Abstract:
BACKGROUND:Aleutian mink disease has major economic consequences on the mink farming industry worldwide, as it causes a disease that affects both the fur quality and the health and welfare of the mink. The virus causing this disease is a single-stranded DNA virus of the genus Amdoparvovirus belonging to the family of Parvoviridae. In Denmark, infection with AMDV has largely been restricted to a region in the northern part of the country since 2001, affecting only 5% of the total Danish mink farms. However, in 2015 outbreaks of AMDV were diagnosed in all parts of the country. Initial analyses revealed that the out breaks were caused by two different strains of AMDV that were significant different from the circulating Danish strains. To track the source of these outbreaks, a major investigation of global AMDV strains was initiated. METHODS:Samples from 13 different countries were collected and partial NS1 gene was sequenced and subjected to phylogenetic analyses. RESULTS:The analyses revealed that AMDV exhibited substantial genetic diversity. No clear country wise clustering was evident, but exchange of viruses between countries was revealed. One of the Danish outbreaks was caused by a strain of AMDV that closely resembled a strain originating from Sweden. In contrast, we did not identify any potential source for the other and more widespread outbreak strain. CONCLUSION:To the authors knowledge this is the first major global phylogenetic study of contemporary AMDV partial NS1 sequences. The study proved that partial NS1 sequencing can be used to distinguish virus strains belonging to major clusters. The partial NS1 sequencing can therefore be a helpful tool in combination with epidemiological data, in relation to outbreak tracking. However detailed information on farm to farm transmission requires full genome sequencing.
journal_name
Virol Jjournal_title
Virology journalauthors
Ryt-Hansen P,Hagberg EE,Chriél M,Struve T,Pedersen AG,Larsen LE,Hjulsager CKdoi
10.1186/s12985-017-0898-ysubject
Has Abstractpub_date
2017-11-22 00:00:00pages
231issue
1issn
1743-422Xpii
10.1186/s12985-017-0898-yjournal_volume
14pub_type
杂志文章相关文献
Virology Journal文献大全abstract::Intracellular influenza virus nucleoprotein (NP) is characterized by a high efficiency of homo-polymers formation, however their antigenic structure is still incompletely known. Herein, we report that RNase-resistant intracellular NP homo-polymers have a highly ordered conformational antigenic epitope, which depends o...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-5-37
更新日期:2008-02-29 00:00:00
abstract:BACKGROUND:A vaccine against all four dengue virus (DENV) serotypes includes the formulation of one genotype of each serotype. Although genetic similarities among genotypes within a serotype are higher as compared to those among serotypes, differences in the immunogenicity of the included genotypes would be a critical ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-0967-x
更新日期:2018-03-27 00:00:00
abstract:BACKGROUND:Jamestown Canyon virus (JCV), family Bunyaviridae, is a mosquito-borne pathogen endemic in the United States and Canada that can cause encephalitis in humans and is considered an emerging threat to public health. The virus is genetically similar to Inkoo virus circulating in Europe, suggesting that much of t...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-136
更新日期:2011-03-24 00:00:00
abstract:BACKGROUND:Respiratory syncytial virus (RSV), human Rhinovirus (HRV) and human Metapneumo Virus (HMPV) are important viral pathogens causing acute respiratory tract infections in the hospitalized patients. Sensitive and accurate detection of RSV, HRV and HMPV is necessary for clinical diagnosis and treatment. RESULTS:...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-1061-0
更新日期:2018-10-30 00:00:00
abstract:BACKGROUND:Avian influenza virus (AIV) is classified into two pathotypes, low pathogenic (LP) and high pathogenic (HP), based on virulence in chickens.Differences in pathogenicity between HPAIV and LPAIV might eventually be related to specific characteristics of strains, tissue tropism and host responses. METHODS:To s...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-61
更新日期:2012-03-06 00:00:00
abstract::Ten potential reference genes were compared for their use in experiments investigating cellular mRNA expression of virus infected cells. Human cell lines were infected with Cytomegalovirus, Human Herpesvirus-6, Camelpox virus, SARS coronavirus or Yellow fever virus. The expression levels of these genes and the viral r...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-2-7
更新日期:2005-02-10 00:00:00
abstract::The most common etiologic agents causing chronic hepatitis are hepatitis C and B viruses (HCV and HBV, respectively). Chronic infection caused by HCV is considered one of the major causative agents of liver cirrhosis and hepatocellular carcinoma worldwide. In combination with the increasing rate of new HCV infections,...
journal_title:Virology journal
pub_type: 杂志文章,评审
doi:10.1186/1743-422X-9-109
更新日期:2012-06-12 00:00:00
abstract:BACKGROUND:Tumor necrosis factor-alpha-induced protein 8-like 2 (TIPE2) is a novel target and molecule in the negative regulation of immune homeostasis. The present study aimed to investigate the dynamic expression of TIPE2 mRNA during the progression of chronic hepatitis B virus (HBV) infection. METHODS:A total of 19...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-019-1224-7
更新日期:2019-10-28 00:00:00
abstract:BACKGROUND:Porcine circovirus type-2b (PCV2b) is recognized as the etiological agent of the various clinical manifestations of porcine circovirus-associated disease (PCVAD). Previous studies have demonstrated effectiveness of chimeric PCV1-2 vaccines against PCV2b challenge. In this study, the efficacy of inactivated a...
journal_title:Virology journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12985-015-0338-9
更新日期:2015-07-30 00:00:00
abstract:BACKGROUND:Open reading frame 58 (ORF58) of varicella-zoster virus (VZV) lies at the 3'end of the Unique long (UL) region and its functional is unknown. In order to clarify whether ORF58 is essential for the growth of VZV, we constructed a deletion mutant of ORF58 (pOka-BACDelta58) from the Oka parental genome cloned i...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-5-54
更新日期:2008-04-30 00:00:00
abstract:BACKGROUND:Dengue viruses (DENV) are the most important arboviruses of humans and cause significant disease. Infection with DENV elicits antibody responses to the envelope glycoprotein, predominantly against immunodominant, cross-reactive, weakly-neutralizing epitopes. These weakly-neutralizing antibodies are implicate...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-115
更新日期:2012-06-18 00:00:00
abstract:BACKGROUND:Viruses interact with host cellular factors to construct a more favourable environment for their efficient replication. Expression of cyclophilin B (CypB), a cellular peptidyl-prolyl cis-trans isomerase (PPIase), was found to be significantly up-regulated. Recently, a number of studies have shown that CypB i...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-017-0781-x
更新日期:2017-06-15 00:00:00
abstract:BACKGROUND:The ESCRT (endosomal sorting complex required for transport) machinery functions to sort cellular receptors into the lumen of the multivesicular body (MVB) prior to lysosomal degradation. ESCRT components can also be recruited by enveloped viruses to sites of viral assembly where they have been proposed to m...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-5-23
更新日期:2008-02-11 00:00:00
abstract:BACKGROUND:Saffold Virus (SAFV) is a human cardiovirus that is suspected of causing infection of the central nervous system (CNS) in children. While recent animal studies have started to elucidate the pathogenesis of SAFV, very little is known about the mechanisms behind it. METHOD:In this study, we attempted to eluci...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0654-8
更新日期:2016-11-25 00:00:00
abstract:BACKGROUND:Human adenoviruses (Ads) have substantial potential for clinical applications in cancer patients. Conditionally replicating adenoviruses (CRAds) include oncolytic adenoviruses in which expression of the immediate early viral transactivator protein E1A is controlled by a cancer cell-selective promoter. To enh...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-175
更新日期:2010-07-29 00:00:00
abstract:BACKGROUND:Rodent borne hantaviruses are emerging viruses infecting humans through inhalation. They cause hemorrhagic fever with renal syndrome and hemorrhagic cardiopulmonary syndrome. Recently, hantaviruses have been detected in other small mammals such as Soricomorpha (shrews, moles) and Chiroptera (bats), suggested...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-020-01477-w
更新日期:2020-12-29 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) infection is of growing concern in public health with around 350 million chronically infected individuals worldwide. Although the IFN-alpha/rivabirin is the only approved therapy with 10-30% clinical efficacy, the protective molecular mechanism involved during the treatment is still u...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-2-81
更新日期:2005-09-12 00:00:00
abstract:BACKGROUND:Norovirus (NoV) has been recognized as the leading cause of both outbreaks and sporadic cases of acute gastroenteritis in children and adults worldwide. Stool samples collected from outpatients with clinical symptoms of acute gastroenteritis in all age groups at the First People's Hospital in Huzhou, Huzhou,...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0370-9
更新日期:2015-09-11 00:00:00
abstract:BACKGROUND:Endometrial cancer (EC) is one of the most common gynecological malignancies globally. Although progress has been made in surgical and other adjuvant therapies, there is still a great need to develop new approaches to further reduce the incidence and mortality of EC. Oncolytic virotherapy offers a novel prom...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-0975-x
更新日期:2018-04-10 00:00:00
abstract:BACKGROUND:Nonstructural glycoprotein 4 (NSP4) encoded by rotavirus is the only viral protein currently believed to function as an enterotoxin. NSP4 is synthesized as an intracellular transmembrane glycoprotein and as such is essential for virus assembly. Infection of polarized Caco-2 cells with rotavirus also results ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-551
更新日期:2011-12-20 00:00:00
abstract:BACKGROUND:The reovirus M1 genome segment encodes the mu2 protein, a structurally minor component of the viral core, which has been identified as a transcriptase cofactor, nucleoside and RNA triphosphatase, and microtubule-binding protein. The mu2 protein is the most poorly understood of the reovirus structural protein...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-1-6
更新日期:2004-09-23 00:00:00
abstract:BACKGROUND:Multi-resistant Achromobacter xylosoxidans has been recognized as an emerging pathogen causing nosocomially acquired infections during the last years. Phages as natural opponents could be an alternative to fight such infections. Bacteriophages against this opportunistic pathogen were isolated in a recent stu...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-14
更新日期:2014-01-27 00:00:00
abstract:BACKGROUND:Local epidemiology of Dengue is defined by the genetic diversity of the circulating Dengue virus (DENV) strains. This important information is not available for the virus strains from most parts of the Indian subcontinent. The present study focused on the genetic diversity of the serotype 3 DENV strains (DEN...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-37
更新日期:2013-01-29 00:00:00
abstract:BACKGROUND:The amino terminus of the tobacco etch virus (TEV) capsid protein is located on the external surface of infectious TEV particles, as proposed by previous studies and an in silico model. The epsilon amino groups on the exposed lysine residues are available for chemical conjugation to any given protein, and ca...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-75
更新日期:2012-03-27 00:00:00
abstract:BACKGROUND:HIV-1 entry into cells is a multifaceted process involving target cell CD4 and the chemokine receptors, CXCR4 or CCR5. The lipid composition of the host cell plays a significant role in the HIV fusion process as it orchestrates the appropriate disposition of CD4 and co-receptors required for HIV-1 envelope g...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-3-104
更新日期:2006-12-22 00:00:00
abstract::Modified vaccinia virus Ankara (MVA) has become a promising vaccine vector due to its immunogenicity and its proven safety in humans. As a general approach for stringent and rapid selection of recombinant MVA, we assessed marker rescue of the essential viral D4R gene in an engineered deletion mutant that is fully repl...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-529
更新日期:2011-12-12 00:00:00
abstract:BACKGROUND:Aleutian mink disease virus (AMDV) is the cause of a chronic immune complex disease, Aleutian disease (AD), which is common in mink-producing countries. In 2005, implementation of an AMDV eradication programme in Finland created a need for an automated high-throughput assay. The aim of this study was to vali...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-141
更新日期:2014-08-08 00:00:00
abstract:BACKGROUND:Influenza viruses are characterized by their highly variable surface proteins HA and NA. The third surface protein M2 is a nearly invariant protein in all Influenza A strains. Despite extensive studies in other animal models, this study is the first to describe the use of recombinant M2 protein and a peptide...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-206
更新日期:2013-06-24 00:00:00
abstract:BACKGROUND:Tomato yellow leaf curl virus (TYLCV), a monopartite begomovirus (family Geminiviridae) is responsible for heavy yield losses for tomato production around the globe. In Oman at least five distinct begomoviruses cause disease in tomato, including TYLCV. Unusually, TYLCV infections in Oman are sometimes associ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0263-y
更新日期:2015-03-04 00:00:00
abstract:INTRODUCTION:Despite being a leading infectious cause of childhood disability globally, testing for cytomegalovirus (CMV) infections in pregnancy is generally not done in Sub-Sahara Africa (SSA), where breastfeeding practice is almost universal. Whilst CMV and human immunodeficiency virus (HIV) are both endemic in SSA,...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-021-01494-3
更新日期:2021-01-29 00:00:00