Changes in Blood microRNA Expression and Early Metabolic Responsiveness 21 Days Following Bariatric Surgery.

abstract：:Obesity is a prominent metabolic disease that predisposes individuals to multiple comorbidities, including type 2 diabetes mellitus, cardiovascular diseases, and cancer. Elevated circulating levels of fatty acids contribute to the development of obesity, in part, by targeting the hypothalamus. Palmitate, the most abun...

journal_title：Frontiers in endocrinology

authors： Tran A,He W,Jiang N,Chen JTC,Belsham DD

更新日期：2020-06-12 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fendo.2018.00031.]. ...

journal_title：Frontiers in endocrinology

authors： Beattie J,Al-Khafaji H,Noer PR,Alkharobi HE,Alhodhodi A,Meade J,El-Gendy R,Oxvig C

更新日期：2018-09-04 00:00:00

abstract：:It has been generally assumed that insulin circulates freely in blood. However it can also interact with plasma proteins. Insulin receptors are located in the membrane of target cells and consist of an alpha and beta subunits with a tyrosine kinase cytoplasmic domain. The ectodomain, called soluble insulin receptor (S...

journal_title：Frontiers in endocrinology

authors： Hiriart M,Sanchez-Soto C,Diaz-Garcia CM,Castanares DT,Avitia M,Velasco M,Mas-Oliva J,Macias-Silva M,González-Villalpando C,Delgado-Coello B,Sosa-Garrocho M,Vidaltamayo R,Fuentes-Silva D

更新日期：2014-06-19 00:00:00

abstract：:This review focuses on the biologic importance of the vitamin D binding protein (DBP) with emphasis on its regulation of total and free vitamin D metabolite levels in various clinical conditions. Nearly all DBP is produced in the liver, where its regulation is influenced by estrogen, glucocorticoids and inflammatory c...

journal_title：Frontiers in endocrinology

authors： Bikle DD,Schwartz J

更新日期：2019-05-28 00:00:00

abstract：:Type 2 diabetes affects racial/ethnic minorities at an alarming rate in the US and in many countries around the world. The quality of health care provided to these groups is often suboptimal, resulting in worse patient-related outcomes when compared to those in mainstream populations. Understanding the complex biologi...

journal_title：Frontiers in endocrinology

authors： Caballero AE

更新日期：2018-08-28 00:00:00

abstract：:Aim: Exercise training elicits diverse effects on brown (BAT) and white adipose tissue (WAT) physiology in rodents housed below their thermoneutral zone (i.e., 28-32°C). In these conditions, BAT is chronically hyperactive and, unlike human residence, closer to thermoneutrality. Therefore, we set out to determine the e...

journal_title：Frontiers in endocrinology

authors： Aldiss P,Lewis JE,Lupini I,Bloor I,Chavoshinejad R,Boocock DJ,Miles AK,Ebling FJP,Budge H,Symonds ME

更新日期：2020-03-20 00:00:00

abstract：Objectives:Based on data from the China National Health Survey, we aimed to examine the association between body height and cardiometabolic disease (CMD) in a large adult population from Shaanxi province, and further to test whether this association was hinged upon other population characteristics. Methods:This popula...

journal_title：Frontiers in endocrinology

authors： Yuan Y,Zhou B,Wang S,Ma J,Dong F,Yang M,Zhang Z,Niu W

更新日期：2020-12-21 00:00:00

abstract：:Reproductive status is tightly coupled to metabolic state in females, and ovarian cycling in mammals is halted when energy output exceeds energy input, a metabolic condition known as negative energy balance. This inhibition of reproductive function during negative energy balance occurs due to suppression of gonadotrop...

journal_title：Frontiers in endocrinology

authors： True C,Grove KL,Smith MS

更新日期：2011-10-17 00:00:00

abstract：:Background: Slow-wave activity (SWA) in non-rapid eye movement (NREM) sleep, obtained by spectral analysis of the electroencephalogram, is a marker of the depth or intensity of NREM sleep. Higher levels of SWA are associated with lower arousability during NREM sleep and protect against sleep fragmentation. Multiple st...

journal_title：Frontiers in endocrinology

authors： Morselli LL,Temple KA,Leproult R,Ehrmann DA,Van Cauter E,Mokhlesi B

更新日期：2018-07-12 00:00:00

abstract：:Osteoporosis is metabolic bone disease caused by an altered balance between bone anabolism and catabolism. This dysregulated balance is responsible for fragile bones that fracture easily after minor falls. With an aging population, the incidence is rising and as yet pharmaceutical options to restore this imbalance is ...

journal_title：Frontiers in endocrinology

authors： Bergen DJM,Kague E,Hammond CL

更新日期：2019-01-29 00:00:00

abstract：:Rationale: Hypoxia induces leptin gene expression in human adipocytes via hypoxia-inducible factors (HIF-α/β). Under ambient moderate hypoxia, leptin in adipocytes is elevated for at least 14 days. Leptin is supposedly involved in the reduced food intake, increased utilization of fatty acids for energy production and ...

journal_title：Frontiers in endocrinology

authors： Rausch LK,Hofer M,Pramsohler S,Kaser S,Ebenbichler C,Haacke S,Gatterer H,Netzer NC

更新日期：2018-10-18 00:00:00

abstract：:In a contribution to this Research Topic Erkki Somersalo and Daniela Calvetti carried out a mathematical analysis of neurotransmitter pathways in brain, modeling compartmental nitrogen flux among several major participants - ammonia, glutamine, glutamate, GABA, and selected amino acids. This analysis is important beca...

journal_title：Frontiers in endocrinology

authors： Cooper AJ

更新日期：2013-11-18 00:00:00

abstract：:The brain is composed of neurons and non-neuronal cells, with the latter encompassing glial, ependymal and endothelial cells, as well as pericytes and progenitor cells. Studies aimed at understanding how the brain operates have traditionally focused on neurons, but the importance of non-neuronal cells has become incre...

journal_title：Frontiers in endocrinology

authors： Argente-Arizón P,Freire-Regatillo A,Argente J,Chowen JA

更新日期：2015-03-26 00:00:00

abstract：:Maternal over-nutrition can lead to metabolic disorders in offspring, whereas maternal dietary genistein may have beneficial effects on the metabolic health of offspring. Our objective was to determine whether maternal dietary genistein could attenuate the detrimental effects of a maternal high-fat diet on their offsp...

journal_title：Frontiers in endocrinology

authors： Zhou L,Xiao X,Zhang Q,Zheng J,Li M,Yu M,Wang X,Deng M,Zhai X,Li R

更新日期：2018-09-04 00:00:00

abstract：:The mammalian genome contains four genes encoding GABA transporters (GAT1, slc6a1; GAT2, slc6a13; GAT3, slc6a11; BGT1, slc6a12) and five glutamate transporter genes (EAAT1, slc1a3; EAAT2, slc1a2; EAAT3, slc1a1; EAAT4, slc1a6; EAAT5, slc1a7). These transporters keep the extracellular levels of GABA and excitatory amino...

journal_title：Frontiers in endocrinology

authors： Zhou Y,Danbolt NC

更新日期：2013-11-11 00:00:00

abstract：:Anaplastic thyroid cancer is known to be the most lethal malignancy among endocrine tumors for its extremely limited survival rate after diagnosis. As a result of this poor survival prognosis, multimodal therapy is currently under investigation to address this global concern. In this reported case, the 125I seed impla...

journal_title：Frontiers in endocrinology

authors： Niu Y,Ding Z,Deng X,Guo B,Kang J,Wu B,Fan Y

更新日期：2020-04-22 00:00:00

abstract：:Sex pheromone production in most moths is initiated following pheromone biosynthesis activating neuropeptide receptor (PBANR) activation. PBANR was initially cloned from pheromone glands (PGs) of Helicoverpa zea and Bombyx mori. The B. mori PBANR is characterized by a relatively long C-terminus that is essential for l...

journal_title：Frontiers in endocrinology

authors： Lee JM,Hull JJ,Kawai T,Goto C,Kurihara M,Tanokura M,Nagata K,Nagasawa H,Matsumoto S

更新日期：2012-01-24 00:00:00

abstract：:Background: The management of children and adolescents with chronic kidney disease (CKD) and growth failure candidate for recombinant human growth hormone therapy (rhGH) is based on an appraisal of the literature established on a 2006 consensus statement and 2019 Clinical practice recommendations. The performance of t...

journal_title：Frontiers in endocrinology

authors： Cappa M,Maghnie M,Carbone V,Chioma L,Errichiello C,Giavoli C,Giordano M,Guazzarotti L,Klain A,Montini G,Murer L,Parpagnoli M,Pecoraro C,Pesce S,Verrina E

更新日期：2020-09-02 00:00:00

abstract：:Background: The relative contribution of reduced insulin sensitivity (Si) or insulin secretion to impaired fasting glucose (IFG) or diabetes mellitus (DM) has not been clarified in active acromegaly. An intravenous glucose tolerance test (IVGTT) was never used for the calculation of Si, acute insulin response (AIRg), ...

journal_title：Frontiers in endocrinology

authors： Niculescu DA,Dusceac R,Caragheorgheopol A,Popescu N,Poiana C

更新日期：2019-09-18 00:00:00

abstract：Background:In addition to inborn metabolic disorders, altered metabolic profiles were reported to be associated with the risk and prognosis of some non-metabolic diseases, while as a rare metabolic disease, the overall secondary metabolic spectrum in congenital hyperinsulinemic hypoglycemia (HH) is largely undetermined...

journal_title：Frontiers in endocrinology

authors： Xu ZR,Zhu XY,Lu W,Sun WH,Cheng RQ,Ni JW,Xi L,Hussain K,Luo FH,Zhang MY

更新日期：2020-10-08 00:00:00

abstract：INTRODUCTION:Risk of testicular germ cell tumors (TGCT) is consistently associated with a history of cryptorchidism (CO) in epidemiologic studies. Factors modifying the association may provide insights regarding etiology of TGCT and suggest a basis for individualized care of CO. To identify modifiers of the CO-TGCT ass...

journal_title：Frontiers in endocrinology

authors： Banks K,Tuazon E,Berhane K,Koh CJ,De Filippo RE,Chang A,Kim SS,Daneshmand S,Davis-Dao C,Lewinger JP,Bernstein L,Cortessis VK

更新日期：2013-02-18 00:00:00

abstract：:In mammals, glucosensing markers reside in brain areas known to play an important role in the control of food intake. The best characterized glucosensing mechanism is that dependent on glucokinase (GK) whose activation by increased levels of glucose leads in specific hypothalamic neurons to decreased or increased acti...

journal_title：Frontiers in endocrinology

authors： Otero-Rodiño C,Rocha A,Sánchez E,Álvarez-Otero R,Soengas JL,Cerdá-Reverter JM

更新日期：2019-04-18 00:00:00

abstract：Objective:Inflammation plays a central role in the pathogenesis of metabolic syndrome (MetS). Cyclophilin B (CypB) can be constitutively secreted in response to inflammatory stimuli and oxidative stress, participating in tissue or systemic inflammation. We investigated the relationship between CypB and MetS in both hum...

journal_title：Frontiers in endocrinology

authors： Zhang H,Fan Q,Xie H,Lu L,Tao R,Wang F,Xi R,Hu J,Chen Q,Shen W,Zhang R,Yan X

更新日期：2017-12-22 00:00:00

abstract：:Osteocytes are the most abundant (~95%) cells in bone with the longest half-life (~25 years) in humans. In the past osteocytes have been regarded as vestigial cells in bone, since they are buried inside the tough bone matrix. However, during the last 30 years it has become clear that osteocytes are as important as bon...

journal_title：Frontiers in endocrinology

authors： Pathak JL,Bravenboer N,Klein-Nulend J

更新日期：2020-07-08 00:00:00

abstract：:Gonadotropin-releasing hormone (GnRH) is the primary regulator of mammalian reproductive function in both males and females. It acts via G-protein coupled receptors on gonadotropes to stimulate synthesis and secretion of the gonadotropin hormones luteinizing hormone and follicle-stimulating hormone. These receptors co...

journal_title：Frontiers in endocrinology

authors： Perrett RM,McArdle CA

更新日期：2013-11-20 00:00:00

abstract：:Atherosclerosis results from endothelial cell dysfunction and inflammatory processes affecting both macro- and microvasculature which are involved in vascular diabetic complications. Glucagon-like peptide-1 (GLP-1) is an incretin hormone responsible for amplification of insulin secretion when nutrients are given orall...

journal_title：Frontiers in endocrinology

authors： Alonso N,Julián MT,Puig-Domingo M,Vives-Pi M

更新日期：2012-09-07 00:00:00

abstract：:Last two decades of structure-function studies performed in numerous laboratories provided substantial progress in understanding basic science, physiological, pathophysiological, pharmacological, and comparative aspects of glycoprotein hormones (GPHs) and their cognate receptors. Multiple concepts and models developed...

journal_title：Frontiers in endocrinology

authors： Szkudlinski MW

更新日期：2015-10-19 00:00:00

abstract：:Osteogenesis imperfecta (OI) is an inherited connective tissue disorder characterized by bone fragility and is characterized by clinical and genetic heterogeneity. Previous studies showed that the same mutation (c.-14C> T) of the IFITM5 gene is responsible for autosomal dominant OI type V. However, the mutation has a ...

journal_title：Frontiers in endocrinology

authors： Cao YJ,Wei Z,Zhang H,Zhang ZL

更新日期：2019-06-12 00:00:00

abstract：:Introduction: Adrenal myelolipomas are usually isolated benign adrenal lesions, but can be adjacent to steroid-secreting adrenocortical tumors. We studied the aberrant regulation of cortisol secretion in a 61 year-old woman with combined bilateral myelolipomas and primary bilateral macronodular adrenal hyperplasia (BM...

journal_title：Frontiers in endocrinology

authors： Larose S,Bondaz L,Mermejo LM,Latour M,Prosmanne O,Bourdeau I,Lacroix A

更新日期：2019-09-11 00:00:00

abstract：:11-ketotestosterone (11-KT) is a non-aromatizable and the most potent androgen in a few teleost. It has been reported that 11-KT in serum had a high concentration and increased sharply before the period of yolk deposition in females of few fishes. The aim of this study was to analyze the role of 11-KT both in vivo and...

journal_title：Frontiers in endocrinology

authors： Wang W,Zhu H,Tian Z,Sun A,Dong Y,Dong T,Hu H

更新日期：2020-03-25 00:00:00