The Potential Role of Platelet-Related microRNAs in the Development of Cardiovascular Events in High-Risk Populations, Including Diabetic Patients: A Review.

abstract：:Although the pathogenesis of Polycystic Ovary Syndrome (PCOS) is still unclear, the disturbance of hypothalamic-pituitary-gonadal (HPG) axis is suspected to be the main culprit in the development of PCOS. Kisspeptin, a hypothalamic peptide encoded by the KISS1 gene, is widely reported as a key factor in the regulation...

journal_title：Frontiers in endocrinology

authors： Tang R,Ding X,Zhu J

更新日期：2019-05-10 00:00:00

abstract：:Follicle stimulating hormone (FSH) plays a key role in human reproduction through, among others, induction of spermatogenesis in men and production of estrogen in women. The function FSH is performed upon binding to its cognate receptor-follicle-stimulating hormone receptor (FSHR) expressed on the surface of target ce...

journal_title：Frontiers in endocrinology

authors： Szymańska K,Kałafut J,Przybyszewska A,Paziewska B,Adamczuk G,Kiełbus M,Rivero-Müller A

更新日期：2018-12-13 00:00:00

abstract：:Sex pheromone production in most moths is initiated following pheromone biosynthesis activating neuropeptide receptor (PBANR) activation. PBANR was initially cloned from pheromone glands (PGs) of Helicoverpa zea and Bombyx mori. The B. mori PBANR is characterized by a relatively long C-terminus that is essential for l...

journal_title：Frontiers in endocrinology

authors： Lee JM,Hull JJ,Kawai T,Goto C,Kurihara M,Tanokura M,Nagata K,Nagasawa H,Matsumoto S

更新日期：2012-01-24 00:00:00

abstract：:Background: Female overweight/obesity has been reported to be associated with compromised pregnancy outcomes in fresh embryo transfer cycles. It is unclear whether the cumulative live birth rate (CLBR) is adversely affected after all viable embryos are transferred from the first ovarian stimulation cycle. Objectives: ...

journal_title：Frontiers in endocrinology

authors： Ding W,Zhang FL,Liu XC,Hu LL,Dai SJ,Li G,Kong HJ,Guo YH

更新日期：2019-08-02 00:00:00

abstract：:As one of the most serious complications of diabetes, diabetic cardiomyopathy (DCM) imposes a huge burden on individuals and society, and represents a major public health problem. It has long been recognized that physical exercise has important health benefits for patients with type 2 diabetes, and regular physical ex...

journal_title：Frontiers in endocrinology

authors： Zheng J,Cheng J,Zheng S,Zhang L,Guo X,Zhang J,Xiao X

更新日期：2018-12-03 00:00:00

abstract：:Calcium and bone homeostasis are intimately related. On the one hand, bone relies on a sufficient supply of calcium to maintain its structural and mechanical properties and thus largely depends on calcium absorption in the intestine and calcium reabsorption in the kidney. On the other hand, bone serves as a calcium re...

journal_title：Frontiers in endocrinology

authors： Lieben L,Carmeliet G

更新日期：2012-08-20 00:00:00

abstract：:Microtubule-associated protein tau assists in stabilizing microtubules and has been particularly implicated in Alzheimer's disease (AD). Given the importance of tau to AD pathogenesis and therapies, it is important to understand non-classic physiological functions for this protein inside and outside the central nervou...

journal_title：Frontiers in endocrinology

authors： Gonçalves RA,Wijesekara N,Fraser PE,De Felice FG

更新日期：2020-03-12 00:00:00

abstract：:Recent studies support the hypothesis that the adverse effects of early-life adversity and transgenerational stress on neural plasticity and behavior are mediated by inflammation. The objective of the present study was to investigate the immune and behavioral programing effects of intranasal (IN) vasopressin (AVP) and...

journal_title：Frontiers in endocrinology

authors： Murgatroyd CA,Hicks-Nelson A,Fink A,Beamer G,Gurel K,Elnady F,Pittet F,Nephew BC

更新日期：2016-12-14 00:00:00

abstract：:Objective: To study the impact of dose reduction in MDCT images through tube current reduction or sparse sampling on the vertebral bone strength prediction using finite element (FE) analysis for fracture risk assessment. Methods: Routine MDCT data covering lumbar vertebrae of 12 subjects (six male; six female; 74.70 ±...

journal_title：Frontiers in endocrinology

authors： Rayudu NM,Subburaj K,Mei K,Dieckmeyer M,Kirschke JS,Noël PB,Baum T

更新日期：2020-07-28 00:00:00

abstract：:The past two decades have witnessed many advances in the prevention, treatment, and control of diabetes mellitus (DM) and its complications. Increased screening has led to a greater recognition of type 2 diabetes mellitus (type 2 DM) and prediabetes; however, Hispanics/Latinos, the largest minority group in the US, ha...

journal_title：Frontiers in endocrinology

authors： Avilés-Santa ML,Colón-Ramos U,Lindberg NM,Mattei J,Pasquel FJ,Pérez CM

更新日期：2017-11-10 00:00:00

abstract：:After decades of primarily morphological study, positional cloning of the NPHS1 gene was the landmark event that established aberrant podocyte genetics as a pivotal cause of malfunction of the glomerular filter. This ended any uncertainty whether genetic mutation plays a significant role in hereditary nephrotic syndro...

journal_title：Frontiers in endocrinology

authors： Bierzynska A,Soderquest K,Koziell A

更新日期：2015-01-23 00:00:00

abstract：:Responses to a high fat, high sucrose (HFHS) diet vary greatly among inbred strains of mice. We sought to examine the epigenetic (DNA methylation) changes underlying these differences as well as variation in weight loss when switched to a low-fat chow diet. We surveyed DNA methylation from livers of 45 inbred mouse st...

journal_title：Frontiers in endocrinology

authors： Edillor CR,Parks BW,Mehrabian M,Lusis AJ,Pellegrini M

更新日期：2019-12-20 00:00:00

abstract：Objective:Two missense mutations in KCNQ1, an imprinted gene that encodes the alpha subunit of the voltage-gated potassium channel Kv7.1, cause autosomal dominant growth hormone deficiency and maternally inherited gingival fibromatosis. We evaluated endocrine features, birth size, and subsequent somatic growth of patie...

journal_title：Frontiers in endocrinology

authors： Huttunen H,Hero M,Lääperi M,Känsäkoski J,Swan H,Hirsch JA,Miettinen PJ,Raivio T

更新日期：2018-04-24 00:00:00

abstract：BACKGROUND:Monitoring blood levels of human growth hormone (hGH) in most children with short stature deficiencies is crucial for taking a decision of treatment with extended course of daily and expensive doses of recombinant hGH (rhGH or Somatropin®). Besides, misusing of rhGH by sportsmen is banned by the World Anti-D...

journal_title：Frontiers in endocrinology

authors： Murad H,Assaad JM,Al-Shemali R,Abbady AQ

更新日期：2017-05-30 00:00:00

abstract：Introduction:The oxidative stress associated with glucose variability might be responsible for neuronal damage while autonomic neuropathy (AN) has a detrimental effect on metabolism. The aim of the study was to find relationship between AN and GV in type 1 diabetic patients and to identify further factors that affect G...

journal_title：Frontiers in endocrinology

authors： Nyiraty S,Pesei F,Orosz A,Coluzzi S,Vági OE,Lengyel C,Ábrahám G,Frontoni S,Kempler P,Várkonyi T

更新日期：2018-04-19 00:00:00

abstract：:O-linked β-N-acetylglucosamine (O-GlcNAc) is an abundant and essential intracellular form of protein glycosylation in animals and plants. In humans, dysregulation of O-GlcNAcylation occurs in a wide range of diseases, including cancer, diabetes, and neurodegeneration. Since its discovery more than 30 years ago, great ...

journal_title：Frontiers in endocrinology

authors： Cox NJ,Luo PM,Smith TJ,Bisnett BJ,Soderblom EJ,Boyce M

更新日期：2018-10-15 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV)/AIDS pandemic represents the most significant global health challenge in modern history. This infection leads toward an inflammatory state associated with chronic immune dysregulation activation that tilts the immune-skeletal interface and its deep integration between cell...

journal_title：Frontiers in endocrinology

authors： Delpino MV,Quarleri J

更新日期：2020-09-02 00:00:00

abstract：:Fibrodysplasia ossificans progressiva (FOP) is an autosomal dominant disease, characterized by the formation of heterotopic ossification (HO) in muscles, ligaments, and tendons. Flare-ups, an inflammatory process that often precedes the formation of HO, can occur spontaneously, but trauma is also a common trigger. It ...

journal_title：Frontiers in endocrinology

authors： Botman E,Netelenbos JC,Rustemeyer T,Schoonmade LJ,Nieuwenhuijzen JA,Teunissen BP,Visser M,Raijmakers P,Lammertsma AA,Dahele M,Eekhoff M

更新日期：2020-02-12 00:00:00

abstract：:Early studies recognizing the importance of the decapod eyestalk in the endocrine regulation of crustacean physiology-molting, metabolism, reproduction, osmotic balance, etc.-helped found the field of crustacean endocrinology. Characterization of putative factors in the eyestalk using distinct functional bioassays ult...

journal_title：Frontiers in endocrinology

authors： Chen HY,Toullec JY,Lee CY

更新日期：2020-10-01 00:00:00

abstract：:Human phosphodiesterases (PDEs) comprise a complex superfamily of enzymes derived from 24 genes separated into 11 PDE gene families (PDEs 1-11), expressed in different tissues and cells, including heart and brain. The isoforms PDE4, PDE7, and PDE8 are specific for the second messenger cAMP, which is responsible for me...

journal_title：Frontiers in endocrinology

authors： Bizzi MF,Bolger GB,Korbonits M,Ribeiro-Oliveira A Jr

更新日期：2019-03-19 00:00:00

abstract：:Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is a rare cause of Cushing syndrome. If routine imaging examinations cannot identify the source of ACTH production, long-term follow-up observation is necessary to determine the etiology. We present the case of a middle-aged male with gradual weight gain and a ...

journal_title：Frontiers in endocrinology

authors： Lu L,Meng Q,Xing X,Yuan T,Zhang H,Li N,Wang Y,Cheng Y,Bai C,Wang H,Cheng X,Xiao Y,Pan B,Li Y,Sun J,Liang Z,Zhu H,Wang R,Lu Z

更新日期：2019-10-22 00:00:00

abstract：Introduction:Vitamin D deficiency is an important public health problem worldwide. Vitamin D deficiency confers a significant risk for both skeletal and non-skeletal disorders and a number of lifelong negative health outcomes. The objectives of this evidence-based guidelines document are to provide health care professi...

journal_title：Frontiers in endocrinology

authors： Rusińska A,Płudowski P,Walczak M,Borszewska-Kornacka MK,Bossowski A,Chlebna-Sokół D,Czech-Kowalska J,Dobrzańska A,Franek E,Helwich E,Jackowska T,Kalina MA,Konstantynowicz J,Książyk J,Lewiński A,Łukaszkiewicz J,Marcinowska

更新日期：2018-05-31 00:00:00

abstract：:Today, insulin analogs are used in millions of diabetic patients. Insulin analogs have been developed to achieve more physiological insulin replacement in terms of time-course of the effect. Modifications in the amino acid sequence of the insulin molecule change the pharmacokinetics and pharmacodynamics of the analogs...

journal_title：Frontiers in endocrinology

authors： Sciacca L,Le Moli R,Vigneri R

更新日期：2012-02-10 00:00:00

abstract：:Interferon gamma (IFNγ) is a Th1 cytokine that is critical for innate and adaptive immunity. Toll-like receptors (TLRs) signaling pathways are critical in early host defense against invading pathogens. miR-146a has been reported to participate in the regulation of host immunity. The known mechanisms of integrations be...

journal_title：Frontiers in endocrinology

authors： Peng W,Sun Y,Li GF,He LG,Li RZ,Liang YS,Ding X,Yu X,Zhang Y,Lin HR,Lu DQ

更新日期：2018-02-26 00:00:00

abstract：:Although G protein-coupled receptor (GPCR) internalization has long been considered as a major aspect of the desensitization process that tunes ligand responsiveness, internalization is also involved in receptor resensitization and signaling, as well as the ligand scavenging function of some atypical receptors. Intern...

journal_title：Frontiers in endocrinology

authors： Levoye A,Zwier JM,Jaracz-Ros A,Klipfel L,Cottet M,Maurel D,Bdioui S,Balabanian K,Prézeau L,Trinquet E,Durroux T,Bachelerie F

更新日期：2015-11-09 00:00:00

abstract：:Background: Carney complex (CNC) is a rare multiple endocrine neoplasia syndrome with autosomal dominant inheritance. Affected individuals present with mucocutaneous lentigines/blue nevi, cardiac and noncardiac myxomatous tumors, and multiple endocrine tumors. Mutations in PRKAR1A have been identified as genetic cause...

journal_title：Frontiers in endocrinology

authors： Ralser DJ,Strizek B,Kupczyk P,Stoffel-Wagner B,Altengarten J,Müller A,Woelfle J,Gembruch U,Klingmueller D,Merz WM,Paschkowiak-Christes A

更新日期：2020-05-08 00:00:00

abstract：:Previous work has shown that reduced expression of PLCXD3, a member of the phosphoinositide-specific phospholipases (PI-PLC) family, impaired insulin secretion with an unclear mechanism. In the current study, we aim to investigate the mechanism underlying this effect using human islets and rat INS-1 (832/13) cells. Mi...

journal_title：Frontiers in endocrinology

authors： Aljaibeji H,Mukhopadhyay D,Mohammed AK,Dhaiban S,Hachim MY,Elemam NM,Sulaiman N,Salehi A,Taneera J

更新日期：2019-11-06 00:00:00

abstract：:[This corrects the article on p. 26 in vol. 9, PMID: 29487564.]. ...

journal_title：Frontiers in endocrinology

authors： Konya J,Spurgeon BEJ,Al Qaissi A,Sathyapalan T,Ajjan R,Madden L,Naseem KM,Garrett AT,Kilpatrick E,Atkin SL

更新日期：2018-06-07 00:00:00

abstract：:Introduction: An increase of serum dehydroepiandrosterone (DHEA) sulfate (DHEAS) is observed in premature adrenarche and congenital adrenal hyperplasia. Very high DHEAS levels are typical for adrenal tumors. Approximately 74% of DHEAS is hydrolyzed to DHEA by the steroid sulfatase (STS). The reverse reaction is DHEA s...

journal_title：Frontiers in endocrinology

authors： Iliev DI,Braun R,Sánchez-Guijo A,Hartmann M,Wudy SA,Heckmann D,Bruchelt G,Rösner A,Grosser G,Geyer J,Binder G

更新日期：2020-05-06 00:00:00

abstract：:Thyroid hormone concentrations only become sufficient to maintain a euthyroid state through appropriate stimulation by pituitary thyroid-stimulating hormone (TSH). In such a dynamic system under constant high pressure, guarding against overstimulation becomes vital. Therefore, several defensive mechanisms protect agai...

journal_title：Frontiers in endocrinology

authors： Hoermann R,Midgley JE,Larisch R,Dietrich JW

更新日期：2016-11-07 00:00:00