The Role of Vitamin D Binding Protein, Total and Free 25-Hydroxyvitamin D in Diabetes.


:Vitamin D is important for bone health, but may also have extra-skeletal effects. Vitamin D and its binding protein DBP have immunological effects and may therefore be important in the development of type 1 diabetes (T1DM), and low serum levels of 25-hydroxyvitamin D (25(OH)D) are associated with later development of type 2 diabetes (T2DM). However, it has so far been difficult to convincingly show an effect of vitamin D supplementation on prevention or treatment of diabetes. The serum level of 25(OH)D has traditionally been used as a marker of a subject's vitamin D status. This measurement includes both 25(OH)D bound to DBP and albumin as well as the free from of 25(OH)D. However, according to the free hormone hypothesis, the free form is the biologically active. Previously the free form of 25(OH)D had to be calculated based on measurements of 25(OH)D, DBP, and albumin, but recently a method for direct measurement of free 25(OH)D has become commercially available. This is important in clinical conditions where the amount of DBP is affected, and has caused a renewed interest in which vitamin D metabolite to measure in clinical situations. In the present review the relations between DBP, total and free 25(OH)D in T1DM and T2DM are described.


Jorde R




Has Abstract


2019-02-19 00:00:00








  • Determinants of Slow-Wave Activity in Overweight and Obese Adults: Roles of Sex, Obstructive Sleep Apnea and Testosterone Levels.

    abstract::Background: Slow-wave activity (SWA) in non-rapid eye movement (NREM) sleep, obtained by spectral analysis of the electroencephalogram, is a marker of the depth or intensity of NREM sleep. Higher levels of SWA are associated with lower arousability during NREM sleep and protect against sleep fragmentation. Multiple st...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Morselli LL,Temple KA,Leproult R,Ehrmann DA,Van Cauter E,Mokhlesi B

    更新日期:2018-07-12 00:00:00

  • Recent Advances in Histopathological and Molecular Diagnosis in Pheochromocytoma and Paraganglioma: Challenges for Predicting Metastasis in Individual Patients.

    abstract::Pheochromocytomas and paragangliomas (PHEO/PGL) are rare but occasionally life-threatening neoplasms, and are potentially malignant according to WHO classification in 2017. However, it is also well known that histopathological risk stratification to predict clinical outcome has not yet been established. The first hist...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Yamazaki Y,Gao X,Pecori A,Nakamura Y,Tezuka Y,Omata K,Ono Y,Morimoto R,Satoh F,Sasano H

    更新日期:2020-10-27 00:00:00

  • Elevated Serum Cyclophilin B Levels Are Associated with the Prevalence and Severity of Metabolic Syndrome.

    abstract:Objective:Inflammation plays a central role in the pathogenesis of metabolic syndrome (MetS). Cyclophilin B (CypB) can be constitutively secreted in response to inflammatory stimuli and oxidative stress, participating in tissue or systemic inflammation. We investigated the relationship between CypB and MetS in both hum...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Zhang H,Fan Q,Xie H,Lu L,Tao R,Wang F,Xi R,Hu J,Chen Q,Shen W,Zhang R,Yan X

    更新日期:2017-12-22 00:00:00

  • The Roles of ApoC-III on the Metabolism of Triglyceride-Rich Lipoproteins in Humans.

    abstract::Cardiovascular disease (CVD) is the leading cause of death globally. It is well-established based on evidence accrued during the last three decades that high plasma concentrations of cholesterol-rich atherogenic lipoproteins are causatively linked to CVD, and that lowering these reduces atherosclerotic cardiovascular ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Borén J,Packard CJ,Taskinen MR

    更新日期:2020-07-28 00:00:00

  • Variations in CD14 Gene Are Associated With Autoimmune Thyroid Diseases in the Chinese Population.

    abstract::Autoimmune thyroid diseases (AITDs) are chronic organ-specific autoimmune diseases and mainly include Graves' disease (GD) and Hashimoto's thyroiditis (HT). CD14 is an important component of the immune system as a receptor for gram-negative lipopolysaccharide (LPS). The genetic polymorphisms of CD14 have been confirme...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Jia X,Wang B,Yao Q,Li Q,Zhang J

    更新日期:2019-01-16 00:00:00

  • A Rhodnius prolixus Insulin Receptor and Its Conserved Intracellular Signaling Pathway and Regulation of Metabolism.

    abstract::The insulin signaling pathway is a modulator of metabolism in insects and can regulate functions associated with growth and development, as well as lipid and carbohydrate balance. We have previously reported the presence of an insulin-like peptide and an insulin-like growth factor in Rhodnius prolixus, which are invol...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Defferrari MS,Da Silva SR,Orchard I,Lange AB

    更新日期:2018-12-06 00:00:00

  • The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women.

    abstract::Background: The health benefits of soy are widely reported but there are queries on the effect of soy isoflavones on thyroid function and the underlying mechanism of action. Materials and Methods: We examined the effect of soy isoflavones on reverse tri-iodothyronine (or 3,3',5'-tri-iodothyronine; rT3) in two studies ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Sathyapalan T,Köhrle J,Rijntjes E,Rigby AS,Dargham SR,Kilpatrick ES,Atkin SL

    更新日期:2018-11-22 00:00:00

  • Early-Life Stress, HPA Axis Adaptation, and Mechanisms Contributing to Later Health Outcomes.

    abstract::Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, which then modulates the degree of adaptation and response to a later stressor. It is known that early-life stress can impact on later health but less is known about how early-life stress impairs HPA axis activity, contributing to maladaptation of the str...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Maniam J,Antoniadis C,Morris MJ

    更新日期:2014-05-13 00:00:00

  • Locus of control and obesity.

    abstract::In the developed world, the hazards associated with obesity have largely outstripped the risk of starvation. Obesity remains a difficult public health issue to address, due in large part to the many disciplines involved. A full understanding requires knowledge in the fields of genetics, endocrinology, psychology, soci...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Neymotin F,Nemzer LR

    更新日期:2014-10-07 00:00:00

  • All-Atom Structural Models of the Transmembrane Domains of Insulin and Type 1 Insulin-Like Growth Factor Receptors.

    abstract::The receptor tyrosine kinase superfamily comprises many cell-surface receptors including the insulin receptor (IR) and type 1 insulin-like growth factor receptor (IGF1R) that are constitutively homodimeric transmembrane glycoproteins. Therefore, these receptors require ligand-triggered domain rearrangements rather tha...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Mohammadiarani H,Vashisth H

    更新日期:2016-06-20 00:00:00

  • Rare Germline DICER1 Variants in Pediatric Patients With Cushing's Disease: What Is Their Role?

    abstract::Context: The DICER1 syndrome is a multiple neoplasia disorder caused by germline mutations in the DICER1 gene. In DICER1 patients, aggressive congenital pituitary tumors lead to neonatal Cushing's disease (CD). The role of DICER1 in other corticotropinomas, however, remains unknown. Objective: To perform a comprehensi...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Martínez de LaPiscina I,Hernández-Ramírez LC,Portillo N,Gómez-Gila AL,Urrutia I,Martínez-Salazar R,García-Castaño A,Aguayo A,Rica I,Gaztambide S,Faucz FR,Keil MF,Lodish MB,Quezado M,Pankratz N,Chittiboina P,Lane J,Kay D

    更新日期:2020-07-03 00:00:00

  • Gastrin and Gastric Cancer.

    abstract::Gastric cancer although occurring in reduced frequency is still an important disease, partly because of the bad prognosis when occurring in western countries. This decline in occurrence may mainly be due to the reduced prevalence of Helicobacter pylori (Hp) infection, which is the most important cause of gastric cance...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Waldum HL,Sagatun L,Mjønes P

    更新日期:2017-01-17 00:00:00

  • Progress in the Diagnosis and Classification of Pituitary Adenomas.

    abstract::Pituitary adenomas are common neoplasms. Their classification is based upon size, invasion of adjacent structures, sporadic or familial cases, biochemical activity, clinical manifestations, morphological characteristics, response to treatment and recurrence. Although they are considered benign tumors, some of them are...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Syro LV,Rotondo F,Ramirez A,Di Ieva A,Sav MA,Restrepo LM,Serna CA,Kovacs K

    更新日期:2015-06-12 00:00:00

  • Very High Dehydroepiandrosterone Sulfate (DHEAS) in Serum of an Overweight Female Adolescent Without a Tumor.

    abstract::Introduction: An increase of serum dehydroepiandrosterone (DHEA) sulfate (DHEAS) is observed in premature adrenarche and congenital adrenal hyperplasia. Very high DHEAS levels are typical for adrenal tumors. Approximately 74% of DHEAS is hydrolyzed to DHEA by the steroid sulfatase (STS). The reverse reaction is DHEA s...

    journal_title:Frontiers in endocrinology



    authors: Iliev DI,Braun R,Sánchez-Guijo A,Hartmann M,Wudy SA,Heckmann D,Bruchelt G,Rösner A,Grosser G,Geyer J,Binder G

    更新日期:2020-05-06 00:00:00

  • Clinical Implications and Impact of Discovery of the Thyroid Hormone Receptor on Integrin αvβ3-A Review.

    abstract::Hypothyroidism has been reported to improve survival in cancer patients but only recently has the putative mechanism been identified as a receptor for thyroxine and tri-iodothyronine on integrin αvβ3. Recognition of divergence of action of the pro-oncogenic L-thyroxine (T4) from pro-metabolic 3,5,3'-triiodo-L-thyronin...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Hercbergs A

    更新日期:2019-08-23 00:00:00

  • IGFBP-5 Promotes Fibrosis via Increasing Its Own Expression and That of Other Pro-fibrotic Mediators.

    abstract::Pulmonary fibrosis is a hallmark of diseases such as systemic sclerosis (SSc, scleroderma) and idiopathic pulmonary fibrosis (IPF). To date, the therapeutic options for patients with pulmonary fibrosis are limited, and organ transplantation remains the most effective option. Insulin-like growth factor-binding protein ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Nguyen XX,Muhammad L,Nietert PJ,Feghali-Bostwick C

    更新日期:2018-10-15 00:00:00

  • Corrigendum: Central Control of Feeding Behavior by the Secretin, PACAP, and Glucagon Family of Peptides.

    abstract::[This corrects the article DOI: 10.3389/fendo.2017.00018.]. ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,已发布勘误


    authors: Sekar R,Wang L,Chow BKC

    更新日期:2018-07-18 00:00:00

  • Adiposity Criteria in Assessing Increased Cardiometabolic Risk in Prepubertal Children.

    abstract::Objective: Adiposity induces the clustering of cardiometabolic risk factors, and pediatric adiposity is a better indicator for adulthood cardiometabolic diseases than pediatric metabolic syndrome. However, the observed prevalence of pediatric adiposity depends on the methods and cut-points used. Therefore, we aimed to...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Tompuri TT,Jääskeläinen J,Lindi V,Laaksonen DE,Eloranta AM,Viitasalo A,Laitinen T,Lakka TA

    更新日期:2019-06-26 00:00:00

  • Preliminary Findings Show Maternal Hypothyroidism May Contribute to Abnormal Cortical Morphology in Offspring.

    abstract::In rodents, insufficient thyroid hormone (TH) gestationally has adverse effects on cerebral cortex development. Comparable studies of humans examining how TH insufficiency affects cortical morphology are limited to children with congenital hypothyroidism or offspring of hypothyroxinemic women; effects on cortex of chi...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Lischinsky JE,Skocic J,Clairman H,Rovet J

    更新日期:2016-02-25 00:00:00

  • Olfactory Receptors in Semen and in the Male Tract: From Proteome to Proteins.

    abstract::The estimated number of testicular olfactory receptors (ORs) in mammals range between 20 and 66. Previous data reported the role of hOR17-4 and mOR23 in sperm-oocyte chemiotaxis. Proteomic analysis was performed to understand which are the ORs expressed in seminal plasma. Seminal samples by four fertile men were analy...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Milardi D,Colussi C,Grande G,Vincenzoni F,Pierconti F,Mancini F,Baroni S,Castagnola M,Marana R,Pontecorvi A

    更新日期:2018-01-23 00:00:00

  • High Expression of Complement Components in the Kidneys of Type 2 Diabetic Rats With Diabetic Nephropathy.

    abstract::Background: Diabetic nephropathy (DN) is the leading cause of end-stage failure of the kidneys; however, its pathogenesis remains unknown. This study assessed the expression of complement components in the kidneys of rats with type 2 DN to investigate their role in DN. Methods: A rat model of type 2 DN was induced by ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Huang Y,Xu J,Wu X,Chen X,Bai X,Zhuang Y,Fang J,Lin X

    更新日期:2019-07-09 00:00:00

  • 3-Iodothyronamine Activates a Set of Membrane Proteins in Murine Hypothalamic Cell Lines.

    abstract::3-Iodothyronamine (3-T1AM) is an endogenous thyroid hormone metabolite. The profound pharmacological effects of 3-T1AM on energy metabolism and thermal homeostasis have raised interest to elucidate its signaling properties in tissues that pertain to metabolic regulation and thermogenesis. Previous studies identified G...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Bräunig J,Mergler S,Jyrch S,Hoefig CS,Rosowski M,Mittag J,Biebermann H,Khajavi N

    更新日期:2018-09-11 00:00:00

  • Cytokines, Adipokines, and Bone Markers at Rest and in Response to Plyometric Exercise in Obese vs Normal Weight Adolescent Females.

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    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Kurgan N,McKee K,Calleja M,Josse AR,Klentrou P

    更新日期:2020-12-11 00:00:00

  • Disruption in Thyroid Signaling Pathway: A Mechanism for the Effect of Endocrine-Disrupting Chemicals on Child Neurodevelopment.

    abstract::Thyroid hormones are crucial in normal brain development. Transient and mild thyroid hormone insufficiency in pregnancy is also associated with impaired neurodevelopment in the offspring (e.g., 3-4 IQ score loss in association with maternal free thyroxine in the lowest fifth percentile). While inadequate iodine intake...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Ghassabian A,Trasande L

    更新日期:2018-04-30 00:00:00

  • Melanocortin Regulation of Inflammation.

    abstract::Adrenocorticotropic hormone (ACTH), and α-, β-, and γ-melanocyte-stimulating hormones (α-, β-, γ-MSH), collectively known as melanocortins, together with their receptors (melanocortin receptors), are components of an ancient modulatory system. The clinical use of ACTH in the treatment of rheumatoid arthritis started i...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Wang W,Guo DY,Lin YJ,Tao YX

    更新日期:2019-10-09 00:00:00

  • Regulatory Role of RNA N6-Methyladenosine Modification in Bone Biology and Osteoporosis.

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    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Chen X,Hua W,Huang X,Chen Y,Zhang J,Li G

    更新日期:2020-01-10 00:00:00

  • Cytokines and Abnormal Glucose and Lipid Metabolism.

    abstract::Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory cytokines, myokines, and osteokines, contribute substantially to the development of abnormal glucose and lipid metabolism. Some cytokines play a positive role in metabolism action, while others have a negative metabolic role l...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Shi J,Fan J,Su Q,Yang Z

    更新日期:2019-10-30 00:00:00

  • Regulation and Possible Functions of Kisspeptin in the Medial Amygdala.

    abstract::Kisspeptin, encoded by the Kiss1 gene, is required for reproduction. Humans and mice lacking kisspeptin or its receptor, Kiss1r, have impairments in reproductive physiology and fertility. In addition to being located in the hypothalamus in the anteroventral periventricular and arcuate nuclei, kisspeptin neurons are al...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Stephens SBZ,Kauffman AS

    更新日期:2017-08-07 00:00:00

  • Low Prevalence of Isolated Growth Hormone Deficiency in Patients After Brain Injury: Results From a Phase II Pilot Study.

    abstract::Growth hormone deficiency (GHD) results in an impaired health-related quality of life (HrQoL) and cognitive impairment in the attention and memory domain. GHD is assumed to be a frequent finding after brain injury due to traumatic brain injury (TBI), aneurysmal subarachnoid hemorrhage (SAH) or ischemic stroke. Hence, ...

    journal_title:Frontiers in endocrinology



    authors: Leonhardt M,Kopczak A,Schäpers B,Limbrock J,Sämann PG,Czisch M,von Steinbuechel N,Jordan M,Schneider HJ,Schneider M,Sievers C,Stalla GK

    更新日期:2018-12-17 00:00:00

  • Differential Roles of Two Leptin Gene Paralogues on Food Intake and Hepatic Metabolism Regulation in Mandarin Fish.

    abstract::Leptin affects food intake regulation and energy homeostasis in mammals, as opposed to mammals who have a single leptin gene, fish have duplicated leptin gene paralogues. Until now, most functional studies on fish focused on the first reported paralogue without much explanation on specific gene paralogue. This study s...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Yuan XC,Liang XF,Cai WJ,Li AX,Huang D,He S

    更新日期:2020-08-14 00:00:00