DNA Methylation Changes More Slowly Than Physiological States in Response to Weight Loss in Genetically Diverse Mouse Strains.

abstract：:Hypothyroidism has been reported to improve survival in cancer patients but only recently has the putative mechanism been identified as a receptor for thyroxine and tri-iodothyronine on integrin αvβ3. Recognition of divergence of action of the pro-oncogenic L-thyroxine (T4) from pro-metabolic 3,5,3'-triiodo-L-thyronin...

journal_title：Frontiers in endocrinology

authors： Hercbergs A

更新日期：2019-08-23 00:00:00

abstract：:In a contribution to this Research Topic Erkki Somersalo and Daniela Calvetti carried out a mathematical analysis of neurotransmitter pathways in brain, modeling compartmental nitrogen flux among several major participants - ammonia, glutamine, glutamate, GABA, and selected amino acids. This analysis is important beca...

journal_title：Frontiers in endocrinology

authors： Cooper AJ

更新日期：2013-11-18 00:00:00

abstract：:The Twist proteins (Twist-1 and -2) are highly conserved developmental proteins with key roles for the transcriptional regulation in mesenchymal cell lineages. They belong to the super-family of bHLH proteins and exhibit bi-functional roles as both activators and repressors of gene transcription. The Twist proteins ar...

journal_title：Frontiers in endocrinology

authors： Dobrian AD

更新日期：2012-08-30 00:00:00

abstract：:Animals store metabolic energy as electrochemical gradients. At least 50% of mammalian energy is expended to maintain electrochemical gradients across the inner mitochondrial membrane (H+), the sarcoplasmic reticulum (Ca++), and the plasma membrane (Na+/K+). The potential energy of these gradients can be used to perfo...

journal_title：Frontiers in endocrinology

authors： Geisler CE,Kentch KP,Renquist BJ

更新日期：2017-09-01 00:00:00

abstract：:Pituitary adenomas (PA) are amongst the most prevalent intracranial tumors, causing complications by hormonal overproduction or deficiency and tumor mass effects, with 95% of cases occurring sporadically. Associated germline mutations (AIP, MEN1, CDKN1B, PRKAR1A, SDHx) and Xq26.3 microduplications are increasingly ide...

journal_title：Frontiers in endocrinology

authors： van den Broek MFM,van Nesselrooij BPM,Verrijn Stuart AA,van Leeuwaarde RS,Valk GD

更新日期：2019-12-10 00:00:00

abstract：:The insulin-like growth factor (IGF) family plays key roles in growth and development. In the cornea, IGF family members have been implicated in proliferation, differentiation, and migration, critical events that maintain a smooth refracting surface that is essential for vision. The IGF family is composed of multiple ...

journal_title：Frontiers in endocrinology

authors： Stuard WL,Titone R,Robertson DM

更新日期：2020-03-03 00:00:00

abstract：:Pineal metastasis is an exceedingly rare finding in patients with systemic malignancies. Such lesions are typically the manifestation of a primary lung cancer; nonetheless, a variety of malignancies have been reported to disseminate to the pineal gland including gastrointestinal, endocrine, and skin cancers, among oth...

journal_title：Frontiers in endocrinology

authors： Cuoco JA,Kortz MW,Benko MJ,Jarrett RW,Rogers CM,Witcher MR,Marvin EA

更新日期：2020-10-23 00:00:00

abstract：:At least 57 independent loci within the human genome confer varying degrees of risk for the development of type 1 diabetes (T1D). The majority of these variants are thought to contribute to overall genetic risk by modulating host innate and adaptive immune responses, ultimately resulting in a loss of immunological tol...

journal_title：Frontiers in endocrinology

authors： Wallet MA,Santostefano KE,Terada N,Brusko TM

更新日期：2017-10-18 00:00:00

abstract：:Background: Associations between vitiligo and thyroid disorders have been suggested, However, the prevalence of thyroid disorders in vitiligo vary widely. Purpose: To conduct a systematic review and meta-analysis assessing the prevalence of thyroid disorders in patients with vitiligo. Method: The PubMed, Cochrane Libr...

journal_title：Frontiers in endocrinology

authors： Yuan J,Sun C,Jiang S,Lu Y,Zhang Y,Gao XH,Wu Y,Chen HD

更新日期：2019-01-15 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fendo.2019.00025.]. ...

journal_title：Frontiers in endocrinology

authors： Bhusal A,Rahman MH,Lee IK,Suk K

更新日期：2019-04-09 00:00:00

abstract：Objective:Two missense mutations in KCNQ1, an imprinted gene that encodes the alpha subunit of the voltage-gated potassium channel Kv7.1, cause autosomal dominant growth hormone deficiency and maternally inherited gingival fibromatosis. We evaluated endocrine features, birth size, and subsequent somatic growth of patie...

journal_title：Frontiers in endocrinology

authors： Huttunen H,Hero M,Lääperi M,Känsäkoski J,Swan H,Hirsch JA,Miettinen PJ,Raivio T

更新日期：2018-04-24 00:00:00

abstract：:The orexigenic peptide hormone ghrelin is synthesized in the stomach and its receptor growth hormone secretagogue receptor (GHSR1a) is expressed mainly in the central nervous system (CNS). In this review, we confine our discussion to the physiological role of GHSR1a in the brain. Paradoxically, despite broad expressio...

journal_title：Frontiers in endocrinology

authors： Kern A,Grande C,Smith RG

更新日期：2014-08-18 00:00:00

abstract：:The origin of the coronavirus disease 2019 (COVID-19) pandemic is zoonotic. The circadian day-night is the rhythmic clue to organisms for their synchronized body functions. The "development for mankind" escalated the use of artificial light at night (ALAN). In this article, we tried to focus on the possible influence ...

journal_title：Frontiers in endocrinology

authors： Khan ZA,Yumnamcha T,Mondal G,Devi SD,Rajiv C,Labala RK,Sanjita Devi H,Chattoraj A

更新日期：2020-09-10 00:00:00

abstract：:In rodents, insufficient thyroid hormone (TH) gestationally has adverse effects on cerebral cortex development. Comparable studies of humans examining how TH insufficiency affects cortical morphology are limited to children with congenital hypothyroidism or offspring of hypothyroxinemic women; effects on cortex of chi...

journal_title：Frontiers in endocrinology

authors： Lischinsky JE,Skocic J,Clairman H,Rovet J

更新日期：2016-02-25 00:00:00

abstract：:The estimated number of testicular olfactory receptors (ORs) in mammals range between 20 and 66. Previous data reported the role of hOR17-4 and mOR23 in sperm-oocyte chemiotaxis. Proteomic analysis was performed to understand which are the ORs expressed in seminal plasma. Seminal samples by four fertile men were analy...

journal_title：Frontiers in endocrinology

authors： Milardi D,Colussi C,Grande G,Vincenzoni F,Pierconti F,Mancini F,Baroni S,Castagnola M,Marana R,Pontecorvi A

更新日期：2018-01-23 00:00:00

abstract：:Previous work has shown that reduced expression of PLCXD3, a member of the phosphoinositide-specific phospholipases (PI-PLC) family, impaired insulin secretion with an unclear mechanism. In the current study, we aim to investigate the mechanism underlying this effect using human islets and rat INS-1 (832/13) cells. Mi...

journal_title：Frontiers in endocrinology

authors： Aljaibeji H,Mukhopadhyay D,Mohammed AK,Dhaiban S,Hachim MY,Elemam NM,Sulaiman N,Salehi A,Taneera J

更新日期：2019-11-06 00:00:00

abstract：:JAK2 is a member of the Janus kinase (JAKs) family of non-receptor protein tyrosine kinases, which includes JAK1-3 and TYK2. JAKs serve as the cytoplasmic signaling components of cytokine receptors and are activated through cytokine-mediated trans-phosphorylation, which leads to receptor phosphorylation and recruitmen...

journal_title：Frontiers in endocrinology

authors： Hubbard SR

更新日期：2018-01-05 00:00:00

abstract：:RET gene rearrangements (RET/PTCs) represent together with BRAF point mutations the two major groups of mutations involved in papillary thyroid carcinoma (PTC) initiation and progression. In this review, we will examine the mechanisms involved in RET/PTC-induced thyroid cell transformation. In detail, we will summariz...

journal_title：Frontiers in endocrinology

authors： Menicali E,Moretti S,Voce P,Romagnoli S,Avenia N,Puxeddu E

更新日期：2012-05-22 00:00:00

abstract：:Biological steroids were traditionally thought to be synthesized exclusively by the adrenal glands and gonads. Recent decades have seen the discovery of neurosteroid production that acts locally within the central nervous system to affect physiology and behavior. These actions include, for example, regulation of aggre...

journal_title：Frontiers in endocrinology

authors： Wingfield JC,Wacker DW,Bentley GE,Tsutsui K

更新日期：2018-06-18 00:00:00

abstract：:Estetrol (E4) is a natural human estrogen present at high concentrations during pregnancy. Due to its high oral bioavailability and long plasma half-life, E4 is particularly suitable for therapeutic applications. E4 acts as a selective estrogen receptor (ER) modulator, exerting estrogenic actions on the endometrium or...

journal_title：Frontiers in endocrinology

authors： Giretti MS,Montt Guevara MM,Cecchi E,Mannella P,Palla G,Spina S,Bernacchi G,Di Bello S,Genazzani AR,Genazzani AD,Simoncini T

更新日期：2014-05-26 00:00:00

abstract：:Despite the long-held belief that growth hormone supplementation provides psychosocial benefits to patients with Turner syndrome (TS), this assumption has never been rigorously tested in a randomized control trial. As a sub-study of the Canadian growth-hormone trial, parent-, and patient-completed standardized questio...

journal_title：Frontiers in endocrinology

authors： Rovet JF,Van Vliet G

更新日期：2019-03-13 00:00:00

abstract：:Given that obesity and associated disorder type II diabetes mellitus have reached epidemic proportions worldwide, the development of efficient prevention and therapeutic interventions is a global public health interest. There is now a large body of evidence suggesting that the micro-organisms colonizing the human gut,...

journal_title：Frontiers in endocrinology

authors： Gérard C,Vidal H

更新日期：2019-01-30 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of a nuclear receptor superfamily and acts as a ligand-dependent transcription factor, playing key roles in maintenance of adipose tissue and in regulation of glucose and lipid homeostasis. This receptor is the target of thiazolidinediones, a class o...

journal_title：Frontiers in endocrinology

authors： Ribeiro Filho HV,Bernardi Videira N,Bridi AV,Tittanegro TH,Helena Batista FA,de Carvalho Pereira JG,de Oliveira PSL,Bajgelman MC,Le Maire A,Figueira ACM

更新日期：2018-02-01 00:00:00

abstract：:Measuring salivary cortisol is both convenient and non-invasive for patients; however, its usefulness as a marker for monitoring medical therapy has not yet been established. The aim of this study was to assess the utility of multiple salivary cortisol measurements in patients with Cushing's syndrome (CS) during medic...

journal_title：Frontiers in endocrinology

authors： Yoshida K,Fukuoka H,Odake Y,Nakajima S,Tachibana M,Ito J,Hosokawa Y,Yamada T,Miura H,Suematsu N,Matsumoto R,Bando H,Suda K,Nishizawa H,Iguchi G,Ogawa W,Takahashi Y

更新日期：2018-01-11 00:00:00

abstract：:Background: Gestational diabetes mellitus (GDM) has become a public health problem in China. Objective: To examine the association of dietary protein intake before and during pregnancy with the risk of GDM. Design: Dietary intake before pregnancy and during the first and second trimesters of pregnancy was assessed usi...

journal_title：Frontiers in endocrinology

authors： Liang Y,Gong Y,Zhang X,Yang D,Zhao D,Quan L,Zhou R,Bao W,Cheng G

更新日期：2018-10-11 00:00:00

abstract：:Objective: To study the impact of dose reduction in MDCT images through tube current reduction or sparse sampling on the vertebral bone strength prediction using finite element (FE) analysis for fracture risk assessment. Methods: Routine MDCT data covering lumbar vertebrae of 12 subjects (six male; six female; 74.70 ±...

journal_title：Frontiers in endocrinology

authors： Rayudu NM,Subburaj K,Mei K,Dieckmeyer M,Kirschke JS,Noël PB,Baum T

更新日期：2020-07-28 00:00:00

abstract：:The reproduction of seasonal breeders is modulated by exposure to light in an interval of 24 h defined as photoperiod. The interruption of reproductive functions in seasonally breeding rodents is accompanied by the suppression of the Kiss1 gene expression, which is known to be essential for reproduction. In non-season...

journal_title：Frontiers in endocrinology

authors： Bohlen TM,Silveira MA,Buonfiglio DDC,Ferreira-Neto HC,Cipolla-Neto J,Donato J Jr,Frazao R

更新日期：2018-02-20 00:00:00

abstract：:Graves' hyperthyroidism is caused by autoantibodies directed against the thyroid-stimulating hormone receptor (TSHR) that mimic the action of TSH. The establishment of Graves' hyperthyroidism in experimental animals has proven to be an important approach to dissect the mechanisms of self-tolerance breakdown that lead ...

journal_title：Frontiers in endocrinology

authors： Luo Y,Yoshihara A,Oda K,Ishido Y,Suzuki K

更新日期：2016-11-14 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is the commonest endocrine abnormality in women of reproductive age typically presenting with chronic oligo- or anovulation, clinical, or biochemical hyperandrogenism and polycystic ovarian morphology (PCOM). Restoring mono-ovulation is the ultimate goal of ovulation induction and most...

journal_title：Frontiers in endocrinology

authors： Laven JSE

更新日期：2019-02-12 00:00:00

abstract：:Objective: Prolactin and progesterone are implicated in glucose homeostasis in and outside of pregnancy. However, their associations with gestational diabetes (GDM) risk were not well-understood. This study investigates this question in a prospective and longitudinal cohort. Methods: This is a nested case-control stud...

journal_title：Frontiers in endocrinology

authors： Li M,Song Y,Rawal S,Hinkle SN,Zhu Y,Tekola-Ayele F,Ferrara A,Tsai MY,Zhang C

更新日期：2020-02-27 00:00:00