Abstract:
:Natriuretic hormones (NH) include three groups of compounds: the natriuretic peptides (ANP, BNP and CNP), the gastrointestinal peptides (guanylin and uroguanylin), and endogenous cardiac steroids. These substances induce the kidney to excrete sodium and therefore participate in the regulation of sodium and water homeostasis, blood volume, and blood pressure (BP). In addition to their peripheral functions, these hormones act as neurotransmitters or neuromodulators in the brain. In this review, the established information on the biosynthesis, release and function of NH is discussed, with particular focus on their role in brain function. The available literature on the expression patterns of each of the NH and their receptors in the brain is summarized, followed by the evidence for their roles in modulating brain function. Although numerous open questions exist regarding this issue, the available data support the notion that NH participate in the central regulation of BP, neuroprotection, satiety, and various psychiatric conditions, including anxiety, addiction, and depressive disorders. In addition, the interactions between the different NH in the periphery and the brain are discussed.
journal_name
Front Endocrinol (Lausanne)journal_title
Frontiers in endocrinologyauthors
Hodes A,Lichtstein Ddoi
10.3389/fendo.2014.00201subject
Has Abstractpub_date
2014-11-28 00:00:00pages
201issn
1664-2392journal_volume
5pub_type
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journal_title:Frontiers in endocrinology
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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abstract::Hard tissue regeneration represents a challenge for the Regenerative Medicine and Mesenchymal stem cells (MSCs) could be a successful therapeutic strategy. T-LysYal® (T-Lys), a new derivative of Hyaluronic Acid (HA) possessing a superior stability, has already been proved efficient in repairing corneal epithelial cell...
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journal_title:Frontiers in endocrinology
pub_type: 杂志文章
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更新日期:2020-04-30 00:00:00
abstract::[This corrects the article DOI: 10.3389/fendo.2019.00025.]. ...
journal_title:Frontiers in endocrinology
pub_type: 杂志文章,已发布勘误
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更新日期:2019-04-09 00:00:00