Quantitative analysis of neurotransmitter pathways under steady state conditions - a perspective.


:In a contribution to this Research Topic Erkki Somersalo and Daniela Calvetti carried out a mathematical analysis of neurotransmitter pathways in brain, modeling compartmental nitrogen flux among several major participants - ammonia, glutamine, glutamate, GABA, and selected amino acids. This analysis is important because cerebral nitrogen metabolism is perturbed in many diseases, including liver disease and inborn errors of the urea cycle. These diseases result in an elevation of blood ammonia, which is neurotoxic. Here, a brief description is provided of the discovery of cerebral metabolic compartmentation of nitrogen metabolism - a key feature of cerebral glutamate-glutamine and GABA-glutamine cycles. The work of Somersalo and Calvetti is discussed as a model for future studies of normal and pathological cerebral ammonia metabolism.


Cooper AJ




Has Abstract


2013-11-18 00:00:00








  • Recent Advances in Histopathological and Molecular Diagnosis in Pheochromocytoma and Paraganglioma: Challenges for Predicting Metastasis in Individual Patients.

    abstract::Pheochromocytomas and paragangliomas (PHEO/PGL) are rare but occasionally life-threatening neoplasms, and are potentially malignant according to WHO classification in 2017. However, it is also well known that histopathological risk stratification to predict clinical outcome has not yet been established. The first hist...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Yamazaki Y,Gao X,Pecori A,Nakamura Y,Tezuka Y,Omata K,Ono Y,Morimoto R,Satoh F,Sasano H

    更新日期:2020-10-27 00:00:00

  • Application and Utility of Continuous Glucose Monitoring in Pregnancy: A Systematic Review.

    abstract::Background: In the past decade, continuous glucose monitoring (CGM) has been proven to have similar accuracy to self-monitoring of blood glucose (SMBG) and yet provides better therapy optimization and detects trends in glucose values due to higher frequency of testing. Even though the feasibility and utility of CGM ha...

    journal_title:Frontiers in endocrinology



    authors: Yu Q,Aris IM,Tan KH,Li LJ

    更新日期:2019-10-11 00:00:00

  • A Rare Case of Pituitary Melanoma Metastasis: A Dramatic and Prolonged Response to Dabrafenib-Trametinib Therapy.

    abstract::Introduction: Pituitary metastases (PM) are rare events and to date only very few cases of melanoma PM have been described in literature up to now. Case Presentation: We describe the clinical history of a 33-year-old male patient who underwent surgical excision of an inter-scapular melanoma in 2008. The subsequent fol...

    journal_title:Frontiers in endocrinology



    authors: Mormando M,Puliani G,Barnabei A,Lauretta R,Bianchini M,Chiefari A,Russillo M,Cognetti F,Romano L,Appetecchia M

    更新日期:2020-07-23 00:00:00

  • Mechanisms linking excess adiposity and carcinogenesis promotion.

    abstract::Obesity constitutes one of the most important metabolic diseases being associated to insulin resistance development and increased cardiovascular risk. Association between obesity and cancer has also been well established for several tumor types, such as breast cancer in post-menopausal women, colorectal, and prostate ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Pérez-Hernández AI,Catalán V,Gómez-Ambrosi J,Rodríguez A,Frühbeck G

    更新日期:2014-05-01 00:00:00

  • Evaluating All Potential Oral Complications of Diabetes Mellitus.

    abstract::Diabetes mellitus (DM) is associated with several microvascular and macrovascular complications, such as retinopathy, nephropathy, neuropathy, and cardiovascular diseases. The pathogenesis of these complications is complex, and involves metabolic and hemodynamic disturbances, including hyperglycemia, insulin resistanc...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Verhulst MJL,Loos BG,Gerdes VEA,Teeuw WJ

    更新日期:2019-02-18 00:00:00

  • Experimental Evidence and Clinical Implications of Pituitary Adenoma Stem Cells.

    abstract::Pituitary adenomas, accounting for 15% of diagnosed intracranial neoplasms, are usually benign and pharmacologically and surgically treatable; however, the critical location, mass effects and hormone hypersecretion sustain their significant morbidity. Approximately 35% of pituitary tumors show a less benign course sin...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Würth R,Thellung S,Corsaro A,Barbieri F,Florio T

    更新日期:2020-02-20 00:00:00

  • Association of BRCA Mutations and Anti-müllerian Hormone Level in Young Breast Cancer Patients.

    abstract::Background: Several preclinical and clinical studies have suggested that BRCA-mutation carriers may have decreased ovarian reserve. However, data in this area are limited and inconsistent, especially in young breast cancer patients. Objective: This study evaluated the association between BRCA mutation status and serum...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Son KA,Lee DY,Choi D

    更新日期:2019-04-11 00:00:00

  • Pharmacotherapy for the Treatment of Overweight and Obesity in Children, Adolescents, and Young Adults in a Large Health System in the US.

    abstract::Lifestyle modifications focused on diet, physical activity, and behavior have a modest impact on weight reduction in children, adolescents, and young adults (YA) with overweight and obesity. Several anti-obesity medications (AOMs) have been approved by the Food and Drug Administration (FDA) for use among adult patient...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Czepiel KS,Perez NP,Campoverde Reyes KJ,Sabharwal S,Stanford FC

    更新日期:2020-05-13 00:00:00

  • Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions.

    abstract::This review focuses on the biologic importance of the vitamin D binding protein (DBP) with emphasis on its regulation of total and free vitamin D metabolite levels in various clinical conditions. Nearly all DBP is produced in the liver, where its regulation is influenced by estrogen, glucocorticoids and inflammatory c...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Bikle DD,Schwartz J

    更新日期:2019-05-28 00:00:00

  • Vitiligo and Autoimmune Thyroid Disorders.

    abstract::Vitiligo represents the most common cause of acquired skin, hair, and oral depigmentation, affecting 0.5-1% of the population worldwide. It is clinically characterized by the appearance of disfiguring circumscribed skin macules following melanocyte destruction by autoreactive cytotoxic T lymphocytes. Patients affected...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Baldini E,Odorisio T,Sorrenti S,Catania A,Tartaglia F,Carbotta G,Pironi D,Rendina R,D'Armiento E,Persechino S,Ulisse S

    更新日期:2017-10-27 00:00:00

  • Clinical Relevance of Genetic Analysis in Patients With Pituitary Adenomas: A Systematic Review.

    abstract::Pituitary adenomas (PA) are amongst the most prevalent intracranial tumors, causing complications by hormonal overproduction or deficiency and tumor mass effects, with 95% of cases occurring sporadically. Associated germline mutations (AIP, MEN1, CDKN1B, PRKAR1A, SDHx) and Xq26.3 microduplications are increasingly ide...

    journal_title:Frontiers in endocrinology



    authors: van den Broek MFM,van Nesselrooij BPM,Verrijn Stuart AA,van Leeuwaarde RS,Valk GD

    更新日期:2019-12-10 00:00:00

  • Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis.

    abstract::Obesity has emerged as one of the most burdensome conditions in modern society. In this context, understanding the mechanisms controlling food intake is critical. At present, the adipocyte-derived hormone leptin and the pancreatic β-cell-derived hormone insulin are considered the principal anorexigenic hormones. Altho...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Thon M,Hosoi T,Ozawa K

    更新日期:2016-10-20 00:00:00

  • Postoperative Neck Ultrasonography Surveillance After Thyroidectomy in Patients With Medullary Thyroid Carcinoma: A Multicenter Study.

    abstract:Background:For detecting tumor recurrence of medullary thyroid carcinoma (MTC) in the neck, an appropriate frequency and interval of postoperative ultrasonography (US) surveillance remains unclear. This study aimed to assess an appropriate interval and frequency of postoperative neck US surveillance for detecting tumor...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Ahn HS,Kim DW,Lee YJ,Lee CY,Kim JH,Choi YJ,Lee S,Ryoo I,Huh JY,Sung JY,Kwak JY,Baek HJ

    更新日期:2018-03-15 00:00:00

  • Differential Function of Melatonin MT1 and MT2 Receptors in REM and NREM Sleep.

    abstract::The pathophysiological function of the G-protein coupled melatonin MT1 and MT2 receptors has not yet been well-clarified. Recent advancements using selective MT1/ MT2 receptor ligands and MT1/MT2 receptor knockout mice have suggested that the activation of the MT1 receptors are mainly implicated in the regulation of r...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Gobbi G,Comai S

    更新日期:2019-03-01 00:00:00

  • Determinants of Slow-Wave Activity in Overweight and Obese Adults: Roles of Sex, Obstructive Sleep Apnea and Testosterone Levels.

    abstract::Background: Slow-wave activity (SWA) in non-rapid eye movement (NREM) sleep, obtained by spectral analysis of the electroencephalogram, is a marker of the depth or intensity of NREM sleep. Higher levels of SWA are associated with lower arousability during NREM sleep and protect against sleep fragmentation. Multiple st...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Morselli LL,Temple KA,Leproult R,Ehrmann DA,Van Cauter E,Mokhlesi B

    更新日期:2018-07-12 00:00:00

  • The Role of KCNQ1 Mutations and Maternal Beta Blocker Use During Pregnancy in the Growth of Children With Long QT Syndrome.

    abstract:Objective:Two missense mutations in KCNQ1, an imprinted gene that encodes the alpha subunit of the voltage-gated potassium channel Kv7.1, cause autosomal dominant growth hormone deficiency and maternally inherited gingival fibromatosis. We evaluated endocrine features, birth size, and subsequent somatic growth of patie...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Huttunen H,Hero M,Lääperi M,Känsäkoski J,Swan H,Hirsch JA,Miettinen PJ,Raivio T

    更新日期:2018-04-24 00:00:00

  • Glucose Transporters in Diabetic Kidney Disease-Friends or Foes?

    abstract::Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and a common cause of end-stage renal disease worldwide. DKD manifests as an increased urinary protein excretion (albuminuria). Multiple studies have shown that insulin resistance correlates with the development of albuminuria in non-diabe...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Wasik AA,Lehtonen S

    更新日期:2018-04-09 00:00:00

  • SIRT1 and Estrogen Signaling Cooperation for Breast Cancer Onset and Progression.

    abstract::Breast cancer remains a significant female mortality cause. It constitutes a multifactorial disease for which research on environmental factors offers little help in predicting onset or progression. The pursuit for its foundations by analyzing hormonal changes as a motive for disease development, indicates that increa...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Liarte S,Alonso-Romero JL,Nicolás FJ

    更新日期:2018-09-27 00:00:00

  • Finite Element Analysis-Based Vertebral Bone Strength Prediction Using MDCT Data: How Low Can We Go?

    abstract::Objective: To study the impact of dose reduction in MDCT images through tube current reduction or sparse sampling on the vertebral bone strength prediction using finite element (FE) analysis for fracture risk assessment. Methods: Routine MDCT data covering lumbar vertebrae of 12 subjects (six male; six female; 74.70 ±...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Rayudu NM,Subburaj K,Mei K,Dieckmeyer M,Kirschke JS,Noël PB,Baum T

    更新日期:2020-07-28 00:00:00

  • Integrated Analysis of Multiple Microarray Studies to Identify Novel Gene Signatures in Non-alcoholic Fatty Liver Disease.

    abstract::Background: Non-alcoholic fatty liver disease (NAFLD) is a well-known cause of liver dysfunction and has become a common chronic liver disease in many countries. However, the intrinsic molecular mechanisms underlying the pathogenesis of NAFLD have not yet been fully elucidated. Methods: We obtained the gene expression...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Jia X,Zhai T

    更新日期:2019-08-30 00:00:00

  • Alteration of ACTH and Cortisol Levels After Estradiol Valerate Treatment in a Male Subject With Gender Dysphoria: A Case Report.

    abstract::Background: The number of subjects with gender dysphoria has been increasing. In general, male-to-female transsexual subjects are treated with estradiol valerate therapy. In this report, we showed the time course of ACTH and cortisol levels after estradiol valerate injection in a male subject with gender dysphoria. It...

    journal_title:Frontiers in endocrinology



    authors: Anno T,Kawasaki F,Shigemoto R,Irie S,Mune T,Kaku K,Kaneto H

    更新日期:2019-11-05 00:00:00

  • Role of adaptor proteins in secretory granule biogenesis and maturation.

    abstract::In the regulated secretory pathway, secretory granules (SGs) store peptide hormones that are released on demand. SGs are formed at the trans-Golgi network and must undergo a maturation process to become responsive to secretagogues. The production of mature SGs requires concentrating newly synthesized soluble content p...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Bonnemaison ML,Eipper BA,Mains RE

    更新日期:2013-08-14 00:00:00

  • Natriuretic hormones in brain function.

    abstract::Natriuretic hormones (NH) include three groups of compounds: the natriuretic peptides (ANP, BNP and CNP), the gastrointestinal peptides (guanylin and uroguanylin), and endogenous cardiac steroids. These substances induce the kidney to excrete sodium and therefore participate in the regulation of sodium and water homeo...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Hodes A,Lichtstein D

    更新日期:2014-11-28 00:00:00

  • Assessing Urinary Metabolomics in Giant Pandas Using Chromatography/Mass Spectrometry: Pregnancy-Related Changes in the Metabolome.

    abstract::Giant pandas represent one of the most endangered species worldwide, and their reproductive capacity is extremely low. They have a relatively long gestational period, mainly because embryo implantation is delayed. Giant panda cubs comprise only a small proportion of the mother's body weight, making it difficult to det...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Cao M,Li C,Liu Y,Cai K,Chen L,Yuan C,Zhao Z,Zhang B,Hou R,Zhou X

    更新日期:2020-04-16 00:00:00

  • Incidence and Risk Factors of Gestational Diabetes Mellitus: A Prospective Cohort Study in Qingdao, China.

    abstract::Background: Obesity and maternal age are the two most important factors independently affecting the risk of gestational diabetes mellitus (GDM). However, the age differences in the association between obesity and GDM remain unclear. The objectives of this cohort study included: (1) to determine the current incidence o...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Li G,Wei T,Ni W,Zhang A,Zhang J,Xing Y,Xing Q

    更新日期:2020-09-11 00:00:00

  • Hypothyroidism and Adverse Endpoints in Diabetic Patients: A Systematic Review and Meta-Analysis.

    abstract::Background: This study investigated the relationship strength between hypothyroidism and cardiovascular and renal outcomes in diabetic patients. Methods: The electronic databases PubMed, EmBase, and Cochrane library were screened for relevant studies published before November 2018. The outcomes included major cardiova...

    journal_title:Frontiers in endocrinology



    authors: Zhang S,Feng G,Kang F,Guo Y,Ti H,Hao L,Gao P,Gao J

    更新日期:2020-01-10 00:00:00

  • The Genetic and Molecular Mechanisms of Congenital Hyperinsulinism.

    abstract::Congenital hyperinsulinism (CHI) is a heterogenous and complex disorder in which the unregulated insulin secretion from pancreatic beta-cells leads to hyperinsulinaemic hypoglycaemia. The severity of hypoglycaemia varies depending on the underlying molecular mechanism and genetic defects. The genetic and molecular cau...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Galcheva S,Demirbilek H,Al-Khawaga S,Hussain K

    更新日期:2019-02-26 00:00:00

  • Spinal Cord Injury as a Model of Bone-Muscle Interactions: Therapeutic Implications From in vitro and in vivo Studies.

    abstract::Spinal cord injuries (SCIs) represent a variety of conditions related to the damage of the spinal cord with consequent musculoskeletal repercussions. The bone and muscle tissues share several catabolic pathways that lead to variable degrees of disability in SCI patients. In this review article, we provide a comprehens...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Invernizzi M,de Sire A,Renò F,Cisari C,Runza L,Baricich A,Carda S,Fusco N

    更新日期:2020-04-15 00:00:00

  • Perilipin 5 Reduces Oxidative Damage Associated With Lipotoxicity by Activating the PI3K/ERK-Mediated Nrf2-ARE Signaling Pathway in INS-1 Pancreatic β-Cells.

    abstract::Oxidative stress induced by free fatty acid overload in pancreatic β-cells is a potential contributory factor to dysfunction of insulin secretion and apoptotic cell death. Perilipin 5 (Plin5) has been reported to ameliorate oxidative stress-mediated damage in non-insulin-secreting tissues. We tested the hypothesis tha...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章


    authors: Zhu Y,Ren C,Zhang M,Zhong Y

    更新日期:2020-03-31 00:00:00

  • Macroautophagy and the oncogene-induced senescence.

    abstract::The oncogene-induced senescence is emerging as a potent tumor suppressor mechanism and as a possible therapeutic target. Macroautophagy is intimately linked to the senescence condition setup, although its role has not been elucidated yet. Here, we discuss up-to-date concepts of senescence-related macroautophagy and ev...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审


    authors: Grasso D,Vaccaro MI

    更新日期:2014-09-29 00:00:00