Abstract:
Background:Renal function is profoundly influenced by thyroid hormone levels. This study was designed to evaluate the association between preoperative thyroid hormones and postoperative acute kidney injury (AKI) in acute type A aortic dissection (ATAAD) patients. Methods:A total of 88 patients with ATAAD who underwent surgeries in Beijing Anzhen Hospital and 274 healthy controls from July 2016 to December 2016 were included in this study. Propensity-score matching was used to compare thyroid hormone levels. Additionally, in a cohort study of ATAAD patients, multivariable regression and stratification analyses were conducted to examine the association of preoperative thyroid hormones with postoperative AKI. Results:Compared with healthy controls, ATAAD patients presented with lower preoperative levels of total triiodothyronine (TT3) (P < 0.01), free triiodothyronine (FT3) (P < 0.01), and thyroid-stimulating hormone (TSH) (P < 0.01) and a higher preoperative level of free thyroxine (FT4) (P < 0.01). The overall occurrence of postoperative AKI was 45.5%. Multivariate regression revealed that low levels of TT3 (OR = 0.07, 95% CI, 0.01-0.86, P = 0.04) were independently associated with postoperative AKI. Subgroup analyses showed that the association between TT3 and AKI was significant in patients with normal TSH levels (OR = 0.001 95% CI, 0.001-0.16, P < 0.01) but not in patients with lower TSH levels (P = 0.12). Conclusion:The present study showed that a low level of TT3 was a predictor of postoperative AKI in ATAAD patients, especially in patients with normal TSH. The thyroid function should be checked before surgical intervention of patients with ATAAD, and patients with low T3 might be at higher risk of postoperative AKI.
journal_name
Front Endocrinol (Lausanne)journal_title
Frontiers in endocrinologyauthors
Liu J,Xue Y,Jiang W,Zhang H,Zhao Ydoi
10.3389/fendo.2020.588149subject
Has Abstractpub_date
2020-11-18 00:00:00pages
588149issn
1664-2392journal_volume
11pub_type
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journal_title:Frontiers in endocrinology
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journal_title:Frontiers in endocrinology
pub_type: 杂志文章,评审
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abstract::Licorice has been used as a medicinal plant from 2.500 years. It shows a wide range of biological and pharmacological activities, including anti-inflammatory and immune regulatory actions. One of its most known effects is the induction of hypertension, and it can induce what appears to be pseudohyperaldosteronism, due...
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abstract::Circulating microRNAs are potential biomarkers of type 2 diabetes mellitus (T2DM) and related complications. Here, we investigated the association of microRNA-15a with early retinal damage in T2DM. A cohort of untreated subjects screened for intermediate/high risk of T2DM, according to a score assessment questionnaire...
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abstract::Background: This study investigated the relationship strength between hypothyroidism and cardiovascular and renal outcomes in diabetic patients. Methods: The electronic databases PubMed, EmBase, and Cochrane library were screened for relevant studies published before November 2018. The outcomes included major cardiova...
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abstract::Besides aging, a number of non-modifiable lifestyle-related factors, such as smoking, elevated consumption of caffeine and alcohol, stress, agonist sports, chronic exposure to environmental pollutants, and other nutritional habits exert a negative impact on a women's fertility. In particular, metabolic disorders inclu...
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abstract::The reproduction of seasonal breeders is modulated by exposure to light in an interval of 24 h defined as photoperiod. The interruption of reproductive functions in seasonally breeding rodents is accompanied by the suppression of the Kiss1 gene expression, which is known to be essential for reproduction. In non-season...
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abstract::[This corrects the article DOI: 10.3389/fendo.2019.00025.]. ...
journal_title:Frontiers in endocrinology
pub_type: 杂志文章,已发布勘误
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更新日期:2019-04-09 00:00:00
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pub_type: 杂志文章
doi:10.3389/fendo.2020.00290
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pub_type: 杂志文章
doi:10.3389/fendo.2012.00052
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pub_type: 杂志文章,评审
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journal_title:Frontiers in endocrinology
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pub_type: 杂志文章
doi:10.3389/fendo.2013.00099
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doi:10.3389/fendo.2019.00751
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doi:10.3389/fendo.2018.00659
更新日期:2018-11-16 00:00:00
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doi:10.3389/fendo.2017.00303
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