Early stages of the natriuretic hormone story.

Abstract:

:The paper reviews the early stages of the research on natriuretic hormone. The described experimental work was designed and accomplished in several internationally recognized laboratories where the author was invited to extend his projects. The cross-circulation experiments in animals with acutely increased extracellular fluid volume documented, that in the mechanism of natriuresis - besides a series of the physical natriuretic factors - there is still room for an active humoral natriuretic substance. This substance inhibited the sodium transporting enzyme, Na,K-ATPase, in the frog skin. Analogous inhibition of the renal Na,K-ATPase may be partly responsible for the increased sodium excretion. It was further shown that the extent of natriuresis is positively modulated by the concentration of sodium in the cerebrospinal fluid detected in the anterior-third ventricle region (AV3V) in the brain.

authors

Lichardus B

doi

10.3389/fendo.2014.00180

subject

Has Abstract

pub_date

2014-11-11 00:00:00

pages

180

issn

1664-2392

journal_volume

5

pub_type

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