Association of BRCA Mutations and Anti-müllerian Hormone Level in Young Breast Cancer Patients.

abstract：:Last two decades of structure-function studies performed in numerous laboratories provided substantial progress in understanding basic science, physiological, pathophysiological, pharmacological, and comparative aspects of glycoprotein hormones (GPHs) and their cognate receptors. Multiple concepts and models developed...

journal_title：Frontiers in endocrinology

authors： Szkudlinski MW

更新日期：2015-10-19 00:00:00

abstract：:Background: Congenital Hyperinsulinism (CHI) is an important cause of severe and persistent hypoglycaemia in infancy and childhood. The focal form (CHI-F) of CHI can be potentially cured by pancreatic lesionectomy. While diagnostic characteristics of CHI-F pancreatic histopathology are well-recognized, correlation wit...

journal_title：Frontiers in endocrinology

authors： Craigie RJ,Salomon-Estebanez M,Yau D,Han B,Mal W,Newbould M,Cheesman E,Bitetti S,Mohamed Z,Sajjan R,Padidela R,Skae M,Flanagan S,Ellard S,Cosgrove KE,Banerjee I,Dunne MJ

更新日期：2018-10-17 00:00:00

abstract：Background:In adults, excess adiposity has been associated with low-grade, chronic inflammation and compromised bone health, but less is known about these linkages in children. The purpose of this study was to compare the circulating levels of inflammatory cytokines, adipokines, osteokines, and bone markers at rest and...

journal_title：Frontiers in endocrinology

authors： Kurgan N,McKee K,Calleja M,Josse AR,Klentrou P

更新日期：2020-12-11 00:00:00

abstract：:Obesity is a prominent metabolic disease that predisposes individuals to multiple comorbidities, including type 2 diabetes mellitus, cardiovascular diseases, and cancer. Elevated circulating levels of fatty acids contribute to the development of obesity, in part, by targeting the hypothalamus. Palmitate, the most abun...

journal_title：Frontiers in endocrinology

authors： Tran A,He W,Jiang N,Chen JTC,Belsham DD

更新日期：2020-06-12 00:00:00

abstract：:Vitamin D is important for bone health, but may also have extra-skeletal effects. Vitamin D and its binding protein DBP have immunological effects and may therefore be important in the development of type 1 diabetes (T1DM), and low serum levels of 25-hydroxyvitamin D (25(OH)D) are associated with later development of ...

journal_title：Frontiers in endocrinology

authors： Jorde R

更新日期：2019-02-19 00:00:00

abstract：:Endocrine disrupting chemicals (EDCs) are chemicals that interfere with the organizational or activational effects of hormones. Although the vast majority of the EDC literature focuses on steroid hormone signaling related impacts, growing evidence from a myriad of species reveals that the nonapeptide hormones vasopres...

journal_title：Frontiers in endocrinology

authors： Patisaul HB

更新日期：2017-06-19 00:00:00

abstract：:11-ketotestosterone (11-KT) is a non-aromatizable and the most potent androgen in a few teleost. It has been reported that 11-KT in serum had a high concentration and increased sharply before the period of yolk deposition in females of few fishes. The aim of this study was to analyze the role of 11-KT both in vivo and...

journal_title：Frontiers in endocrinology

authors： Wang W,Zhu H,Tian Z,Sun A,Dong Y,Dong T,Hu H

更新日期：2020-03-25 00:00:00

abstract：:Pulmonary fibrosis is a hallmark of diseases such as systemic sclerosis (SSc, scleroderma) and idiopathic pulmonary fibrosis (IPF). To date, the therapeutic options for patients with pulmonary fibrosis are limited, and organ transplantation remains the most effective option. Insulin-like growth factor-binding protein ...

journal_title：Frontiers in endocrinology

authors： Nguyen XX,Muhammad L,Nietert PJ,Feghali-Bostwick C

更新日期：2018-10-15 00:00:00

abstract：:The orexigenic peptide hormone ghrelin is synthesized in the stomach and its receptor growth hormone secretagogue receptor (GHSR1a) is expressed mainly in the central nervous system (CNS). In this review, we confine our discussion to the physiological role of GHSR1a in the brain. Paradoxically, despite broad expressio...

journal_title：Frontiers in endocrinology

authors： Kern A,Grande C,Smith RG

更新日期：2014-08-18 00:00:00

abstract：:Cardiovascular disease (CVD) is the leading cause of death globally. It is well-established based on evidence accrued during the last three decades that high plasma concentrations of cholesterol-rich atherogenic lipoproteins are causatively linked to CVD, and that lowering these reduces atherosclerotic cardiovascular ...

journal_title：Frontiers in endocrinology

authors： Borén J,Packard CJ,Taskinen MR

更新日期：2020-07-28 00:00:00

abstract：:Background: Early metabolic responses following bariatric surgery appear greater than expected given the initial weight loss and coincide with improvement in diabetes. We hypothesized that small non-coding microRNA changes might contribute to regulating mechanisms for metabolic changes and weight loss in patients with...

journal_title：Frontiers in endocrinology

authors： Atkin SL,Ramachandran V,Yousri NA,Benurwar M,Simper SC,McKinlay R,Adams TD,Najafi-Shoushtari SH,Hunt SC

更新日期：2019-01-04 00:00:00

abstract：:Background: Non-alcoholic fatty liver disease (NAFLD) is a well-known cause of liver dysfunction and has become a common chronic liver disease in many countries. However, the intrinsic molecular mechanisms underlying the pathogenesis of NAFLD have not yet been fully elucidated. Methods: We obtained the gene expression...

journal_title：Frontiers in endocrinology

authors： Jia X,Zhai T

更新日期：2019-08-30 00:00:00

abstract：:The present study aimed to compare effects of increasing chronic stress load on the stress response of European seabass (Dicentrarchus labrax) and gilthead seabream (Sparus aurata) to identify neuroendocrine functions that regulate this response. Fish were left undisturbed (controls) or exposed to three levels of chro...

journal_title：Frontiers in endocrinology

authors： Samaras A,Espírito Santo C,Papandroulakis N,Mitrizakis N,Pavlidis M,Höglund E,Pelgrim TNM,Zethof J,Spanings FAT,Vindas MA,Ebbesson LOE,Flik G,Gorissen M

更新日期：2018-08-13 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fendo.2018.00031.]. ...

journal_title：Frontiers in endocrinology

authors： Beattie J,Al-Khafaji H,Noer PR,Alkharobi HE,Alhodhodi A,Meade J,El-Gendy R,Oxvig C

更新日期：2018-09-04 00:00:00

abstract：:G protein-coupled estrogen receptor (GPER) in the amygdala and the dorsal hippocampus mediates actions of estradiol on anxiety, social recognition and spatial memory. In addition, GPER participates in the estrogenic regulation of synaptic function in the amygdala and in the process of adult neurogenesis in the dentate...

journal_title：Frontiers in endocrinology

authors： Llorente R,Marraudino M,Carrillo B,Bonaldo B,Simon-Areces J,Abellanas-Pérez P,Rivero-Aguilar M,Fernandez-Garcia JM,Pinos H,Garcia-Segura LM,Collado P,Grassi D

更新日期：2020-08-07 00:00:00

abstract：Introduction:The oxidative stress associated with glucose variability might be responsible for neuronal damage while autonomic neuropathy (AN) has a detrimental effect on metabolism. The aim of the study was to find relationship between AN and GV in type 1 diabetic patients and to identify further factors that affect G...

journal_title：Frontiers in endocrinology

authors： Nyiraty S,Pesei F,Orosz A,Coluzzi S,Vági OE,Lengyel C,Ábrahám G,Frontoni S,Kempler P,Várkonyi T

更新日期：2018-04-19 00:00:00

abstract：:Although the pathogenesis of Polycystic Ovary Syndrome (PCOS) is still unclear, the disturbance of hypothalamic-pituitary-gonadal (HPG) axis is suspected to be the main culprit in the development of PCOS. Kisspeptin, a hypothalamic peptide encoded by the KISS1 gene, is widely reported as a key factor in the regulation...

journal_title：Frontiers in endocrinology

authors： Tang R,Ding X,Zhu J

更新日期：2019-05-10 00:00:00

abstract：:Hypothyroidism has been reported to improve survival in cancer patients but only recently has the putative mechanism been identified as a receptor for thyroxine and tri-iodothyronine on integrin αvβ3. Recognition of divergence of action of the pro-oncogenic L-thyroxine (T4) from pro-metabolic 3,5,3'-triiodo-L-thyronin...

journal_title：Frontiers in endocrinology

authors： Hercbergs A

更新日期：2019-08-23 00:00:00

abstract：:We treat the biological significance of prostaglandins (PGs) and their known receptors in insect biology. PGs and related eicosanoids are oxygenated derivatives of arachidonic acid (AA) and two other C20 polyunsaturated fatty acids. PGs are mostly appreciated in the context of biomedicine, but a growing body of litera...

journal_title：Frontiers in endocrinology

authors： Stanley D,Kim Y

更新日期：2011-12-30 00:00:00

abstract：:The receptor tyrosine kinase superfamily comprises many cell-surface receptors including the insulin receptor (IR) and type 1 insulin-like growth factor receptor (IGF1R) that are constitutively homodimeric transmembrane glycoproteins. Therefore, these receptors require ligand-triggered domain rearrangements rather tha...

journal_title：Frontiers in endocrinology

authors： Mohammadiarani H,Vashisth H

更新日期：2016-06-20 00:00:00

abstract：:Objectives: To evaluate the impact of metformin (MTF) use on TSH levels, thyroid volume and volume of benign thyroid nodules (TNs). Additionally, to study if iodine status influences the outcomes. Methods: A total of 23 euthyroid patients (42 TNs) with benign thyroid nodules, diagnosed by fine needle aspiration biopsy...

journal_title：Frontiers in endocrinology

authors： Dos Santos PB,Gertrudes LN,Conceição FL,de Andrade BM,de Carvalho DP,Vaisman M,Teixeira PFDS

更新日期：2019-07-17 00:00:00

abstract：:Over the past decade, the increasing prevalence of obesity and its associated metabolic disorders constitutes one of the most concerning healthcare issues for countries worldwide. In an effort to curb the increased mortality and morbidity derived from the obesity epidemic, various therapeutic strategies have been deve...

journal_title：Frontiers in endocrinology

authors： Ong BX,Brunmeir R,Zhang Q,Peng X,Idris M,Liu C,Xu F

更新日期：2020-02-27 00:00:00

abstract：:Women with impaired ovarian reserve or poor ovarian response (POR) to exogenous gonadotropin stimulation present a challenge for reproductive specialists. The primary reasons relate to the still limited knowledge about the POR pathophysiology and the lack of practical solutions for the management of these conditions. ...

journal_title：Frontiers in endocrinology

authors： Esteves SC,Roque M,Bedoschi GM,Conforti A,Humaidan P,Alviggi C

更新日期：2018-08-17 00:00:00

abstract：:Background: Intracystic hemorrhage can present occasionally during ultrasound-guided percutaneous microwave ablation (PMWA) for cystic thyroid nodules. It can affect treatment outcome, can lead to ablation failure, and even conversion to open surgery. We aim to avoid such cases in the future by exploring their causes ...

journal_title：Frontiers in endocrinology

authors： Dong S,Sun L,Xu J,Han Z,Liu J

更新日期：2020-09-08 00:00:00

abstract：:The plasticity of the individual epigenetic landscape that goes to countless rearrangements throughout life is closely the reflection of environmental factors such as chemical exposure, socio-economic status and nutrient intakes both early and late in life. The Mini Nutritional Assessment (MNA) is a well-validated too...

journal_title：Frontiers in endocrinology

authors： Montesanto A,D'Aquila P,Rossano V,Passarino G,Bellizzi D

更新日期：2019-10-01 00:00:00

abstract：:Neurokinin B (NKB) is a member of the tachykinin (tac) family that plays important roles in mammalian growth by modulating prolactin (PRL) synthesis and secretion and causing contraction of the stomach and intestine. However, its potential role in regulating growth of teleosts is less clear. We aimed to explore the ro...

journal_title：Frontiers in endocrinology

authors： Zhang Z,Wen H,Li Y,Li Q,Li W,Zhou Y,Wang L,Liu Y,Lyu L,Qi X

更新日期：2019-08-14 00:00:00

abstract：:The G-protein coupled parathyroid hormone 2 receptor (PTH2R) is concentrated in endocrine and limbic regions in the forebrain. Its endogenous ligand, tuberoinfundibular peptide of 39 residues (TIP39), is synthesized in only two brain regions, within the posterior thalamus and the lateral pons. TIP39-expressing neurons...

journal_title：Frontiers in endocrinology

authors： Dobolyi A,Dimitrov E,Palkovits M,Usdin TB

更新日期：2012-10-08 00:00:00

abstract：:Chemokines are small molecules that play a crucial role as chemoattractants for several cell types, and their components are associated with host immune responses and repair mechanisms. Chemokines selectively recruit monocytes, neutrophils, and lymphocytes and induce chemotaxis through the activation of G protein-coup...

journal_title：Frontiers in endocrinology

authors： Siddiqui JA,Partridge NC

更新日期：2017-03-29 00:00:00

abstract：:Licorice has been used as a medicinal plant from 2.500 years. It shows a wide range of biological and pharmacological activities, including anti-inflammatory and immune regulatory actions. One of its most known effects is the induction of hypertension, and it can induce what appears to be pseudohyperaldosteronism, due...

journal_title：Frontiers in endocrinology

authors： Sabbadin C,Bordin L,Donà G,Manso J,Avruscio G,Armanini D

更新日期：2019-07-18 00:00:00

abstract：:Germline development in vivo is dependent on the environment formed by somatic cells and the differentiation cues they provide; hence, the impact of local factors is highly relevant to the production of sperm. Knowledge of how somatic and germline cells interact is central to achieving biomedical goals relating to res...

journal_title：Frontiers in endocrinology

authors： Loveland KL,Klein B,Pueschl D,Indumathy S,Bergmann M,Loveland BE,Hedger MP,Schuppe HC

更新日期：2017-11-20 00:00:00