The "A to Z" of Managing Type 2 Diabetes in Culturally Diverse Populations.

abstract：:Context: The DICER1 syndrome is a multiple neoplasia disorder caused by germline mutations in the DICER1 gene. In DICER1 patients, aggressive congenital pituitary tumors lead to neonatal Cushing's disease (CD). The role of DICER1 in other corticotropinomas, however, remains unknown. Objective: To perform a comprehensi...

journal_title：Frontiers in endocrinology

authors： Martínez de LaPiscina I,Hernández-Ramírez LC,Portillo N,Gómez-Gila AL,Urrutia I,Martínez-Salazar R,García-Castaño A,Aguayo A,Rica I,Gaztambide S,Faucz FR,Keil MF,Lodish MB,Quezado M,Pankratz N,Chittiboina P,Lane J,Kay D

更新日期：2020-07-03 00:00:00

abstract：:Objective: Acromegalic patients display a distinct neuropsychological profile and suffer from chronic physical complaints. We aimed to investigate in more detail these aspects in acromegalic patients, dependent on influencing factors like disease activity, age, sex, chronic medication, surgery, pituitary radiation, pi...

journal_title：Frontiers in endocrinology

authors： Zimmermann A,Zwerenz R,Droste M,Schöfl C,Strasburger CJ,Plöckinger U,Ziagaki A,Honegger J,Dixius A,Millaku B,Toenges G,Beutel ME,Weber MM

更新日期：2018-07-17 00:00:00

abstract：:Besides aging, a number of non-modifiable lifestyle-related factors, such as smoking, elevated consumption of caffeine and alcohol, stress, agonist sports, chronic exposure to environmental pollutants, and other nutritional habits exert a negative impact on a women's fertility. In particular, metabolic disorders inclu...

journal_title：Frontiers in endocrinology

authors： Silvestris E,Lovero D,Palmirotta R

更新日期：2019-06-07 00:00:00

abstract：Purpose:To assess whether volumetric vertebral bone mineral density (BMD) measured with opportunistic quantitative computed tomography (QCT) (i.e., CT acquired for other reasons) can predict osteoporotic fracture occurrence in a prospective clinical cohort and how this performs in comparison to dual-energy X-ray absorp...

journal_title：Frontiers in endocrinology

authors： Leonhardt Y,May P,Gordijenko O,Koeppen-Ursic VA,Brandhorst H,Zimmer C,Makowski MR,Baum T,Kirschke JS,Gersing AS,Seifert-Klauss V,Schwaiger BJ

更新日期：2020-11-09 00:00:00

abstract：:McCune-Albright Syndrome (MAS; OMIM # 174800) is a rare, sporadic disease caused by a post-zygotic, activating mutation in the guanine-nucleotide binding protein α-subunit (GNAS1) gene. MAS is characterized by the clinical triad of polyostotic fibrous dysplasia of bone, café-au-lait skin pigmentation and peripheral pr...

journal_title：Frontiers in endocrinology

authors： Corica D,Aversa T,Pepe G,De Luca F,Wasniewska M

更新日期：2018-06-22 00:00:00

abstract：:Dopamine (DA) has a vital role in the central nervous system and also modulates lipid and glucose metabolism. The present study aimed to investigate the effect of dopamine on insulin secretion and the underlying mechanisms in rat pancreatic β-cells. Data from the radioimmunoassay indicated that dopamine inhibited insu...

journal_title：Frontiers in endocrinology

authors： Liu M,Ren L,Zhong X,Ding Y,Liu T,Liu Z,Yang X,Cui L,Yang L,Fan Y,Liu Y,Zhang Y

更新日期：2020-04-07 00:00:00

abstract：:Testosterone is responsible for several changes in the brain, including behavioral and emotional responses, memory, and cognition. Given this, we investigated changes in the brain wave profile caused by supplementation with exogenous testosterone in both castrated and non-castrated rats. We also investigated the serum...

journal_title：Frontiers in endocrinology

authors： Estumano DP,Ferreira LO,Bezerra PAL,da Silva MCP,Jardim GC,Santos GFS,Gustavo KS,Mattos BG,Ramos JAB,Jóia de Mello V,da Costa ET,Lopes DCF,Hamoy M

更新日期：2019-09-24 00:00:00

abstract：:Obesity is associated with inflammation and type 2 diabetes. Innate immune system comprised of cellular and molecular components plays an important role in the inflammatory reactions. Immune cells like macrophages and their cell surface pattern-recognition receptors (PRRs) are representative for innate immunity promot...

journal_title：Frontiers in endocrinology

authors： Yamamoto Y,Yamamoto H

更新日期：2013-08-21 00:00:00

abstract：:Objective: This study aimed to test associations between type 2 diabetes mellitus (T2DM) and metabolites in urea cycle including arginine, citrulline and ornithine. Methods:This study used a hospital-based cross-sectional study design. We retrieved medical notes of 401 in-patients with onset of T2DM within 2 years and...

journal_title：Frontiers in endocrinology

authors： Cao YF,Li J,Zhang Z,Liu J,Sun XY,Feng XF,Luo HH,Yang W,Li SN,Yang X,Fang ZZ

更新日期：2019-02-18 00:00:00

abstract：Introduction:Obesity is associated with a higher risk of abortion in women undergoing in vitro fertilization (IVF). Whether thrombophilia amplifies this risk is currently unclear. The aim of this study was to evaluate the effects of thrombophilia on the risk of abortion in obese women treated with IVF. Methods:Patient...

journal_title：Frontiers in endocrinology

authors： Candeloro M,Di Nisio M,Ponzano A,Tiboni GM,Potere N,Tana M,Rutjes AWS,Porreca E

更新日期：2020-12-23 00:00:00

abstract：:Spinal cord injuries (SCIs) represent a variety of conditions related to the damage of the spinal cord with consequent musculoskeletal repercussions. The bone and muscle tissues share several catabolic pathways that lead to variable degrees of disability in SCI patients. In this review article, we provide a comprehens...

journal_title：Frontiers in endocrinology

authors： Invernizzi M,de Sire A,Renò F,Cisari C,Runza L,Baricich A,Carda S,Fusco N

更新日期：2020-04-15 00:00:00

abstract：:In neuroendocrine cells, prohormones move from the endoplasmic reticulum to the Golgi complex (GC), where they are sorted and packed into secretory granules. The GC is considered the central station of the secretory pathway of proteins and lipids en route to their final destination. In most mammalian cells, it is form...

journal_title：Frontiers in endocrinology

authors： Martínez-Alonso E,Tomás M,Martínez-Menárguez JA

更新日期：2013-03-28 00:00:00

abstract：Background:Repeated radioiodine (131I) treatment (RT) are commonly performed in patients with 131I-avid distant metastatic differentiated thyroid cancer (DM-DTC), but more precise indications remain indeterminate. This prospective study was conducted to explore predictors for biochemical response (BR) to next RT. Meth...

journal_title：Frontiers in endocrinology

authors： Sa R,Cheng L,Jin Y,Fu H,Shen Y,Chen L

更新日期：2020-11-16 00:00:00

abstract：:Reproductive status is tightly coupled to metabolic state in females, and ovarian cycling in mammals is halted when energy output exceeds energy input, a metabolic condition known as negative energy balance. This inhibition of reproductive function during negative energy balance occurs due to suppression of gonadotrop...

journal_title：Frontiers in endocrinology

authors： True C,Grove KL,Smith MS

更新日期：2011-10-17 00:00:00

abstract：:Germline development in vivo is dependent on the environment formed by somatic cells and the differentiation cues they provide; hence, the impact of local factors is highly relevant to the production of sperm. Knowledge of how somatic and germline cells interact is central to achieving biomedical goals relating to res...

journal_title：Frontiers in endocrinology

authors： Loveland KL,Klein B,Pueschl D,Indumathy S,Bergmann M,Loveland BE,Hedger MP,Schuppe HC

更新日期：2017-11-20 00:00:00

abstract：:At least 57 independent loci within the human genome confer varying degrees of risk for the development of type 1 diabetes (T1D). The majority of these variants are thought to contribute to overall genetic risk by modulating host innate and adaptive immune responses, ultimately resulting in a loss of immunological tol...

journal_title：Frontiers in endocrinology

authors： Wallet MA,Santostefano KE,Terada N,Brusko TM

更新日期：2017-10-18 00:00:00

abstract：:Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is a rare cause of Cushing syndrome. If routine imaging examinations cannot identify the source of ACTH production, long-term follow-up observation is necessary to determine the etiology. We present the case of a middle-aged male with gradual weight gain and a ...

journal_title：Frontiers in endocrinology

authors： Lu L,Meng Q,Xing X,Yuan T,Zhang H,Li N,Wang Y,Cheng Y,Bai C,Wang H,Cheng X,Xiao Y,Pan B,Li Y,Sun J,Liang Z,Zhu H,Wang R,Lu Z

更新日期：2019-10-22 00:00:00

abstract：:The insulin-like growth factor (IGF) family plays key roles in growth and development. In the cornea, IGF family members have been implicated in proliferation, differentiation, and migration, critical events that maintain a smooth refracting surface that is essential for vision. The IGF family is composed of multiple ...

journal_title：Frontiers in endocrinology

authors： Stuard WL,Titone R,Robertson DM

更新日期：2020-03-03 00:00:00

abstract：:Multiple Endocrine Neoplasia type 1 (MEN1) is a rare autosomal dominant inherited condition, causing significant morbidity, and a reduction of life expectancy. A timely and accurate diagnosis of MEN1 is paramount to improve disease outcomes. This enables early identification of tumor manifestations allowing timely tre...

journal_title：Frontiers in endocrinology

authors： de Laat JM,van Leeuwaarde RS,Valk GD

更新日期：2018-09-11 00:00:00

abstract：:Ovarian stimulation in a gonadotropin-releasing hormone (GnRH) antagonist protocol with the use of GnRH agonist for final oocyte maturation is the state-of-the-art treatment in patients with an expected or known high response to avoid or at least reduce significantly the risk for development of ovarian hyperstimulatio...

journal_title：Frontiers in endocrinology

authors： Lawrenz B,Samir S,Garrido N,Melado L,Engelmann N,Fatemi HM

更新日期：2018-02-15 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV)/AIDS pandemic represents the most significant global health challenge in modern history. This infection leads toward an inflammatory state associated with chronic immune dysregulation activation that tilts the immune-skeletal interface and its deep integration between cell...

journal_title：Frontiers in endocrinology

authors： Delpino MV,Quarleri J

更新日期：2020-09-02 00:00:00

abstract：:Background: The number of subjects with gender dysphoria has been increasing. In general, male-to-female transsexual subjects are treated with estradiol valerate therapy. In this report, we showed the time course of ACTH and cortisol levels after estradiol valerate injection in a male subject with gender dysphoria. It...

journal_title：Frontiers in endocrinology

authors： Anno T,Kawasaki F,Shigemoto R,Irie S,Mune T,Kaku K,Kaneto H

更新日期：2019-11-05 00:00:00

abstract：:Background: The long noncoding RNA (lncRNA) functions as a regulator of initiation, progression, and metastasis of thyroid carcinomas. lncRNA OTUD6B antisense RNA 1 (OTUD6B-AS1) is a tumor-suppressive noncoding RNA in clear cell renal cell carcinoma. The role of OTUD6B-AS1 in thyroid carcinomas has not been reported y...

journal_title：Frontiers in endocrinology

authors： Wang Z,Xia F,Feng T,Jiang B,Wang W,Li X

更新日期：2020-03-17 00:00:00

abstract：:Introduction: Pituitary metastases (PM) are rare events and to date only very few cases of melanoma PM have been described in literature up to now. Case Presentation: We describe the clinical history of a 33-year-old male patient who underwent surgical excision of an inter-scapular melanoma in 2008. The subsequent fol...

journal_title：Frontiers in endocrinology

authors： Mormando M,Puliani G,Barnabei A,Lauretta R,Bianchini M,Chiefari A,Russillo M,Cognetti F,Romano L,Appetecchia M

更新日期：2020-07-23 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) is a pleotropic metabolic regulator, expression of which is elevated during fasting. To this end, the precise role played by FGF21 in the biology of fasting has been the subject of several recent studies, which have demonstrated contributions to the regulation of both lipid and carb...

journal_title：Frontiers in endocrinology

authors： Antonellis PJ,Hayes MP,Adams AC

更新日期：2016-06-30 00:00:00

abstract：:Cardiovascular disease (CVD) is the leading cause of death globally. It is well-established based on evidence accrued during the last three decades that high plasma concentrations of cholesterol-rich atherogenic lipoproteins are causatively linked to CVD, and that lowering these reduces atherosclerotic cardiovascular ...

journal_title：Frontiers in endocrinology

authors： Borén J,Packard CJ,Taskinen MR

更新日期：2020-07-28 00:00:00

abstract：:Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and a common cause of end-stage renal disease worldwide. DKD manifests as an increased urinary protein excretion (albuminuria). Multiple studies have shown that insulin resistance correlates with the development of albuminuria in non-diabe...

journal_title：Frontiers in endocrinology

authors： Wasik AA,Lehtonen S

更新日期：2018-04-09 00:00:00

abstract：:Background: Consistent evidence have demonstrated that patients with primary aldosteronism (PA) have higher risk of cardiovascular events to patients with essential hypertension (EH). Whether the long-term risk of mortality for PA patients is higher than EH patients is unclear. We aim to compare the long-term mortalit...

journal_title：Frontiers in endocrinology

authors： Meng Z,Dai Z,Huang K,Xu C,Zhang YG,Zheng H,Liu TZ

更新日期：2020-03-10 00:00:00

abstract：:The majority of embryonal tumors or childhood blastomas derive from pluripotent progenitors or fetal stem cells that acquire cancer stem cell (CSC) properties: multipotency, self-renewal ability, metastatic potential, chemoresistance, more pronounced levels of drug transporters, enhanced DNA-damage repair mechanisms, ...

journal_title：Frontiers in endocrinology

authors： Veschi V,Verona F,Thiele CJ

更新日期：2019-11-19 00:00:00

abstract：:Most of the described structures of podocytes in health and disease have been inferred from light and electron microscopic studies of rodent models. The variation in filtration barrier features is measured on micrographs, the aim being statistical significance. This is the technical campaign waged against kidney disea...

journal_title：Frontiers in endocrinology

authors： Neal CR

更新日期：2015-02-23 00:00:00