Lamprey IGF-Binding Protein-3 Has IGF-Dependent and -Independent Actions.

abstract：:The rapid increase of obesity rates worldwide is associated with chronic liver injury due to non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Chronic liver inflammation drives hepatic fibrosis, which is a highly conserved and coordinated protective response to tissue injury, and is a reversible pro...

journal_title：Frontiers in endocrinology

authors： Cho EH

更新日期：2018-08-21 00:00:00

abstract：:Successful discontinuation of cabergoline (CAB) treatment has been reported in 31-75% of prolactinomas patients treated for at least 2 years. In contrast, it is not well established whether CAB therapy can be successfully withdrawn after a failed first attempt. This prospective open trial was designed to address this ...

journal_title：Frontiers in endocrinology

authors： Vilar L,Albuquerque JL,Gadelha PS,Rangel Filho F,Siqueira AM,da Fonseca MM,Viana KF,Gomes BS,Lyra R

更新日期：2015-02-04 00:00:00

abstract：:Measuring salivary cortisol is both convenient and non-invasive for patients; however, its usefulness as a marker for monitoring medical therapy has not yet been established. The aim of this study was to assess the utility of multiple salivary cortisol measurements in patients with Cushing's syndrome (CS) during medic...

journal_title：Frontiers in endocrinology

authors： Yoshida K,Fukuoka H,Odake Y,Nakajima S,Tachibana M,Ito J,Hosokawa Y,Yamada T,Miura H,Suematsu N,Matsumoto R,Bando H,Suda K,Nishizawa H,Iguchi G,Ogawa W,Takahashi Y

更新日期：2018-01-11 00:00:00

abstract：:Responses to a high fat, high sucrose (HFHS) diet vary greatly among inbred strains of mice. We sought to examine the epigenetic (DNA methylation) changes underlying these differences as well as variation in weight loss when switched to a low-fat chow diet. We surveyed DNA methylation from livers of 45 inbred mouse st...

journal_title：Frontiers in endocrinology

authors： Edillor CR,Parks BW,Mehrabian M,Lusis AJ,Pellegrini M

更新日期：2019-12-20 00:00:00

abstract：:To identify if the absence of the vasoactive intestinal peptide (VIP) gene enhances susceptibility to death from metastatic bladder cancer, two strains of mice were injected with MB49 murine bladder cancer cells. The growth and spread of the cancer was measured over a period of 4 weeks in C57BL/6 mice and 5 weeks in V...

journal_title：Frontiers in endocrinology

authors： Mirsaidi N,Burns MP,McClain SA,Forsyth E,Li J,Dukes B,Lin D,Nahvi R,Giraldo J,Patton M,Wang P,Lin K,Miller E,Ratliff T,Hamidi S,Crist S,Takemaru KI,Szema A

更新日期：2017-08-07 00:00:00

abstract：:The extracellular signal-regulated kinases (ERKs) are key components of multiple important cell signaling pathways regulating diverse biological responses. This signaling is characterized by phosphorylation cascades leading to ERK1/2 activation and promoted by various cell surface receptors including G protein-coupled...

journal_title：Frontiers in endocrinology

authors： Ayoub MA,Trebaux J,Vallaghe J,Charrier-Savournin F,Al-Hosaini K,Gonzalez Moya A,Pin JP,Pfleger KD,Trinquet E

更新日期：2014-06-23 00:00:00

abstract：:Neuropeptides are the largest group of insect hormones. They are produced in the central and peripheral nervous systems and affect insect development, reproduction, feeding, and behavior. A variety of neuropeptide families have been identified in insects. One of these families is the PBAN/pyrokinin family defined by a...

journal_title：Frontiers in endocrinology

authors： Choi MY,Vander Meer RK

更新日期：2012-02-24 00:00:00

abstract：:A direct action of thyrotropin (TSH, thyroid-stimulating hormone) on bone precursors in humans is controversial. Studies in rodent models have provided conflicting findings. We used cells derived from a moderately differentiated osteosarcoma stably overexpressing human TSH receptors (TSHRs) as a model of osteoblast pr...

journal_title：Frontiers in endocrinology

authors： Boutin A,Gershengorn MC,Neumann S

更新日期：2020-05-20 00:00:00

abstract：:Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation of PCOS and 3- the r...

journal_title：Frontiers in endocrinology

authors： Dewailly D,Barbotin AL,Dumont A,Catteau-Jonard S,Robin G

更新日期：2020-09-09 00:00:00

abstract：:During the last decades, adipogenesis has become an emerging field of study in aquaculture due to the relevance of the adipose tissue in many physiological processes and its connection with the endocrine system. In this sense, recent studies have translated into the establishment of preadipocyte culture models from se...

journal_title：Frontiers in endocrinology

authors： Salmerón C,Riera-Heredia N,Gutiérrez J,Navarro I,Capilla E

更新日期：2016-08-22 00:00:00

abstract：:The increase of life expectancy has led to the increase of age-related diseases such as osteoporosis. Osteoporosis is characterized by bone weakening promoting the occurrence of fractures with defective bone regeneration. Men aged over 50 have a prevalence for osteoporosis of 20%, which is related to a decline in sex ...

journal_title：Frontiers in endocrinology

authors： Beranger GE,Djedaini M,Battaglia S,Roux CH,Scheideler M,Heymann D,Amri EZ,Pisani DF

更新日期：2015-05-19 00:00:00

abstract：:Pituitary adenomas (PA) are amongst the most prevalent intracranial tumors, causing complications by hormonal overproduction or deficiency and tumor mass effects, with 95% of cases occurring sporadically. Associated germline mutations (AIP, MEN1, CDKN1B, PRKAR1A, SDHx) and Xq26.3 microduplications are increasingly ide...

journal_title：Frontiers in endocrinology

authors： van den Broek MFM,van Nesselrooij BPM,Verrijn Stuart AA,van Leeuwaarde RS,Valk GD

更新日期：2019-12-10 00:00:00

abstract：:Oxidative stress induced by free fatty acid overload in pancreatic β-cells is a potential contributory factor to dysfunction of insulin secretion and apoptotic cell death. Perilipin 5 (Plin5) has been reported to ameliorate oxidative stress-mediated damage in non-insulin-secreting tissues. We tested the hypothesis tha...

journal_title：Frontiers in endocrinology

authors： Zhu Y,Ren C,Zhang M,Zhong Y

更新日期：2020-03-31 00:00:00

abstract：:In addition to the obvious differences in body shape, there are substantial differences in lipid metabolism between men and women. These differences include how dietary fatty acids are handled, the secretion and clearance of very low-density lipoprotein-triglycerides, the release rates of free fatty acids (FFA) from a...

journal_title：Frontiers in endocrinology

authors： Santosa S,Jensen MD

更新日期：2015-07-02 00:00:00

abstract：:The human lutropin (hLH)/choriogonadotropin (hCG) receptor (LHCGR) can be activated by binding two slightly different gonadotropic glycoprotein hormones, choriogonadotropin (CG) - secreted by the placenta, and lutropin (LH) - produced by the pituitary. They induce different signaling profiles at the LHCGR. This cannot...

journal_title：Frontiers in endocrinology

authors： Grzesik P,Kreuchwig A,Rutz C,Furkert J,Wiesner B,Schuelein R,Kleinau G,Gromoll J,Krause G

更新日期：2015-09-22 00:00:00

abstract：:Objectives: To assess the diagnostic potential of bidirectional axial transmission (BDAT) ultrasound, and high-resolution peripheral quantitative computed tomography (HR-pQCT) in X-linked hypophosphatemia (XLH, OMIM #307800), a rare genetic disorder of phosphate metabolism caused by mutations in the PHEX gene. Methods...

journal_title：Frontiers in endocrinology

authors： Raimann A,Mehany SN,Feil P,Weber M,Pietschmann P,Boni-Mikats A,Klepochova R,Krššák M,Häusler G,Schneider J,Patsch JM,Raum K

更新日期：2020-06-09 00:00:00

abstract：:Background: Non-alcoholic fatty liver disease (NAFLD) is a well-known cause of liver dysfunction and has become a common chronic liver disease in many countries. However, the intrinsic molecular mechanisms underlying the pathogenesis of NAFLD have not yet been fully elucidated. Methods: We obtained the gene expression...

journal_title：Frontiers in endocrinology

authors： Jia X,Zhai T

更新日期：2019-08-30 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fendo.2017.00018.]. ...

journal_title：Frontiers in endocrinology

authors： Sekar R,Wang L,Chow BKC

更新日期：2018-07-18 00:00:00

abstract：:Introduction: Secondary hyperparathyroidism (sHPT) is a common hormonal complication of chronic kidney disease. There are several therapeutic options for sHPT management aiming at calcium-phosphorus balance normalization and decrease of parathormone secretion. Objectives: The aim of this retrospective, observational s...

journal_title：Frontiers in endocrinology

authors： Zawierucha J,Malyszko J,Malyszko JS,Prystacki T,Marcinkowski WP,Dryl-Rydzynska T

更新日期：2019-02-05 00:00:00

abstract：:Women with impaired ovarian reserve or poor ovarian response (POR) to exogenous gonadotropin stimulation present a challenge for reproductive specialists. The primary reasons relate to the still limited knowledge about the POR pathophysiology and the lack of practical solutions for the management of these conditions. ...

journal_title：Frontiers in endocrinology

authors： Esteves SC,Roque M,Bedoschi GM,Conforti A,Humaidan P,Alviggi C

更新日期：2018-08-17 00:00:00

abstract：:The p53-related gene p63 is required for epithelial cell establishment and its expression is often altered in tumor cells. Great strides have been made in understanding the pathways and mechanisms that regulate p63 levels, such as the Wnt, Hedgehog, Notch, and EGFR pathways. We discuss here the multiple signaling path...

journal_title：Frontiers in endocrinology

authors： Yoh K,Prywes R

更新日期：2015-04-28 00:00:00

abstract：:Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is a rare cause of Cushing syndrome. If routine imaging examinations cannot identify the source of ACTH production, long-term follow-up observation is necessary to determine the etiology. We present the case of a middle-aged male with gradual weight gain and a ...

journal_title：Frontiers in endocrinology

authors： Lu L,Meng Q,Xing X,Yuan T,Zhang H,Li N,Wang Y,Cheng Y,Bai C,Wang H,Cheng X,Xiao Y,Pan B,Li Y,Sun J,Liang Z,Zhu H,Wang R,Lu Z

更新日期：2019-10-22 00:00:00

abstract：:Atherosclerosis results from endothelial cell dysfunction and inflammatory processes affecting both macro- and microvasculature which are involved in vascular diabetic complications. Glucagon-like peptide-1 (GLP-1) is an incretin hormone responsible for amplification of insulin secretion when nutrients are given orall...

journal_title：Frontiers in endocrinology

authors： Alonso N,Julián MT,Puig-Domingo M,Vives-Pi M

更新日期：2012-09-07 00:00:00

abstract：:Background: Early metabolic responses following bariatric surgery appear greater than expected given the initial weight loss and coincide with improvement in diabetes. We hypothesized that small non-coding microRNA changes might contribute to regulating mechanisms for metabolic changes and weight loss in patients with...

journal_title：Frontiers in endocrinology

authors： Atkin SL,Ramachandran V,Yousri NA,Benurwar M,Simper SC,McKinlay R,Adams TD,Najafi-Shoushtari SH,Hunt SC

更新日期：2019-01-04 00:00:00

abstract：:Besides aging, a number of non-modifiable lifestyle-related factors, such as smoking, elevated consumption of caffeine and alcohol, stress, agonist sports, chronic exposure to environmental pollutants, and other nutritional habits exert a negative impact on a women's fertility. In particular, metabolic disorders inclu...

journal_title：Frontiers in endocrinology

authors： Silvestris E,Lovero D,Palmirotta R

更新日期：2019-06-07 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fendo.2018.00031.]. ...

journal_title：Frontiers in endocrinology

authors： Beattie J,Al-Khafaji H,Noer PR,Alkharobi HE,Alhodhodi A,Meade J,El-Gendy R,Oxvig C

更新日期：2018-09-04 00:00:00

abstract：Purpose:To assess whether volumetric vertebral bone mineral density (BMD) measured with opportunistic quantitative computed tomography (QCT) (i.e., CT acquired for other reasons) can predict osteoporotic fracture occurrence in a prospective clinical cohort and how this performs in comparison to dual-energy X-ray absorp...

journal_title：Frontiers in endocrinology

authors： Leonhardt Y,May P,Gordijenko O,Koeppen-Ursic VA,Brandhorst H,Zimmer C,Makowski MR,Baum T,Kirschke JS,Gersing AS,Seifert-Klauss V,Schwaiger BJ

更新日期：2020-11-09 00:00:00

abstract：:Background: The long noncoding RNA (lncRNA) functions as a regulator of initiation, progression, and metastasis of thyroid carcinomas. lncRNA OTUD6B antisense RNA 1 (OTUD6B-AS1) is a tumor-suppressive noncoding RNA in clear cell renal cell carcinoma. The role of OTUD6B-AS1 in thyroid carcinomas has not been reported y...

journal_title：Frontiers in endocrinology

authors： Wang Z,Xia F,Feng T,Jiang B,Wang W,Li X

更新日期：2020-03-17 00:00:00

abstract：:O-linked β-N-acetylglucosamine (O-GlcNAc) is an abundant and essential intracellular form of protein glycosylation in animals and plants. In humans, dysregulation of O-GlcNAcylation occurs in a wide range of diseases, including cancer, diabetes, and neurodegeneration. Since its discovery more than 30 years ago, great ...

journal_title：Frontiers in endocrinology

authors： Cox NJ,Luo PM,Smith TJ,Bisnett BJ,Soderblom EJ,Boyce M

更新日期：2018-10-15 00:00:00

abstract：:Microtubule-associated protein tau assists in stabilizing microtubules and has been particularly implicated in Alzheimer's disease (AD). Given the importance of tau to AD pathogenesis and therapies, it is important to understand non-classic physiological functions for this protein inside and outside the central nervou...

journal_title：Frontiers in endocrinology

authors： Gonçalves RA,Wijesekara N,Fraser PE,De Felice FG

更新日期：2020-03-12 00:00:00