The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin.

abstract：:Background and Purpose: Many imaging studies have reported structure alterations in patients with type 1 diabetes mellitus (T1DM) by using voxel-based morphometry (VBM). Nevertheless, the results reported were inconsistent and had not been reviewed quantitatively. Accordingly, the quantitative meta-analysis which incl...

journal_title：Frontiers in endocrinology

authors： Liu J,Fan W,Jia Y,Su X,Wu W,Long X,Sun X,Liu J,Sun W,Zhang T,Gong Q,Shi H,Zhu Q,Wang J

更新日期：2020-02-13 00:00:00

abstract：:Background: Non-alcoholic fatty liver disease (NAFLD) is a well-known cause of liver dysfunction and has become a common chronic liver disease in many countries. However, the intrinsic molecular mechanisms underlying the pathogenesis of NAFLD have not yet been fully elucidated. Methods: We obtained the gene expression...

journal_title：Frontiers in endocrinology

authors： Jia X,Zhai T

更新日期：2019-08-30 00:00:00

abstract：INTRODUCTION:Risk of testicular germ cell tumors (TGCT) is consistently associated with a history of cryptorchidism (CO) in epidemiologic studies. Factors modifying the association may provide insights regarding etiology of TGCT and suggest a basis for individualized care of CO. To identify modifiers of the CO-TGCT ass...

journal_title：Frontiers in endocrinology

authors： Banks K,Tuazon E,Berhane K,Koh CJ,De Filippo RE,Chang A,Kim SS,Daneshmand S,Davis-Dao C,Lewinger JP,Bernstein L,Cortessis VK

更新日期：2013-02-18 00:00:00

abstract：:RET gene rearrangements (RET/PTCs) represent together with BRAF point mutations the two major groups of mutations involved in papillary thyroid carcinoma (PTC) initiation and progression. In this review, we will examine the mechanisms involved in RET/PTC-induced thyroid cell transformation. In detail, we will summariz...

journal_title：Frontiers in endocrinology

authors： Menicali E,Moretti S,Voce P,Romagnoli S,Avenia N,Puxeddu E

更新日期：2012-05-22 00:00:00

abstract：:The orexigenic peptide hormone ghrelin is synthesized in the stomach and its receptor growth hormone secretagogue receptor (GHSR1a) is expressed mainly in the central nervous system (CNS). In this review, we confine our discussion to the physiological role of GHSR1a in the brain. Paradoxically, despite broad expressio...

journal_title：Frontiers in endocrinology

authors： Kern A,Grande C,Smith RG

更新日期：2014-08-18 00:00:00

abstract：:The oncogene-induced senescence is emerging as a potent tumor suppressor mechanism and as a possible therapeutic target. Macroautophagy is intimately linked to the senescence condition setup, although its role has not been elucidated yet. Here, we discuss up-to-date concepts of senescence-related macroautophagy and ev...

journal_title：Frontiers in endocrinology

authors： Grasso D,Vaccaro MI

更新日期：2014-09-29 00:00:00

abstract：:Cardiovascular disease (CVD) is the leading cause of death globally. It is well-established based on evidence accrued during the last three decades that high plasma concentrations of cholesterol-rich atherogenic lipoproteins are causatively linked to CVD, and that lowering these reduces atherosclerotic cardiovascular ...

journal_title：Frontiers in endocrinology

authors： Borén J,Packard CJ,Taskinen MR

更新日期：2020-07-28 00:00:00

abstract：:It has been generally assumed that insulin circulates freely in blood. However it can also interact with plasma proteins. Insulin receptors are located in the membrane of target cells and consist of an alpha and beta subunits with a tyrosine kinase cytoplasmic domain. The ectodomain, called soluble insulin receptor (S...

journal_title：Frontiers in endocrinology

authors： Hiriart M,Sanchez-Soto C,Diaz-Garcia CM,Castanares DT,Avitia M,Velasco M,Mas-Oliva J,Macias-Silva M,González-Villalpando C,Delgado-Coello B,Sosa-Garrocho M,Vidaltamayo R,Fuentes-Silva D

更新日期：2014-06-19 00:00:00

abstract：:Vitiligo represents the most common cause of acquired skin, hair, and oral depigmentation, affecting 0.5-1% of the population worldwide. It is clinically characterized by the appearance of disfiguring circumscribed skin macules following melanocyte destruction by autoreactive cytotoxic T lymphocytes. Patients affected...

journal_title：Frontiers in endocrinology

authors： Baldini E,Odorisio T,Sorrenti S,Catania A,Tartaglia F,Carbotta G,Pironi D,Rendina R,D'Armiento E,Persechino S,Ulisse S

更新日期：2017-10-27 00:00:00

abstract：:To investigate the expression of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) in the aorta of subclinical hypothyroidism (SCH) rat model. The mechanisms underlying thyrotropin (TSH) affecting eNOS and PGRN expression in human umbilical vein endothelial cells (HUVECs) cultured in vitro were investigat...

journal_title：Frontiers in endocrinology

authors： Jiang F,Wang H,Bao S,Zhou H,Zhang Y,Yan Y,Lai Y,Teng W,Shan Z

更新日期：2018-07-05 00:00:00

abstract：Introduction:Obesity is associated with a higher risk of abortion in women undergoing in vitro fertilization (IVF). Whether thrombophilia amplifies this risk is currently unclear. The aim of this study was to evaluate the effects of thrombophilia on the risk of abortion in obese women treated with IVF. Methods:Patient...

journal_title：Frontiers in endocrinology

authors： Candeloro M,Di Nisio M,Ponzano A,Tiboni GM,Potere N,Tana M,Rutjes AWS,Porreca E

更新日期：2020-12-23 00:00:00

abstract：:Aging represents one of the most complicated and highly integrated somatic processes. Healthy aging is suggested to rely upon the coherent regulation of hormonal and neuronal communication between the central nervous system and peripheral tissues. The hypothalamus is one of the main structures in the body responsible ...

journal_title：Frontiers in endocrinology

authors： Martin B,Chadwick W,Janssens J,Premont RT,Schmalzigaug R,Becker KG,Lehrmann E,Wood WH,Zhang Y,Siddiqui S,Park SS,Cong WN,Daimon CM,Maudsley S

更新日期：2016-01-18 00:00:00

abstract：:Congenital hyperinsulinism (CHI) is a heterogenous and complex disorder in which the unregulated insulin secretion from pancreatic beta-cells leads to hyperinsulinaemic hypoglycaemia. The severity of hypoglycaemia varies depending on the underlying molecular mechanism and genetic defects. The genetic and molecular cau...

journal_title：Frontiers in endocrinology

authors： Galcheva S,Demirbilek H,Al-Khawaga S,Hussain K

更新日期：2019-02-26 00:00:00

abstract：:Aim: Exercise training elicits diverse effects on brown (BAT) and white adipose tissue (WAT) physiology in rodents housed below their thermoneutral zone (i.e., 28-32°C). In these conditions, BAT is chronically hyperactive and, unlike human residence, closer to thermoneutrality. Therefore, we set out to determine the e...

journal_title：Frontiers in endocrinology

authors： Aldiss P,Lewis JE,Lupini I,Bloor I,Chavoshinejad R,Boocock DJ,Miles AK,Ebling FJP,Budge H,Symonds ME

更新日期：2020-03-20 00:00:00

abstract：:Background: Associations between vitiligo and thyroid disorders have been suggested, However, the prevalence of thyroid disorders in vitiligo vary widely. Purpose: To conduct a systematic review and meta-analysis assessing the prevalence of thyroid disorders in patients with vitiligo. Method: The PubMed, Cochrane Libr...

journal_title：Frontiers in endocrinology

authors： Yuan J,Sun C,Jiang S,Lu Y,Zhang Y,Gao XH,Wu Y,Chen HD

更新日期：2019-01-15 00:00:00

abstract：:Objective: To study the impact of dose reduction in MDCT images through tube current reduction or sparse sampling on the vertebral bone strength prediction using finite element (FE) analysis for fracture risk assessment. Methods: Routine MDCT data covering lumbar vertebrae of 12 subjects (six male; six female; 74.70 ±...

journal_title：Frontiers in endocrinology

authors： Rayudu NM,Subburaj K,Mei K,Dieckmeyer M,Kirschke JS,Noël PB,Baum T

更新日期：2020-07-28 00:00:00

abstract：:This review focuses on the biologic importance of the vitamin D binding protein (DBP) with emphasis on its regulation of total and free vitamin D metabolite levels in various clinical conditions. Nearly all DBP is produced in the liver, where its regulation is influenced by estrogen, glucocorticoids and inflammatory c...

journal_title：Frontiers in endocrinology

authors： Bikle DD,Schwartz J

更新日期：2019-05-28 00:00:00

abstract：:Obesity is associated with inflammation and type 2 diabetes. Innate immune system comprised of cellular and molecular components plays an important role in the inflammatory reactions. Immune cells like macrophages and their cell surface pattern-recognition receptors (PRRs) are representative for innate immunity promot...

journal_title：Frontiers in endocrinology

authors： Yamamoto Y,Yamamoto H

更新日期：2013-08-21 00:00:00

abstract：:Neurons and pancreatic endocrine cells have a common physiology and express a similar toolkit of transcription factors during development. To explain these common features, it has been hypothesized that pancreatic cells most likely co-opted a pre-existing gene regulatory program from ancestral neurons. To test this id...

journal_title：Frontiers in endocrinology

authors： Perillo M,Paganos P,Mattiello T,Cocurullo M,Oliveri P,Arnone MI

更新日期：2018-11-02 00:00:00

abstract：:Lifestyle modifications focused on diet, physical activity, and behavior have a modest impact on weight reduction in children, adolescents, and young adults (YA) with overweight and obesity. Several anti-obesity medications (AOMs) have been approved by the Food and Drug Administration (FDA) for use among adult patient...

journal_title：Frontiers in endocrinology

authors： Czepiel KS,Perez NP,Campoverde Reyes KJ,Sabharwal S,Stanford FC

更新日期：2020-05-13 00:00:00

abstract：:The islet amyloid polypeptide (IAPP) or amylin maintains a key role in metabolism. This 37-residues-peptide could form pancreatic amyloids, which are a characteristic feature of diabetes mellitus type 2. However, some species do not form amyloid fibril structures. By employing a biomimetic approach, we generated an ex...

journal_title：Frontiers in endocrinology

authors： Pulido-Capiz A,Díaz-Molina R,Martínez-Navarro I,Guevara-Olaya LA,Casanueva-Pérez E,Mas-Oliva J,Rivero IA,García-González V

更新日期：2018-06-25 00:00:00

abstract：Background:Left ventricular (LV) diastolic dysfunction has been demonstrated to be an independent predictor of the future heart failure. Heart failure is one of the severe complications caused by overt hyperthyroidism. However, the effects of overt hyperthyroidism on diastolic dysfunction are conflicting, and little is...

journal_title：Frontiers in endocrinology

authors： Li H,Zeng R,Liao Y,Fu M,Zhang H,Wang L,Li Y

更新日期：2021-01-08 00:00:00

abstract：:Objective: Prolactin and progesterone are implicated in glucose homeostasis in and outside of pregnancy. However, their associations with gestational diabetes (GDM) risk were not well-understood. This study investigates this question in a prospective and longitudinal cohort. Methods: This is a nested case-control stud...

journal_title：Frontiers in endocrinology

authors： Li M,Song Y,Rawal S,Hinkle SN,Zhu Y,Tekola-Ayele F,Ferrara A,Tsai MY,Zhang C

更新日期：2020-02-27 00:00:00

abstract：:Gonadotropin-inhibitory hormone (GnIH) was first identified in the Japanese quail as a hypothalamic neuropeptide inhibitor of gonadotropin secretion. Subsequent studies have shown that GnIH is present in the brains of birds including songbirds, and mammals including humans. The identified avian and mammalian GnIH pept...

journal_title：Frontiers in endocrinology

authors： Ubuka T,Son YL,Tobari Y,Tsutsui K

更新日期：2012-11-28 00:00:00

abstract：Background:In addition to inborn metabolic disorders, altered metabolic profiles were reported to be associated with the risk and prognosis of some non-metabolic diseases, while as a rare metabolic disease, the overall secondary metabolic spectrum in congenital hyperinsulinemic hypoglycemia (HH) is largely undetermined...

journal_title：Frontiers in endocrinology

authors： Xu ZR,Zhu XY,Lu W,Sun WH,Cheng RQ,Ni JW,Xi L,Hussain K,Luo FH,Zhang MY

更新日期：2020-10-08 00:00:00

abstract：:Introduction: Adrenal myelolipomas are usually isolated benign adrenal lesions, but can be adjacent to steroid-secreting adrenocortical tumors. We studied the aberrant regulation of cortisol secretion in a 61 year-old woman with combined bilateral myelolipomas and primary bilateral macronodular adrenal hyperplasia (BM...

journal_title：Frontiers in endocrinology

authors： Larose S,Bondaz L,Mermejo LM,Latour M,Prosmanne O,Bourdeau I,Lacroix A

更新日期：2019-09-11 00:00:00

abstract：:Kisspeptin, encoded by the Kiss1 gene, is required for reproduction. Humans and mice lacking kisspeptin or its receptor, Kiss1r, have impairments in reproductive physiology and fertility. In addition to being located in the hypothalamus in the anteroventral periventricular and arcuate nuclei, kisspeptin neurons are al...

journal_title：Frontiers in endocrinology

authors： Stephens SBZ,Kauffman AS

更新日期：2017-08-07 00:00:00

abstract：:In some organisms and cells, oxygen availability influences oxygen consumption. In this review, we examine this phenomenon of hypoxic hypometabolism (HH), discussing its features, mechanisms, and implications. Small mammals and other vertebrate species exhibit "oxyconformism," a downregulation of metabolic rate and bo...

journal_title：Frontiers in endocrinology

authors： Gu C,Jun JC

更新日期：2018-11-13 00:00:00

abstract：:Some newly described steroid-related compounds, also found in the rest of the body, are formed and active in the central nervous system, particularly in the brain. Some are of pharmacological and physiopathological interest. We specifically report on two compounds, "MAP4343," a new neurosteroid very efficient antidepr...

journal_title：Frontiers in endocrinology

authors： Baulieu EE

更新日期：2018-06-15 00:00:00

abstract：:McCune-Albright Syndrome (MAS; OMIM # 174800) is a rare, sporadic disease caused by a post-zygotic, activating mutation in the guanine-nucleotide binding protein α-subunit (GNAS1) gene. MAS is characterized by the clinical triad of polyostotic fibrous dysplasia of bone, café-au-lait skin pigmentation and peripheral pr...

journal_title：Frontiers in endocrinology

authors： Corica D,Aversa T,Pepe G,De Luca F,Wasniewska M

更新日期：2018-06-22 00:00:00