Novel Aspects Concerning the Functional Cross-Talk between the Insulin/IGF-I System and Estrogen Signaling in Cancer Cells.

Abstract:

:The insulin/IGF system plays an important role in cancer progression. Accordingly, elevated levels of circulating insulin have been associated with an increased cancer risk as well as with aggressive and metastatic cancer phenotypes. Numerous studies have documented that estrogens cooperate with the insulin/IGF system in multiple pathophysiological conditions. The biological responses to estrogens are mainly mediated by the estrogen receptors (ER)α and ERβ, which act as transcription factors; however, several studies have recently demonstrated that a member of the G protein-coupled receptors, named GPR30/G-protein estrogen receptor (GPER), is also involved in the estrogen signaling in normal and malignant cells as well as in cancer-associated fibroblasts (CAFs). In this regard, novel mechanisms linking the action of estrogens through GPER with the insulin/IGF system have been recently demonstrated. This review recapitulates the relevant aspects of this functional cross-talk between the insulin/IGF and the estrogenic GPER transduction pathways, which occurs in various cell types and may account for cancer progression.

authors

De Marco P,Cirillo F,Vivacqua A,Malaguarnera R,Belfiore A,Maggiolini M

doi

10.3389/fendo.2015.00030

subject

Has Abstract

pub_date

2015-03-06 00:00:00

pages

30

issn

1664-2392

journal_volume

6

pub_type

杂志文章,评审
  • Association of GPx1 P198L and CAT C-262T Genetic Variations With Polycystic Ovary Syndrome in Chinese Women.

    abstract::Background: Oxidative stress plays an important role in the pathogenesis of polycystic ovary syndrome (PCOS). Glutathione peroxidase 1 (GPx1) and catalase (CAT) are the major intracellular antioxidant enzymes that can detoxify hydrogen peroxide into water, preventing cellular injury from reactive oxygen species. The a...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00771

    authors: Sun Y,Li S,Liu H,Gong Y,Bai H,Huang W,Liu Q,Guan L,Fan P

    更新日期:2019-11-08 00:00:00

  • Disruption in Thyroid Signaling Pathway: A Mechanism for the Effect of Endocrine-Disrupting Chemicals on Child Neurodevelopment.

    abstract::Thyroid hormones are crucial in normal brain development. Transient and mild thyroid hormone insufficiency in pregnancy is also associated with impaired neurodevelopment in the offspring (e.g., 3-4 IQ score loss in association with maternal free thyroxine in the lowest fifth percentile). While inadequate iodine intake...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2018.00204

    authors: Ghassabian A,Trasande L

    更新日期:2018-04-30 00:00:00

  • Genes and podocytes - new insights into mechanisms of podocytopathy.

    abstract::After decades of primarily morphological study, positional cloning of the NPHS1 gene was the landmark event that established aberrant podocyte genetics as a pivotal cause of malfunction of the glomerular filter. This ended any uncertainty whether genetic mutation plays a significant role in hereditary nephrotic syndro...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2014.00226

    authors: Bierzynska A,Soderquest K,Koziell A

    更新日期:2015-01-23 00:00:00

  • Isogenic Cellular Systems Model the Impact of Genetic Risk Variants in the Pathogenesis of Type 1 Diabetes.

    abstract::At least 57 independent loci within the human genome confer varying degrees of risk for the development of type 1 diabetes (T1D). The majority of these variants are thought to contribute to overall genetic risk by modulating host innate and adaptive immune responses, ultimately resulting in a loss of immunological tol...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2017.00276

    authors: Wallet MA,Santostefano KE,Terada N,Brusko TM

    更新日期:2017-10-18 00:00:00

  • Perilipin 5 Reduces Oxidative Damage Associated With Lipotoxicity by Activating the PI3K/ERK-Mediated Nrf2-ARE Signaling Pathway in INS-1 Pancreatic β-Cells.

    abstract::Oxidative stress induced by free fatty acid overload in pancreatic β-cells is a potential contributory factor to dysfunction of insulin secretion and apoptotic cell death. Perilipin 5 (Plin5) has been reported to ameliorate oxidative stress-mediated damage in non-insulin-secreting tissues. We tested the hypothesis tha...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00166

    authors: Zhu Y,Ren C,Zhang M,Zhong Y

    更新日期:2020-03-31 00:00:00

  • Effects of Growth Hormone Replacement on Peripheral Muscle and Exercise Capacity in Severe Growth Hormone Deficiency.

    abstract:Objective:The aim of this study is to evaluate the effect of growth hormone therapy (rGH) on mitochondrial function on peripheral muscle and to correlate with exercise capacity in subjects with severe adult growth hormone deficiency (GHD). Design:Six months, double-blind, randomized, crossover, placebo-controlled tria...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00056

    authors: Gonzalez S,Sathyapalan T,Javed Z,Atkin SL

    更新日期:2018-02-23 00:00:00

  • The Unique Metabolic Characteristics of Bone Marrow Adipose Tissue.

    abstract::Bone marrow adipose tissue (MAT) is distinct from white adipose tissue (WAT) or brown adipose tissue (BAT) for its location, feature and function. As a largely ignored adipose depot, it is situated in bone marrow space and resided with bone tissue side-by-side. MAT is considered not only as a regulator of bone metabol...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2019.00069

    authors: Li Y,Meng Y,Yu X

    更新日期:2019-02-08 00:00:00

  • Arcuate AgRP neurons and the regulation of energy balance.

    abstract::The arcuate nucleus of the hypothalamus contains at least two populations of neurons that continuously monitor signals reflecting energy status and promote the appropriate behavioral and metabolic responses to changes in energy demand. Activation of neurons making pro-opiomelanocortin (POMC) decreases food intake and ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2012.00169

    authors: Cansell C,Denis RG,Joly-Amado A,Castel J,Luquet S

    更新日期:2012-12-27 00:00:00

  • A Synoptic Overview of Neurovascular Interactions in the Foot.

    abstract::Diabetes is a worldwide public health concern as it is associated with various complications. One of the major complications of diabetes is diabetic foot syndrome that results in catastrophic events such as ulceration and amputation. Therefore, the main four strategies of diabetic foot care involve risk prediction, pr...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2020.00308

    authors: Balasubramanian G,Vas P,Chockalingam N,Naemi R

    更新日期:2020-05-22 00:00:00

  • miR-181b-5p May Regulate Muscle Growth in Tilapia by Targeting Myostatin b.

    abstract::Background: Myostatin (Mstn), a member of the TGF-β superfamily, is a negative regulator of skeletal muscle mass in mammals. Precise regulation of Mstn expression is important for somite growth in fish. MicroRNA (miRNA), a type of small non-coding RNA, regulates gene expression at the post-transcriptional level and pa...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00812

    authors: Zhao Z,Yu X,Jia J,Yang G,Sun C,Li W

    更新日期:2019-12-03 00:00:00

  • WNT Signaling and Bone: Lessons From Skeletal Dysplasias and Disorders.

    abstract::Skeletal dysplasias are a diverse group of heritable diseases affecting bone and cartilage growth. Throughout the years, the molecular defect underlying many of the diseases has been identified. These identifications led to novel insights in the mechanisms regulating bone and cartilage growth and homeostasis. One of t...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2020.00165

    authors: Huybrechts Y,Mortier G,Boudin E,Van Hul W

    更新日期:2020-04-09 00:00:00

  • SIRT1 and Estrogen Signaling Cooperation for Breast Cancer Onset and Progression.

    abstract::Breast cancer remains a significant female mortality cause. It constitutes a multifactorial disease for which research on environmental factors offers little help in predicting onset or progression. The pursuit for its foundations by analyzing hormonal changes as a motive for disease development, indicates that increa...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2018.00552

    authors: Liarte S,Alonso-Romero JL,Nicolás FJ

    更新日期:2018-09-27 00:00:00

  • Molecular Structure and Diversity of PBAN/pyrokinin Family Peptides in Ants.

    abstract::Neuropeptides are the largest group of insect hormones. They are produced in the central and peripheral nervous systems and affect insect development, reproduction, feeding, and behavior. A variety of neuropeptide families have been identified in insects. One of these families is the PBAN/pyrokinin family defined by a...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2012.00032

    authors: Choi MY,Vander Meer RK

    更新日期:2012-02-24 00:00:00

  • Three Therapeutic Strategies: Cinacalcet, Paricalcitol or Both in Secondary Hyperparathyroidism Treatment in Hemodialysed Patients During 1-Year Observational Study-A Comparison.

    abstract::Introduction: Secondary hyperparathyroidism (sHPT) is a common hormonal complication of chronic kidney disease. There are several therapeutic options for sHPT management aiming at calcium-phosphorus balance normalization and decrease of parathormone secretion. Objectives: The aim of this retrospective, observational s...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00040

    authors: Zawierucha J,Malyszko J,Malyszko JS,Prystacki T,Marcinkowski WP,Dryl-Rydzynska T

    更新日期:2019-02-05 00:00:00

  • People Are Taller in Countries With Better Environmental Conditions.

    abstract::Background: Height is considered an indicator of health and well-being of an individual and population. Height variation results from a complex interaction of genetic, environmental, socioeconomic, and cultural influences. In order to understand the contribution of environmental stress associated with the child's grow...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.00106

    authors: German A,Mesch G,Hochberg Z

    更新日期:2020-03-11 00:00:00

  • Allostatic Load and Stress Physiology in European Seabass (Dicentrarchus labrax L.) and Gilthead Seabream (Sparus aurata L.).

    abstract::The present study aimed to compare effects of increasing chronic stress load on the stress response of European seabass (Dicentrarchus labrax) and gilthead seabream (Sparus aurata) to identify neuroendocrine functions that regulate this response. Fish were left undisturbed (controls) or exposed to three levels of chro...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00451

    authors: Samaras A,Espírito Santo C,Papandroulakis N,Mitrizakis N,Pavlidis M,Höglund E,Pelgrim TNM,Zethof J,Spanings FAT,Vindas MA,Ebbesson LOE,Flik G,Gorissen M

    更新日期:2018-08-13 00:00:00

  • Effect of Endometrial Thickness Change in Response to Progesterone Administration on Pregnancy Outcomes in Frozen-Thawed Embryo Transfer: Analysis of 4465 Cycles.

    abstract:Objective:To evaluate whether endometrial thickness (EMT) change in response to progesterone has an effect on pregnancy outcomes in frozen-thawed embryo transfer (FET) cycles. Design:Retrospective observational study. Setting:Tertiary-care academic medical center. Participants:4465 infertile women undergoing their f...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.546232

    authors: Ye J,Zhang J,Gao H,Zhu Y,Wang Y,Cai R,Kuang Y

    更新日期:2020-10-29 00:00:00

  • A role for the androgen metabolite, 5alpha androstane 3beta, 17beta diol (3β-diol) in the regulation of the hypothalamo-pituitary-adrenal axis.

    abstract::Activation of the hypothalamo-pituitary-adrenal (HPA) axis is a basic reaction of animals to environmental perturbations that threaten homeostasis. These responses are ultimately regulated by neurons residing within the paraventricular nucleus (PVN) of the hypothalamus. Within the PVN, corticotrophin-releasing hormone...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2011.00065

    authors: Handa RJ,Sharma D,Uht R

    更新日期:2011-11-10 00:00:00

  • The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women.

    abstract::Background: The health benefits of soy are widely reported but there are queries on the effect of soy isoflavones on thyroid function and the underlying mechanism of action. Materials and Methods: We examined the effect of soy isoflavones on reverse tri-iodothyronine (or 3,3',5'-tri-iodothyronine; rT3) in two studies ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00698

    authors: Sathyapalan T,Köhrle J,Rijntjes E,Rigby AS,Dargham SR,Kilpatrick ES,Atkin SL

    更新日期:2018-11-22 00:00:00

  • Vitiligo and Autoimmune Thyroid Disorders.

    abstract::Vitiligo represents the most common cause of acquired skin, hair, and oral depigmentation, affecting 0.5-1% of the population worldwide. It is clinically characterized by the appearance of disfiguring circumscribed skin macules following melanocyte destruction by autoreactive cytotoxic T lymphocytes. Patients affected...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2017.00290

    authors: Baldini E,Odorisio T,Sorrenti S,Catania A,Tartaglia F,Carbotta G,Pironi D,Rendina R,D'Armiento E,Persechino S,Ulisse S

    更新日期:2017-10-27 00:00:00

  • Sonographic and Elastographic Features of Extra- and Intrathyroidal Ectopic Thymus Mimicking Malignancy: Differential Diagnosis in Children.

    abstract::Thyroid nodules with ultrasound (US) cancer risk features and extra-thyroid lesions suggesting malignant lymph nodes, require prompt diagnosis, especially in children. The US pattern of intrathyroidal ectopic thymus (IET) can strongly suggest papillary thyroid carcinoma (PTC). The extra-thyroid ectopic thymic tissue (...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2019.00223

    authors: Stasiak M,Adamczewski Z,Stawerska R,Krawczyk T,Tomaszewska M,Lewiński A

    更新日期:2019-04-10 00:00:00

  • Arginine Vasotocin Preprohormone Is Expressed in Surprising Regions of the Teleost Forebrain.

    abstract::Nonapeptides play a fundamental role in the regulation of social behavior, among numerous other functions. In particular, arginine vasopressin and its non-mammalian homolog, arginine vasotocin (AVT), have been implicated in regulating affiliative, reproductive, and aggressive behavior in many vertebrate species. Where...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2017.00195

    authors: Rodriguez-Santiago M,Nguyen J,Winton LS,Weitekamp CA,Hofmann HA

    更新日期:2017-08-14 00:00:00

  • Hypertriglyceridemia and Atherosclerosis: Using Human Research to Guide Mechanistic Studies in Animal Models.

    abstract::Human studies support a strong association between hypertriglyceridemia and atherosclerotic cardiovascular disease (CVD). However, whether a causal relationship exists between hypertriglyceridemia and increased CVD risk is still unclear. One plausible explanation for the difficulty establishing a clear causal role for...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2020.00504

    authors: Basu D,Bornfeldt KE

    更新日期:2020-08-06 00:00:00

  • Anti-Obesity Effect of Dictyophora indusiata Mushroom Polysaccharide (DIP) in High Fat Diet-Induced Obesity via Regulating Inflammatory Cascades and Intestinal Microbiome.

    abstract::Obesity is a multifactorial metabolic disorder characterized by low-grade chronic inflammation, hyper-permeability of the gut epithelium, and perturbation of the intestinal microbiome. Despite the numerous therapeutic efficacies of Dictyophora indusiata mushroom, its biological activity in alleviating obesity through ...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2020.558874

    authors: Kanwal S,Aliya S,Xin Y

    更新日期:2020-11-19 00:00:00

  • Physical Exercise and Its Protective Effects on Diabetic Cardiomyopathy: What Is the Evidence?

    abstract::As one of the most serious complications of diabetes, diabetic cardiomyopathy (DCM) imposes a huge burden on individuals and society, and represents a major public health problem. It has long been recognized that physical exercise has important health benefits for patients with type 2 diabetes, and regular physical ex...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2018.00729

    authors: Zheng J,Cheng J,Zheng S,Zhang L,Guo X,Zhang J,Xiao X

    更新日期:2018-12-03 00:00:00

  • Changes in Men's Salivary Testosterone and Cortisol Levels, and in Sexual Desire after Smelling Female Axillary and Vulvar Scents.

    abstract::Several studies have shown that a woman's vaginal or axillary odors convey information on her attractivity. Yet, whether such scents induce psychoneuroendocrinological changes in perceivers is still controversial. We studied if smelling axillary and vulvar odors collected in the periovulatory and late luteal phases of...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2013.00159

    authors: Cerda-Molina AL,Hernández-López L,de la O CE,Chavira-Ramírez R,Mondragón-Ceballos R

    更新日期:2013-10-28 00:00:00

  • A Short-Day Photoperiod Delays the Timing of Puberty in Female Mice via Changes in the Kisspeptin System.

    abstract::The reproduction of seasonal breeders is modulated by exposure to light in an interval of 24 h defined as photoperiod. The interruption of reproductive functions in seasonally breeding rodents is accompanied by the suppression of the Kiss1 gene expression, which is known to be essential for reproduction. In non-season...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章

    doi:10.3389/fendo.2018.00044

    authors: Bohlen TM,Silveira MA,Buonfiglio DDC,Ferreira-Neto HC,Cipolla-Neto J,Donato J Jr,Frazao R

    更新日期:2018-02-20 00:00:00

  • Low Prevalence of Isolated Growth Hormone Deficiency in Patients After Brain Injury: Results From a Phase II Pilot Study.

    abstract::Growth hormone deficiency (GHD) results in an impaired health-related quality of life (HrQoL) and cognitive impairment in the attention and memory domain. GHD is assumed to be a frequent finding after brain injury due to traumatic brain injury (TBI), aneurysmal subarachnoid hemorrhage (SAH) or ischemic stroke. Hence, ...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2018.00723

    authors: Leonhardt M,Kopczak A,Schäpers B,Limbrock J,Sämann PG,Czisch M,von Steinbuechel N,Jordan M,Schneider HJ,Schneider M,Sievers C,Stalla GK

    更新日期:2018-12-17 00:00:00

  • Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis.

    abstract::Obesity has emerged as one of the most burdensome conditions in modern society. In this context, understanding the mechanisms controlling food intake is critical. At present, the adipocyte-derived hormone leptin and the pancreatic β-cell-derived hormone insulin are considered the principal anorexigenic hormones. Altho...

    journal_title:Frontiers in endocrinology

    pub_type: 杂志文章,评审

    doi:10.3389/fendo.2016.00138

    authors: Thon M,Hosoi T,Ozawa K

    更新日期:2016-10-20 00:00:00

  • Effects of Sodium-Glucose Cotransporter Inhibitor/Glucagon-Like Peptide-1 Receptor Agonist Add-On to Insulin Therapy on Glucose Homeostasis and Body Weight in Patients With Type 1 Diabetes: A Network Meta-Analysis.

    abstract::Many patients with type 1 diabetes (T1D) do not achieve the glycemic target goal with insulin treatment. In this study, we aimed to evaluate the efficacy and safety of add-on to insulin therapy in patients with T1D. We conducted direct and indirect network meta-analyses using Bayesian models and ranked hypoglycemic ag...

    journal_title:Frontiers in endocrinology

    pub_type:

    doi:10.3389/fendo.2020.00553

    authors: Kim YJ,Hwang SD,Lim S

    更新日期:2020-08-19 00:00:00