Serum free thyroid hormones in T3-toxicosis: a study of 35 patients.

Abstract:

:Few data are available on serum free thyroid hormone concentration in patients with T3-toxicosis. In this study total and free T4 and T3 and TBG were evaluated in 35 subjects with T3-toxicosis, including 12 with untreated Graves' disease, 5 Graves' patients on methimazole treatment, 13 with autonomous adenoma, 3 with multinodular goiter, and 2 with subacute thyroiditis. T4, T3, free T4 (FT4), free T3 (FT3) as well as calculated T4/TBG and T3/TBG ratios were significantly higher in patients than in 37 healthy controls. Serum FT4 levels above the normal range were found in 19 subjects with T3-toxicosis (9 with untreated and one with methimazole-treated Graves' disease, 6 with autonomous adenoma, 1 with multinodular goiter and 2 with subacute thyroiditis). These data, together with the few previous reports, indicate that high FT4 levels are present in about half of the patients with so called T3-toxicosis, and that this occurs more frequently in diffuse than nodular goiter. It is suggested that the term T3-toxicosis be used only for those subjects with normal total and free T4.

journal_name

J Endocrinol Invest

authors

Ferrari C,Romussi M,Rampini P,Benco R,Boghen M,Paracchi A,Frezzati S

doi

10.1007/BF03350562

subject

Has Abstract

pub_date

1983-02-01 00:00:00

pages

55-8

issue

1

eissn

0391-4097

issn

1720-8386

journal_volume

6

pub_type

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