Abstract:
:To analyze the inhibitory effect of hormone replacement therapy (HRT) on bone resorption, we measured urinary excretion of C-telopeptide (CTX) and N-telopeptide (NTX) of type I collagen as new markers of bone resorption and assessed their correlation with bone mineral density, in comparison with urinary pyridinoline (Pyr), deoxypyridinoline (D-Pyr) and hydoxyproline (Hpr). CTX and NTX, in addition to Pyr, D-Pyr, and Hpr, in urinary samples from 33 postmenopausal women with climacteric symptoms who were treated with 0.625 mg conjugate equine estrogen and 2.5 mg medroxyprogesterone acetate for 12 months were measured using ELISA for each telopeptide. Bone mineral density in the lumbar spine was also measured by dual energy X-ray absorptiometry. Similar to Pyr, D-Pyr, and Hpr, urinary excretions of CTX and NTX significantly decreased during the continuous administration of conjugate equine estrogen and medroxyprogesterone acetate for 12 months. The magnitudes of the reduction of CTX and NTX were significantly greater than those of Pyr, D-Pyr, and Hpr. CTX and NTX correlated well with Pyr, D-Pyr, and Hpr, and there was a good correlation between CTX and NTX. Unlike Pyr, D-Pyr, and Hpr, the pretreatment values of CTX and NTX correlated negatively with bone mineral density at baseline. These results suggest that, among the markers for bone resorption, the changes in CTX and NTX could be greater than those in Pyr, D-Pyr, and Hpr during HRT in postmenopausal women.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Taga M,Uemura T,Minaguchi Hdoi
10.1007/BF03347294subject
Has Abstractpub_date
1998-03-01 00:00:00pages
154-9issue
3eissn
0391-4097issn
1720-8386journal_volume
21pub_type
杂志文章abstract::Thyrocytes from normal and goitrous portions of the thyroid gland from a patient with an enormous (635 gm) goiter were cultured in media, and their relative abilities to uptake thymidine, synthesize DNA, and secrete Tg and T4 were assessed. Tg, T4 and the ratio Tg/T4 in media at 72 h were 120 micrograms/dl, 1.6 microg...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348184
更新日期:1987-10-01 00:00:00
abstract::Final height was evaluated in 47 patients with classical 21-hydroxylase treated since diagnosis, and in 29 patients with nonclassical (NC) 21-hydroxylase deficiency who had never been treated before reaching final adult height. Classical patients achieved final heights consistently below the mean for the general popul...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::Pheochromocytoma (PHEO) occasionally associates with pathological lesions of the adrenal cortex. In most of them, ectopic adrenocorticotropic hormone (ACTH) produced by PHEO resulted in bilateral adrenocortical hyperplasia. The coexistence of PHEO and pre-clinical Cushing's syndrome (PCS) of the same adrenal gland has...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347247
更新日期:2005-06-01 00:00:00
abstract::The IGFs are ubiquitous and have pleoitropic effects. They are critical for normal growth and development, and for normal functioning of adult tissues. A liver-specific gene-deletion knockout of the IGF-I gene resulted in a mouse model with reduced circulating IGF-I levels, that led to insulin resistance due to the se...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Increasing evidence showed that telomere length was shorter in age-related diseases, but the mechanism of this phenomenon is still unclear. AIM:To determine whether telomere shortening occurs in Type 1 diabetes (T1D) and Type 2 diabetes (T2D), and explore the effect of antioxidant status on the telomere len...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/9036
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The Arnolfini portrait painted by Jan van Eyck in 1434 remains one of the most puzzling yet alluring paintings of prerenaissance western art. PURPOSE:The painting is renowned for its exactitude in brush strokes, textures and the distinctive morphology of the main character Arnolfini. The nature of these req...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-017-0751-6
更新日期:2018-01-01 00:00:00
abstract::The intravenous injection of calcium gluconate (0.11 mM/kg body weight) into conscious thyroidectomized pigs elicits a 30% rise in both ionized and total calcium concentrations of plasma, which return to basal levels within 180 min. The administration of calcitonin (2.5-10 MRC U/kg body weight) reduces this time to 30...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350579
更新日期:1983-04-01 00:00:00
abstract::The outcome of radioiodine therapy of Graves' hyperthyroidism was retrospectively evaluated in 274 consecutive patients treated from 1975 to 1984. At 1-yr follow-up, permanent hypothyroidism occurred in 36.9% of patients and the cumulative incidence of hypothyroidism progressively increased up to 79.3% after 7-10 yr. ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348615
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:Adiponectin has emerged over the last decade as a key adipokine linking obesity, insulin resistance, and Type 2 diabetes. However, the molecular mechanisms controlling adiponectin expression in adipose tissue are not fully elucidated. Furthermore, increasing evidence indicates that peroxisome proliferator-ac...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347056
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Studies from every continent have shown that only around 50% of the patients subjected to thyroid hormone replacement have TSH in the normal range. However, to date, there are no consistent data about Brazil. OBJECTIVES:To evaluate levothyroxine (LT4) replacement treatment in patients with primary hypothyro...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,多中心研究
doi:10.3275/8810
更新日期:2013-07-01 00:00:00
abstract::The effect of exogenous prednisone on serum thyrotropin (TSH), thyroxine (T4), and triiodothyronine (T3) concentrations was investigated in four patients with non-functioning thyroid glands receiving T4 replacement therapy. Orally administered prednisone, in a dose of 20 mg each day for nine days, resulted in a signif...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350367
更新日期:1978-04-01 00:00:00
abstract::The research suggests that adiponectin plays an important role in sensitizing insulin action. It is interesting to find that the lower levels of adiponectin exist in the plasma of obese and Type 2 diabetes subjects and in the adipose tissue of obese, db/db mice, and insulin-resistant individuals. However, the underlyi...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346688
更新日期:2011-01-01 00:00:00
abstract::IGF-I stimulates protein synthesis, lowers blood glucose, and affects cell differentiation. The main production site of IGF-I is the liver. One of its binding proteins, IGFBP-1, is also produced by the liver. It is well known that ethanol affects the function of the human liver. Long-term alcohol abuse may therefore n...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03343879
更新日期:2001-07-01 00:00:00
abstract::We report an original application of quantitative reverse transcription-polymerase chain reaction (Q.RT-PCR) for the evaluation of atrial natriuretic factor (ANF), brain natriuretic peptide (BNP) and beta-actin mRNA in small atrial samples (10-15 mg). A fixed amount of total RNA was simultaneously reverse transcribed ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03343655
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:The determination of (a) iodine deficiency, and (b) the relation between the iodized salt consumption in the Isparta province of Turkey. METHODS:Five hundred students between 6-11 yr of age were evaluated. With a questionnaire, the subjects were asked whether they were using iodine-containing salt or not. Af...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03344181
更新日期:2006-09-01 00:00:00
abstract::Anatomy studies normally precede physiology. While the anatomy of the penis and the biochemical and molecular regulation of erection are largely known, the exact anatomical description of the human clitoris was produced in 1998, the taxonomy of female sexual dysfunctions classified in 1999, and biochemistry of female ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Vitamin D exerts pleiotropic effects and few studies are available in the Italian population. AIM:Aim of our study was to evaluate vitamin D status in children living in Northern Italy. METHODS:We studied vitamin D levels in a population of 113 normal weight (NW) and 444 obese (OB) children, prepubertal an...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-014-0108-3
更新日期:2014-09-01 00:00:00
abstract::During a multicentric pilot screening program for congenital hypothyroidism a comparison between the results obtained from Urbino, an area characterized by low iodine supply and endemic goiter, and Rome, a non-endemic area, has been made. The evaluation of neonatal urinary iodine excretion in the two areas showed sign...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350156
更新日期:1988-04-01 00:00:00
abstract::Plasma T4, T3, and TSH, and total and 131l-labeled T4 and T3 in thyroid digests were determined in male and female rats from birth to 30--45 days postnatally. Mothers and offspring were fed a high-iodine Purina diet throughout. In both sexes, plasma T4 was less than 1 microgram/100ml at birth but rose linearly to a pe...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350975
更新日期:1978-10-01 00:00:00
abstract::The effects of growth hormone-releasing hormone (GHRH) were studied on densely granulated somatotroph adenoma cells and sparsely granulated somatotroph adenoma cells in culture by measuring release of growth hormone (GH) as well as ultrastructural morphometrical parameters and comparing them with those of control aden...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350727
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:In vitro islet expansion has recently drawn interest for its potential application in diabetes therapy, while how islet cells adapt to in vitro circumstances is not quite clear. AIM:Proteomics changes of cultivated islet cells under different conditions were examined in this study. MATERIAL/SUBJECTS AND ME...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/7275
更新日期:2011-12-01 00:00:00
abstract::Experimental data concerning the role of serotonin (5-HT) in the control of gonadotropins secretion remain controversial: different receptors subtypes should mediate the serotoninergic action. In the present work we analyzed in prepubertal and adult male rats the FSH and LH responses after administration of the follow...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347993
更新日期:1997-07-01 00:00:00
abstract::To verify if the entity of the peak GH responses to the GHRH+arginine (ARG) test is able to show different degree forms of GH deficiency (GHD), we linked these responses with the number of other anterior pituitary deficits. These anterior pituitary deficits were also related with IGF-I levels. To this purpose, we stud...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03345381
更新日期:2005-03-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the prevalence and risk factors associated with female sexual dysfunction (FSD) in young women with type 1 diabetes treated with different intensive insulin regimens. METHODS:Type 1 diabetic women aged 18-35 years were included in this study if they had stable couple relat...
journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章
doi:10.1007/s40618-016-0542-5
更新日期:2017-02-01 00:00:00
abstract::It has been shown that human calcitonin (hCT) is absorbed through the nasal mucosa when administered together with promoters like sodium glycocholate (SGC) or dihydrofusinate. The aim of this study was to compare the clinical and metabolic effect of intranasal (in) and intramuscular (im) hCT in patients with osteoporo...
journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF03350260
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:In the last decades, a higher incidence of congenital hypothyroidism (CH) has been recorded in Italy (1:1940) and worldwide, mainly due to the shift to lower screening TSH cutoffs. Although CH can also be caused by dysgenetic defects, most CH cases have recently been found to be more frequently associated wi...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/s40618-015-0288-5
更新日期:2015-08-01 00:00:00
abstract::We examined the distribution of nuclear T3 in mature rat brain with the aim of determining specific targets of thyroid hormones within this tissue. Saturation experiments, performed in 9 different structures of the brain and in 4 parts of the cortex, revealed the presence of a single class of binding sites with a mean...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348511
更新日期:1985-08-01 00:00:00
abstract::According to recent studies showing the presence of estrogens receptors (ERs) in the human female lower urinary tract, we performed ER and progesterone receptor (PR) assays in fresh frozen and paraffin embedded biopsies taken from the urinary bladder. Fourteen females undergoing endoscopy during staging for gynecologi...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347639
更新日期:1992-11-01 00:00:00
abstract::Human GH (hGH) is a heterogeneous protein hormone consisting of several isoforms. This heterogeneity is the consequence of multiple hGH genes, mRNA splicing, post-translational modifications, and peripheral metabolism, and it represents one important reason for the disparity among GH assay results from different labor...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.3275/8647
更新日期:2012-11-01 00:00:00
abstract::The diagnosis of growth hormone (GH) deficiency (GHD) is currently based on failure to increase plasma GH levels to an arbitrary cutoff point of 7 or 10 micrograms/l in response to two provocative stimuli. False negative responses to these tests, however, frequently occur thus reducing their diagnostic reliability. Th...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349569
更新日期:1990-04-01 00:00:00