RAGE-Mediated Inflammation, Type 2 Diabetes, and Diabetic Vascular Complication.

abstract：:Gonadotropin-releasing hormone (GnRH) is the ultimate output signal of an intricate network of neuroendocrine factors that, acting on the pituitary, trigger gonadotropin release. In turn, gonadotropins exert their trophic action on the gonads to stimulate the synthesis of sex steroids thus completing the gonadotropic ...

journal_title：Frontiers in endocrinology

authors： Navarro VM

更新日期：2012-04-02 00:00:00

abstract：:Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is a rare cause of Cushing syndrome. If routine imaging examinations cannot identify the source of ACTH production, long-term follow-up observation is necessary to determine the etiology. We present the case of a middle-aged male with gradual weight gain and a ...

journal_title：Frontiers in endocrinology

authors： Lu L,Meng Q,Xing X,Yuan T,Zhang H,Li N,Wang Y,Cheng Y,Bai C,Wang H,Cheng X,Xiao Y,Pan B,Li Y,Sun J,Liang Z,Zhu H,Wang R,Lu Z

更新日期：2019-10-22 00:00:00

abstract：Background:Many studies suggest that the small ubiquitin-like modifier 4 (SUMO4) M55V gene polymorphism (rs237025) may be associated with an increased risk of type 2 diabetes mellitus (T2DM). However, due to other conflicting results, a clear consensus is lacking in the matter. Objective and methods:A meta-analysis co...

journal_title：Frontiers in endocrinology

authors： Li YY,Wang H,Yang XX,Geng HY,Gong G,Kim HJ,Zhou YH,Wu JJ

更新日期：2017-11-02 00:00:00

abstract：:Diabetes mellitus (DM) is associated with several microvascular and macrovascular complications, such as retinopathy, nephropathy, neuropathy, and cardiovascular diseases. The pathogenesis of these complications is complex, and involves metabolic and hemodynamic disturbances, including hyperglycemia, insulin resistanc...

journal_title：Frontiers in endocrinology

authors： Verhulst MJL,Loos BG,Gerdes VEA,Teeuw WJ

更新日期：2019-02-18 00:00:00

abstract：:Poor sleep and obesity are both extraordinarily common in the US adolescent population and often occur simultaneously. This review explores the links between obesity and sleep, outlining what is known about the relationships between sleep characteristics, obesity, and cardiometabolic risk factors in youth. Sleep durat...

journal_title：Frontiers in endocrinology

authors： Gohil A,Hannon TS

更新日期：2018-07-10 00:00:00

abstract：:Ovarian stimulation in a gonadotropin-releasing hormone (GnRH) antagonist protocol with the use of GnRH agonist for final oocyte maturation is the state-of-the-art treatment in patients with an expected or known high response to avoid or at least reduce significantly the risk for development of ovarian hyperstimulatio...

journal_title：Frontiers in endocrinology

authors： Lawrenz B,Samir S,Garrido N,Melado L,Engelmann N,Fatemi HM

更新日期：2018-02-15 00:00:00

abstract：:Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, which then modulates the degree of adaptation and response to a later stressor. It is known that early-life stress can impact on later health but less is known about how early-life stress impairs HPA axis activity, contributing to maladaptation of the str...

journal_title：Frontiers in endocrinology

authors： Maniam J,Antoniadis C,Morris MJ

更新日期：2014-05-13 00:00:00

abstract：:Introduction: Secondary hyperparathyroidism (sHPT) is a common hormonal complication of chronic kidney disease. There are several therapeutic options for sHPT management aiming at calcium-phosphorus balance normalization and decrease of parathormone secretion. Objectives: The aim of this retrospective, observational s...

journal_title：Frontiers in endocrinology

authors： Zawierucha J,Malyszko J,Malyszko JS,Prystacki T,Marcinkowski WP,Dryl-Rydzynska T

更新日期：2019-02-05 00:00:00

abstract：:Introduction: An increase of serum dehydroepiandrosterone (DHEA) sulfate (DHEAS) is observed in premature adrenarche and congenital adrenal hyperplasia. Very high DHEAS levels are typical for adrenal tumors. Approximately 74% of DHEAS is hydrolyzed to DHEA by the steroid sulfatase (STS). The reverse reaction is DHEA s...

journal_title：Frontiers in endocrinology

authors： Iliev DI,Braun R,Sánchez-Guijo A,Hartmann M,Wudy SA,Heckmann D,Bruchelt G,Rösner A,Grosser G,Geyer J,Binder G

更新日期：2020-05-06 00:00:00

abstract：:Progression and severity of type 1 diabetes is dependent upon inflammatory induction of nitric oxide production and consequent pancreatic β-cell damage. Glucocorticoids (GCs) are highly effective anti-inflammatory agents but have been precluded in type 1 diabetes and in islet transplantation protocols because they exa...

journal_title：Frontiers in endocrinology

authors： Liu X,Turban S,Carter RN,Ahmad S,Ramage L,Webster SP,Walker BR,Seckl JR,Morton NM

更新日期：2014-10-14 00:00:00

abstract：:Multiple Endocrine Neoplasia type 1 (MEN1) is a rare autosomal dominant inherited condition, causing significant morbidity, and a reduction of life expectancy. A timely and accurate diagnosis of MEN1 is paramount to improve disease outcomes. This enables early identification of tumor manifestations allowing timely tre...

journal_title：Frontiers in endocrinology

authors： de Laat JM,van Leeuwaarde RS,Valk GD

更新日期：2018-09-11 00:00:00

abstract：:Parathyroid (PTH) exploration surgery carries the risk of developing post-operative thyroiditis due to vigorous manual manipulation of the thyroid gland during surgery. Post-operative thyroiditis has a wide spectrum of clinical manifestations. However, it remains underreported. Here, we describe a case of post-operati...

journal_title：Frontiers in endocrinology

authors： Hakami YA

更新日期：2015-08-18 00:00:00

abstract：Objective:Two missense mutations in KCNQ1, an imprinted gene that encodes the alpha subunit of the voltage-gated potassium channel Kv7.1, cause autosomal dominant growth hormone deficiency and maternally inherited gingival fibromatosis. We evaluated endocrine features, birth size, and subsequent somatic growth of patie...

journal_title：Frontiers in endocrinology

authors： Huttunen H,Hero M,Lääperi M,Känsäkoski J,Swan H,Hirsch JA,Miettinen PJ,Raivio T

更新日期：2018-04-24 00:00:00

abstract：:Last two decades of structure-function studies performed in numerous laboratories provided substantial progress in understanding basic science, physiological, pathophysiological, pharmacological, and comparative aspects of glycoprotein hormones (GPHs) and their cognate receptors. Multiple concepts and models developed...

journal_title：Frontiers in endocrinology

authors： Szkudlinski MW

更新日期：2015-10-19 00:00:00

abstract：:Background: The effect of testosterone supplementation in patients with chronic heart failure (CHF) remains uncertain. Methods: A meta-analysis of randomized controlled trials (RCTs) was performed. RCTs that evaluate the chronic effect of testosterone supplementation on exercise capacity and cardiac function in CHF we...

journal_title：Frontiers in endocrinology

authors： Tao J,Liu X,Bai W

更新日期：2020-03-13 00:00:00

abstract：:Insulin-like growth factor-binding proteins (IGFBPs) are multifunctional proteins that possess IGF-dependent and -independent actions. Recent studies suggest that its IGF-independent action appeared early and that the IGF-binding function may have been acquired later in evolution. The timing of the emergence of IGF-de...

journal_title：Frontiers in endocrinology

authors： Zhong Y,Duan C

更新日期：2017-01-18 00:00:00

abstract：Background:Renal function is profoundly influenced by thyroid hormone levels. This study was designed to evaluate the association between preoperative thyroid hormones and postoperative acute kidney injury (AKI) in acute type A aortic dissection (ATAAD) patients. Methods:A total of 88 patients with ATAAD who underwent...

journal_title：Frontiers in endocrinology

authors： Liu J,Xue Y,Jiang W,Zhang H,Zhao Y

更新日期：2020-11-18 00:00:00

abstract：:Activation of the hypothalamo-pituitary-adrenal (HPA) axis is a basic reaction of animals to environmental perturbations that threaten homeostasis. These responses are ultimately regulated by neurons residing within the paraventricular nucleus (PVN) of the hypothalamus. Within the PVN, corticotrophin-releasing hormone...

journal_title：Frontiers in endocrinology

authors： Handa RJ,Sharma D,Uht R

更新日期：2011-11-10 00:00:00

abstract：:A well-functioning hematopoietic system requires a certain robustness and flexibility to maintain appropriate quantities of functional mature blood cells, such as red blood cells and platelets. This review focuses on the cytokine receptor that plays a significant role in thrombopoiesis: the receptor for thrombopoietin...

journal_title：Frontiers in endocrinology

authors： Varghese LN,Defour JP,Pecquet C,Constantinescu SN

更新日期：2017-03-31 00:00:00

abstract：:Graves' disease (GD) is an organ-specific autoimmune disease, and thyrotropin (TSH) receptor (TSHR) is a major autoantigen in this condition. Since the extracellular domain of human TSHR (TSHR-ECD) is shed into the circulation, TSHR-ECD is a preferentially immunogenic portion of TSHR. Both genetic factors and environm...

journal_title：Frontiers in endocrinology

authors： Inaba H,De Groot LJ,Akamizu T

更新日期：2016-08-23 00:00:00

abstract：:Classically, the modulation of brain function and behavior by steroid hormones was linked exclusively to secretion by peripheral endocrine glands. Subsequently, steroid actions within the brain were shown dependent upon either synthesis and secretion by peripheral organs or by production within the CNS itself using pe...

journal_title：Frontiers in endocrinology

authors： Remage-Healey L,Saldanha CJ,Schlinger BA

更新日期：2011-09-29 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) is a pleotropic metabolic regulator, expression of which is elevated during fasting. To this end, the precise role played by FGF21 in the biology of fasting has been the subject of several recent studies, which have demonstrated contributions to the regulation of both lipid and carb...

journal_title：Frontiers in endocrinology

authors： Antonellis PJ,Hayes MP,Adams AC

更新日期：2016-06-30 00:00:00

abstract：:Over the last decades, thyroid hormone metabolites (THMs) received marked attention as it has been demonstrated that they are bioactive compounds. Their concentrations were determined by immunoassay or mass-spectrometry methods. Among those metabolites, 3,5-diiodothyronine (3,5-T2), occurs at low nanomolar concentrati...

journal_title：Frontiers in endocrinology

authors： Köhrle J,Lehmphul I,Pietzner M,Renko K,Rijntjes E,Richards K,Anselmo J,Danielsen M,Jonklaas J

更新日期：2020-01-08 00:00:00

abstract：:The G-protein coupled parathyroid hormone 2 receptor (PTH2R) is concentrated in endocrine and limbic regions in the forebrain. Its endogenous ligand, tuberoinfundibular peptide of 39 residues (TIP39), is synthesized in only two brain regions, within the posterior thalamus and the lateral pons. TIP39-expressing neurons...

journal_title：Frontiers in endocrinology

authors： Dobolyi A,Dimitrov E,Palkovits M,Usdin TB

更新日期：2012-10-08 00:00:00

abstract：:Energy balance plays an important role in the control of reproduction. However, the cellular and molecular mechanisms connecting the two systems are not well understood especially in teleosts. The hypothalamus plays a crucial role in the regulation of both energy balance and reproduction, and contains a number of neur...

journal_title：Frontiers in endocrinology

authors： Shahjahan M,Kitahashi T,Parhar IS

更新日期：2014-03-25 00:00:00

abstract：:Co-heritability of hypertension and insulin resistance (IR) within families not only implies genetic susceptibility may be responsible for these complex traits but also suggests a rational that biological candidate genes for hypertension may serve as markers for features of the metabolic syndrome (MetS). Thus we deter...

journal_title：Frontiers in endocrinology

authors： Ho LT,Hsu YP,Hsiao CF,Ting CT,Shih KC,Chuang LM,Masaki K,Grove J,Quertermous T,Juan CC,Lin MW,Chiang SC,Chen YD

更新日期：2013-11-28 00:00:00

abstract：Background:For detecting tumor recurrence of medullary thyroid carcinoma (MTC) in the neck, an appropriate frequency and interval of postoperative ultrasonography (US) surveillance remains unclear. This study aimed to assess an appropriate interval and frequency of postoperative neck US surveillance for detecting tumor...

journal_title：Frontiers in endocrinology

authors： Ahn HS,Kim DW,Lee YJ,Lee CY,Kim JH,Choi YJ,Lee S,Ryoo I,Huh JY,Sung JY,Kwak JY,Baek HJ

更新日期：2018-03-15 00:00:00

abstract：:Anti-Müllerian hormone reflects the continuum of the functional ovarian reserve, and as such can predict ovarian response to gonadotropin stimulation and be used to individualize treatment pathways to improve efficacy and safety. However, consistent with other biomarkers and age-based prediction models it has limited ...

journal_title：Frontiers in endocrinology

authors： Li HWR,Nelson SM

更新日期：2020-12-09 00:00:00

abstract：:The infertile patients with aging ovaries-also sometimes referred to as impending premature ovarian insufficiency (POI), impending premature ovarian failure (POF), or poor ovarian responders (POR), constitute a significant and increasing bulk of the patients appealing to IVF/ART. Different causes have been cited in th...

journal_title：Frontiers in endocrinology

authors： Blumenfeld Z

更新日期：2020-04-17 00:00:00

abstract：:Autoimmune thyroid diseases (AITDs) are chronic organ-specific autoimmune diseases and mainly include Graves' disease (GD) and Hashimoto's thyroiditis (HT). CD14 is an important component of the immune system as a receptor for gram-negative lipopolysaccharide (LPS). The genetic polymorphisms of CD14 have been confirme...

journal_title：Frontiers in endocrinology

authors： Jia X,Wang B,Yao Q,Li Q,Zhang J

更新日期：2019-01-16 00:00:00