The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women.

abstract：:Ghrelin is a peptide hormone that is acylated with a fatty acid, usually n-octanoic acid, at the third amino acid (aa) residue (usually a serine or threonine), and this acylation is known to be essential for ghrelin activity not only in mammals but also in non-mammals, such as fish. However, the modification mechanism...

journal_title：Frontiers in endocrinology

authors： Kaiya H,Andoh T,Ichikawa T,Amiya N,Matsuda K,Kangawa K,Miyazato M

更新日期：2013-09-03 00:00:00

abstract：:Evidence that adult humans have functional brown adipose tissue has stirred interest in the possibility that the impressive effectiveness of induction of brown adipocytes to reduce obesity in mice may be translated to the human condition. A major focus recently on the identification of signaling and transcription fact...

journal_title：Frontiers in endocrinology

authors： Kozak LP

更新日期：2011-10-31 00:00:00

abstract：:Congenital hypogonadotrophic hypogonadism (CHH) is a rare but important etiology of pubertal failure and infertility, resulting from impaired gonadotrophin-releasing hormone secretion or action. Despite the availability of effective hormonal therapies, the majority of men with CHH experience unsatisfactory outcomes, i...

journal_title：Frontiers in endocrinology

authors： Swee DS,Quinton R

更新日期：2019-02-21 00:00:00

abstract：:Autoimmune thyroid diseases (AITDs) are chronic organ-specific autoimmune diseases and mainly include Graves' disease (GD) and Hashimoto's thyroiditis (HT). CD14 is an important component of the immune system as a receptor for gram-negative lipopolysaccharide (LPS). The genetic polymorphisms of CD14 have been confirme...

journal_title：Frontiers in endocrinology

authors： Jia X,Wang B,Yao Q,Li Q,Zhang J

更新日期：2019-01-16 00:00:00

abstract：:Growth hormone deficiency (GHD) results in an impaired health-related quality of life (HrQoL) and cognitive impairment in the attention and memory domain. GHD is assumed to be a frequent finding after brain injury due to traumatic brain injury (TBI), aneurysmal subarachnoid hemorrhage (SAH) or ischemic stroke. Hence, ...

journal_title：Frontiers in endocrinology

authors： Leonhardt M,Kopczak A,Schäpers B,Limbrock J,Sämann PG,Czisch M,von Steinbuechel N,Jordan M,Schneider HJ,Schneider M,Sievers C,Stalla GK

更新日期：2018-12-17 00:00:00

abstract：:SIRT7 is one of seven mammalian sirtuins that functions as an NAD+-dependent histone/protein deacetylase. SIRT7 is the least well-known member of the sirtuin family, but recent efforts have identified its involvement in various cellular processes, such as ribosome biogenesis, gene expression, cellular metabolism and c...

journal_title：Frontiers in endocrinology

authors： Wu D,Li Y,Zhu KS,Wang H,Zhu WG

更新日期：2018-11-19 00:00:00

abstract：:Pituitary adenomas (PA) are amongst the most prevalent intracranial tumors, causing complications by hormonal overproduction or deficiency and tumor mass effects, with 95% of cases occurring sporadically. Associated germline mutations (AIP, MEN1, CDKN1B, PRKAR1A, SDHx) and Xq26.3 microduplications are increasingly ide...

journal_title：Frontiers in endocrinology

authors： van den Broek MFM,van Nesselrooij BPM,Verrijn Stuart AA,van Leeuwaarde RS,Valk GD

更新日期：2019-12-10 00:00:00

abstract：:Phthalates are ubiquitous environmental endocrine-disrupting chemicals suspected to interfere with developmental androgen action leading to adverse effects on male reproductive function. Prenatal exposure studies in rodents show cryptorchidism, hypospadias and reduced testicular volume (TV), testosterone and anogenita...

journal_title：Frontiers in endocrinology

authors： Hart RJ,Frederiksen H,Doherty DA,Keelan JA,Skakkebaek NE,Minaee NS,McLachlan R,Newnham JP,Dickinson JE,Pennell CE,Norman RJ,Main KM

更新日期：2018-06-04 00:00:00

abstract：:Introduction: To improve detection of undiagnosed diabetes in Africa, there is movement to replace the OGTT with A1C. The performance of A1C in the absence of hemoglobin-related micronutrient deficiencies, anemia and heterozygous hemoglobinopathies is unknown. Therefore, we determined in 441 African-born blacks living...

journal_title：Frontiers in endocrinology

authors： Briker SM,Aduwo JY,Mugeni R,Horlyck-Romanovsky MF,DuBose CW,Mabundo LS,Hormenu T,Chung ST,Ha J,Sherman A,Sumner AE

更新日期：2019-08-07 00:00:00

abstract：:Catecholamine (CA) secretion from the adrenal medullary tissue is a key step of the adaptive response triggered by an organism to cope with stress. Whereas molecular and cellular secretory processes have been extensively studied at the single chromaffin cell level, data available for the whole gland level are much sca...

journal_title：Frontiers in endocrinology

authors： De Nardi F,Lefort C,Bréard D,Richomme P,Legros C,Guérineau NC

更新日期：2017-09-25 00:00:00

abstract：:Introduction: Pituitary metastases (PM) are rare events and to date only very few cases of melanoma PM have been described in literature up to now. Case Presentation: We describe the clinical history of a 33-year-old male patient who underwent surgical excision of an inter-scapular melanoma in 2008. The subsequent fol...

journal_title：Frontiers in endocrinology

authors： Mormando M,Puliani G,Barnabei A,Lauretta R,Bianchini M,Chiefari A,Russillo M,Cognetti F,Romano L,Appetecchia M

更新日期：2020-07-23 00:00:00

abstract：:Atherosclerosis results from endothelial cell dysfunction and inflammatory processes affecting both macro- and microvasculature which are involved in vascular diabetic complications. Glucagon-like peptide-1 (GLP-1) is an incretin hormone responsible for amplification of insulin secretion when nutrients are given orall...

journal_title：Frontiers in endocrinology

authors： Alonso N,Julián MT,Puig-Domingo M,Vives-Pi M

更新日期：2012-09-07 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV)/AIDS pandemic represents the most significant global health challenge in modern history. This infection leads toward an inflammatory state associated with chronic immune dysregulation activation that tilts the immune-skeletal interface and its deep integration between cell...

journal_title：Frontiers in endocrinology

authors： Delpino MV,Quarleri J

更新日期：2020-09-02 00:00:00

abstract：Background:Since hypothyroidism is a fairly common dysfunction, levothyroxine (L-T4) is one of the most prescribed medications. Approximately 70% of the administered L-T4 dose is absorbed. The absorption process takes place in the small intestine. Some disorders of the digestive system and some medicines, supplements, ...

journal_title：Frontiers in endocrinology

authors： Benvenga S,Capodicasa G,Perelli S,Ferrari SM,Fallahi P,Antonelli A

更新日期：2018-04-18 00:00:00

abstract：:The G Protein-Coupled Estrogen Receptor (GPER) is a novel membrane-bound receptor that mediates non-genomic actions of the primary female sex hormone 17β-estradiol. Studies over the past two decades have elucidated the beneficial actions of this receptor in a number of cardiometabolic diseases. This review will focus ...

journal_title：Frontiers in endocrinology

authors： Groban L,Tran QK,Ferrario CM,Sun X,Cheng CP,Kitzman DW,Wang H,Lindsey SH

更新日期：2020-01-14 00:00:00

abstract：:A well-functioning hematopoietic system requires a certain robustness and flexibility to maintain appropriate quantities of functional mature blood cells, such as red blood cells and platelets. This review focuses on the cytokine receptor that plays a significant role in thrombopoiesis: the receptor for thrombopoietin...

journal_title：Frontiers in endocrinology

authors： Varghese LN,Defour JP,Pecquet C,Constantinescu SN

更新日期：2017-03-31 00:00:00

abstract：:Exercise training triggers numerous positive adaptations through the regulation of genes controlling muscle structure and function. Epigenetic modifications, including DNA methylation, participate in transcriptional activation by allowing the recruitment of the transcription machinery to gene promoters. Exercise induc...

journal_title：Frontiers in endocrinology

authors： Pattamaprapanont P,Garde C,Fabre O,Barrès R

更新日期：2016-12-23 00:00:00

abstract：:Initially identified as monomers, G protein-coupled receptors (GPCRs) can also form functional homo- and heterodimers that act as distinct signaling hubs for cellular signal integration. We previously found that the angiotensin II (Ang II) type 1 receptor (AT1R) and the prostaglandin F2α (PGF2α) receptor (FP), both im...

journal_title：Frontiers in endocrinology

authors： Fillion D,Devost D,Sleno R,Inoue A,Hébert TE

更新日期：2019-03-18 00:00:00

abstract：Objective:To evaluate whether endometrial thickness (EMT) change in response to progesterone has an effect on pregnancy outcomes in frozen-thawed embryo transfer (FET) cycles. Design:Retrospective observational study. Setting:Tertiary-care academic medical center. Participants:4465 infertile women undergoing their f...

journal_title：Frontiers in endocrinology

authors： Ye J,Zhang J,Gao H,Zhu Y,Wang Y,Cai R,Kuang Y

更新日期：2020-10-29 00:00:00

abstract：:Transient activation of the hypothalamic-pituitary-gonadal axis in early infancy plays an important role in male genital development and sexual differentiation of the brain, but factors contributing to individual variation in testosterone levels during this period are poorly understood. We measured salivary testostero...

journal_title：Frontiers in endocrinology

authors： Xia K,Yu Y,Ahn M,Zhu H,Zou F,Gilmore JH,Knickmeyer RC

更新日期：2014-10-30 00:00:00

abstract：:Graves' Orbitopathy (GO) is the most frequent extrathyroidal manifestation of Graves' disease (GD). Its ultimate cause remains unclear, but it is commonly considered an autoimmune disorder due to self recognition of autoantigens constitutively expressed by orbital fibroblasts (OFs), and thyroid epithelial cells. High ...

journal_title：Frontiers in endocrinology

authors： Lanzolla G,Vannucchi G,Ionni I,Campi I,Sileo F,Lazzaroni E,Marinò M

更新日期：2020-01-22 00:00:00

abstract：:There is increasing evidence supporting the characterization of the pesticide DDT and its metabolite, DDE, as obesogens and metabolic disruptors. Elucidating the mechanism is critical to understanding whether the association of DDT and DDE with obesity and diabetes is in fact causal. One area of research investigating...

journal_title：Frontiers in endocrinology

authors： Elmore SE,La Merrill MA

更新日期：2019-03-12 00:00:00

abstract：:Platelet activation plays a pivotal role in the development and progression of atherosclerosis, which often leads to potentially fatal ischemic events at later stages of the disease. Platelets and platelet microvesicles (PMVs) contain large amounts of microRNA (miRNA), which contributes largely to the pool of circulat...

journal_title：Frontiers in endocrinology

authors： Pordzik J,Pisarz K,De Rosa S,Jones AD,Eyileten C,Indolfi C,Malek L,Postula M

更新日期：2018-03-20 00:00:00

abstract：:Vertebrate eyes are known to contain circadian clocks, but their regulatory mechanisms remain largely unknown. To address this, we used a cell line from human retinal pigment epithelium (hRPE-YC) with stable coexpression of reporters for molecular clock oscillations (Bmal1-luciferase) and intracellular Ca2+ concentrat...

journal_title：Frontiers in endocrinology

authors： Morioka E,Kanda Y,Koizumi H,Miyamoto T,Ikeda M

更新日期：2018-03-19 00:00:00

abstract：:The tropical freshwater zebrafish has recently emerged as a valuable model organism for the study of adipose tissue biology and obesity-related disease. The strengths of the zebrafish model system are its wealth of genetic mutants, transgenic tools, and amenability to high-resolution imaging of cell dynamics within li...

journal_title：Frontiers in endocrinology

authors： Wafer R,Tandon P,Minchin JEN

更新日期：2017-05-22 00:00:00

abstract：:The increase of life expectancy has led to the increase of age-related diseases such as osteoporosis. Osteoporosis is characterized by bone weakening promoting the occurrence of fractures with defective bone regeneration. Men aged over 50 have a prevalence for osteoporosis of 20%, which is related to a decline in sex ...

journal_title：Frontiers in endocrinology

authors： Beranger GE,Djedaini M,Battaglia S,Roux CH,Scheideler M,Heymann D,Amri EZ,Pisani DF

更新日期：2015-05-19 00:00:00

abstract：:Insulin resistance (IR) is a pathological condition strongly associated with obesity. However, corticosteroids or growth hormone therapy and genetic diseases may affect insulin sensitivity lifelong. In obese children and adolescents of any age there is an evident association between IR and an increased prevalence of t...

journal_title：Frontiers in endocrinology

authors： Tagi VM,Giannini C,Chiarelli F

更新日期：2019-06-04 00:00:00

abstract：:The human lutropin (hLH)/choriogonadotropin (hCG) receptor (LHCGR) can be activated by binding two slightly different gonadotropic glycoprotein hormones, choriogonadotropin (CG) - secreted by the placenta, and lutropin (LH) - produced by the pituitary. They induce different signaling profiles at the LHCGR. This cannot...

journal_title：Frontiers in endocrinology

authors： Grzesik P,Kreuchwig A,Rutz C,Furkert J,Wiesner B,Schuelein R,Kleinau G,Gromoll J,Krause G

更新日期：2015-09-22 00:00:00

abstract：:Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory cytokines, myokines, and osteokines, contribute substantially to the development of abnormal glucose and lipid metabolism. Some cytokines play a positive role in metabolism action, while others have a negative metabolic role l...

journal_title：Frontiers in endocrinology

authors： Shi J,Fan J,Su Q,Yang Z

更新日期：2019-10-30 00:00:00

abstract：:The brain is composed of neurons and non-neuronal cells, with the latter encompassing glial, ependymal and endothelial cells, as well as pericytes and progenitor cells. Studies aimed at understanding how the brain operates have traditionally focused on neurons, but the importance of non-neuronal cells has become incre...

journal_title：Frontiers in endocrinology

authors： Argente-Arizón P,Freire-Regatillo A,Argente J,Chowen JA

更新日期：2015-03-26 00:00:00