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Oxytocin reduces the activity of N-methyl-D-aspartate receptors in cultured neurons.

Abstract：

:N-Methyl-D-Aspartate(NMDA)-sensitive glutamate receptors, are critically involved in the induction of the learning process. Activation of NMDA receptors by glutamate lead to massive influx of extracellular Ca2+, with ensuing activation of a variety of Ca(2+)-dependent enzymes, including protein kinase C. This triggers a cascade of intracellular reactions which is essential for memory formation. In culture neurons, high concentrations of oxytocin (> 1 microM) attenuate the stimulation of 45Ca2+ influx promoted by glutamate through the activation NMDA receptors. In addition, the hormone reduces glutamate-stimulated [3H]4-beta-phorbol 12,13-dibutyrate (PdBu) binding in intact cells, a parameter that reflects the translocation of protein kinase C from the cytosol to the cell membrane. Taken collectively, these results indicate that oxytocin reduces the activity of NMDA receptors, thus impairing one of the major substrates for the induction of learning and memory.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Caruso S,Agnello C,Campo MG,Nicoletti F

doi

10.1007/BF03348959

subject

Has Abstract

pub_date

1993-12-01 00:00:00

pages

921-4

issue

11

eissn

0391-4097

issn

1720-8386

journal_volume

16

pub_type

杂志文章

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