Signals that determine the fate of osteoblastic cells.

abstract：UNLABELLED:Hexarelin (HEX) is a synthetic hexapeptide with strong GH-stimulating activity. We evaluated GH response (expressed as maximum value after stimulus [Cmax] and as area under the curve [AUC]) to HEX at the doses of 1 microg/kg i.v. (HEX 1) and 2 microg/kg i.v. (HEX 2), in comparison with the responses to GHRH ...

journal_title：Journal of endocrinological investigation

authors： Guzzaloni G,Grugni G,Morabito F

更新日期：1999-05-01 00:00:00

abstract：:Steroid 21-hydroxylase deficiency (21OHD) compromises about 95% of all cases of congenital adrenal hyperplasia. We have characterized the disease-causing mutations in the steroid 21-hydroxylase genes of 19 Chilean patients (12 females and 7 males) with the simple virilizing (SV) form of 21OHD and compared them with ot...

journal_title：Journal of endocrinological investigation

authors： Fardella CE,Poggi H,Soto J,Torrealba I,Cattani A,Ugarte F,Cortinez A,Foradori A

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:To our knowledge, no case of remission in autoimmune Addison's disease has previously been reported. We describe a patient with primary adrenal insufficiency caused by autoimmune adrenalitis in whom partial remission was observed after 7 yr. CASE:A 39-yr-old male was referred because of extreme fatigue, weig...

journal_title：Journal of endocrinological investigation

authors： Smans LC,Zelissen PM

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Placental hypoxia has been implicated in the pathogenesis of pre-eclampsia. Hypoxia inducible factor-1α (HIF-1α) is activated by low oxygen tension and is a key regulator of genes involved in the cellular responses to hypoxia. AIM:We determined whether maternal blood c.1722C>T (Pro582Ser) and c.1790G>A (Ala...

journal_title：Journal of endocrinological investigation

authors： Kim SY,Park SY,Lim JH,Lee BY,Yang JH,Ryu HM

更新日期：2012-07-01 00:00:00

abstract：:The genetic factors determining bone mineral density (BMD) are not well characterized. Many studies have investigated the relationship between the fokI polymorphism of vitamin D receptor (VDR) gene in diverse populations and gender, resulting in conflicting outcomes. Because peak bone mass in men is closely related to...

journal_title：Journal of endocrinological investigation

authors： Bolu SE,Orkunoglu Suer FE,Deniz F,Uckaya G,Imirzalioglu N,Kutlu M

更新日期：2005-10-01 00:00:00

abstract：AIMS:To investigate the prevalence of metabolic syndrome and its components in both rural and urban Chinese population. SUBJECTS AND METHODS:A population-based crosssectional survey was conducted in Qingdao, China in 2006 with 6100 Chinese aged 35-74 yr invited and 5355 who attended; 3357 subjects, 1562 urban (46.5%) ...

journal_title：Journal of endocrinological investigation

authors： Zhao J,Pang ZC,Zhang L,Gao WG,Wang SJ,Ning F,Nan HR,Ren J,Qiao Q,Qingdao 2006 Diabetes Survey Group.

更新日期：2011-06-01 00:00:00

abstract：:Few data are available on serum free thyroid hormone concentration in patients with T3-toxicosis. In this study total and free T4 and T3 and TBG were evaluated in 35 subjects with T3-toxicosis, including 12 with untreated Graves' disease, 5 Graves' patients on methimazole treatment, 13 with autonomous adenoma, 3 with ...

journal_title：Journal of endocrinological investigation

authors： Ferrari C,Romussi M,Rampini P,Benco R,Boghen M,Paracchi A,Frezzati S

更新日期：1983-02-01 00:00:00

abstract：AIMS AND METHODS:Factor analysis is a multivariate correlation technique frequently employed to characterise the aggregation of abnormalities underlying the metabolic syndrome (MS), but scarcely used in obese adolescents. Aim of the study was to investigate the clustering of anthropometric and metabolic variables relat...

journal_title：Journal of endocrinological investigation

authors： Lafortuna CL,Adorni F,Agosti F,De Col A,Zennaro R,Caranti D,Sartorio A

更新日期：2009-06-01 00:00:00

abstract：:A 33-year-old female presented in 1966 with striking pigmentation, typical of Addison's disease, and amenorrhea. Endocrine assessment then showed normal basal serum cortisol and urinary hydroxysteroid levels, but serum cortisol did not respond to stimulation with either exogenous ACTH or lysine vasopressin. Steroid re...

journal_title：Journal of endocrinological investigation

authors： Whitehead EM,Atkinson AB,Hadden DR,Weaver J,Sheridan B

更新日期：1989-03-01 00:00:00

abstract：:The in vivo suppressive effect of glucose and insulin on plasma free fatty acid concentrations was investigated in obese subjects with (n = 6) and without (n = 6) Type 2 (non-insulin-dependent) diabetes mellitus during a 4h-hyperglycemic glucose clamp (about 11.2 mmol/l). Somatostatin was infused (250 micrograms/h) du...

journal_title：Journal of endocrinological investigation

authors： Zancanaro C,Cigolini M,Bonora E,Moghetti P,Querena M,Muggeo M

更新日期：1990-01-01 00:00:00

abstract：:Two radioimmunological techniques for the measurement of anti-alpha-galactosyl (anti-Gal) antibodies were developed and we demonstrated that this antibody is present in the serum of most untreated patients with Graves' disease, thyroid-associated ophthalmopathy (TAO) and autoimmune thyroiditis. Thyrotropin-binding inh...

journal_title：Journal of endocrinological investigation

authors： Winand RJ,Winand-Devigne J,Cox C,Caulier C,Meurisse M

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:To determine the difference of serum levels of 10 adipokines (apelin, chemerin, fatty acid-binding protein-4, fibroblast growth factor-21, monocyte chemoattractant protein-1, nesfatin-1, omentin-1, resistin, vaspin, and visfatin) among women with gestational diabetes and healthy pregnant controls. MATERIALS ...

journal_title：Journal of endocrinological investigation

authors： Bellos I,Fitrou G,Pergialiotis V,Perrea DN,Daskalakis G

更新日期：2019-06-01 00:00:00

abstract：:Seventy-one white women within 6 months to 6 years postmenopause were randomly assigned to three treatment groups: (a) placebo, (b) calcium, (c) cyclic estrogen-progestin plus calcium. Calcium was given as calcium carbonate with meals to attain an intake of 1,700 mg daily in the latter two groups. All women received 4...

journal_title：Journal of endocrinological investigation

authors： Aloia JF,Vaswani A,Yeh JK,McGowan DM,Ross P

更新日期：1991-12-01 00:00:00

abstract：:To analyze the inhibitory effect of hormone replacement therapy (HRT) on bone resorption, we measured urinary excretion of C-telopeptide (CTX) and N-telopeptide (NTX) of type I collagen as new markers of bone resorption and assessed their correlation with bone mineral density, in comparison with urinary pyridinoline (...

journal_title：Journal of endocrinological investigation

authors： Taga M,Uemura T,Minaguchi H

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:In vitro data have shown conflicting results in terms of the effect of leptin on granulosa cells steroidogenesis. AIM:The aim of the present study was to investigate the effect of low and high doses of leptin on basal and FSH-induced steroids secretion by human luteinized granulosa cells in culture. MATERI...

journal_title：Journal of endocrinological investigation

authors： Karamouti M,Kollia P,Kallitsaris A,Vamvakopoulos N,Kollios G,Messinis IE

更新日期：2009-05-01 00:00:00

abstract：INTRODUCTION:Vitamin D (VD) insufficiency has been repeatedly observed in the medical conditions associated with inflammation, such as cardiovascular disease, diabetes and depression. However, contrasting to the observational evidence, randomized trials of VD supplementation failed to demonstrate such link. Given the r...

journal_title：Journal of endocrinological investigation

authors： Jiang P,Zhang L,Zhu W,Li H,Dang R,Tang M

更新日期：2014-11-01 00:00:00

abstract：:Recombinant human thyroid-stimulating hormone (rhTSH) was developed to safely provide exogenous TSH stimulation in patients on thyroid hormone suppression therapy (THST), which is integral to long-term management of well-differentiated thyroid cancer. Such stimulation allows detection of thyroid remnant and neoplastic...

journal_title：Journal of endocrinological investigation

authors： Incerti C

更新日期：1999-01-01 00:00:00

abstract：:Recently, highly purified bovine thyrotropin (bTSH) of pituitary origin, as well as recombinant human (h) TSH free of lutropin (LH) contamination, has been reported to activate the LH/choriogonadotropin receptor (LH/CGR). These data challenge the concept of TSH specificity for its own receptor. We, therefore, re-evalu...

journal_title：Journal of endocrinological investigation

authors： Nagayama Y,Yamasaki H,Takeshita A,Kimura H,Ashizawa K,Yokoyama N,Yamashita S,Rapoport B,Nagataki S

更新日期：1995-04-01 00:00:00

abstract：:Keratoconus is a bilateral non-inflammatory corneal ectasia with an incidence of approximately 1 per 2000 in the general population. The etiology of keratoconus is multifactorial, although not completely understood. Several clinical observations suggest that thyroid gland dysfunction is associated with keratoconus pat...

journal_title：Journal of endocrinological investigation

authors： Gatzioufas Z,Thanos S

更新日期：2008-03-01 00:00:00

abstract：AIM:Adult subjects with Prader-Willi syndrome (PWS) may show several conditions that are associated with an activation of innate immunity such as obesity, deficient GH secretion or hypogonadism. Our aim was to study whether obese adult PWS subjects show an additional low-grade systemic inflammation (LGSI) in relation t...

journal_title：Journal of endocrinological investigation

authors： Caixàs A,Giménez-Palop O,Broch M,Vilardell C,Megía A,Simón I,Giménez-Pérez G,Mauricio D,Vendrell J,Richart C,González-Clemente JM

更新日期：2008-02-01 00:00:00

abstract：:Severe bleeding into the peritoneal cavity from a ruptured ovulatory follicle is a rare complication in women receiving anticoagulation therapy. A number of both surgical and non surgical methods have been proposed to solve this problem. We adopted a novel therapeutic approach in a 40-year old patient who presented wi...

journal_title：Journal of endocrinological investigation

authors： Ulrich U,Rossmanith WG

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:In obese subjects it has been shown that cortisol (F) contributes to the reduction in insulin sensitivity, suggesting a role in the development of the metabolic syndrome (MS). AIM:The aim of this retrospective study was to evaluate the relationship between F and components of MS in 1,027 obese children and ...

journal_title：Journal of endocrinological investigation

authors： Guzzetti C,Pilia S,Ibba A,Loche S

更新日期：2014-01-01 00:00:00

abstract：:The type of dietary fat affects the action of insulin by changes induced in the fatty acid composition of cell membranes. Little is known, however, about the effects of dietary fatty acids on insulin secretion or the possible relation between the fatty acid composition of the membrane phospholipids and insulin secreti...

journal_title：Journal of endocrinological investigation

authors： Tinahones FJ,Pareja A,Soriguer FJ,Gómez-Zumaquero JM,Cardona F,Rojo-Martínez G

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Mutations of the thyrotropin receptor (TSHR) and/or Gαs gene have been found in a number of, but not all, autonomously functioning thyroid nodules (AFTNs). Recently, in a 15-year-old girl with a hyperfunctioning papillary thyroid carcinoma, we found two somatic and germline single nucleotide polymorphisms (S...

journal_title：Journal of endocrinological investigation

authors： Vicchio TM,Giovinazzo S,Certo R,Cucinotta M,Micali C,Baldari S,Benvenga S,Trimarchi F,Campennì A,Ruggeri RM

更新日期：2014-07-01 00:00:00

abstract：AIM:We investigated inpatients with and without Type 2 diabetes mellitus, aged over 60 yr, to compare their vitamin D status and calcium homeostatic parameters. MATERIALS AND METHODS:We studied 140 patients consecutively admitted to our Internal Medicine Unit during the year 2010 (61 from November to April, 79 from Ma...

journal_title：Journal of endocrinological investigation

authors： Carnevale V,Inglese M,Annese MA,De Matthaeis A,Santini SA,Frusciante V,Fontana A,Copetti M,Pellegrini F,D'Amico G

更新日期：2012-10-01 00:00:00

abstract：:Established methods for definitive ablation of autonomous thyroid nodules are surgery and radioiodine. Since it has been demonstrated that percutaneous ethanol injection can inactivate parathyroid adenomas and small hepatocellular carcinomas, we started a trial of this treatment in patients with autonomous thyroid nod...

journal_title：Journal of endocrinological investigation

authors： Paracchi A,Ferrari C,Livraghi T,Reschini E,Macchi RM,Bergonzi M,Raineri P

更新日期：1992-05-01 00:00:00

abstract：PURPOSE:Intravenous glucocorticoids (ivGCs) given as 12-weekly infusions are the first-line treatment for moderate-to-severe and active Graves' orbitopathy (GO), but they are not always effective. In this study, we evaluated whether response at 6 weeks correlated with outcomes at 12 (end of intervention) and 24 (follow...

journal_title：Journal of endocrinological investigation

authors： Bartalena L,Veronesi G,Krassas GE,Wiersinga WM,Marcocci C,Marinò M,Salvi M,Daumerie C,Bournaud C,Stahl M,Sassi L,Azzolini C,Boboridis KG,Mourits MP,Soeters MR,Baldeschi L,Nardi M,Currò N,Boschi A,Bernard M,von Arx

更新日期：2017-05-01 00:00:00

abstract：:We investigated the influence of calcium ions on the secretion of anterior pituitary hormones basally and in response to exogenous hypothalamic releasing factors in 6 men with pituitary tumors. To this end, concentrations of LH, FSH, TSH, growth hormone and prolactin were measured in blood collected at 10-min interval...

journal_title：Journal of endocrinological investigation

authors： Davis M,Nassberg B,Borges JL,Iranmanesh A,Lizzaralde G,Santen RJ,Drake C,Rogol AD,Kaiser DL,Thorner MO

更新日期：1987-10-01 00:00:00

abstract：OBJECTIVE:To investigate the inflammatory markers in polycystic ovary syndrome (PCOS) and associations of these markers with obesity and in vitro fertilization (IVF) outcomes. METHODS:A total of 292 women underwent IVF procedure either with PCOS (n = 146) or without PCOS (n = 146, age, and body mass index (BMI) matche...

journal_title：Journal of endocrinological investigation

authors： Çakıroğlu Y,Vural F,Vural B

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:Leptin is associated with cardiovascular risk factors (e.g. hypertension, insulin resistance, kidney disease and excess body weight). Experimental studies showed that leptin might affect serum uric acid, by modulation of the uric acid excretion. However, there are few observational data on the relationship betw...

journal_title：Journal of endocrinological investigation

authors： D'Elia L,Giaquinto A,Cappuccio FP,Iacone R,Russo O,Strazzullo P,Galletti F

更新日期：2020-05-01 00:00:00