Licorice: From Pseudohyperaldosteronism to Therapeutic Uses.

abstract：Background:Renal function is profoundly influenced by thyroid hormone levels. This study was designed to evaluate the association between preoperative thyroid hormones and postoperative acute kidney injury (AKI) in acute type A aortic dissection (ATAAD) patients. Methods:A total of 88 patients with ATAAD who underwent...

journal_title：Frontiers in endocrinology

authors： Liu J,Xue Y,Jiang W,Zhang H,Zhao Y

更新日期：2020-11-18 00:00:00

abstract：:In some organisms and cells, oxygen availability influences oxygen consumption. In this review, we examine this phenomenon of hypoxic hypometabolism (HH), discussing its features, mechanisms, and implications. Small mammals and other vertebrate species exhibit "oxyconformism," a downregulation of metabolic rate and bo...

journal_title：Frontiers in endocrinology

authors： Gu C,Jun JC

更新日期：2018-11-13 00:00:00

abstract：:Cholecystokinin (CCK) was discovered in 1928 in jejunal extracts as a gallbladder contraction factor. It was later shown to be member of a peptide family, which are all ligands for the CCK1 and CCK2 receptors. CCK peptides are known to be synthetized in small intestinal endocrine I-cells and cerebral neurons. But in a...

journal_title：Frontiers in endocrinology

authors： Rehfeld JF

更新日期：2017-04-13 00:00:00

abstract：:Background: The management of children and adolescents with chronic kidney disease (CKD) and growth failure candidate for recombinant human growth hormone therapy (rhGH) is based on an appraisal of the literature established on a 2006 consensus statement and 2019 Clinical practice recommendations. The performance of t...

journal_title：Frontiers in endocrinology

authors： Cappa M,Maghnie M,Carbone V,Chioma L,Errichiello C,Giavoli C,Giordano M,Guazzarotti L,Klain A,Montini G,Murer L,Parpagnoli M,Pecoraro C,Pesce S,Verrina E

更新日期：2020-09-02 00:00:00

abstract：:Skeletal dysplasias are a diverse group of heritable diseases affecting bone and cartilage growth. Throughout the years, the molecular defect underlying many of the diseases has been identified. These identifications led to novel insights in the mechanisms regulating bone and cartilage growth and homeostasis. One of t...

journal_title：Frontiers in endocrinology

authors： Huybrechts Y,Mortier G,Boudin E,Van Hul W

更新日期：2020-04-09 00:00:00

abstract：:Osteoporosis is a metabolic skeletal disorder in which bone mass is depleted and bone structure is destroyed to the degree that bone becomes fragile and prone to fractures. Emerging evidence suggests that N6-methyladenosine (m6A) modification, a novel epitranscriptomic marker, has a significant role in bone developmen...

journal_title：Frontiers in endocrinology

authors： Chen X,Hua W,Huang X,Chen Y,Zhang J,Li G

更新日期：2020-01-10 00:00:00

abstract：:Fibrodysplasia ossificans progressiva (FOP) is an autosomal dominant disease, characterized by the formation of heterotopic ossification (HO) in muscles, ligaments, and tendons. Flare-ups, an inflammatory process that often precedes the formation of HO, can occur spontaneously, but trauma is also a common trigger. It ...

journal_title：Frontiers in endocrinology

authors： Botman E,Netelenbos JC,Rustemeyer T,Schoonmade LJ,Nieuwenhuijzen JA,Teunissen BP,Visser M,Raijmakers P,Lammertsma AA,Dahele M,Eekhoff M

更新日期：2020-02-12 00:00:00

abstract：:Animals store metabolic energy as electrochemical gradients. At least 50% of mammalian energy is expended to maintain electrochemical gradients across the inner mitochondrial membrane (H+), the sarcoplasmic reticulum (Ca++), and the plasma membrane (Na+/K+). The potential energy of these gradients can be used to perfo...

journal_title：Frontiers in endocrinology

authors： Geisler CE,Kentch KP,Renquist BJ

更新日期：2017-09-01 00:00:00

abstract：:Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is a rare cause of Cushing syndrome. If routine imaging examinations cannot identify the source of ACTH production, long-term follow-up observation is necessary to determine the etiology. We present the case of a middle-aged male with gradual weight gain and a ...

journal_title：Frontiers in endocrinology

authors： Lu L,Meng Q,Xing X,Yuan T,Zhang H,Li N,Wang Y,Cheng Y,Bai C,Wang H,Cheng X,Xiao Y,Pan B,Li Y,Sun J,Liang Z,Zhu H,Wang R,Lu Z

更新日期：2019-10-22 00:00:00

abstract：:[This corrects the article on p. 26 in vol. 9, PMID: 29487564.]. ...

journal_title：Frontiers in endocrinology

authors： Konya J,Spurgeon BEJ,Al Qaissi A,Sathyapalan T,Ajjan R,Madden L,Naseem KM,Garrett AT,Kilpatrick E,Atkin SL

更新日期：2018-06-07 00:00:00

abstract：:Congenital hyperinsulinism (CHI) is a heterogenous and complex disorder in which the unregulated insulin secretion from pancreatic beta-cells leads to hyperinsulinaemic hypoglycaemia. The severity of hypoglycaemia varies depending on the underlying molecular mechanism and genetic defects. The genetic and molecular cau...

journal_title：Frontiers in endocrinology

authors： Galcheva S,Demirbilek H,Al-Khawaga S,Hussain K

更新日期：2019-02-26 00:00:00

abstract：:Background: Congenital Hyperinsulinism (CHI) is an important cause of severe and persistent hypoglycaemia in infancy and childhood. The focal form (CHI-F) of CHI can be potentially cured by pancreatic lesionectomy. While diagnostic characteristics of CHI-F pancreatic histopathology are well-recognized, correlation wit...

journal_title：Frontiers in endocrinology

authors： Craigie RJ,Salomon-Estebanez M,Yau D,Han B,Mal W,Newbould M,Cheesman E,Bitetti S,Mohamed Z,Sajjan R,Padidela R,Skae M,Flanagan S,Ellard S,Cosgrove KE,Banerjee I,Dunne MJ

更新日期：2018-10-17 00:00:00

abstract：:Background: Gestational diabetes (GDM) is associated with adverse short- and long-term maternal and fetal outcomes. Observational data support a link between sleep-disordered breathing (SDB) during pregnancy and GDM. However, it is unknown whether treatment of SDB with continuous positive airway pressure (CPAP) improv...

journal_title：Frontiers in endocrinology

authors： Pamidi S,Meltzer SJ,Garfield N,Lavigne L,Olha A,Khalyfa A,Benedetti A,Tremblay G,Gagnon R,Rey E,Dasgupta K,Kimoff RJ

更新日期：2018-11-16 00:00:00

abstract：:Sex steroids play essential roles in the modulation of synaptic plasticity and neuroprotection in the hippocampus. Accumulating evidence shows that hippocampal neurons synthesize both estrogen and androgen. Recently, we also revealed the hippocampal synthesis of corticosteroids. The accurate concentrations of these hi...

journal_title：Frontiers in endocrinology

authors： Hojo Y,Higo S,Kawato S,Hatanaka Y,Ooishi Y,Murakami G,Ishii H,Komatsuzaki Y,Ogiue-Ikeda M,Mukai H,Kimoto T

更新日期：2011-10-10 00:00:00

abstract：:In mammals, glucosensing markers reside in brain areas known to play an important role in the control of food intake. The best characterized glucosensing mechanism is that dependent on glucokinase (GK) whose activation by increased levels of glucose leads in specific hypothalamic neurons to decreased or increased acti...

journal_title：Frontiers in endocrinology

authors： Otero-Rodiño C,Rocha A,Sánchez E,Álvarez-Otero R,Soengas JL,Cerdá-Reverter JM

更新日期：2019-04-18 00:00:00

abstract：Background:Many studies suggest that the small ubiquitin-like modifier 4 (SUMO4) M55V gene polymorphism (rs237025) may be associated with an increased risk of type 2 diabetes mellitus (T2DM). However, due to other conflicting results, a clear consensus is lacking in the matter. Objective and methods:A meta-analysis co...

journal_title：Frontiers in endocrinology

authors： Li YY,Wang H,Yang XX,Geng HY,Gong G,Kim HJ,Zhou YH,Wu JJ

更新日期：2017-11-02 00:00:00

abstract：:The mammalian genome contains four genes encoding GABA transporters (GAT1, slc6a1; GAT2, slc6a13; GAT3, slc6a11; BGT1, slc6a12) and five glutamate transporter genes (EAAT1, slc1a3; EAAT2, slc1a2; EAAT3, slc1a1; EAAT4, slc1a6; EAAT5, slc1a7). These transporters keep the extracellular levels of GABA and excitatory amino...

journal_title：Frontiers in endocrinology

authors： Zhou Y,Danbolt NC

更新日期：2013-11-11 00:00:00

abstract：:Background: Insulin resistance (IR) is the hallmark of PCOS and it is known that exercise may decrease it. What is unknown is whether exercise may mechanistically alter the underlying IR, attenuating the dynamic lipid induced IR in insulin resistant subjects. Methods: 12 women with polycystic ovary syndrome (PCOS) and...

journal_title：Frontiers in endocrinology

authors： Aye MM,Butler AE,Kilpatrick ES,Kirk R,Vince R,Rigby AS,Sandeman D,Atkin SL

更新日期：2018-10-05 00:00:00

abstract：:The islet amyloid polypeptide (IAPP) or amylin maintains a key role in metabolism. This 37-residues-peptide could form pancreatic amyloids, which are a characteristic feature of diabetes mellitus type 2. However, some species do not form amyloid fibril structures. By employing a biomimetic approach, we generated an ex...

journal_title：Frontiers in endocrinology

authors： Pulido-Capiz A,Díaz-Molina R,Martínez-Navarro I,Guevara-Olaya LA,Casanueva-Pérez E,Mas-Oliva J,Rivero IA,García-González V

更新日期：2018-06-25 00:00:00

abstract：:Both males and females of heliothine moths utilize sex-pheromones during the mating process. Females produce and release a sex pheromone for the long-range attraction of males for mating. Production of sex pheromone in females is controlled by the peptide hormone (pheromone biosynthesis activating neuropeptide, PBAN)....

journal_title：Frontiers in endocrinology

authors： Jurenka R,Rafaeli A

更新日期：2011-10-10 00:00:00

abstract：:The brain orchestrates organ function and regulates whole body metabolism by the concerted action of neurons and glia cells in the central nervous system. To do so, the brain has tremendously high energy consumption and relies mainly on glucose utilization and mitochondrial function in order to exert its function. As ...

journal_title：Frontiers in endocrinology

authors： Castro JP,Wardelmann K,Grune T,Kleinridders A

更新日期：2018-04-26 00:00:00

abstract：:The plasticity of the individual epigenetic landscape that goes to countless rearrangements throughout life is closely the reflection of environmental factors such as chemical exposure, socio-economic status and nutrient intakes both early and late in life. The Mini Nutritional Assessment (MNA) is a well-validated too...

journal_title：Frontiers in endocrinology

authors： Montesanto A,D'Aquila P,Rossano V,Passarino G,Bellizzi D

更新日期：2019-10-01 00:00:00

abstract：:Autoimmune thyroid diseases (AITDs) are chronic organ-specific autoimmune diseases and mainly include Graves' disease (GD) and Hashimoto's thyroiditis (HT). CD14 is an important component of the immune system as a receptor for gram-negative lipopolysaccharide (LPS). The genetic polymorphisms of CD14 have been confirme...

journal_title：Frontiers in endocrinology

authors： Jia X,Wang B,Yao Q,Li Q,Zhang J

更新日期：2019-01-16 00:00:00

abstract：:The oncogene-induced senescence is emerging as a potent tumor suppressor mechanism and as a possible therapeutic target. Macroautophagy is intimately linked to the senescence condition setup, although its role has not been elucidated yet. Here, we discuss up-to-date concepts of senescence-related macroautophagy and ev...

journal_title：Frontiers in endocrinology

authors： Grasso D,Vaccaro MI

更新日期：2014-09-29 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fendo.2019.00025.]. ...

journal_title：Frontiers in endocrinology

authors： Bhusal A,Rahman MH,Lee IK,Suk K

更新日期：2019-04-09 00:00:00

abstract：:O-linked β-N-acetylglucosamine (O-GlcNAc) is an abundant and essential intracellular form of protein glycosylation in animals and plants. In humans, dysregulation of O-GlcNAcylation occurs in a wide range of diseases, including cancer, diabetes, and neurodegeneration. Since its discovery more than 30 years ago, great ...

journal_title：Frontiers in endocrinology

authors： Cox NJ,Luo PM,Smith TJ,Bisnett BJ,Soderblom EJ,Boyce M

更新日期：2018-10-15 00:00:00

abstract：:Brown adipose tissue (BAT) non-shivering thermogenesis impacts energy homeostasis in rodents and humans. Mitochondrial uncoupling protein 1 in brown fat cells produces heat by dissipating the energy generated by fatty acid and glucose oxidation. In addition to thermogenesis and despite its small relative size, sympath...

journal_title：Frontiers in endocrinology

authors： Festuccia WT,Blanchard PG,Deshaies Y

更新日期：2011-12-21 00:00:00

abstract：:The extracellular signal-regulated kinases (ERKs) are key components of multiple important cell signaling pathways regulating diverse biological responses. This signaling is characterized by phosphorylation cascades leading to ERK1/2 activation and promoted by various cell surface receptors including G protein-coupled...

journal_title：Frontiers in endocrinology

authors： Ayoub MA,Trebaux J,Vallaghe J,Charrier-Savournin F,Al-Hosaini K,Gonzalez Moya A,Pin JP,Pfleger KD,Trinquet E

更新日期：2014-06-23 00:00:00

abstract：Introduction:Obesity is associated with a higher risk of abortion in women undergoing in vitro fertilization (IVF). Whether thrombophilia amplifies this risk is currently unclear. The aim of this study was to evaluate the effects of thrombophilia on the risk of abortion in obese women treated with IVF. Methods:Patient...

journal_title：Frontiers in endocrinology

authors： Candeloro M,Di Nisio M,Ponzano A,Tiboni GM,Potere N,Tana M,Rutjes AWS,Porreca E

更新日期：2020-12-23 00:00:00

abstract：:Background: Disturbance of immunometabolic signaling is a key process involved in the progression of obesity. Microglia-the resident immune cells in the brain, initiate local immune responses. It is known that hypercaloric diets lead to microglial activation. Previously, we observed that hypothalamic microglial cells ...

journal_title：Frontiers in endocrinology

authors： Milanova IV,Kalsbeek MJT,Wang XL,Korpel NL,Stenvers DJ,Wolff SEC,de Goede P,Heijboer AC,Fliers E,la Fleur SE,Kalsbeek A,Yi CX

更新日期：2019-06-26 00:00:00