Adult Body Height and Cardiometabolic Disease Risk: The China National Health Survey in Shaanxi.

abstract：:The pathophysiological function of the G-protein coupled melatonin MT1 and MT2 receptors has not yet been well-clarified. Recent advancements using selective MT1/ MT2 receptor ligands and MT1/MT2 receptor knockout mice have suggested that the activation of the MT1 receptors are mainly implicated in the regulation of r...

journal_title：Frontiers in endocrinology

authors： Gobbi G,Comai S

更新日期：2019-03-01 00:00:00

abstract：:Human studies support a strong association between hypertriglyceridemia and atherosclerotic cardiovascular disease (CVD). However, whether a causal relationship exists between hypertriglyceridemia and increased CVD risk is still unclear. One plausible explanation for the difficulty establishing a clear causal role for...

journal_title：Frontiers in endocrinology

authors： Basu D,Bornfeldt KE

更新日期：2020-08-06 00:00:00

abstract：:Sex steroids play essential roles in the modulation of synaptic plasticity and neuroprotection in the hippocampus. Accumulating evidence shows that hippocampal neurons synthesize both estrogen and androgen. Recently, we also revealed the hippocampal synthesis of corticosteroids. The accurate concentrations of these hi...

journal_title：Frontiers in endocrinology

authors： Hojo Y,Higo S,Kawato S,Hatanaka Y,Ooishi Y,Murakami G,Ishii H,Komatsuzaki Y,Ogiue-Ikeda M,Mukai H,Kimoto T

更新日期：2011-10-10 00:00:00

abstract：:Exercise training triggers numerous positive adaptations through the regulation of genes controlling muscle structure and function. Epigenetic modifications, including DNA methylation, participate in transcriptional activation by allowing the recruitment of the transcription machinery to gene promoters. Exercise induc...

journal_title：Frontiers in endocrinology

authors： Pattamaprapanont P,Garde C,Fabre O,Barrès R

更新日期：2016-12-23 00:00:00

abstract：:Remodeling of the cellular distribution of gap junctions formed mainly by connexin-43 (Cx43) can be related to the increased incidence of cardiac arrhythmias. It has been shown that adaptation to chronic intermittent hypobaric hypoxia (IHH) attenuates the incidence and severity of ischemic and reperfusion ventricular ...

journal_title：Frontiers in endocrinology

authors： Kohutova J,Elsnicova B,Holzerova K,Neckar J,Sebesta O,Jezkova J,Vecka M,Vebr P,Hornikova D,Szeiffova Bacova B,Egan Benova T,Hlavackova M,Tribulova N,Kolar F,Novakova O,Zurmanova JM

更新日期：2019-01-25 00:00:00

abstract：:We are witnessing a rapid worldwide increase in the incidence of papillary thyroid carcinoma (PTC) in the last thirty years. Extensive implementation of cancer screening and wide availability of neck ultrasound or other imaging studies is the main reason responsible for this phenomenon. It resulted in a detection of a...

journal_title：Frontiers in endocrinology

authors： Krajewska J,Kukulska A,Oczko-Wojciechowska M,Kotecka-Blicharz A,Drosik-Rutowicz K,Haras-Gil M,Jarzab B,Handkiewicz-Junak D

更新日期：2020-10-06 00:00:00

abstract：:Gonadotropin-inhibitory hormone (GnIH) was first identified in Japanese quail to be an inhibitor of gonadotropin synthesis and release. GnIH peptides have since been identified in all vertebrates, and all share an LPXRFamide (X = L or Q) motif at their C-termini. The receptor for GnIH is the G protein-coupled receptor...

journal_title：Frontiers in endocrinology

authors： Ubuka T,Son YL,Tobari Y,Narihiro M,Bentley GE,Kriegsfeld LJ,Tsutsui K

更新日期：2014-01-27 00:00:00

abstract：:RFamide-related peptide-3 (RFRP-3) [mammalian ortholog to gonadotropin-inhibiting hormone (GnIH)] potently inhibits gonadotropin secretion in mammals. Studies of RFRP-3 immunoreactivity and Rfrp expression (the gene encoding RFRP-3) in mammalian brains have uncovered several possible pathways regulating RFRP-3 neurons...

journal_title：Frontiers in endocrinology

authors： Poling MC,Kauffman AS

更新日期：2015-09-24 00:00:00

abstract：:It is now well-established that the pathways that control lymphocyte metabolism and function are intimately linked, and changes in lymphocyte metabolism can influence and direct cellular function. Interestingly, a number of recent advances indicate that lymphocyte identity and metabolism is partially controlled via ep...

journal_title：Frontiers in endocrinology

authors： Warren JL,MacIver NJ

更新日期：2019-07-11 00:00:00

abstract：:Estetrol (E4) is a natural human estrogen present at high concentrations during pregnancy. Due to its high oral bioavailability and long plasma half-life, E4 is particularly suitable for therapeutic applications. E4 acts as a selective estrogen receptor (ER) modulator, exerting estrogenic actions on the endometrium or...

journal_title：Frontiers in endocrinology

authors： Giretti MS,Montt Guevara MM,Cecchi E,Mannella P,Palla G,Spina S,Bernacchi G,Di Bello S,Genazzani AR,Genazzani AD,Simoncini T

更新日期：2014-05-26 00:00:00

abstract：:Background: Gestational diabetes (GDM) is associated with adverse short- and long-term maternal and fetal outcomes. Observational data support a link between sleep-disordered breathing (SDB) during pregnancy and GDM. However, it is unknown whether treatment of SDB with continuous positive airway pressure (CPAP) improv...

journal_title：Frontiers in endocrinology

authors： Pamidi S,Meltzer SJ,Garfield N,Lavigne L,Olha A,Khalyfa A,Benedetti A,Tremblay G,Gagnon R,Rey E,Dasgupta K,Kimoff RJ

更新日期：2018-11-16 00:00:00

abstract：:Responses to a high fat, high sucrose (HFHS) diet vary greatly among inbred strains of mice. We sought to examine the epigenetic (DNA methylation) changes underlying these differences as well as variation in weight loss when switched to a low-fat chow diet. We surveyed DNA methylation from livers of 45 inbred mouse st...

journal_title：Frontiers in endocrinology

authors： Edillor CR,Parks BW,Mehrabian M,Lusis AJ,Pellegrini M

更新日期：2019-12-20 00:00:00

abstract：:The mammalian genome contains four genes encoding GABA transporters (GAT1, slc6a1; GAT2, slc6a13; GAT3, slc6a11; BGT1, slc6a12) and five glutamate transporter genes (EAAT1, slc1a3; EAAT2, slc1a2; EAAT3, slc1a1; EAAT4, slc1a6; EAAT5, slc1a7). These transporters keep the extracellular levels of GABA and excitatory amino...

journal_title：Frontiers in endocrinology

authors： Zhou Y,Danbolt NC

更新日期：2013-11-11 00:00:00

abstract：:Neuropeptides are the largest group of insect hormones. They are produced in the central and peripheral nervous systems and affect insect development, reproduction, feeding, and behavior. A variety of neuropeptide families have been identified in insects. One of these families is the PBAN/pyrokinin family defined by a...

journal_title：Frontiers in endocrinology

authors： Choi MY,Vander Meer RK

更新日期：2012-02-24 00:00:00

abstract：:Evidence that adult humans have functional brown adipose tissue has stirred interest in the possibility that the impressive effectiveness of induction of brown adipocytes to reduce obesity in mice may be translated to the human condition. A major focus recently on the identification of signaling and transcription fact...

journal_title：Frontiers in endocrinology

authors： Kozak LP

更新日期：2011-10-31 00:00:00

abstract：:In a contribution to this Research Topic Erkki Somersalo and Daniela Calvetti carried out a mathematical analysis of neurotransmitter pathways in brain, modeling compartmental nitrogen flux among several major participants - ammonia, glutamine, glutamate, GABA, and selected amino acids. This analysis is important beca...

journal_title：Frontiers in endocrinology

authors： Cooper AJ

更新日期：2013-11-18 00:00:00

abstract：:A substantial body of evidence supports that the gut microbiota plays a pivotal role in the regulation of metabolic, endocrine and immune functions. In recent years, there has been growing recognition of the involvement of the gut microbiota in the modulation of multiple neurochemical pathways through the highly inter...

journal_title：Frontiers in endocrinology

authors： Silva YP,Bernardi A,Frozza RL

更新日期：2020-01-31 00:00:00

abstract：:Germline development in vivo is dependent on the environment formed by somatic cells and the differentiation cues they provide; hence, the impact of local factors is highly relevant to the production of sperm. Knowledge of how somatic and germline cells interact is central to achieving biomedical goals relating to res...

journal_title：Frontiers in endocrinology

authors： Loveland KL,Klein B,Pueschl D,Indumathy S,Bergmann M,Loveland BE,Hedger MP,Schuppe HC

更新日期：2017-11-20 00:00:00

abstract：:Radiotherapy continues to be one of the most accepted medical treatments for cancer. Localized irradiation is the most common treatment for prostate, pancreatic, rectal, cervical and endometrial malignancies. Conventional localized fractions are total doses of 30-62Gy at 1.8-2Gy per fraction, with administration of ~6...

journal_title：Frontiers in endocrinology

authors： Costa S,Reagan MR

更新日期：2019-08-29 00:00:00

abstract：Background:Renal function is profoundly influenced by thyroid hormone levels. This study was designed to evaluate the association between preoperative thyroid hormones and postoperative acute kidney injury (AKI) in acute type A aortic dissection (ATAAD) patients. Methods:A total of 88 patients with ATAAD who underwent...

journal_title：Frontiers in endocrinology

authors： Liu J,Xue Y,Jiang W,Zhang H,Zhao Y

更新日期：2020-11-18 00:00:00

abstract：:Osteogenesis imperfecta (OI) is an inherited connective tissue disorder characterized by bone fragility and is characterized by clinical and genetic heterogeneity. Previous studies showed that the same mutation (c.-14C> T) of the IFITM5 gene is responsible for autosomal dominant OI type V. However, the mutation has a ...

journal_title：Frontiers in endocrinology

authors： Cao YJ,Wei Z,Zhang H,Zhang ZL

更新日期：2019-06-12 00:00:00

abstract：:Background: POU1F1 is an essential transcription factor for the differentiation, proliferation and survival of somatotrophs, lactotrophs, and thyrotrophs. Mutations in the POU1F1 gene are characterized by growth hormone (GH), thyrotropin, and prolactin deficiencies, commonly presenting with growth retardation and cent...

journal_title：Frontiers in endocrinology

authors： Majdoub H,Amselem S,Legendre M,Rath S,Bercovich D,Tenenbaum-Rakover Y

更新日期：2019-06-27 00:00:00

abstract：:Failure of uterine vascular transformation is associated with pregnancy complications including Intra Uterine Growth Restriction (IUGR). The decidua and its immune cell populations play a key role in the earliest stages of this process. Here we investigate the hypothesis that abnormal decidualization and failure of ma...

journal_title：Frontiers in endocrinology

authors： Dunk C,Kwan M,Hazan A,Walker S,Wright JK,Harris LK,Jones RL,Keating S,Kingdom JCP,Whittle W,Maxwell C,Lye SJ

更新日期：2019-03-20 00:00:00

abstract：:Background: Several preclinical and clinical studies have suggested that BRCA-mutation carriers may have decreased ovarian reserve. However, data in this area are limited and inconsistent, especially in young breast cancer patients. Objective: This study evaluated the association between BRCA mutation status and serum...

journal_title：Frontiers in endocrinology

authors： Son KA,Lee DY,Choi D

更新日期：2019-04-11 00:00:00

abstract：:Linagliptin, one of the five dipeptidyl peptidase-4 inhibitors available, has recently entered the market both in the US and in most European countries for treatment of type 2 diabetes mellitus. It presents a xanthine-based structure, and is characterized by unique pharmacokinetics, with non-linear profile, long termi...

journal_title：Frontiers in endocrinology

authors： Sortino MA,Sinagra T,Canonico PL

更新日期：2013-02-26 00:00:00

abstract：:Background: The long noncoding RNA (lncRNA) functions as a regulator of initiation, progression, and metastasis of thyroid carcinomas. lncRNA OTUD6B antisense RNA 1 (OTUD6B-AS1) is a tumor-suppressive noncoding RNA in clear cell renal cell carcinoma. The role of OTUD6B-AS1 in thyroid carcinomas has not been reported y...

journal_title：Frontiers in endocrinology

authors： Wang Z,Xia F,Feng T,Jiang B,Wang W,Li X

更新日期：2020-03-17 00:00:00

abstract：:Background: Obesity and maternal age are the two most important factors independently affecting the risk of gestational diabetes mellitus (GDM). However, the age differences in the association between obesity and GDM remain unclear. The objectives of this cohort study included: (1) to determine the current incidence o...

journal_title：Frontiers in endocrinology

authors： Li G,Wei T,Ni W,Zhang A,Zhang J,Xing Y,Xing Q

更新日期：2020-09-11 00:00:00

abstract：:Growth hormone deficiency (GHD) results in an impaired health-related quality of life (HrQoL) and cognitive impairment in the attention and memory domain. GHD is assumed to be a frequent finding after brain injury due to traumatic brain injury (TBI), aneurysmal subarachnoid hemorrhage (SAH) or ischemic stroke. Hence, ...

journal_title：Frontiers in endocrinology

authors： Leonhardt M,Kopczak A,Schäpers B,Limbrock J,Sämann PG,Czisch M,von Steinbuechel N,Jordan M,Schneider HJ,Schneider M,Sievers C,Stalla GK

更新日期：2018-12-17 00:00:00

abstract：:Background: Height is considered an indicator of health and well-being of an individual and population. Height variation results from a complex interaction of genetic, environmental, socioeconomic, and cultural influences. In order to understand the contribution of environmental stress associated with the child's grow...

journal_title：Frontiers in endocrinology

authors： German A,Mesch G,Hochberg Z

更新日期：2020-03-11 00:00:00

abstract：:Reproductive status is tightly coupled to metabolic state in females, and ovarian cycling in mammals is halted when energy output exceeds energy input, a metabolic condition known as negative energy balance. This inhibition of reproductive function during negative energy balance occurs due to suppression of gonadotrop...

journal_title：Frontiers in endocrinology

authors： True C,Grove KL,Smith MS

更新日期：2011-10-17 00:00:00