Molecular approaches to the analysis of deformed wing virus replication and pathogenesis in the honey bee, Apis mellifera.

abstract：BACKGROUND:The major obstacle to cure of HIV type-1 infection is the presence of the HIV reservoir, hidden from the immune system and insensitive to combined antiretroviral therapy (cART). Eradication approaches have been hindered by the difficulty for accurately monitoring its size in vivo, especially in the lymphoid ...

journal_title：Virology journal

authors： Rochat MA,Schlaepfer E,Kuster SP,Li D,Audige A,Ivic S,Fahrny A,Speck RF

更新日期：2018-12-17 00:00:00

abstract：BACKGROUND:Fast, reliable and easy to handle methods are required to facilitate urgently needed point-of-care testing (POCT) in the current coronavirus pandemic. Life-threatening severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread all over the world, infecting more than 33,500,000 people and...

journal_title：Virology journal

authors： Mautner L,Baillie CK,Herold HM,Volkwein W,Guertler P,Eberle U,Ackermann N,Sing A,Pavlovic M,Goerlich O,Busch U,Wassill L,Huber I,Baiker A

更新日期：2020-10-21 00:00:00

abstract：BACKGROUND:There are over 100 known human adenovirus (HAdV) types, which are able to cause a broad variety of different self-limiting but also lethal diseases especially in immunocompromised patients. Only limited information about the pathogenesis and biology of the majority of these virus types is available. In the p...

journal_title：Virology journal

authors： Mese K,Bunz O,Schellhorn S,Volkwein W,Jung D,Gao J,Zhang W,Baiker A,Ehrhardt A

更新日期：2020-04-09 00:00:00

abstract：:Hairpin RNAs have been used to confer resistance to viruses in plants through RNA silencing. However, it has not been demonstrated that RNA silencing was effective against inoculation by aphids of non-persistently transmitted viruses, the major route of plant virus spread in nature. As a proof-of-principle strategy, w...

journal_title：Virology journal

authors： Vargas M,Martínez-García B,Díaz-Ruíz JR,Tenllado F

更新日期：2008-03-19 00:00:00

abstract：BACKGROUND:The use of sequence independent methods combined with next generation sequencing for identification purposes in clinical samples appears promising and exciting results have been achieved to understand unexplained infections. One sequence independent method, Virus Discovery based on cDNA Amplified Fragment Le...

journal_title：Virology journal

authors： Shaukat S,Angez M,Alam MM,Jebbink MF,Deijs M,Canuti M,Sharif S,de Vries M,Khurshid A,Mahmood T,van der Hoek L,Zaidi SS

更新日期：2014-08-12 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) Core protein regulates multiple signaling pathways and alters cellular genes expression responsible for HCV induced pathogenesis leading to hepatocellular carcinoma (HCC). Prevalence of HCV genotype 3a associated HCC is higher in Pakistan as compare to the rest of world; however the m...

journal_title：Virology journal

authors： Jahan S,Khaliq S,Siddiqi MH,Ijaz B,Ahmad W,Ashfaq UA,Hassan S

更新日期：2011-11-23 00:00:00

abstract：:The Filoviridae family comprises of Ebola and Marburg viruses, which are known to cause lethal hemorrhagic fever. However, there is no effective anti-viral therapy or licensed vaccines currently available for these human pathogens. The envelope glycoprotein (GP) of Ebola virus, which mediates entry into target cells, ...

journal_title：Virology journal

authors： Bhattacharyya S,Hope TJ

更新日期：2011-01-12 00:00:00

abstract：BACKGROUND:Chikungunya virus (CHIKV) is transmitted via mosquito bite and potentially by aerosol, causing chikungunya fever and arthritic disease in humans. There are currently no licensed vaccines or antiviral therapeutics to protect against CHIKV infection in humans. Animal models recapitulating human disease, especi...

journal_title：Virology journal

authors： Cirimotich CM,Vela EM,Garver J,Barnewall RE,Miller BD,Meister GT,Rogers JV

更新日期：2017-07-20 00:00:00

abstract：BACKGROUND:The family Mesoniviridae (order Nidovirales) comprises of a group of positive-sense, single-stranded RNA ([+]ssRNA) viruses isolated from mosquitoes. FINDINGS:Thirteen novel insect-specific virus isolates were obtained from mosquitoes collected in Indonesia, Thailand and the USA. By electron microscopy, the...

journal_title：Virology journal

authors： Vasilakis N,Guzman H,Firth C,Forrester NL,Widen SG,Wood TG,Rossi SL,Ghedin E,Popov V,Blasdell KR,Walker PJ,Tesh RB

更新日期：2014-05-20 00:00:00

abstract：BACKGROUND:HIV-1 entry into cells is a multifaceted process involving target cell CD4 and the chemokine receptors, CXCR4 or CCR5. The lipid composition of the host cell plays a significant role in the HIV fusion process as it orchestrates the appropriate disposition of CD4 and co-receptors required for HIV-1 envelope g...

journal_title：Virology journal

authors： Ablan S,Rawat SS,Viard M,Wang JM,Puri A,Blumenthal R

更新日期：2006-12-22 00:00:00

abstract：:Avian influenza virus H9N2 isolates cause a mild influenza-like illness in humans. However, the pathogenesis of the H9N2 subtypes in human remains to be investigated. Using a human alveolar epithelial cell line A549 as host, we found that A/Quail/Hong Kong/G1/97 (H9N2/G1), which shares 6 viral "internal genes" with th...

journal_title：Virology journal

authors： Lee DC,Mok CK,Law AH,Peiris M,Lau AS

更新日期：2010-03-25 00:00:00

abstract：BACKGROUND:Multiple studies proved that miRNAs have a causal role in tumorigenesis. Some miRNAs are regulated by epigenetic alterations in their promoter regions and can be activated by chromatin- modifying drugs. METHODS:We treated cervical cancer cells with 5-aza-2'-deoxycytidine and get a microarray analysis. Dysre...

journal_title：Virology journal

authors： Yao T,Rao Q,Liu L,Zheng C,Xie Q,Liang J,Lin Z

更新日期：2013-06-03 00:00:00

abstract：BACKGROUND:Foot-and-mouth disease (FMD) is an extremely contagious viral disease of cattle, pigs, sheep, goats, and many cloven-hoofed wild animals. FMDV serotypes O and Asia 1 have circulated separately in China during the last fifty years, and eliminating infected animals and vaccination are the main policies to prev...

journal_title：Virology journal

authors： Wu L,Jiang T,Lu ZJ,Yang YM,Sun P,Liang Z,Li D,Fu YF,Cao YM,Liu XT,Liu ZX

更新日期：2011-04-23 00:00:00

abstract：BACKGROUND:The global spread of the highly pathogenic avian influenza H5N1 virus has stimulated interest in a better understanding of the mechanisms of H5N1 dispersal, including the potential role of migratory birds as carriers. Although wild birds have been found dead during H5N1 outbreaks, evidence suggests that othe...

journal_title：Virology journal

authors： Ip HS,Flint PL,Franson JC,Dusek RJ,Derksen DV,Gill RE Jr,Ely CR,Pearce JM,Lanctot RB,Matsuoka SM,Irons DB,Fischer JB,Oates RM,Petersen MR,Fondell TF,Rocque DA,Pedersen JC,Rothe TC

更新日期：2008-06-04 00:00:00

abstract：BACKGROUND:The influenza RNA dependent RNA polymerase synthesizes viral RNA in the nucleus as functional viral ribonucleoprotein (vRNP) complexes with RNA and nucleoprotein (NP). The N-terminus of NP contains an unconventional nuclear localization signal (NLS) important for initial vRNP nuclear localization but which a...

journal_title：Virology journal

authors： Sanchez A,Guerrero-Juarez CF,Ramirez J,Newcomb LL

更新日期：2014-08-31 00:00:00

abstract：BACKGROUND:Ebola viruses (EBOVs) cause severe hemorrhagic fever with a high mortality rate. At present, there are no licensed vaccines or efficient therapies to combat EBOV infection. Previous studies have shown that both humoral and cellular immune responses are crucial for controlling Ebola infection. CD8+ T cells pl...

journal_title：Virology journal

authors： Wu S,Yu T,Song X,Yi S,Hou L,Chen W

更新日期：2012-06-13 00:00:00

abstract：:An 80-year-old man with no history of an immune-compromising disorder was diagnosed with progressive multifocal leukoencephalopathy (PML). He presented with dysphagia and left-sided weakness; magnetic resonance imaging demonstrated marked signal abnormality in the subcortical white matter of the left frontal lobe and ...

journal_title：Virology journal

authors： Vaklavas C,Sotelo-Rafiq EP,Lovy J,Escobar MA,Tsimberidou AM

更新日期：2010-09-28 00:00:00

abstract：BACKGROUND:Begomoviruses have emerged as serious problem for vegetable and fiber crops in the recent past, frequently in tropical and subtropical region of the world. The association of begomovirus with eggplant yellow mosaic disease is hitherto unknown apart from one report from Thailand. A survey in Nagpur, Central I...

journal_title：Virology journal

authors： Pratap D,Kashikar AR,Mukherjee SK

更新日期：2011-06-16 00:00:00

abstract：BACKGROUND:Aleutian mink disease has major economic consequences on the mink farming industry worldwide, as it causes a disease that affects both the fur quality and the health and welfare of the mink. The virus causing this disease is a single-stranded DNA virus of the genus Amdoparvovirus belonging to the family of P...

journal_title：Virology journal

authors： Ryt-Hansen P,Hagberg EE,Chriél M,Struve T,Pedersen AG,Larsen LE,Hjulsager CK

更新日期：2017-11-22 00:00:00

abstract：:Filamentous bacteriophages have been used in numerous applications for the display of antibodies and random peptide libraries. Here we describe the introduction of a 13 amino acid sequence LASIFEAQKIEWR (designated BT, which is biotinylated in vivo by E. coli) into the N termini of four of the five structural proteins...

journal_title：Virology journal

authors： Smelyanski L,Gershoni JM

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Recently, a new subset of CD4(+)T helper cell termed Follicular helper T cells (Tfh), which play a pivotal role in B cell activation and differentiation in lymphoid structures, has been reported to participate in some certain autoimmune diseases. But whether Tfh cells are involved in the pathogenesis of VMC ...

journal_title：Virology journal

authors： Yang F,Mo WH,Tan BP,Wei XM,Wang H

更新日期：2015-02-11 00:00:00

abstract：:We undertook one of the most detailed studies on the distribution of alpha2,3 sialic acid (SA)-galactose (gal) (avian type) and alpha2,6SA-gal (human type) receptors on different tissues of chickens, ducks and turkeys of varying age groups. On the tracheal epithelium, all 3 bird species expressed strong positive stain...

journal_title：Virology journal

authors： Pillai SP,Lee CW

更新日期：2010-01-12 00:00:00

abstract：BACKGROUND:Crimean-Congo Hemorrhagic Fever virus (CCHFV), a member of the genus Nairovirus, family Bunyaviridae, is a tick-borne pathogen causing severe disease in humans. To better understand the CCHFV life cycle and explore potential intervention strategies, we studied the biosynthesis and intracellular targeting of ...

journal_title：Virology journal

authors： Haferkamp S,Fernando L,Schwarz TF,Feldmann H,Flick R

更新日期：2005-04-25 00:00:00

abstract：BACKGROUND:Hepatitis B virus (HBV) genotype F (HBV/F) is considered to be indigenous to the Americas, but its emergence and spread in the continent remain unknown. Previously, only two HBV/F complete genome sequences from Brazil were available, limiting the contribution of Brazilian isolates to the phylogenetic studies...

journal_title：Virology journal

authors： Mello FC,Araujo OC,Lago BV,Motta-Castro AR,Moraes MT,Gomes SA,Bello G,Araujo NM

更新日期：2013-07-16 00:00:00

abstract：BACKGROUND:During October 2010, Egypt reported an outbreak of acute hemorrhagic conjunctivitis (AHC). A total of 1831 cases were reported from three governorates; 1703 cases in El Daqahliya, 92 cases in Port Said, and 36 in Damietta. The purpose of this study was to identify and characterize the causative agent associa...

journal_title：Virology journal

authors： Ayoub EA,Shafik CF,Gaynor AM,Mohareb EW,Amin MA,Yassin AS,El-Refaey S,Genedy M,Kandeel A

更新日期：2013-03-25 00:00:00

abstract：:Vaccinia virus protein A33 (A33VACV) plays an important role in protection against orthopoxviruses, and hence is included in experimental multi-subunit smallpox vaccines. In this study we show that single-dose vaccination with recombinant Sindbis virus expressing A33VACV, is sufficient to protect mice against lethal c...

journal_title：Virology journal

authors： Paran N,Lustig S,Zvi A,Erez N,Israely T,Melamed S,Politi B,Ben-Nathan D,Schneider P,Lachmi B,Israeli O,Stein D,Levin R,Olshevsky U

更新日期：2013-07-10 00:00:00

abstract：BACKGROUND:Hepatitis B virus (HBV) causes significant morbidity and mortality globally primarily due to its ability to cause hepatitis, liver cirrhosis and hepatocellular carcinoma. The Kenya National Blood Transfusion Services screens for Hepatitis B antibodies using the chemiluminescent microparticle immunoassay meth...

journal_title：Virology journal

authors： Aluora PO,Muturi MW,Gachara G

更新日期：2020-11-13 00:00:00

abstract：BACKGROUND:Longitudinal mark-recapture studies of rodents in two sites in the Mbaracayú Biosphere Reserve in the Interior Atlantic Forest of eastern Paraguay have revealed a complex and intriguing pattern of hantaviruses harbored by rodents in this area. Full-length sequencing and phylogenetic analyses were conducted f...

journal_title：Virology journal

authors： Chu YK,Owen RD,Jonsson CB

更新日期：2011-08-12 00:00:00

abstract：BACKGROUND:Nipah virus (NiV) is a zoonotic virus belonging to the henipavirus genus in the family Paramyxoviridae. Since NiV was first identified in 1999, outbreaks have continued to occur in humans in Bangladesh and India on an almost annual basis with case fatality rates reported between 40% and 100%. METHODS:Ferret...

journal_title：Virology journal

authors： Pallister JA,Klein R,Arkinstall R,Haining J,Long F,White JR,Payne J,Feng YR,Wang LF,Broder CC,Middleton D

更新日期：2013-07-16 00:00:00

abstract：BACKGROUND:Nuclear factor-kappaB (NF-κB) is an inducible transcription factor that plays a key role in inflammation and immune responses, as well as in the regulation of cell proliferation and survival. Previous studies by our group and others have demonstrated that porcine reproductive and respiratory syndrome virus (...

journal_title：Virology journal

authors： Fang Y,Fang L,Wang Y,Lei Y,Luo R,Wang D,Chen H,Xiao S

更新日期：2012-04-30 00:00:00