Morpho-functional architecture of the Golgi complex of neuroendocrine cells.

abstract：:Background: Bologna criteria poor ovarian responders have a very low prognosis. Although, it has been proposed that LH supplementation could be beneficial in women with previous hypo-response to FSH. There are no studies comparing the cumulative live birth rates (LBRs) between corifollitropin alfa (CFA) and highly pur...

journal_title：Frontiers in endocrinology

authors： Errázuriz J,Romito A,Drakopoulos P,Frederix B,Racca A,De Munck N,Tournaye H,De Vos M,Blockeel C

更新日期：2019-03-22 00:00:00

abstract：:A substantial body of evidence supports that the gut microbiota plays a pivotal role in the regulation of metabolic, endocrine and immune functions. In recent years, there has been growing recognition of the involvement of the gut microbiota in the modulation of multiple neurochemical pathways through the highly inter...

journal_title：Frontiers in endocrinology

authors： Silva YP,Bernardi A,Frozza RL

更新日期：2020-01-31 00:00:00

abstract：:Linagliptin, one of the five dipeptidyl peptidase-4 inhibitors available, has recently entered the market both in the US and in most European countries for treatment of type 2 diabetes mellitus. It presents a xanthine-based structure, and is characterized by unique pharmacokinetics, with non-linear profile, long termi...

journal_title：Frontiers in endocrinology

authors： Sortino MA,Sinagra T,Canonico PL

更新日期：2013-02-26 00:00:00

abstract：:Ghrelin is a peptide hormone that is acylated with a fatty acid, usually n-octanoic acid, at the third amino acid (aa) residue (usually a serine or threonine), and this acylation is known to be essential for ghrelin activity not only in mammals but also in non-mammals, such as fish. However, the modification mechanism...

journal_title：Frontiers in endocrinology

authors： Kaiya H,Andoh T,Ichikawa T,Amiya N,Matsuda K,Kangawa K,Miyazato M

更新日期：2013-09-03 00:00:00

abstract：:Cardiovascular disease (CVD) is the leading cause of death globally. It is well-established based on evidence accrued during the last three decades that high plasma concentrations of cholesterol-rich atherogenic lipoproteins are causatively linked to CVD, and that lowering these reduces atherosclerotic cardiovascular ...

journal_title：Frontiers in endocrinology

authors： Borén J,Packard CJ,Taskinen MR

更新日期：2020-07-28 00:00:00

abstract：:We treat the biological significance of prostaglandins (PGs) and their known receptors in insect biology. PGs and related eicosanoids are oxygenated derivatives of arachidonic acid (AA) and two other C20 polyunsaturated fatty acids. PGs are mostly appreciated in the context of biomedicine, but a growing body of litera...

journal_title：Frontiers in endocrinology

authors： Stanley D,Kim Y

更新日期：2011-12-30 00:00:00

abstract：:Background: The management of children and adolescents with chronic kidney disease (CKD) and growth failure candidate for recombinant human growth hormone therapy (rhGH) is based on an appraisal of the literature established on a 2006 consensus statement and 2019 Clinical practice recommendations. The performance of t...

journal_title：Frontiers in endocrinology

authors： Cappa M,Maghnie M,Carbone V,Chioma L,Errichiello C,Giavoli C,Giordano M,Guazzarotti L,Klain A,Montini G,Murer L,Parpagnoli M,Pecoraro C,Pesce S,Verrina E

更新日期：2020-09-02 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fendo.2018.00031.]. ...

journal_title：Frontiers in endocrinology

authors： Beattie J,Al-Khafaji H,Noer PR,Alkharobi HE,Alhodhodi A,Meade J,El-Gendy R,Oxvig C

更新日期：2018-09-04 00:00:00

abstract：:Atherosclerosis results from endothelial cell dysfunction and inflammatory processes affecting both macro- and microvasculature which are involved in vascular diabetic complications. Glucagon-like peptide-1 (GLP-1) is an incretin hormone responsible for amplification of insulin secretion when nutrients are given orall...

journal_title：Frontiers in endocrinology

authors： Alonso N,Julián MT,Puig-Domingo M,Vives-Pi M

更新日期：2012-09-07 00:00:00

abstract：:Sex steroids play essential roles in the modulation of synaptic plasticity and neuroprotection in the hippocampus. Accumulating evidence shows that hippocampal neurons synthesize both estrogen and androgen. Recently, we also revealed the hippocampal synthesis of corticosteroids. The accurate concentrations of these hi...

journal_title：Frontiers in endocrinology

authors： Hojo Y,Higo S,Kawato S,Hatanaka Y,Ooishi Y,Murakami G,Ishii H,Komatsuzaki Y,Ogiue-Ikeda M,Mukai H,Kimoto T

更新日期：2011-10-10 00:00:00

abstract：:Physiological concentrations of the green tea extract epigallocatechin-3-gallate (EGCG) caused growth inhibition in estrogen receptor α (ERα)-positive MCF7 cells that was associated with down-regulation of the ERα and reduced insulin-like growth factor binding protein-2 abundance and increased protein abundance of the...

journal_title：Frontiers in endocrinology

authors： Zeng L,Holly JM,Perks CM

更新日期：2014-05-07 00:00:00

abstract：:Kisspeptin, a novel neuropeptide product of the Kiss1 gene, activates the G protein-coupled membrane receptor G protein-coupled receptor 54 (now termed Kiss1r). Over the last 15 years, the importance of the kisspeptin system has been the subject of much debate in the mammalian research field. At the heart of the debat...

journal_title：Frontiers in endocrinology

authors： Ohga H,Selvaraj S,Matsuyama M

更新日期：2018-04-04 00:00:00

abstract：:Despite the long-held belief that growth hormone supplementation provides psychosocial benefits to patients with Turner syndrome (TS), this assumption has never been rigorously tested in a randomized control trial. As a sub-study of the Canadian growth-hormone trial, parent-, and patient-completed standardized questio...

journal_title：Frontiers in endocrinology

authors： Rovet JF,Van Vliet G

更新日期：2019-03-13 00:00:00

abstract：:Exercise training triggers numerous positive adaptations through the regulation of genes controlling muscle structure and function. Epigenetic modifications, including DNA methylation, participate in transcriptional activation by allowing the recruitment of the transcription machinery to gene promoters. Exercise induc...

journal_title：Frontiers in endocrinology

authors： Pattamaprapanont P,Garde C,Fabre O,Barrès R

更新日期：2016-12-23 00:00:00

abstract：:Background and Purpose: Many imaging studies have reported structure alterations in patients with type 1 diabetes mellitus (T1DM) by using voxel-based morphometry (VBM). Nevertheless, the results reported were inconsistent and had not been reviewed quantitatively. Accordingly, the quantitative meta-analysis which incl...

journal_title：Frontiers in endocrinology

authors： Liu J,Fan W,Jia Y,Su X,Wu W,Long X,Sun X,Liu J,Sun W,Zhang T,Gong Q,Shi H,Zhu Q,Wang J

更新日期：2020-02-13 00:00:00

abstract：:Testicular cancer represents the more frequent solid tumor affecting males aged 15-35 years. In the last decades, its incidence showed a progressive increased probably due to genetic and environmental factors. Despite exposure to some viruses such as HIV, HCV, EBV, and HPV is frequently related to cancer development, ...

journal_title：Frontiers in endocrinology

authors： Garolla A,Pizzol D,Bertoldo A,Ghezzi M,Carraro U,Ferlin A,Foresta C

更新日期：2012-12-21 00:00:00

abstract：:SIRT7 is one of seven mammalian sirtuins that functions as an NAD+-dependent histone/protein deacetylase. SIRT7 is the least well-known member of the sirtuin family, but recent efforts have identified its involvement in various cellular processes, such as ribosome biogenesis, gene expression, cellular metabolism and c...

journal_title：Frontiers in endocrinology

authors： Wu D,Li Y,Zhu KS,Wang H,Zhu WG

更新日期：2018-11-19 00:00:00

abstract：:Breast cancer remains a significant female mortality cause. It constitutes a multifactorial disease for which research on environmental factors offers little help in predicting onset or progression. The pursuit for its foundations by analyzing hormonal changes as a motive for disease development, indicates that increa...

journal_title：Frontiers in endocrinology

authors： Liarte S,Alonso-Romero JL,Nicolás FJ

更新日期：2018-09-27 00:00:00

abstract：:Background: This study investigated the relationship strength between hypothyroidism and cardiovascular and renal outcomes in diabetic patients. Methods: The electronic databases PubMed, EmBase, and Cochrane library were screened for relevant studies published before November 2018. The outcomes included major cardiova...

journal_title：Frontiers in endocrinology

authors： Zhang S,Feng G,Kang F,Guo Y,Ti H,Hao L,Gao P,Gao J

更新日期：2020-01-10 00:00:00

abstract：:The placenta is the chief regulator of nutrient supply to the growing embryo during gestation. As such, adequate placental function is instrumental for developmental progression throughout intrauterine development. One of the most common complications during pregnancy is insufficient growth of the fetus, a problem ter...

journal_title：Frontiers in endocrinology

authors： Woods L,Perez-Garcia V,Hemberger M

更新日期：2018-09-27 00:00:00

abstract：:Primary small cell carcinoma of the breast (SCCB) is a rare tumor subtype comprising <0.1% of all breast carcinomas. Here we present a case of thyroid transcription factor-1 (TTF-1) positive SCCB that recurred within 3 years of diagnosis in the lung and lymph nodes. Given the small number of cases, no clear guidelines...

journal_title：Frontiers in endocrinology

authors： Boutrid H,Kassem M,Tozbikian G,Morgan E,White J,Shah M,Vandeusen J,Sardesai S,Williams N,Stover DG,Lustberg M,Wesolowski R,Pudavalli V,Williams TM,Konda B,Fortier S,Carbone D,Ramaswamy B,Cherian MA

更新日期：2020-04-29 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV)/AIDS pandemic represents the most significant global health challenge in modern history. This infection leads toward an inflammatory state associated with chronic immune dysregulation activation that tilts the immune-skeletal interface and its deep integration between cell...

journal_title：Frontiers in endocrinology

authors： Delpino MV,Quarleri J

更新日期：2020-09-02 00:00:00

abstract：:Obesity is a prominent metabolic disease that predisposes individuals to multiple comorbidities, including type 2 diabetes mellitus, cardiovascular diseases, and cancer. Elevated circulating levels of fatty acids contribute to the development of obesity, in part, by targeting the hypothalamus. Palmitate, the most abun...

journal_title：Frontiers in endocrinology

authors： Tran A,He W,Jiang N,Chen JTC,Belsham DD

更新日期：2020-06-12 00:00:00

abstract：:O-linked N-acetylglucosaminylation (O-GlcNAcylation) is a reversible post-translational modification consisting in the addition of a sugar moiety to serine/threonine residues of cytosolic or nuclear proteins. Catalyzed by O-GlcNAc-transferase (OGT) and removed by O-GlcNAcase, this dynamic modification is dependent on ...

journal_title：Frontiers in endocrinology

authors： Fardini Y,Dehennaut V,Lefebvre T,Issad T

更新日期：2013-08-12 00:00:00

abstract：:The prolactin receptor (PRLR) is emerging as a therapeutic target in oncology. Knowledge-based drug design led to the development of a pure PRLR antagonist (Del1-9-G129R-hPRL) that was recently shown to prevent PRL-induced mouse prostate tumorogenesis. In humans, the first gain-of-function mutation of the PRLR (PRLR(I...

journal_title：Frontiers in endocrinology

authors： Tallet E,Fernandez I,Zhang C,Salsac M,Gregor N,Ayoub MA,Pin JP,Trinquet E,Goffin V

更新日期：2011-09-16 00:00:00

abstract：:Germline development in vivo is dependent on the environment formed by somatic cells and the differentiation cues they provide; hence, the impact of local factors is highly relevant to the production of sperm. Knowledge of how somatic and germline cells interact is central to achieving biomedical goals relating to res...

journal_title：Frontiers in endocrinology

authors： Loveland KL,Klein B,Pueschl D,Indumathy S,Bergmann M,Loveland BE,Hedger MP,Schuppe HC

更新日期：2017-11-20 00:00:00

abstract：:3-Iodothyronamine (3-T1AM) is an endogenous thyroid hormone metabolite. The profound pharmacological effects of 3-T1AM on energy metabolism and thermal homeostasis have raised interest to elucidate its signaling properties in tissues that pertain to metabolic regulation and thermogenesis. Previous studies identified G...

journal_title：Frontiers in endocrinology

authors： Bräunig J,Mergler S,Jyrch S,Hoefig CS,Rosowski M,Mittag J,Biebermann H,Khajavi N

更新日期：2018-09-11 00:00:00

abstract：:Autophagy requires the conjugation of autophagy-related protein 12 (ATG12) to autophagy-related protein 5 (ATG5) through covalent attachment. However, the signals regulating ATG12-ATG5 conjugation are unclear. The larval midgut of lepidopteran insects performs autophagy and apoptosis sequentially during the transition...

journal_title：Frontiers in endocrinology

authors： Li YB,Yang T,Wang JX,Zhao XF

更新日期：2018-02-07 00:00:00

abstract：:GPER-1 is a novel membrane sited G protein-coupled estrogen receptor. Clinical studies have shown that patients suffering an estrogen receptor α (ERα)/GPER-1 positive, breast cancer have a lower survival rate than those who have developed ERα-positive/GPER-1 negative tumors. Moreover, absence of GPER-1 improves the pr...

journal_title：Frontiers in endocrinology

authors： Molina L,Bustamante F,Ortloff A,Ramos I,Ehrenfeld P,Figueroa CD

更新日期：2020-09-30 00:00:00

abstract：:Obesity is associated with inflammation and type 2 diabetes. Innate immune system comprised of cellular and molecular components plays an important role in the inflammatory reactions. Immune cells like macrophages and their cell surface pattern-recognition receptors (PRRs) are representative for innate immunity promot...

journal_title：Frontiers in endocrinology

authors： Yamamoto Y,Yamamoto H

更新日期：2013-08-21 00:00:00