New insights into the control of pulsatile GnRH release: the role of Kiss1/neurokinin B neurons.

abstract：:Insulin resistance (IR) is a pathological condition strongly associated with obesity. However, corticosteroids or growth hormone therapy and genetic diseases may affect insulin sensitivity lifelong. In obese children and adolescents of any age there is an evident association between IR and an increased prevalence of t...

journal_title：Frontiers in endocrinology

authors： Tagi VM,Giannini C,Chiarelli F

更新日期：2019-06-04 00:00:00

abstract：:Exercise training triggers numerous positive adaptations through the regulation of genes controlling muscle structure and function. Epigenetic modifications, including DNA methylation, participate in transcriptional activation by allowing the recruitment of the transcription machinery to gene promoters. Exercise induc...

journal_title：Frontiers in endocrinology

authors： Pattamaprapanont P,Garde C,Fabre O,Barrès R

更新日期：2016-12-23 00:00:00

abstract：:Objective: To clarify the role and mechanism of miR-17-92 cluster in islet beta-cell repair after streptozotocin intervention. Methods: Genetically engineered mice (miR-17-92βKO) and control RIP-Cre mice were intraperitoneally injected with multiple low dose streptozotocin. Body weight, random blood glucose (RBG), fas...

journal_title：Frontiers in endocrinology

authors： Wan S,Zhang J,Chen X,Lang J,Li L,Chen F,Tian L,Meng Y,Yu X

更新日期：2020-01-23 00:00:00

abstract：:Follicle stimulating hormone (FSH) plays a key role in human reproduction through, among others, induction of spermatogenesis in men and production of estrogen in women. The function FSH is performed upon binding to its cognate receptor-follicle-stimulating hormone receptor (FSHR) expressed on the surface of target ce...

journal_title：Frontiers in endocrinology

authors： Szymańska K,Kałafut J,Przybyszewska A,Paziewska B,Adamczuk G,Kiełbus M,Rivero-Müller A

更新日期：2018-12-13 00:00:00

abstract：:Objective: Acromegalic patients display a distinct neuropsychological profile and suffer from chronic physical complaints. We aimed to investigate in more detail these aspects in acromegalic patients, dependent on influencing factors like disease activity, age, sex, chronic medication, surgery, pituitary radiation, pi...

journal_title：Frontiers in endocrinology

authors： Zimmermann A,Zwerenz R,Droste M,Schöfl C,Strasburger CJ,Plöckinger U,Ziagaki A,Honegger J,Dixius A,Millaku B,Toenges G,Beutel ME,Weber MM

更新日期：2018-07-17 00:00:00

abstract：:Background: Congenital Hyperinsulinism (CHI) is an important cause of severe and persistent hypoglycaemia in infancy and childhood. The focal form (CHI-F) of CHI can be potentially cured by pancreatic lesionectomy. While diagnostic characteristics of CHI-F pancreatic histopathology are well-recognized, correlation wit...

journal_title：Frontiers in endocrinology

authors： Craigie RJ,Salomon-Estebanez M,Yau D,Han B,Mal W,Newbould M,Cheesman E,Bitetti S,Mohamed Z,Sajjan R,Padidela R,Skae M,Flanagan S,Ellard S,Cosgrove KE,Banerjee I,Dunne MJ

更新日期：2018-10-17 00:00:00

abstract：:Licorice has been used as a medicinal plant from 2.500 years. It shows a wide range of biological and pharmacological activities, including anti-inflammatory and immune regulatory actions. One of its most known effects is the induction of hypertension, and it can induce what appears to be pseudohyperaldosteronism, due...

journal_title：Frontiers in endocrinology

authors： Sabbadin C,Bordin L,Donà G,Manso J,Avruscio G,Armanini D

更新日期：2019-07-18 00:00:00

abstract：Introduction:Vitamin D deficiency is an important public health problem worldwide. Vitamin D deficiency confers a significant risk for both skeletal and non-skeletal disorders and a number of lifelong negative health outcomes. The objectives of this evidence-based guidelines document are to provide health care professi...

journal_title：Frontiers in endocrinology

authors： Rusińska A,Płudowski P,Walczak M,Borszewska-Kornacka MK,Bossowski A,Chlebna-Sokół D,Czech-Kowalska J,Dobrzańska A,Franek E,Helwich E,Jackowska T,Kalina MA,Konstantynowicz J,Książyk J,Lewiński A,Łukaszkiewicz J,Marcinowska

更新日期：2018-05-31 00:00:00

abstract：:Cushing's disease recurrence following successful pituitary surgery is common and merits prompt and careful diagnosis, as untreated hypercortisolism leads to increased morbidity and mortality. However, an established recurrence definition has not been forthcoming. This poses a diagnostic challenge especially early in ...

journal_title：Frontiers in endocrinology

authors： Hinojosa-Amaya JM,Varlamov EV,McCartney S,Fleseriu M

更新日期：2019-11-08 00:00:00

abstract：:Context: The DICER1 syndrome is a multiple neoplasia disorder caused by germline mutations in the DICER1 gene. In DICER1 patients, aggressive congenital pituitary tumors lead to neonatal Cushing's disease (CD). The role of DICER1 in other corticotropinomas, however, remains unknown. Objective: To perform a comprehensi...

journal_title：Frontiers in endocrinology

authors： Martínez de LaPiscina I,Hernández-Ramírez LC,Portillo N,Gómez-Gila AL,Urrutia I,Martínez-Salazar R,García-Castaño A,Aguayo A,Rica I,Gaztambide S,Faucz FR,Keil MF,Lodish MB,Quezado M,Pankratz N,Chittiboina P,Lane J,Kay D

更新日期：2020-07-03 00:00:00

abstract：Background:The risk of spontaneous abortion in patients with polycystic ovary syndrome (PCOS) undergoing assisted reproductive treatment (ART) is higher than that in patients without PCOS, however, no definitive risk factors have been confirmed to associate with the high spontaneous abortion rate in PCOS patients under...

journal_title：Frontiers in endocrinology

authors： Sun YF,Zhang J,Xu YM,Cao ZY,Wang YZ,Hao GM,Gao BL

更新日期：2020-12-03 00:00:00

abstract：:Background: Carney complex (CNC) is a rare multiple endocrine neoplasia syndrome with autosomal dominant inheritance. Affected individuals present with mucocutaneous lentigines/blue nevi, cardiac and noncardiac myxomatous tumors, and multiple endocrine tumors. Mutations in PRKAR1A have been identified as genetic cause...

journal_title：Frontiers in endocrinology

authors： Ralser DJ,Strizek B,Kupczyk P,Stoffel-Wagner B,Altengarten J,Müller A,Woelfle J,Gembruch U,Klingmueller D,Merz WM,Paschkowiak-Christes A

更新日期：2020-05-08 00:00:00

abstract：:The past two decades have witnessed many advances in the prevention, treatment, and control of diabetes mellitus (DM) and its complications. Increased screening has led to a greater recognition of type 2 diabetes mellitus (type 2 DM) and prediabetes; however, Hispanics/Latinos, the largest minority group in the US, ha...

journal_title：Frontiers in endocrinology

authors： Avilés-Santa ML,Colón-Ramos U,Lindberg NM,Mattei J,Pasquel FJ,Pérez CM

更新日期：2017-11-10 00:00:00

abstract：:The insulin/IGF system plays an important role in cancer progression. Accordingly, elevated levels of circulating insulin have been associated with an increased cancer risk as well as with aggressive and metastatic cancer phenotypes. Numerous studies have documented that estrogens cooperate with the insulin/IGF system...

journal_title：Frontiers in endocrinology

authors： De Marco P,Cirillo F,Vivacqua A,Malaguarnera R,Belfiore A,Maggiolini M

更新日期：2015-03-06 00:00:00

abstract：:Besides aging, a number of non-modifiable lifestyle-related factors, such as smoking, elevated consumption of caffeine and alcohol, stress, agonist sports, chronic exposure to environmental pollutants, and other nutritional habits exert a negative impact on a women's fertility. In particular, metabolic disorders inclu...

journal_title：Frontiers in endocrinology

authors： Silvestris E,Lovero D,Palmirotta R

更新日期：2019-06-07 00:00:00

abstract：Background:Levothyroxine sodium (LT4) is the therapy of choice for hypothyroidism. In the last decade, new LT4 formulations, such as liquid and softgel capsules, became available. Even if some evidence has been reached in the efficacy of liquid LT4 in patients with suboptimal TSH on tablet LT4, the usefulness of softge...

journal_title：Frontiers in endocrinology

authors： Trimboli P,Virili C,Centanni M,Giovanella L

更新日期：2018-03-21 00:00:00

abstract：:This brief review describes some representative methodological approaches to the isolation of putative endogenous inhibitors of epithelial sodium transport - i.e., as ouabain-like factors (OLF) that inhibit the sodium transport enzyme Na-K-ATPase or inhibit the epithelial sodium channel (ENaC). Gel chromatography and ...

journal_title：Frontiers in endocrinology

authors： Kramer HJ

更新日期：2015-05-20 00:00:00

abstract：:Regenerative medicine is a multidisciplinary field that aims to determine different factors and develop various methods to regenerate impaired tissues, organs, and cells in the disease and impairment conditions. When treatment procedures are specified according to the individual's information, the leading role of pers...

journal_title：Frontiers in endocrinology

authors： Arjmand B,Tayanloo-Beik A,Foroughi Heravani N,Alaei S,Payab M,Alavi-Moghadam S,Goodarzi P,Gholami M,Larijani B

更新日期：2020-07-17 00:00:00

abstract：:Polybrominated diphenyl ethers (PBDEs) were used as flame-retardant additives starting 1965 and were recently withdrawn from commerce in North America and Europe. Approximately 1/5 of the total U.S. population were born when environmental concentrations of PBDE plateaued at their maximum. Accumulating evidence suggest...

journal_title：Frontiers in endocrinology

authors： Khalil A,Cevik SE,Hung S,Kolla S,Roy MA,Suvorov A

更新日期：2018-09-20 00:00:00

abstract：:Osteoporosis is metabolic bone disease caused by an altered balance between bone anabolism and catabolism. This dysregulated balance is responsible for fragile bones that fracture easily after minor falls. With an aging population, the incidence is rising and as yet pharmaceutical options to restore this imbalance is ...

journal_title：Frontiers in endocrinology

authors： Bergen DJM,Kague E,Hammond CL

更新日期：2019-01-29 00:00:00

abstract：:Vitamin D is important for bone health, but may also have extra-skeletal effects. Vitamin D and its binding protein DBP have immunological effects and may therefore be important in the development of type 1 diabetes (T1DM), and low serum levels of 25-hydroxyvitamin D (25(OH)D) are associated with later development of ...

journal_title：Frontiers in endocrinology

authors： Jorde R

更新日期：2019-02-19 00:00:00

abstract：:Transient activation of the hypothalamic-pituitary-gonadal axis in early infancy plays an important role in male genital development and sexual differentiation of the brain, but factors contributing to individual variation in testosterone levels during this period are poorly understood. We measured salivary testostero...

journal_title：Frontiers in endocrinology

authors： Xia K,Yu Y,Ahn M,Zhu H,Zou F,Gilmore JH,Knickmeyer RC

更新日期：2014-10-30 00:00:00

abstract：:Background: Amiodarone-induced thyrotoxicosis (AIT) is associated with significant morbidity and mortality, particularly in patients with cardiac failure. The aim of the study was to evaluate the management of AIT at a tertiary hospital specialising in cardiac failure and transplantation. Methods: Retrospective audit ...

journal_title：Frontiers in endocrinology

authors： Isaacs M,Costin M,Bova R,Barrett HL,Heffernan D,Samaras K,Greenfield JR

更新日期：2018-08-22 00:00:00

abstract：:Introduction: Pituitary metastases (PM) are rare events and to date only very few cases of melanoma PM have been described in literature up to now. Case Presentation: We describe the clinical history of a 33-year-old male patient who underwent surgical excision of an inter-scapular melanoma in 2008. The subsequent fol...

journal_title：Frontiers in endocrinology

authors： Mormando M,Puliani G,Barnabei A,Lauretta R,Bianchini M,Chiefari A,Russillo M,Cognetti F,Romano L,Appetecchia M

更新日期：2020-07-23 00:00:00

abstract：:G protein-coupled estrogen receptor (GPER) in the amygdala and the dorsal hippocampus mediates actions of estradiol on anxiety, social recognition and spatial memory. In addition, GPER participates in the estrogenic regulation of synaptic function in the amygdala and in the process of adult neurogenesis in the dentate...

journal_title：Frontiers in endocrinology

authors： Llorente R,Marraudino M,Carrillo B,Bonaldo B,Simon-Areces J,Abellanas-Pérez P,Rivero-Aguilar M,Fernandez-Garcia JM,Pinos H,Garcia-Segura LM,Collado P,Grassi D

更新日期：2020-08-07 00:00:00

abstract：:Human phosphodiesterases (PDEs) comprise a complex superfamily of enzymes derived from 24 genes separated into 11 PDE gene families (PDEs 1-11), expressed in different tissues and cells, including heart and brain. The isoforms PDE4, PDE7, and PDE8 are specific for the second messenger cAMP, which is responsible for me...

journal_title：Frontiers in endocrinology

authors： Bizzi MF,Bolger GB,Korbonits M,Ribeiro-Oliveira A Jr

更新日期：2019-03-19 00:00:00

abstract：:Co-heritability of hypertension and insulin resistance (IR) within families not only implies genetic susceptibility may be responsible for these complex traits but also suggests a rational that biological candidate genes for hypertension may serve as markers for features of the metabolic syndrome (MetS). Thus we deter...

journal_title：Frontiers in endocrinology

authors： Ho LT,Hsu YP,Hsiao CF,Ting CT,Shih KC,Chuang LM,Masaki K,Grove J,Quertermous T,Juan CC,Lin MW,Chiang SC,Chen YD

更新日期：2013-11-28 00:00:00

abstract：Objective:Both vitamin D and K2 are involved in a number of metabolic processes, including bone metabolism; however, associations between the vitamins are not fully understood. The aim of the study was to evaluate serum concentrations of 25-hydroxyvitamin D [25(OH)D] in adult patients receiving long-term acenocoumarol ...

journal_title：Frontiers in endocrinology

authors： Sawicka-Powierza J,Konstantynowicz J,Jablonska E,Zelazowska-Rutkowska B,Jelski W,Abramowicz P,Sasinowski C,Chlabicz S

更新日期：2018-05-04 00:00:00

abstract：:RFamide-related peptide-3 (RFRP-3) [mammalian ortholog to gonadotropin-inhibiting hormone (GnIH)] potently inhibits gonadotropin secretion in mammals. Studies of RFRP-3 immunoreactivity and Rfrp expression (the gene encoding RFRP-3) in mammalian brains have uncovered several possible pathways regulating RFRP-3 neurons...

journal_title：Frontiers in endocrinology

authors： Poling MC,Kauffman AS

更新日期：2015-09-24 00:00:00

abstract：:Primary small cell carcinoma of the breast (SCCB) is a rare tumor subtype comprising <0.1% of all breast carcinomas. Here we present a case of thyroid transcription factor-1 (TTF-1) positive SCCB that recurred within 3 years of diagnosis in the lung and lymph nodes. Given the small number of cases, no clear guidelines...

journal_title：Frontiers in endocrinology

authors： Boutrid H,Kassem M,Tozbikian G,Morgan E,White J,Shah M,Vandeusen J,Sardesai S,Williams N,Stover DG,Lustberg M,Wesolowski R,Pudavalli V,Williams TM,Konda B,Fortier S,Carbone D,Ramaswamy B,Cherian MA

更新日期：2020-04-29 00:00:00