Regulation and Function of RFRP-3 (GnIH) Neurons during Postnatal Development.

abstract：:Somatostatin is highly expressed in mammalian brain and is involved in many brain functions such as motor activity, sleep, sensory, and cognitive processes. Five somatostatin receptors have been described: sst(1), sst(2) (A and B), sst(3), sst(4), and sst(5), all belonging to the G-protein-coupled receptor family. Dur...

journal_title：Frontiers in endocrinology

authors： Martel G,Dutar P,Epelbaum J,Viollet C

更新日期：2012-12-06 00:00:00

abstract：:The post-translational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) is regulated by a unique couple of enzymes. O-GlcNAc transferase (OGT) transfers the GlcNAc residue from UDP-GlcNAc, the final product of the hexosamine biosynthetic pathway (HBP), whereas O-GlcNAcase (OGA) removes it. This st...

journal_title：Frontiers in endocrinology

authors： Steenackers A,Olivier-Van Stichelen S,Baldini SF,Dehennaut V,Toillon RA,Le Bourhis X,El Yazidi-Belkoura I,Lefebvre T

更新日期：2016-05-25 00:00:00

abstract：:The brain is composed of neurons and non-neuronal cells, with the latter encompassing glial, ependymal and endothelial cells, as well as pericytes and progenitor cells. Studies aimed at understanding how the brain operates have traditionally focused on neurons, but the importance of non-neuronal cells has become incre...

journal_title：Frontiers in endocrinology

authors： Argente-Arizón P,Freire-Regatillo A,Argente J,Chowen JA

更新日期：2015-03-26 00:00:00

abstract：:We sought to determine the efficacy of 12 weeks high-intensity interval training (HIIT), compared to moderate-intensity continuous training (MICT) on glucose control, cardiometabolic risk and microvascular complication markers in men living with type 2 diabetes (T2D). Both modalities were combined with resistance trai...

journal_title：Frontiers in endocrinology

authors： Wormgoor SG,Dalleck LC,Zinn C,Borotkanics R,Harris NK

更新日期：2018-08-28 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fendo.2017.00018.]. ...

journal_title：Frontiers in endocrinology

authors： Sekar R,Wang L,Chow BKC

更新日期：2018-07-18 00:00:00

abstract：:Type 2 diabetes prevalence is increasing dramatically worldwide. Metabolic surgery is the most effective treatment for selected patients with diabetes and/or obesity. When compared to intensive medical therapy and lifestyle intervention, metabolic surgery has shown superiority in achieving glycemic improvement, reduci...

journal_title：Frontiers in endocrinology

authors： Pérez-Pevida B,Escalada J,Miras AD,Frühbeck G

更新日期：2019-09-19 00:00:00

abstract：:Spinal cord injuries (SCIs) represent a variety of conditions related to the damage of the spinal cord with consequent musculoskeletal repercussions. The bone and muscle tissues share several catabolic pathways that lead to variable degrees of disability in SCI patients. In this review article, we provide a comprehens...

journal_title：Frontiers in endocrinology

authors： Invernizzi M,de Sire A,Renò F,Cisari C,Runza L,Baricich A,Carda S,Fusco N

更新日期：2020-04-15 00:00:00

abstract：:The islet amyloid polypeptide (IAPP) or amylin maintains a key role in metabolism. This 37-residues-peptide could form pancreatic amyloids, which are a characteristic feature of diabetes mellitus type 2. However, some species do not form amyloid fibril structures. By employing a biomimetic approach, we generated an ex...

journal_title：Frontiers in endocrinology

authors： Pulido-Capiz A,Díaz-Molina R,Martínez-Navarro I,Guevara-Olaya LA,Casanueva-Pérez E,Mas-Oliva J,Rivero IA,García-González V

更新日期：2018-06-25 00:00:00

abstract：:Multiple Endocrine Neoplasia type 1 (MEN1) is a rare autosomal dominant inherited condition, causing significant morbidity, and a reduction of life expectancy. A timely and accurate diagnosis of MEN1 is paramount to improve disease outcomes. This enables early identification of tumor manifestations allowing timely tre...

journal_title：Frontiers in endocrinology

authors： de Laat JM,van Leeuwaarde RS,Valk GD

更新日期：2018-09-11 00:00:00

abstract：Background:Levothyroxine sodium (LT4) is the therapy of choice for hypothyroidism. In the last decade, new LT4 formulations, such as liquid and softgel capsules, became available. Even if some evidence has been reached in the efficacy of liquid LT4 in patients with suboptimal TSH on tablet LT4, the usefulness of softge...

journal_title：Frontiers in endocrinology

authors： Trimboli P,Virili C,Centanni M,Giovanella L

更新日期：2018-03-21 00:00:00

abstract：:Background: Myostatin (Mstn), a member of the TGF-β superfamily, is a negative regulator of skeletal muscle mass in mammals. Precise regulation of Mstn expression is important for somite growth in fish. MicroRNA (miRNA), a type of small non-coding RNA, regulates gene expression at the post-transcriptional level and pa...

journal_title：Frontiers in endocrinology

authors： Zhao Z,Yu X,Jia J,Yang G,Sun C,Li W

更新日期：2019-12-03 00:00:00

abstract：AIM:The leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (DM) is coronary artery disease (CAD), a condition often asymptomatic but severe in these patients. Although glucose metabolism impairment and oxidative stress are known actors in the endothelial dysfunction/remodeling that occur...

journal_title：Frontiers in endocrinology

authors： Infante T,Forte E,Aiello M,Salvatore M,Cavaliere C

更新日期：2017-08-21 00:00:00

abstract：:Phthalates are ubiquitous environmental endocrine-disrupting chemicals suspected to interfere with developmental androgen action leading to adverse effects on male reproductive function. Prenatal exposure studies in rodents show cryptorchidism, hypospadias and reduced testicular volume (TV), testosterone and anogenita...

journal_title：Frontiers in endocrinology

authors： Hart RJ,Frederiksen H,Doherty DA,Keelan JA,Skakkebaek NE,Minaee NS,McLachlan R,Newnham JP,Dickinson JE,Pennell CE,Norman RJ,Main KM

更新日期：2018-06-04 00:00:00

abstract：:After decades of primarily morphological study, positional cloning of the NPHS1 gene was the landmark event that established aberrant podocyte genetics as a pivotal cause of malfunction of the glomerular filter. This ended any uncertainty whether genetic mutation plays a significant role in hereditary nephrotic syndro...

journal_title：Frontiers in endocrinology

authors： Bierzynska A,Soderquest K,Koziell A

更新日期：2015-01-23 00:00:00

abstract：:Background: IL-36α is involved in the pathogenesis of a variety of autoimmune diseases, but the relationship between IL-36α and Graves' disease (GD) has rarely investigated. In the present study, we aimed to explore the expression of IL-36α and elucidate the potential role of IL-36α in GD. Methods: The expression of I...

journal_title：Frontiers in endocrinology

authors： Yao QM,Li L,Song ZY,Wang B,Qin Q,An XF,Zhang JA

更新日期：2018-10-09 00:00:00

abstract：:Neurons and pancreatic endocrine cells have a common physiology and express a similar toolkit of transcription factors during development. To explain these common features, it has been hypothesized that pancreatic cells most likely co-opted a pre-existing gene regulatory program from ancestral neurons. To test this id...

journal_title：Frontiers in endocrinology

authors： Perillo M,Paganos P,Mattiello T,Cocurullo M,Oliveri P,Arnone MI

更新日期：2018-11-02 00:00:00

abstract：:Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory cytokines, myokines, and osteokines, contribute substantially to the development of abnormal glucose and lipid metabolism. Some cytokines play a positive role in metabolism action, while others have a negative metabolic role l...

journal_title：Frontiers in endocrinology

authors： Shi J,Fan J,Su Q,Yang Z

更新日期：2019-10-30 00:00:00

abstract：:Pulmonary fibrosis is a hallmark of diseases such as systemic sclerosis (SSc, scleroderma) and idiopathic pulmonary fibrosis (IPF). To date, the therapeutic options for patients with pulmonary fibrosis are limited, and organ transplantation remains the most effective option. Insulin-like growth factor-binding protein ...

journal_title：Frontiers in endocrinology

authors： Nguyen XX,Muhammad L,Nietert PJ,Feghali-Bostwick C

更新日期：2018-10-15 00:00:00

abstract：:Breast cancer (BC) is one of the most common malignancies and the leading cause of cancer-related mortality in women. Androgen receptor (AR) is frequently expressed in diverse BC subtypes. Accumulating evidence has revealed that AR might be a predictive or prognostic factor and a drug target in BC. AR expression and A...

journal_title：Frontiers in endocrinology

authors： Chen M,Yang Y,Xu K,Li L,Huang J,Qiu F

更新日期：2020-09-02 00:00:00

abstract：:Obesity is a multifactorial metabolic disorder characterized by low-grade chronic inflammation, hyper-permeability of the gut epithelium, and perturbation of the intestinal microbiome. Despite the numerous therapeutic efficacies of Dictyophora indusiata mushroom, its biological activity in alleviating obesity through ...

journal_title：Frontiers in endocrinology

authors： Kanwal S,Aliya S,Xin Y

更新日期：2020-11-19 00:00:00

abstract：:[This corrects the article on p. 219 in vol. 8, PMID: 28912754.]. ...

journal_title：Frontiers in endocrinology

authors： Zengin A,Fulford AJ,Sawo Y,Jarjou LM,Schoenmakers I,Goldberg G,Prentice A,Ward KA

更新日期：2018-04-16 00:00:00

abstract：:Gonadotropin-releasing hormone 1 (GnRH1) and its receptor (GnRHR1) drive mammalian reproduction via regulation of the gonadotropins. Yet, a second form of GnRH (GnRH2) and its receptor (GnRHR2) also exist in mammals. GnRH2 has been completely conserved throughout 500 million years of evolution, signifying high selecti...

journal_title：Frontiers in endocrinology

authors： Desaulniers AT,Cederberg RA,Lents CA,White BR

更新日期：2017-12-11 00:00:00

abstract：:The AMP-activated protein kinase (AMPK) is an important cellular energy sensor. Its activation under energetic stress is known to activate energy-producing pathways and to inactivate energy-consuming pathways, promoting ATP preservation and cell survival. AMPK has been shown to play protective role in many pathophysio...

journal_title：Frontiers in endocrinology

authors： Gélinas R,Dontaine J,Horman S,Beauloye C,Bultot L,Bertrand L

更新日期：2018-09-13 00:00:00

abstract：:Pregnancy-associated plasma protein-A (PAPP-A) and its homolog PAPP-A2 are enzymes that modulate the availability and mitogenic activity of insulin-like growth factor-I (IGF-I). PAPP-A has been implicated in numerous cancers but reports on PAPP-A2 in malignancy are non-existent. In a prospective observational study of...

journal_title：Frontiers in endocrinology

authors： Hjortebjerg R,Espelund U,Rasmussen TR,Folkersen B,Steiniche T,Georgsen JB,Oxvig C,Frystyk J

更新日期：2020-09-02 00:00:00

abstract：:Background: Female overweight/obesity has been reported to be associated with compromised pregnancy outcomes in fresh embryo transfer cycles. It is unclear whether the cumulative live birth rate (CLBR) is adversely affected after all viable embryos are transferred from the first ovarian stimulation cycle. Objectives: ...

journal_title：Frontiers in endocrinology

authors： Ding W,Zhang FL,Liu XC,Hu LL,Dai SJ,Li G,Kong HJ,Guo YH

更新日期：2019-08-02 00:00:00

abstract：:Enteroendocrine cells lining the gut epithelium constitute the largest endocrine organ in the body and secrete over 20 different hormones in response to cues from ingested foods and changes in nutritional status. Not only do these hormones convey signals from the gut to the brain via the gut-brain axis, they also act ...

journal_title：Frontiers in endocrinology

authors： Sun EWL,Martin AM,Young RL,Keating DJ

更新日期：2019-01-04 00:00:00

abstract：:Poor sleep and obesity are both extraordinarily common in the US adolescent population and often occur simultaneously. This review explores the links between obesity and sleep, outlining what is known about the relationships between sleep characteristics, obesity, and cardiometabolic risk factors in youth. Sleep durat...

journal_title：Frontiers in endocrinology

authors： Gohil A,Hannon TS

更新日期：2018-07-10 00:00:00

abstract：:The origin of the coronavirus disease 2019 (COVID-19) pandemic is zoonotic. The circadian day-night is the rhythmic clue to organisms for their synchronized body functions. The "development for mankind" escalated the use of artificial light at night (ALAN). In this article, we tried to focus on the possible influence ...

journal_title：Frontiers in endocrinology

authors： Khan ZA,Yumnamcha T,Mondal G,Devi SD,Rajiv C,Labala RK,Sanjita Devi H,Chattoraj A

更新日期：2020-09-10 00:00:00

abstract：:The reproduction of seasonal breeders is modulated by exposure to light in an interval of 24 h defined as photoperiod. The interruption of reproductive functions in seasonally breeding rodents is accompanied by the suppression of the Kiss1 gene expression, which is known to be essential for reproduction. In non-season...

journal_title：Frontiers in endocrinology

authors： Bohlen TM,Silveira MA,Buonfiglio DDC,Ferreira-Neto HC,Cipolla-Neto J,Donato J Jr,Frazao R

更新日期：2018-02-20 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is the commonest endocrine abnormality in women of reproductive age typically presenting with chronic oligo- or anovulation, clinical, or biochemical hyperandrogenism and polycystic ovarian morphology (PCOM). Restoring mono-ovulation is the ultimate goal of ovulation induction and most...

journal_title：Frontiers in endocrinology

authors： Laven JSE

更新日期：2019-02-12 00:00:00