Abstract:
:Established methods for definitive ablation of autonomous thyroid nodules are surgery and radioiodine. Since it has been demonstrated that percutaneous ethanol injection can inactivate parathyroid adenomas and small hepatocellular carcinomas, we started a trial of this treatment in patients with autonomous thyroid nodules. Twenty-eight patients, 22 toxic and 6 nontoxic, all with undetectable thyrotropin serum levels and suppressed extranodular tissue on scintigraphy, were treated. Treatment consisted of percutaneous intranodular ethanol injection under ultrasound guidance. The total amount of alcohol injected ranged from 0.4 to 2.2 times the estimated nodule volume, divided into 4 to 9 injections performed at 2 to 7 day intervals. Most patients were treated with a single cycle of injections, but 7 of them required 2 cycles. The signs and symptoms of hyperthyroidism disappeared in all cases. Apparently complete cure (normal serum free thyroid hormones, thyrotropin in basal conditions and after thyrotropin releasing hormone, reactivation of extranodular tissue on scintigraphy with nodule no longer visible) was obtained in 17 patients (13 after 1 cycle and 4 after 2 cycles). Partial cure (normal serum free thyroid hormone levels, detectable thyrotropin levels with normal or blunted response to thyrotropin releasing hormone and partial reactivation of extranodular tissue on scintigraphy with nodule or parts of it still visible) was obtained in 10 patients (8 after 1 cycle and 2 after 2 cycles). In 1 patient with a very large nodule thyrotropin levels remained undetectable, but thyroid hormone levels eventually became normal. No recurrences were observed after a follow-up of 12 to 32 months (mean 20 months). No serious side effects were encountered. A clinically valuable result was obtained in all patients. These data suggest that this form of treatment could constitute an alternative to surgery and radioiodine for the ablation of autonomous thyroid nodules.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Paracchi A,Ferrari C,Livraghi T,Reschini E,Macchi RM,Bergonzi M,Raineri Pdoi
10.1007/BF03348753keywords:
subject
Has Abstractpub_date
1992-05-01 00:00:00pages
353-62issue
5eissn
0391-4097issn
1720-8386journal_volume
15pub_type
杂志文章abstract:OBJECTIVE:The aim of this study was to investigate the hypothesis that interleukin-1beta (IL-1beta) might be involved in the increase of the circulating levels of placental-derived CRH leading to the initiation of pre-term labor. SUBJECTS AND METHODS:Forty-eight primigravidae with a singleton viable pregnancy between ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347393
更新日期:2007-01-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03345319
更新日期:2005-11-01 00:00:00
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journal_title:Journal of endocrinological investigation
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更新日期:2000-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s40618-020-01244-2
更新日期:2020-11-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349744
更新日期:1995-06-01 00:00:00
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journal_title:Journal of endocrinological investigation
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doi:10.3275/8655
更新日期:2013-06-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350607
更新日期:1983-06-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
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更新日期:2000-03-01 00:00:00
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更新日期:2007-09-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348490
更新日期:1985-06-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348033
更新日期:1997-12-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348681
更新日期:1992-02-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-014-0198-y
更新日期:2015-05-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346892
更新日期:1997-03-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/s40618-016-0473-1
更新日期:2016-10-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-018-0913-1
更新日期:2019-03-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-018-0973-2
更新日期:2019-06-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/BF03350917
更新日期:2004-01-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type:
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更新日期:2002-01-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,meta分析
doi:10.1007/s40618-019-01047-0
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doi:10.1007/BF03350225
更新日期:1988-12-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03344087
更新日期:2006-02-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03343930
更新日期:2001-11-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348799
更新日期:1992-07-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
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更新日期:2016-08-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-018-0918-9
更新日期:2018-12-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346300
更新日期:2007-04-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章
doi:10.1007/BF03346315
更新日期:2007-05-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/8013
更新日期:2012-09-01 00:00:00