nevertheless, there is still a lack of therapies to prevent the substantial r...

journal_title：Frontiers in endocrinology

authors： Fleiss B,Wong F,Brownfoot F,Shearer IK,Baud O,Walker DW,Gressens P,Tolcos M

更新日期：2019-03-29 00:00:00

abstract：:Background: Disturbance of immunometabolic signaling is a key process involved in the progression of obesity. Microglia-the resident immune cells in the brain, initiate local immune responses. It is known that hypercaloric diets lead to microglial activation. Previously, we observed that hypothalamic microglial cells ...

journal_title：Frontiers in endocrinology

authors： Milanova IV,Kalsbeek MJT,Wang XL,Korpel NL,Stenvers DJ,Wolff SEC,de Goede P,Heijboer AC,Fliers E,la Fleur SE,Kalsbeek A,Yi CX

更新日期：2019-06-26 00:00:00

abstract：:This brief review describes some representative methodological approaches to the isolation of putative endogenous inhibitors of epithelial sodium transport - i.e., as ouabain-like factors (OLF) that inhibit the sodium transport enzyme Na-K-ATPase or inhibit the epithelial sodium channel (ENaC). Gel chromatography and ...

journal_title：Frontiers in endocrinology

authors： Kramer HJ

更新日期：2015-05-20 00:00:00

abstract：:Objective: To study the impact of dose reduction in MDCT images through tube current reduction or sparse sampling on the vertebral bone strength prediction using finite element (FE) analysis for fracture risk assessment. Methods: Routine MDCT data covering lumbar vertebrae of 12 subjects (six male; six female; 74.70 ±...

journal_title：Frontiers in endocrinology

authors： Rayudu NM,Subburaj K,Mei K,Dieckmeyer M,Kirschke JS,Noël PB,Baum T

更新日期：2020-07-28 00:00:00

abstract：:Physiological concentrations of the green tea extract epigallocatechin-3-gallate (EGCG) caused growth inhibition in estrogen receptor α (ERα)-positive MCF7 cells that was associated with down-regulation of the ERα and reduced insulin-like growth factor binding protein-2 abundance and increased protein abundance of the...

journal_title：Frontiers in endocrinology

authors： Zeng L,Holly JM,Perks CM

更新日期：2014-05-07 00:00:00

abstract：:Hard tissue regeneration represents a challenge for the Regenerative Medicine and Mesenchymal stem cells (MSCs) could be a successful therapeutic strategy. T-LysYal® (T-Lys), a new derivative of Hyaluronic Acid (HA) possessing a superior stability, has already been proved efficient in repairing corneal epithelial cell...

journal_title：Frontiers in endocrinology

authors： Di Benedetto A,Posa F,Marazzi M,Kalemaj Z,Grassi R,Lo Muzio L,Comite MD,Cavalcanti-Adam EA,Grassi FR,Mori G

更新日期：2020-05-05 00:00:00

abstract：:Pituitary adenomas, accounting for 15% of diagnosed intracranial neoplasms, are usually benign and pharmacologically and surgically treatable; however, the critical location, mass effects and hormone hypersecretion sustain their significant morbidity. Approximately 35% of pituitary tumors show a less benign course sin...

journal_title：Frontiers in endocrinology

authors： Würth R,Thellung S,Corsaro A,Barbieri F,Florio T

更新日期：2020-02-20 00:00:00

abstract：BACKGROUND:Monitoring blood levels of human growth hormone (hGH) in most children with short stature deficiencies is crucial for taking a decision of treatment with extended course of daily and expensive doses of recombinant hGH (rhGH or Somatropin®). Besides, misusing of rhGH by sportsmen is banned by the World Anti-D...

journal_title：Frontiers in endocrinology

authors： Murad H,Assaad JM,Al-Shemali R,Abbady AQ

更新日期：2017-05-30 00:00:00

abstract：:The 3D arrangement of porous granular biomaterials usable to fill bone defects has received little study. Granular biomaterials occupy 3D space when packed together in a manner that creates a porosity suitable for the invasion of vascular and bone cells. Granules of beta-tricalcium phosphate (β-TCP) were prepared with...

journal_title：Frontiers in endocrinology

authors： Chappard D,Terranova L,Mallet R,Mercier P

更新日期：2015-10-12 00:00:00

abstract：:Several reports in humans as well as transgenic mouse models have shown that estrogens play an important role in male reproduction and fertility. Estrogen receptor alpha (ERα) and beta (ERβ) are expressed in different male tissues including the brain. The estradiol-binding protein GPER1 also mediates estrogen action i...

journal_title：Frontiers in endocrinology

authors： Guercio G,Saraco N,Costanzo M,Marino R,Ramirez P,Berensztein E,Rivarola MA,Belgorosky A

更新日期：2020-02-25 00:00:00

abstract：:Hypothyroidism has been reported to improve survival in cancer patients but only recently has the putative mechanism been identified as a receptor for thyroxine and tri-iodothyronine on integrin αvβ3. Recognition of divergence of action of the pro-oncogenic L-thyroxine (T4) from pro-metabolic 3,5,3'-triiodo-L-thyronin...

journal_title：Frontiers in endocrinology

authors： Hercbergs A

更新日期：2019-08-23 00:00:00