O-GlcNAcylation: A New Cancer Hallmark?

abstract：:O-linked β-N-acetylglucosamine (O-GlcNAc) is an abundant and essential intracellular form of protein glycosylation in animals and plants. In humans, dysregulation of O-GlcNAcylation occurs in a wide range of diseases, including cancer, diabetes, and neurodegeneration. Since its discovery more than 30 years ago, great ...

journal_title：Frontiers in endocrinology

authors： Cox NJ,Luo PM,Smith TJ,Bisnett BJ,Soderblom EJ,Boyce M

更新日期：2018-10-15 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver diseases closely associated with obesity and insulin resistance; deficient growth hormone (GH) action in liver has been implicated as a mechanism. Here, we investigated the evolution of NAFLD in aged mice with liver-sp...

journal_title：Frontiers in endocrinology

authors： Fan Y,Fang X,Tajima A,Geng X,Ranganathan S,Dong H,Trucco M,Sperling MA

更新日期：2014-12-18 00:00:00

abstract：:Introduction: Adrenal myelolipomas are usually isolated benign adrenal lesions, but can be adjacent to steroid-secreting adrenocortical tumors. We studied the aberrant regulation of cortisol secretion in a 61 year-old woman with combined bilateral myelolipomas and primary bilateral macronodular adrenal hyperplasia (BM...

journal_title：Frontiers in endocrinology

authors： Larose S,Bondaz L,Mermejo LM,Latour M,Prosmanne O,Bourdeau I,Lacroix A

更新日期：2019-09-11 00:00:00

abstract：:Background: IL-36α is involved in the pathogenesis of a variety of autoimmune diseases, but the relationship between IL-36α and Graves' disease (GD) has rarely investigated. In the present study, we aimed to explore the expression of IL-36α and elucidate the potential role of IL-36α in GD. Methods: The expression of I...

journal_title：Frontiers in endocrinology

authors： Yao QM,Li L,Song ZY,Wang B,Qin Q,An XF,Zhang JA

更新日期：2018-10-09 00:00:00

abstract：:Background: Intracystic hemorrhage can present occasionally during ultrasound-guided percutaneous microwave ablation (PMWA) for cystic thyroid nodules. It can affect treatment outcome, can lead to ablation failure, and even conversion to open surgery. We aim to avoid such cases in the future by exploring their causes ...

journal_title：Frontiers in endocrinology

authors： Dong S,Sun L,Xu J,Han Z,Liu J

更新日期：2020-09-08 00:00:00

abstract：:Gonadotropin-releasing hormone (GnRH) is the ultimate output signal of an intricate network of neuroendocrine factors that, acting on the pituitary, trigger gonadotropin release. In turn, gonadotropins exert their trophic action on the gonads to stimulate the synthesis of sex steroids thus completing the gonadotropic ...

journal_title：Frontiers in endocrinology

authors： Navarro VM

更新日期：2012-04-02 00:00:00

abstract：:Background: Associations between vitiligo and thyroid disorders have been suggested, However, the prevalence of thyroid disorders in vitiligo vary widely. Purpose: To conduct a systematic review and meta-analysis assessing the prevalence of thyroid disorders in patients with vitiligo. Method: The PubMed, Cochrane Libr...

journal_title：Frontiers in endocrinology

authors： Yuan J,Sun C,Jiang S,Lu Y,Zhang Y,Gao XH,Wu Y,Chen HD

更新日期：2019-01-15 00:00:00

abstract：:In mammals, glucosensing markers reside in brain areas known to play an important role in the control of food intake. The best characterized glucosensing mechanism is that dependent on glucokinase (GK) whose activation by increased levels of glucose leads in specific hypothalamic neurons to decreased or increased acti...

journal_title：Frontiers in endocrinology

authors： Otero-Rodiño C,Rocha A,Sánchez E,Álvarez-Otero R,Soengas JL,Cerdá-Reverter JM

更新日期：2019-04-18 00:00:00

abstract：:Immobilization results in a substantial bone loss and increased fracture risk. Powerful bone anabolic therapies are necessary to counteract the bone loss and reduce fracture risk during periods with immobilization. Intermittent parathyroid hormone 1-34 (PTH) (teriparatide) and PTH related peptide analog abaloparatide ...

journal_title：Frontiers in endocrinology

authors： Brent MB,Thomsen JS,Brüel A

更新日期：2020-10-09 00:00:00

abstract：:Oxidative stress induced by free fatty acid overload in pancreatic β-cells is a potential contributory factor to dysfunction of insulin secretion and apoptotic cell death. Perilipin 5 (Plin5) has been reported to ameliorate oxidative stress-mediated damage in non-insulin-secreting tissues. We tested the hypothesis tha...

journal_title：Frontiers in endocrinology

authors： Zhu Y,Ren C,Zhang M,Zhong Y

更新日期：2020-03-31 00:00:00

abstract：:Vitamin D is important for bone health, but may also have extra-skeletal effects. Vitamin D and its binding protein DBP have immunological effects and may therefore be important in the development of type 1 diabetes (T1DM), and low serum levels of 25-hydroxyvitamin D (25(OH)D) are associated with later development of ...

journal_title：Frontiers in endocrinology

authors： Jorde R

更新日期：2019-02-19 00:00:00

abstract：:In the regulated secretory pathway, secretory granules (SGs) store peptide hormones that are released on demand. SGs are formed at the trans-Golgi network and must undergo a maturation process to become responsive to secretagogues. The production of mature SGs requires concentrating newly synthesized soluble content p...

journal_title：Frontiers in endocrinology

authors： Bonnemaison ML,Eipper BA,Mains RE

更新日期：2013-08-14 00:00:00

abstract：:Sleep duration has become increasingly recognized as an important influencer of health. Epidemiologic and observational studies have shown associations between short sleep duration and increased risk for chronic cardiometabolic disorders, including obesity, type 2 diabetes, and cardiovascular disease. These associatio...

journal_title：Frontiers in endocrinology

authors： Pizinger TM,Aggarwal B,St-Onge MP

更新日期：2018-07-18 00:00:00

abstract：:A substantial body of evidence supports that the gut microbiota plays a pivotal role in the regulation of metabolic, endocrine and immune functions. In recent years, there has been growing recognition of the involvement of the gut microbiota in the modulation of multiple neurochemical pathways through the highly inter...

journal_title：Frontiers in endocrinology

authors： Silva YP,Bernardi A,Frozza RL

更新日期：2020-01-31 00:00:00

abstract：AIM:The leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (DM) is coronary artery disease (CAD), a condition often asymptomatic but severe in these patients. Although glucose metabolism impairment and oxidative stress are known actors in the endothelial dysfunction/remodeling that occur...

journal_title：Frontiers in endocrinology

authors： Infante T,Forte E,Aiello M,Salvatore M,Cavaliere C

更新日期：2017-08-21 00:00:00

abstract：:Background: The management of children and adolescents with chronic kidney disease (CKD) and growth failure candidate for recombinant human growth hormone therapy (rhGH) is based on an appraisal of the literature established on a 2006 consensus statement and 2019 Clinical practice recommendations. The performance of t...

journal_title：Frontiers in endocrinology

authors： Cappa M,Maghnie M,Carbone V,Chioma L,Errichiello C,Giavoli C,Giordano M,Guazzarotti L,Klain A,Montini G,Murer L,Parpagnoli M,Pecoraro C,Pesce S,Verrina E

更新日期：2020-09-02 00:00:00

abstract：:Introduction: Follicular-derived differentiated thyroid carcinoma (DTC) is the most common endocrine and epithelial malignancy in children. The differences in the clinical and pathological features of pediatric vs. adult DTC could relate to a different genetic profile. Few studies are currently available in this issue...

journal_title：Frontiers in endocrinology

authors： Galuppini F,Vianello F,Censi S,Barollo S,Bertazza L,Carducci S,Colato C,Manso J,Rugge M,Iacobone M,Watutantrige Fernando S,Pennelli G,Mian C

更新日期：2019-08-07 00:00:00

abstract：Background:Nonalcoholic steatohepatitis (NASH) is rapidly becoming a major chronic liver disease worldwide. However, little is known concerning the pathogenesis and progression mechanism of NASH. Our aim here is to identify key genes and elucidate their biological function in the progression from hepatic steatosis to N...

journal_title：Frontiers in endocrinology

authors： Ye J,Lin Y,Wang Q,Li Y,Zhao Y,Chen L,Wu Q,Xu C,Zhou C,Sun Y,Ye W,Bai F,Zhou T

更新日期：2020-11-26 00:00:00

abstract：:Although the pathogenesis of Polycystic Ovary Syndrome (PCOS) is still unclear, the disturbance of hypothalamic-pituitary-gonadal (HPG) axis is suspected to be the main culprit in the development of PCOS. Kisspeptin, a hypothalamic peptide encoded by the KISS1 gene, is widely reported as a key factor in the regulation...

journal_title：Frontiers in endocrinology

authors： Tang R,Ding X,Zhu J

更新日期：2019-05-10 00:00:00

abstract：:It has been generally assumed that insulin circulates freely in blood. However it can also interact with plasma proteins. Insulin receptors are located in the membrane of target cells and consist of an alpha and beta subunits with a tyrosine kinase cytoplasmic domain. The ectodomain, called soluble insulin receptor (S...

journal_title：Frontiers in endocrinology

authors： Hiriart M,Sanchez-Soto C,Diaz-Garcia CM,Castanares DT,Avitia M,Velasco M,Mas-Oliva J,Macias-Silva M,González-Villalpando C,Delgado-Coello B,Sosa-Garrocho M,Vidaltamayo R,Fuentes-Silva D

更新日期：2014-06-19 00:00:00

abstract：:GPER-1 is a novel membrane sited G protein-coupled estrogen receptor. Clinical studies have shown that patients suffering an estrogen receptor α (ERα)/GPER-1 positive, breast cancer have a lower survival rate than those who have developed ERα-positive/GPER-1 negative tumors. Moreover, absence of GPER-1 improves the pr...

journal_title：Frontiers in endocrinology

authors： Molina L,Bustamante F,Ortloff A,Ramos I,Ehrenfeld P,Figueroa CD

更新日期：2020-09-30 00:00:00

abstract：:Recent evidence indicates that autophagy-mediated mitochondrial homeostasis is crucial for oxidative stress-related brain damage and repair. The highest concentration of melatonin is in the mitochondria of cells, and melatonin exhibits well-known antioxidant properties. We investigated the impact and mechanism involve...

journal_title：Frontiers in endocrinology

authors： Wang DD,Jin MF,Zhao DJ,Ni H

更新日期：2019-08-08 00:00:00

abstract：:As one of the most serious complications of diabetes, diabetic cardiomyopathy (DCM) imposes a huge burden on individuals and society, and represents a major public health problem. It has long been recognized that physical exercise has important health benefits for patients with type 2 diabetes, and regular physical ex...

journal_title：Frontiers in endocrinology

authors： Zheng J,Cheng J,Zheng S,Zhang L,Guo X,Zhang J,Xiao X

更新日期：2018-12-03 00:00:00

abstract：:The majority of embryonal tumors or childhood blastomas derive from pluripotent progenitors or fetal stem cells that acquire cancer stem cell (CSC) properties: multipotency, self-renewal ability, metastatic potential, chemoresistance, more pronounced levels of drug transporters, enhanced DNA-damage repair mechanisms, ...

journal_title：Frontiers in endocrinology

authors： Veschi V,Verona F,Thiele CJ

更新日期：2019-11-19 00:00:00

abstract：:Older women with type 2 diabetes mellitus (DM) have higher bone mineral density (BMD) but also have higher rates of fracture compared to those without DM. Limited evidence suggests that DM may also be associated with more rapid bone loss. To determine if bone loss rates differ by DM status in older women, we analyzed ...

journal_title：Frontiers in endocrinology

authors： Schwartz AV,Ewing SK,Porzig AM,McCulloch CE,Resnick HE,Hillier TA,Ensrud KE,Black DM,Nevitt MC,Cummings SR,Sellmeyer DE

更新日期：2013-05-30 00:00:00

abstract：:The reproduction of seasonal breeders is modulated by exposure to light in an interval of 24 h defined as photoperiod. The interruption of reproductive functions in seasonally breeding rodents is accompanied by the suppression of the Kiss1 gene expression, which is known to be essential for reproduction. In non-season...

journal_title：Frontiers in endocrinology

authors： Bohlen TM,Silveira MA,Buonfiglio DDC,Ferreira-Neto HC,Cipolla-Neto J,Donato J Jr,Frazao R

更新日期：2018-02-20 00:00:00

abstract：:We sought to determine the efficacy of 12 weeks high-intensity interval training (HIIT), compared to moderate-intensity continuous training (MICT) on glucose control, cardiometabolic risk and microvascular complication markers in men living with type 2 diabetes (T2D). Both modalities were combined with resistance trai...

journal_title：Frontiers in endocrinology

authors： Wormgoor SG,Dalleck LC,Zinn C,Borotkanics R,Harris NK

更新日期：2018-08-28 00:00:00

abstract：:Introduction: Pituitary metastases (PM) are rare events and to date only very few cases of melanoma PM have been described in literature up to now. Case Presentation: We describe the clinical history of a 33-year-old male patient who underwent surgical excision of an inter-scapular melanoma in 2008. The subsequent fol...

journal_title：Frontiers in endocrinology

authors： Mormando M,Puliani G,Barnabei A,Lauretta R,Bianchini M,Chiefari A,Russillo M,Cognetti F,Romano L,Appetecchia M

更新日期：2020-07-23 00:00:00

abstract：:Catecholamine (CA) secretion from the adrenal medullary tissue is a key step of the adaptive response triggered by an organism to cope with stress. Whereas molecular and cellular secretory processes have been extensively studied at the single chromaffin cell level, data available for the whole gland level are much sca...

journal_title：Frontiers in endocrinology

authors： De Nardi F,Lefort C,Bréard D,Richomme P,Legros C,Guérineau NC

更新日期：2017-09-25 00:00:00

abstract：:Poor sleep and obesity are both extraordinarily common in the US adolescent population and often occur simultaneously. This review explores the links between obesity and sleep, outlining what is known about the relationships between sleep characteristics, obesity, and cardiometabolic risk factors in youth. Sleep durat...

journal_title：Frontiers in endocrinology

authors： Gohil A,Hannon TS

更新日期：2018-07-10 00:00:00