Tryptophan Metabolic Pathways and Brain Serotonergic Activity: A Comparative Review.

Abstract:

:The essential amino acid L-tryptophan (Trp) is the precursor of the monoaminergic neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). Numerous studies have shown that elevated dietary Trp has a suppressive effect on aggressive behavior and post-stress plasma cortisol concentrations in vertebrates, including teleosts. These effects are believed to be mediated by the brain serotonergic system, even though all mechanisms involved are not well understood. The rate of 5-HT biosynthesis is limited by Trp availability, but only in neurons of the hindbrain raphe area predominantly expressing the isoform TPH2 of the enzyme tryptophan hydroxylase (TPH). In the periphery as well as in brain areas expressing TPH1, 5-HT synthesis is probably not restricted by Trp availability. Moreover, there are factors affecting Trp influx to the brain. Among those are acute stress, which, in contrast to long-term stress, may result in an increase in brain Trp availability. The mechanisms behind this stress induced increase in brain Trp concentration are not fully understood but sympathetic activation is likely to play an important role. Studies in mammals show that only a minor fraction of Trp is utilized for 5-HT synthesis whereas a larger fraction of the Trp pool enters the kynurenic pathway. The first stage of this pathway is catalyzed by the hepatic enzyme tryptophan 2,3-dioxygenase (TDO) and the extrahepatic enzyme indoleamine 2,3-dioxygenase (IDO), enzymes that are induced by glucocorticoids and pro-inflammatory cytokines, respectively. Thus, chronic stress and infections can shunt available Trp toward the kynurenic pathway and thereby lower 5-HT synthesis. In accordance with this, dietary fatty acids affecting the pro-inflammatory cytokines has been suggested to affect metabolic fate of Trp. While TDO seems to be conserved by evolution in the vertebrate linage, earlier studies suggested that IDO was only present mammals. However, recent phylogenic studies show that IDO paralogues are present within the whole vertebrate linage, however, their involvement in the immune and stress reaction in teleost fishes remains to be investigated. In this review we summarize the results from previous studies on the effects of dietary Trp supplementation on behavior and neuroendocrinology, focusing on possible mechanisms involved in mediating these effects.

authors

Höglund E,Øverli Ø,Winberg S

doi

10.3389/fendo.2019.00158

subject

Has Abstract

pub_date

2019-04-08 00:00:00

pages

158

issn

1664-2392

journal_volume

10

pub_type

杂志文章,评审
  • Assessing Urinary Metabolomics in Giant Pandas Using Chromatography/Mass Spectrometry: Pregnancy-Related Changes in the Metabolome.

    abstract::Giant pandas represent one of the most endangered species worldwide, and their reproductive capacity is extremely low. They have a relatively long gestational period, mainly because embryo implantation is delayed. Giant panda cubs comprise only a small proportion of the mother's body weight, making it difficult to det...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00215

    authors: Cao M,Li C,Liu Y,Cai K,Chen L,Yuan C,Zhao Z,Zhang B,Hou R,Zhou X

    更新日期:2020-04-16 00:00:00

  • Corrigendum: Shared Autonomic Pathways Connect Bone Marrow and Peripheral Adipose Tissues Across the Central Neuraxis.

    abstract::[This corrects the article DOI: 10.3389/fendo.2019.00668.]. ...

    journal_title:Frontiers in endocrinology

    pub_type: 已发布勘误

    doi:10.3389/fendo.2019.00904

    authors: Wee NKY,Lorenz MR,Bekirov Y,Jacquin MF,Scheller EL

    更新日期:2020-01-22 00:00:00

  • High Expression of Complement Components in the Kidneys of Type 2 Diabetic Rats With Diabetic Nephropathy.

    abstract::Background: Diabetic nephropathy (DN) is the leading cause of end-stage failure of the kidneys; however, its pathogenesis remains unknown. This study assessed the expression of complement components in the kidneys of rats with type 2 DN to investigate their role in DN. Methods: A rat model of type 2 DN was induced by ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00459

    authors: Huang Y,Xu J,Wu X,Chen X,Bai X,Zhuang Y,Fang J,Lin X

    更新日期:2019-07-09 00:00:00

  • Differentiated Thyroid Carcinoma in Pediatric Age: Genetic and Clinical Scenario.

    abstract::Introduction: Follicular-derived differentiated thyroid carcinoma (DTC) is the most common endocrine and epithelial malignancy in children. The differences in the clinical and pathological features of pediatric vs. adult DTC could relate to a different genetic profile. Few studies are currently available in this issue...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00552

    authors: Galuppini F,Vianello F,Censi S,Barollo S,Bertazza L,Carducci S,Colato C,Manso J,Rugge M,Iacobone M,Watutantrige Fernando S,Pennelli G,Mian C

    更新日期:2019-08-07 00:00:00

  • The Role of KCNQ1 Mutations and Maternal Beta Blocker Use During Pregnancy in the Growth of Children With Long QT Syndrome.

    abstract:Objective:Two missense mutations in KCNQ1, an imprinted gene that encodes the alpha subunit of the voltage-gated potassium channel Kv7.1, cause autosomal dominant growth hormone deficiency and maternally inherited gingival fibromatosis. We evaluated endocrine features, birth size, and subsequent somatic growth of patie...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00194

    authors: Huttunen H,Hero M,Lääperi M,Känsäkoski J,Swan H,Hirsch JA,Miettinen PJ,Raivio T

    更新日期:2018-04-24 00:00:00

  • Clinical Diversity in Focal Congenital Hyperinsulinism in Infancy Correlates With Histological Heterogeneity of Islet Cell Lesions.

    abstract::Background: Congenital Hyperinsulinism (CHI) is an important cause of severe and persistent hypoglycaemia in infancy and childhood. The focal form (CHI-F) of CHI can be potentially cured by pancreatic lesionectomy. While diagnostic characteristics of CHI-F pancreatic histopathology are well-recognized, correlation wit...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00619

    authors: Craigie RJ,Salomon-Estebanez M,Yau D,Han B,Mal W,Newbould M,Cheesman E,Bitetti S,Mohamed Z,Sajjan R,Padidela R,Skae M,Flanagan S,Ellard S,Cosgrove KE,Banerjee I,Dunne MJ

    更新日期:2018-10-17 00:00:00

  • Luteal Coasting and Individualization of Human Chorionic Gonadotropin Dose after Gonadotropin-Releasing Hormone Agonist Triggering for Final Oocyte Maturation-A Retrospective Proof-of-Concept Study.

    abstract::Ovarian stimulation in a gonadotropin-releasing hormone (GnRH) antagonist protocol with the use of GnRH agonist for final oocyte maturation is the state-of-the-art treatment in patients with an expected or known high response to avoid or at least reduce significantly the risk for development of ovarian hyperstimulatio...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00033

    authors: Lawrenz B,Samir S,Garrido N,Melado L,Engelmann N,Fatemi HM

    更新日期:2018-02-15 00:00:00

  • Distinguishing Patients With Distant Metastatic Differentiated Thyroid Cancer Who Biochemically Benefit From Next Radioiodine Treatment.

    abstract:Background:Repeated radioiodine (131I) treatment (RT) are commonly performed in patients with 131I-avid distant metastatic differentiated thyroid cancer (DM-DTC), but more precise indications remain indeterminate. This prospective study was conducted to explore predictors for biochemical response (BR) to next RT. Meth...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.587315

    authors: Sa R,Cheng L,Jin Y,Fu H,Shen Y,Chen L

    更新日期:2020-11-16 00:00:00

  • D2-Like Receptors Mediate Dopamine-Inhibited Insulin Secretion via Ion Channels in Rat Pancreatic β-Cells.

    abstract::Dopamine (DA) has a vital role in the central nervous system and also modulates lipid and glucose metabolism. The present study aimed to investigate the effect of dopamine on insulin secretion and the underlying mechanisms in rat pancreatic β-cells. Data from the radioimmunoassay indicated that dopamine inhibited insu...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00152

    authors: Liu M,Ren L,Zhong X,Ding Y,Liu T,Liu Z,Yang X,Cui L,Yang L,Fan Y,Liu Y,Zhang Y

    更新日期:2020-04-07 00:00:00

  • AMP-Activated Protein Kinase and O-GlcNAcylation, Two Partners Tightly Connected to Regulate Key Cellular Processes.

    abstract::The AMP-activated protein kinase (AMPK) is an important cellular energy sensor. Its activation under energetic stress is known to activate energy-producing pathways and to inactivate energy-consuming pathways, promoting ATP preservation and cell survival. AMPK has been shown to play protective role in many pathophysio...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2018.00519

    authors: Gélinas R,Dontaine J,Horman S,Beauloye C,Bultot L,Bertrand L

    更新日期:2018-09-13 00:00:00

  • A Short-Day Photoperiod Delays the Timing of Puberty in Female Mice via Changes in the Kisspeptin System.

    abstract::The reproduction of seasonal breeders is modulated by exposure to light in an interval of 24 h defined as photoperiod. The interruption of reproductive functions in seasonally breeding rodents is accompanied by the suppression of the Kiss1 gene expression, which is known to be essential for reproduction. In non-season...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00044

    authors: Bohlen TM,Silveira MA,Buonfiglio DDC,Ferreira-Neto HC,Cipolla-Neto J,Donato J Jr,Frazao R

    更新日期:2018-02-20 00:00:00

  • Arginine Vasotocin Preprohormone Is Expressed in Surprising Regions of the Teleost Forebrain.

    abstract::Nonapeptides play a fundamental role in the regulation of social behavior, among numerous other functions. In particular, arginine vasopressin and its non-mammalian homolog, arginine vasotocin (AVT), have been implicated in regulating affiliative, reproductive, and aggressive behavior in many vertebrate species. Where...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2017.00195

    authors: Rodriguez-Santiago M,Nguyen J,Winton LS,Weitekamp CA,Hofmann HA

    更新日期:2017-08-14 00:00:00

  • Isogenic Cellular Systems Model the Impact of Genetic Risk Variants in the Pathogenesis of Type 1 Diabetes.

    abstract::At least 57 independent loci within the human genome confer varying degrees of risk for the development of type 1 diabetes (T1D). The majority of these variants are thought to contribute to overall genetic risk by modulating host innate and adaptive immune responses, ultimately resulting in a loss of immunological tol...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2017.00276

    authors: Wallet MA,Santostefano KE,Terada N,Brusko TM

    更新日期:2017-10-18 00:00:00

  • Alteration of Testosterone Levels Changes Brain Wave Activity Patterns and Induces Aggressive Behavior in Rats.

    abstract::Testosterone is responsible for several changes in the brain, including behavioral and emotional responses, memory, and cognition. Given this, we investigated changes in the brain wave profile caused by supplementation with exogenous testosterone in both castrated and non-castrated rats. We also investigated the serum...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00654

    authors: Estumano DP,Ferreira LO,Bezerra PAL,da Silva MCP,Jardim GC,Santos GFS,Gustavo KS,Mattos BG,Ramos JAB,Jóia de Mello V,da Costa ET,Lopes DCF,Hamoy M

    更新日期:2019-09-24 00:00:00

  • Steroids and Brain, a Rising Bio-Medical Domain: a Perspective.

    abstract::Some newly described steroid-related compounds, also found in the rest of the body, are formed and active in the central nervous system, particularly in the brain. Some are of pharmacological and physiopathological interest. We specifically report on two compounds, "MAP4343," a new neurosteroid very efficient antidepr...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00316

    authors: Baulieu EE

    更新日期:2018-06-15 00:00:00

  • Central and direct regulation of testicular activity by gonadotropin-inhibitory hormone and its receptor.

    abstract::Gonadotropin-inhibitory hormone (GnIH) was first identified in Japanese quail to be an inhibitor of gonadotropin synthesis and release. GnIH peptides have since been identified in all vertebrates, and all share an LPXRFamide (X = L or Q) motif at their C-termini. The receptor for GnIH is the G protein-coupled receptor...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2014.00008

    authors: Ubuka T,Son YL,Tobari Y,Narihiro M,Bentley GE,Kriegsfeld LJ,Tsutsui K

    更新日期:2014-01-27 00:00:00

  • Very High Dehydroepiandrosterone Sulfate (DHEAS) in Serum of an Overweight Female Adolescent Without a Tumor.

    abstract::Introduction: An increase of serum dehydroepiandrosterone (DHEA) sulfate (DHEAS) is observed in premature adrenarche and congenital adrenal hyperplasia. Very high DHEAS levels are typical for adrenal tumors. Approximately 74% of DHEAS is hydrolyzed to DHEA by the steroid sulfatase (STS). The reverse reaction is DHEA s...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2020.00240

    authors: Iliev DI,Braun R,Sánchez-Guijo A,Hartmann M,Wudy SA,Heckmann D,Bruchelt G,Rösner A,Grosser G,Geyer J,Binder G

    更新日期:2020-05-06 00:00:00

  • Regulation of Placental Development and Its Impact on Fetal Growth-New Insights From Mouse Models.

    abstract::The placenta is the chief regulator of nutrient supply to the growing embryo during gestation. As such, adequate placental function is instrumental for developmental progression throughout intrauterine development. One of the most common complications during pregnancy is insufficient growth of the fetus, a problem ter...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2018.00570

    authors: Woods L,Perez-Garcia V,Hemberger M

    更新日期:2018-09-27 00:00:00

  • Control of Brown Adipose Tissue Glucose and Lipid Metabolism by PPARγ.

    abstract::Brown adipose tissue (BAT) non-shivering thermogenesis impacts energy homeostasis in rodents and humans. Mitochondrial uncoupling protein 1 in brown fat cells produces heat by dissipating the energy generated by fatty acid and glucose oxidation. In addition to thermogenesis and despite its small relative size, sympath...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2011.00084

    authors: Festuccia WT,Blanchard PG,Deshaies Y

    更新日期:2011-12-21 00:00:00

  • Integrated Analysis of Multiple Microarray Studies to Identify Novel Gene Signatures in Non-alcoholic Fatty Liver Disease.

    abstract::Background: Non-alcoholic fatty liver disease (NAFLD) is a well-known cause of liver dysfunction and has become a common chronic liver disease in many countries. However, the intrinsic molecular mechanisms underlying the pathogenesis of NAFLD have not yet been fully elucidated. Methods: We obtained the gene expression...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00599

    authors: Jia X,Zhai T

    更新日期:2019-08-30 00:00:00

  • Bone Maturation as a Predictive Factor of Catch-Up Growth During the First Year of Life in Born Small for Gestational Age Infants: A Prospective Study.

    abstract::Background: About 85-90% of children born small for gestational age (SGA) experience a catch-up growth that occurs mostly during the first year of life and results in a full stature recovery by the age of 2. Objective: To investigate the relation between bone maturation (BM) and catch-up growth during the first year o...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00147

    authors: Pepe G,Calafiore M,Valenzise M,Corica D,Morabito L,Pajno GB,Aversa T,Wasniewska M

    更新日期:2020-03-24 00:00:00

  • β-Cell-Specific Glucocorticoid Reactivation Attenuates Inflammatory β-Cell Destruction.

    abstract::Progression and severity of type 1 diabetes is dependent upon inflammatory induction of nitric oxide production and consequent pancreatic β-cell damage. Glucocorticoids (GCs) are highly effective anti-inflammatory agents but have been precluded in type 1 diabetes and in islet transplantation protocols because they exa...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2014.00165

    authors: Liu X,Turban S,Carter RN,Ahmad S,Ramage L,Webster SP,Walker BR,Seckl JR,Morton NM

    更新日期:2014-10-14 00:00:00

  • Arcuate AgRP neurons and the regulation of energy balance.

    abstract::The arcuate nucleus of the hypothalamus contains at least two populations of neurons that continuously monitor signals reflecting energy status and promote the appropriate behavioral and metabolic responses to changes in energy demand. Activation of neurons making pro-opiomelanocortin (POMC) decreases food intake and ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2012.00169

    authors: Cansell C,Denis RG,Joly-Amado A,Castel J,Luquet S

    更新日期:2012-12-27 00:00:00

  • Pregnancy-Associated Plasma Protein-A2 Is Associated With Mortality in Patients With Lung Cancer.

    abstract::Pregnancy-associated plasma protein-A (PAPP-A) and its homolog PAPP-A2 are enzymes that modulate the availability and mitogenic activity of insulin-like growth factor-I (IGF-I). PAPP-A has been implicated in numerous cancers but reports on PAPP-A2 in malignancy are non-existent. In a prospective observational study of...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00614

    authors: Hjortebjerg R,Espelund U,Rasmussen TR,Folkersen B,Steiniche T,Georgsen JB,Oxvig C,Frystyk J

    更新日期:2020-09-02 00:00:00

  • Cardiovascular Autonomic Neuropathy and Glucose Variability in Patients With Type 1 Diabetes: Is There an Association?

    abstract:Introduction:The oxidative stress associated with glucose variability might be responsible for neuronal damage while autonomic neuropathy (AN) has a detrimental effect on metabolism. The aim of the study was to find relationship between AN and GV in type 1 diabetic patients and to identify further factors that affect G...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00174

    authors: Nyiraty S,Pesei F,Orosz A,Coluzzi S,Vági OE,Lengyel C,Ábrahám G,Frontoni S,Kempler P,Várkonyi T

    更新日期:2018-04-19 00:00:00

  • The Roles of Kisspeptin System in the Reproductive Physiology of Fish With Special Reference to Chub Mackerel Studies as Main Axis.

    abstract::Kisspeptin, a novel neuropeptide product of the Kiss1 gene, activates the G protein-coupled membrane receptor G protein-coupled receptor 54 (now termed Kiss1r). Over the last 15 years, the importance of the kisspeptin system has been the subject of much debate in the mammalian research field. At the heart of the debat...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2018.00147

    authors: Ohga H,Selvaraj S,Matsuyama M

    更新日期:2018-04-04 00:00:00

  • Alteration of ACTH and Cortisol Levels After Estradiol Valerate Treatment in a Male Subject With Gender Dysphoria: A Case Report.

    abstract::Background: The number of subjects with gender dysphoria has been increasing. In general, male-to-female transsexual subjects are treated with estradiol valerate therapy. In this report, we showed the time course of ACTH and cortisol levels after estradiol valerate injection in a male subject with gender dysphoria. It...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2019.00751

    authors: Anno T,Kawasaki F,Shigemoto R,Irie S,Mune T,Kaku K,Kaneto H

    更新日期:2019-11-05 00:00:00

  • Cytokines, Adipokines, and Bone Markers at Rest and in Response to Plyometric Exercise in Obese vs Normal Weight Adolescent Females.

    abstract:Background:In adults, excess adiposity has been associated with low-grade, chronic inflammation and compromised bone health, but less is known about these linkages in children. The purpose of this study was to compare the circulating levels of inflammatory cytokines, adipokines, osteokines, and bone markers at rest and...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.531926

    authors: Kurgan N,McKee K,Calleja M,Josse AR,Klentrou P

    更新日期:2020-12-11 00:00:00

  • Early Diagnosis of Low-Risk Papillary Thyroid Cancer Results Rather in Overtreatment Than a Better Survival.

    abstract::We are witnessing a rapid worldwide increase in the incidence of papillary thyroid carcinoma (PTC) in the last thirty years. Extensive implementation of cancer screening and wide availability of neck ultrasound or other imaging studies is the main reason responsible for this phenomenon. It resulted in a detection of a...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2020.571421

    authors: Krajewska J,Kukulska A,Oczko-Wojciechowska M,Kotecka-Blicharz A,Drosik-Rutowicz K,Haras-Gil M,Jarzab B,Handkiewicz-Junak D

    更新日期:2020-10-06 00:00:00

  • Identification of Putative Natriuretic Hormones Isolated from Human Urine.

    abstract::This brief review describes some representative methodological approaches to the isolation of putative endogenous inhibitors of epithelial sodium transport - i.e., as ouabain-like factors (OLF) that inhibit the sodium transport enzyme Na-K-ATPase or inhibit the epithelial sodium channel (ENaC). Gel chromatography and ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2015.00066

    authors: Kramer HJ

    更新日期:2015-05-20 00:00:00