Diabetes and change in bone mineral density at the hip, calcaneus, spine, and radius in older women.

Abstract:

:Older women with type 2 diabetes mellitus (DM) have higher bone mineral density (BMD) but also have higher rates of fracture compared to those without DM. Limited evidence suggests that DM may also be associated with more rapid bone loss. To determine if bone loss rates differ by DM status in older women, we analyzed BMD data in the Study of Osteoporotic Fractures (SOF) between 1986 and 1998. SOF participants were women ≥65 years at baseline who were recruited from four regions in the U.S. DM was ascertained by self-report. BMD was measured with dual-energy x-ray absorptiometry (DXA) at baseline and at least one follow-up visit at the hip (N = 6624) and calcaneus (N = 6700) and, on a subset of women, at the spine (N = 396) and distal radius (N = 306). Annualized percent change in BMD was compared by DM status, using random effects models. Of 6,867 women with at least one follow-up DXA scan, 409 had DM at baseline. Mean age was 70.8 (SD 4.7) years. Baseline BMD was higher in women with DM at all measured sites. In models adjusted for age and clinic, women with prevalent DM lost bone more rapidly than those without DM at the femoral neck (-0.96 vs. -0.59%/year, p < 0.001), total hip (-0.98 vs. -0.70%/year, p < 0.001), calcaneus (-1.64 vs. -1.40%/year, p = 0.005), and spine (-0.33 vs. +0.33%/year, p = 0.033), but not at the distal radius (-0.97 vs. -0.90%/year, p = 0.91). These findings suggest that despite higher baseline BMD, older women with DM experience more rapid bone loss than those without DM at the hip, spine, and calcaneus, but not the radius. Higher rates of bone loss may partially explain higher fracture rates in older women with DM.

authors

Schwartz AV,Ewing SK,Porzig AM,McCulloch CE,Resnick HE,Hillier TA,Ensrud KE,Black DM,Nevitt MC,Cummings SR,Sellmeyer DE

doi

10.3389/fendo.2013.00062

subject

Has Abstract

pub_date

2013-05-30 00:00:00

pages

62

issn

1664-2392

journal_volume

4

pub_type

杂志文章
  • Regulation of Thermogenic Adipocyte Differentiation and Adaptive Thermogenesis Through Histone Acetylation.

    abstract::Over the past decade, the increasing prevalence of obesity and its associated metabolic disorders constitutes one of the most concerning healthcare issues for countries worldwide. In an effort to curb the increased mortality and morbidity derived from the obesity epidemic, various therapeutic strategies have been deve...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2020.00095

    authors: Ong BX,Brunmeir R,Zhang Q,Peng X,Idris M,Liu C,Xu F

    更新日期:2020-02-27 00:00:00

  • Cryptorchidism and testicular germ cell tumors: comprehensive meta-analysis reveals that association between these conditions diminished over time and is modified by clinical characteristics.

    abstract:INTRODUCTION:Risk of testicular germ cell tumors (TGCT) is consistently associated with a history of cryptorchidism (CO) in epidemiologic studies. Factors modifying the association may provide insights regarding etiology of TGCT and suggest a basis for individualized care of CO. To identify modifiers of the CO-TGCT ass...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2012.00182

    authors: Banks K,Tuazon E,Berhane K,Koh CJ,De Filippo RE,Chang A,Kim SS,Daneshmand S,Davis-Dao C,Lewinger JP,Bernstein L,Cortessis VK

    更新日期:2013-02-18 00:00:00

  • A tale with a Twist: a developmental gene with potential relevance for metabolic dysfunction and inflammation in adipose tissue.

    abstract::The Twist proteins (Twist-1 and -2) are highly conserved developmental proteins with key roles for the transcriptional regulation in mesenchymal cell lineages. They belong to the super-family of bHLH proteins and exhibit bi-functional roles as both activators and repressors of gene transcription. The Twist proteins ar...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2012.00108

    authors: Dobrian AD

    更新日期:2012-08-30 00:00:00

  • Cytokines and Abnormal Glucose and Lipid Metabolism.

    abstract::Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory cytokines, myokines, and osteokines, contribute substantially to the development of abnormal glucose and lipid metabolism. Some cytokines play a positive role in metabolism action, while others have a negative metabolic role l...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2019.00703

    authors: Shi J,Fan J,Su Q,Yang Z

    更新日期:2019-10-30 00:00:00

  • Pineal Gland Metastasis From Poorly Differentiated Carcinoma of Unknown Primary Origin.

    abstract::Pineal metastasis is an exceedingly rare finding in patients with systemic malignancies. Such lesions are typically the manifestation of a primary lung cancer; nonetheless, a variety of malignancies have been reported to disseminate to the pineal gland including gastrointestinal, endocrine, and skin cancers, among oth...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2020.597773

    authors: Cuoco JA,Kortz MW,Benko MJ,Jarrett RW,Rogers CM,Witcher MR,Marvin EA

    更新日期:2020-10-23 00:00:00

  • Spinal Cord Injury as a Model of Bone-Muscle Interactions: Therapeutic Implications From in vitro and in vivo Studies.

    abstract::Spinal cord injuries (SCIs) represent a variety of conditions related to the damage of the spinal cord with consequent musculoskeletal repercussions. The bone and muscle tissues share several catabolic pathways that lead to variable degrees of disability in SCI patients. In this review article, we provide a comprehens...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2020.00204

    authors: Invernizzi M,de Sire A,Renò F,Cisari C,Runza L,Baricich A,Carda S,Fusco N

    更新日期:2020-04-15 00:00:00

  • Improved Glucose and Lipid Metabolism in the Early Life of Female Offspring by Maternal Dietary Genistein Is Associated With Alterations in the Gut Microbiota.

    abstract::Maternal over-nutrition can lead to metabolic disorders in offspring, whereas maternal dietary genistein may have beneficial effects on the metabolic health of offspring. Our objective was to determine whether maternal dietary genistein could attenuate the detrimental effects of a maternal high-fat diet on their offsp...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00516

    authors: Zhou L,Xiao X,Zhang Q,Zheng J,Li M,Yu M,Wang X,Deng M,Zhai X,Li R

    更新日期:2018-09-04 00:00:00

  • Effects of Growth Hormone Replacement on Peripheral Muscle and Exercise Capacity in Severe Growth Hormone Deficiency.

    abstract:Objective:The aim of this study is to evaluate the effect of growth hormone therapy (rGH) on mitochondrial function on peripheral muscle and to correlate with exercise capacity in subjects with severe adult growth hormone deficiency (GHD). Design:Six months, double-blind, randomized, crossover, placebo-controlled tria...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00056

    authors: Gonzalez S,Sathyapalan T,Javed Z,Atkin SL

    更新日期:2018-02-23 00:00:00

  • Fibroblast Growth Factor 1 Promotes Rat Stem Leydig Cell Development.

    abstract::Fibroblast growth factor 1 (FGF1) is reported to be expressed in the testis. How FGF1 affects stem Leydig cell development remains unclear. Here, we report the effects of FGF1 on rat stem Leydig cell development in an ethane dimethane sulfonate (EDS)-treated model. FGF1 (100 ng/testis) significantly increased serum te...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00118

    authors: Chen L,Li X,Wang Y,Song T,Li H,Xie L,Li L,Chen X,Ma L,Chen Y,Lv Y,Li X,Ge RS

    更新日期:2019-03-08 00:00:00

  • Osteogenic and Chondrogenic Potential of the Supramolecular Aggregate T-LysYal®.

    abstract::Hard tissue regeneration represents a challenge for the Regenerative Medicine and Mesenchymal stem cells (MSCs) could be a successful therapeutic strategy. T-LysYal® (T-Lys), a new derivative of Hyaluronic Acid (HA) possessing a superior stability, has already been proved efficient in repairing corneal epithelial cell...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00285

    authors: Di Benedetto A,Posa F,Marazzi M,Kalemaj Z,Grassi R,Lo Muzio L,Comite MD,Cavalcanti-Adam EA,Grassi FR,Mori G

    更新日期:2020-05-05 00:00:00

  • Hypothyroidism and Adverse Endpoints in Diabetic Patients: A Systematic Review and Meta-Analysis.

    abstract::Background: This study investigated the relationship strength between hypothyroidism and cardiovascular and renal outcomes in diabetic patients. Methods: The electronic databases PubMed, EmBase, and Cochrane library were screened for relevant studies published before November 2018. The outcomes included major cardiova...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2019.00889

    authors: Zhang S,Feng G,Kang F,Guo Y,Ti H,Hao L,Gao P,Gao J

    更新日期:2020-01-10 00:00:00

  • Pharmacotherapy for the Treatment of Overweight and Obesity in Children, Adolescents, and Young Adults in a Large Health System in the US.

    abstract::Lifestyle modifications focused on diet, physical activity, and behavior have a modest impact on weight reduction in children, adolescents, and young adults (YA) with overweight and obesity. Several anti-obesity medications (AOMs) have been approved by the Food and Drug Administration (FDA) for use among adult patient...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00290

    authors: Czepiel KS,Perez NP,Campoverde Reyes KJ,Sabharwal S,Stanford FC

    更新日期:2020-05-13 00:00:00

  • Regulatory Role of RNA N6-Methyladenosine Modification in Bone Biology and Osteoporosis.

    abstract::Osteoporosis is a metabolic skeletal disorder in which bone mass is depleted and bone structure is destroyed to the degree that bone becomes fragile and prone to fractures. Emerging evidence suggests that N6-methyladenosine (m6A) modification, a novel epitranscriptomic marker, has a significant role in bone developmen...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2019.00911

    authors: Chen X,Hua W,Huang X,Chen Y,Zhang J,Li G

    更新日期:2020-01-10 00:00:00

  • Non-Mammalian Vertebrates: Distinct Models to Assess the Role of Ion Gradients in Energy Expenditure.

    abstract::Animals store metabolic energy as electrochemical gradients. At least 50% of mammalian energy is expended to maintain electrochemical gradients across the inner mitochondrial membrane (H+), the sarcoplasmic reticulum (Ca++), and the plasma membrane (Na+/K+). The potential energy of these gradients can be used to perfo...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2017.00224

    authors: Geisler CE,Kentch KP,Renquist BJ

    更新日期:2017-09-01 00:00:00

  • Prognostic Impact of Hyponatremia and Hypernatremia in COVID-19 Pneumonia. A HOPE-COVID-19 (Health Outcome Predictive Evaluation for COVID-19) Registry Analysis.

    abstract::Dysnatremia is associated with increased mortality in patients with community-acquired pneumonia. SARS-COV2 (Severe-acute-respiratory syndrome caused by Coronavirus-type 2) pneumonia can be fatal. The aim of this study was to ascertain whether admittance dysnatremia is associated with mortality, sepsis, or intensive t...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.599255

    authors: Ruiz-Sánchez JG,Núñez-Gil IJ,Cuesta M,Rubio MA,Maroun-Eid C,Arroyo-Espliguero R,Romero R,Becerra-Muñoz VM,Uribarri A,Feltes G,Trabattoni D,Molina M,García Aguado M,Pepe M,Cerrato E,Alfonso E,Castro Mejía AF,Roubin SR,

    更新日期:2020-11-30 00:00:00

  • Use of Growth Hormone in the IVF Treatment of Women With Poor Ovarian Reserve.

    abstract::Growth hormone (GH) has been used as an adjunct in the field of female infertility treatment for more than 25 years, although, apart from treating women with GH deficiency its role has not yet been clarified. Contributing to this lack of clarity is that several underpowered studies have been performed on women undergo...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2019.00500

    authors: Hart RJ

    更新日期:2019-07-24 00:00:00

  • Disposition Index in Active Acromegaly.

    abstract::Background: The relative contribution of reduced insulin sensitivity (Si) or insulin secretion to impaired fasting glucose (IFG) or diabetes mellitus (DM) has not been clarified in active acromegaly. An intravenous glucose tolerance test (IVGTT) was never used for the calculation of Si, acute insulin response (AIRg), ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00637

    authors: Niculescu DA,Dusceac R,Caragheorgheopol A,Popescu N,Poiana C

    更新日期:2019-09-18 00:00:00

  • Protease-Activated Receptors in the Intestine: Focus on Inflammation and Cancer.

    abstract::Protease-activated receptors (PARs) belong to the G protein-coupled receptor (GPCR) family. Compared to other GPCRs, the specificity of the four PARs is the lack of physiologically soluble ligands able to induce their activation. Indeed, PARs are physiologically activated after proteolytic cleavage of their N-terminal...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2019.00717

    authors: Sébert M,Sola-Tapias N,Mas E,Barreau F,Ferrand A

    更新日期:2019-10-24 00:00:00

  • Muscle Contraction Induces Acute Hydroxymethylation of the Exercise-Responsive Gene Nr4a3.

    abstract::Exercise training triggers numerous positive adaptations through the regulation of genes controlling muscle structure and function. Epigenetic modifications, including DNA methylation, participate in transcriptional activation by allowing the recruitment of the transcription machinery to gene promoters. Exercise induc...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2016.00165

    authors: Pattamaprapanont P,Garde C,Fabre O,Barrès R

    更新日期:2016-12-23 00:00:00

  • The Role of KCNQ1 Mutations and Maternal Beta Blocker Use During Pregnancy in the Growth of Children With Long QT Syndrome.

    abstract:Objective:Two missense mutations in KCNQ1, an imprinted gene that encodes the alpha subunit of the voltage-gated potassium channel Kv7.1, cause autosomal dominant growth hormone deficiency and maternally inherited gingival fibromatosis. We evaluated endocrine features, birth size, and subsequent somatic growth of patie...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00194

    authors: Huttunen H,Hero M,Lääperi M,Känsäkoski J,Swan H,Hirsch JA,Miettinen PJ,Raivio T

    更新日期:2018-04-24 00:00:00

  • Importance of Illness Acceptance Among Other Factors Affecting Quality of Life in Acromegaly.

    abstract::Introduction: The aim of this study was to analyze psychological factors of patients with acromegaly and assessment of their relationship with the quality of life (QoL) in the context of the control of the disease. Materials and methods: A total sample of 50 patients (62% of females; mean age = 51.66 ± 14.5) with acro...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00899

    authors: Jawiarczyk-Przybyłowska A,Szcześniak D,Ciułkowicz M,Bolanowski M,Rymaszewska J

    更新日期:2020-01-14 00:00:00

  • A role for the androgen metabolite, 5alpha androstane 3beta, 17beta diol (3β-diol) in the regulation of the hypothalamo-pituitary-adrenal axis.

    abstract::Activation of the hypothalamo-pituitary-adrenal (HPA) axis is a basic reaction of animals to environmental perturbations that threaten homeostasis. These responses are ultimately regulated by neurons residing within the paraventricular nucleus (PVN) of the hypothalamus. Within the PVN, corticotrophin-releasing hormone...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2011.00065

    authors: Handa RJ,Sharma D,Uht R

    更新日期:2011-11-10 00:00:00

  • Corrigendum: Central Control of Feeding Behavior by the Secretin, PACAP, and Glucagon Family of Peptides.

    abstract::[This corrects the article DOI: 10.3389/fendo.2017.00018.]. ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,已发布勘误

    doi:10.3389/fendo.2018.00395

    authors: Sekar R,Wang L,Chow BKC

    更新日期:2018-07-18 00:00:00

  • Progress in the Diagnosis and Classification of Pituitary Adenomas.

    abstract::Pituitary adenomas are common neoplasms. Their classification is based upon size, invasion of adjacent structures, sporadic or familial cases, biochemical activity, clinical manifestations, morphological characteristics, response to treatment and recurrence. Although they are considered benign tumors, some of them are...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2015.00097

    authors: Syro LV,Rotondo F,Ramirez A,Di Ieva A,Sav MA,Restrepo LM,Serna CA,Kovacs K

    更新日期:2015-06-12 00:00:00

  • Preliminary Findings Show Maternal Hypothyroidism May Contribute to Abnormal Cortical Morphology in Offspring.

    abstract::In rodents, insufficient thyroid hormone (TH) gestationally has adverse effects on cerebral cortex development. Comparable studies of humans examining how TH insufficiency affects cortical morphology are limited to children with congenital hypothyroidism or offspring of hypothyroxinemic women; effects on cortex of chi...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2016.00016

    authors: Lischinsky JE,Skocic J,Clairman H,Rovet J

    更新日期:2016-02-25 00:00:00

  • Histamine Regulates Molecular Clock Oscillations in Human Retinal Pigment Epithelial Cells via H1 Receptors.

    abstract::Vertebrate eyes are known to contain circadian clocks, but their regulatory mechanisms remain largely unknown. To address this, we used a cell line from human retinal pigment epithelium (hRPE-YC) with stable coexpression of reporters for molecular clock oscillations (Bmal1-luciferase) and intracellular Ca2+ concentrat...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00108

    authors: Morioka E,Kanda Y,Koizumi H,Miyamoto T,Ikeda M

    更新日期:2018-03-19 00:00:00

  • Modulation of Amyloidogenesis Controlled by the C-Terminal Domain of Islet Amyloid Polypeptide Shows New Functions on Hepatocyte Cholesterol Metabolism.

    abstract::The islet amyloid polypeptide (IAPP) or amylin maintains a key role in metabolism. This 37-residues-peptide could form pancreatic amyloids, which are a characteristic feature of diabetes mellitus type 2. However, some species do not form amyloid fibril structures. By employing a biomimetic approach, we generated an ex...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00331

    authors: Pulido-Capiz A,Díaz-Molina R,Martínez-Navarro I,Guevara-Olaya LA,Casanueva-Pérez E,Mas-Oliva J,Rivero IA,García-González V

    更新日期:2018-06-25 00:00:00

  • Insulin analogs and cancer.

    abstract::Today, insulin analogs are used in millions of diabetic patients. Insulin analogs have been developed to achieve more physiological insulin replacement in terms of time-course of the effect. Modifications in the amino acid sequence of the insulin molecule change the pharmacokinetics and pharmacodynamics of the analogs...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2012.00021

    authors: Sciacca L,Le Moli R,Vigneri R

    更新日期:2012-02-10 00:00:00

  • The Nomogram of Clitoral Length and Width in Iranian Term and Preterm Neonates.

    abstract::Background and Objectives: Clitoromegaly is an important parameter in the evaluation of ambiguous genitalia in neonates, but the normative data for clitoral size in newborns have racial/ethnic differences. The present study aimed to determine clitoral length (CL) and clitoral width (CW) values and establish cutoff mea...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00297

    authors: Alaei M,Rohani F,Norouzi E,Hematian Boroujeni N,Tafreshi RI,Salehiniya H,Soheilipour F

    更新日期:2020-06-03 00:00:00

  • Nutrition and Female Fertility: An Interdependent Correlation.

    abstract::Besides aging, a number of non-modifiable lifestyle-related factors, such as smoking, elevated consumption of caffeine and alcohol, stress, agonist sports, chronic exposure to environmental pollutants, and other nutritional habits exert a negative impact on a women's fertility. In particular, metabolic disorders inclu...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2019.00346

    authors: Silvestris E,Lovero D,Palmirotta R

    更新日期:2019-06-07 00:00:00