Therapeutic effects of obeticholic acid (OCA) treatment in a bleomycin-induced pulmonary fibrosis rat model.

abstract：:Thyroid-stimulating antibody (TSAb) activity and the TSH-binding inhibitory immunoglobulin (TBII) index were assessed in 158 patients with Graves' disease who had been treated with 131I 6-14 years earlier. Twenty-one patients (13%) were still hyperthyroid, 45 (28%) were euthyroid, 44 (28%) were subclinically hypothyro...

journal_title：Journal of endocrinological investigation

authors： Yoshida K,Aizawa Y,Kaise N,Fukazawa H,Kiso Y,Sayama N,Mori K,Hori H,Abe K

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:One of the major topics in modern societies is the study of relationships between diet, stress and incidence of metabolic disorders. AIM:This study aimed to investigate possible impairment in glucose-stimulated insulin secretion induced by a high-fat (cow intra-abdominal fat) diet in response to acute stres...

journal_title：Journal of endocrinological investigation

authors： Ghalami J,Zardooz H,Rostamkhani F,Farrokhi B,Hedayati M

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:Initial surgery for medullary thyroid cancer (MTC) with no evidence of lymph node involvement in neck compartments consists of total thyroidectomy and prophylactic central neck dissection. This study evaluated the reliability of a radiotracer technique for the intraoperative detection of sentinel lymph nodes (S...

journal_title：Journal of endocrinological investigation

authors： Puccini M,Manca G,Ugolini C,Candalise V,Passaretti A,Bernardini J,Boni G,Buccianti P

更新日期：2014-09-01 00:00:00

abstract：:17alpha-hydroxylase deficiency (17alpha-OHDS) results in decreased production of cortisol and sex steroids and hypokalemia secondary to excess mineralocorticoids. It has long been known that glucocorticoid deficiency is associated with impaired urinary dilution and increased secretion of vasopressin (AVP). On the othe...

journal_title：Journal of endocrinological investigation

authors： Leal AM,Elias PC,Moreira AC

更新日期：2002-07-01 00:00:00

abstract：:Following presentation and diagnosis, microprolactinomas usually follow a benign course and rarely progress to macroprolactinomas. However, clinically significant enlargement of prolactinomas during pregnancy, presumably related to estrogen stimulation, has been reported. This report describes a patient with amenorrhe...

journal_title：Journal of endocrinological investigation

authors： Garcia MM,Kapcala LP

更新日期：1995-06-01 00:00:00

abstract：:Pyridinoline (Pyr) and deoxypyridinoline (D-Pyr) are two cross-links of collagen molecules, that are present in the extracellular matrix and released during its degradation. Pyr is present in bone and cartilage, but not in significant amounts in other connective tissues and D-Pyr appears to be specific for bone tissue...

journal_title：Journal of endocrinological investigation

authors： Calabresi E,Lasagni L,Franceschelli F,de Leonardis V,Becorpi A,Serio M,Brandi ML

更新日期：1994-09-01 00:00:00

abstract：UNLABELLED:Hypercalcemia occurring in patients with advanced breast cancer (BC) is generally due to osteolytic metastases or to the activity of circulating tumor-derived products. In these conditions, the production of endogenous PTH is reduced. The frequency of hypercalcemia due to primary hyperparathyroidism in breas...

journal_title：Journal of endocrinological investigation

authors： Fierabracci P,Pinchera A,Miccoli P,Conte PF,Vignali E,Zaccagnini M,Marcocci C,Giani C

更新日期：2001-05-01 00:00:00

abstract：:There is increasing evidence that androgen therapy in men may be effectively applied in several conditions to improve well being and health. Classical indications for androgen therapy in males are represented by primary or secondary hypogonadism, delayed puberty, aplastic anemia and that secondary to chronic renal fai...

journal_title：Journal of endocrinological investigation

authors： Gambineri A,Pasquali R

更新日期：2000-03-01 00:00:00

abstract：:This report describes the results of the second part of the collaborative study organized by a working group sponsored by the Community Bureau of Reference of the European Community Commission. The whole study was designed to understand the causes of discrepancy among LH immunoassay methods. In the parent report we de...

journal_title：Journal of endocrinological investigation

authors： Costagliola S,Niccoli P,Florentino M,Carayon P

更新日期：1994-06-01 00:00:00

abstract：:Ketoacidosis is a metabolic alteration caused by absolute or relative insulin deficiency and oversecretion of glucagon. Prompt diagnosis and rapid initiation of treatment are mandatory to avoid the complications and fatal outcome. Reduction of plasma glucose to levels within acceptable limits, block of ketogenesis, re...

journal_title：Journal of endocrinological investigation

authors： Reitano G

更新日期：1989-01-01 00:00:00

abstract：:We have measured eye muscle antibodies, in immunoblotting, in the serum from five patients with severe ophthalmopathy associated with Graves' hyperthyroidism who underwent plasmapheresis, correlating their levels with clinical features of the eye disorder and response to treatment. Blood taken before each plasma excha...

journal_title：Journal of endocrinological investigation

authors： Atabay C,Schrooyen M,Zhang ZG,Salvi M,Glinoer D,Wall JR

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:We previously demonstrated that patients suffering from moderate hypothyroidism were at increased risk of thrombosis contrasting with the bleeding tendency of those presenting severe hypothyroidism. The latter state is associated with hemostatic anomalies including von Willebrand type 1 disease and increased ...

journal_title：Journal of endocrinological investigation

authors： Chadarevian R,Jublanc C,Bruckert E,Giral P,Ankri A,Leenhardt L,Chapman J,Turpin G

更新日期：2005-05-01 00:00:00

abstract：:Scavenger receptor A (SR-A) is the main receptor through which oxidized LDL (oxLDL) and advanced glycation end products get into the cells. The aim of the present study was to investigate the effect of an ACE inhibitor, perindopril, on the expression of SR-A in renal tubulointerstitium of diabetic rats. Diabetes was i...

journal_title：Journal of endocrinological investigation

authors： Sun L,Wen JH,Sun HL,Shu XC,Hu F,Yin DC,Yang Q,Zeng YJ,Sun Y,Liu L

更新日期：2012-05-01 00:00:00

abstract：:We studied 8 insulin dependent stable young diabetics with a mean age of 20 yr. Each patient received 10 mg of diazepam orally after with drawing the baseline blood sample. Subsequent samples were obtained at 30 min intervals for 150 min. The oral administration of diazepam resulted in a significant increase in serum ...

journal_title：Journal of endocrinological investigation

authors： Ajlouni K,El-Khateeb M,El-Zaheri MM,El-Najdawi A

更新日期：1982-05-01 00:00:00

abstract：:Hexarelin (Hex) is a synthetic hexapeptide with potent GH-releasing activity in both animals and men. Aim of this study was to evaluate the GH response to a maximal dose of Hex and GH-releasing hormone (GHRH) in a group of patients with Prader-Willi syndrome (PWS). Seven patients (4 boys and 3 girls, age 2.4-14.2 yr) ...

journal_title：Journal of endocrinological investigation

authors： Cappa M,Raguso G,Palmiotto T,Faedda A,Gurreri F,Neri G,Deghenghi R,Loche S

更新日期：1998-09-01 00:00:00

abstract：PURPOSE:To report the long-term effectiveness and safety of the recombinant human growth hormone Omnitrope®, a somatropin biosimilar to Genotropin®, in Italian patients with growth hormone deficiency (GHD) enrolled in the PATRO Adults study. METHODS:The PATRO Adults study is an ongoing observational, longitudinal, non...

journal_title：Journal of endocrinological investigation

authors： Ferone D,Profka E,Gasco V,Ambrosio MR,Colao A,Di Somma C,Puxeddu E,Arnaldi G,Pagano C,Zecchi E,Pietropoli A,Beck-Peccoz P

更新日期：2017-06-01 00:00:00

abstract：:Experimental data concerning the role of serotonin (5-HT) in the control of gonadotropins secretion remain controversial: different receptors subtypes should mediate the serotoninergic action. In the present work we analyzed in prepubertal and adult male rats the FSH and LH responses after administration of the follow...

journal_title：Journal of endocrinological investigation

authors： Pinilla L,Tena-Sempere M,Aguilar E

更新日期：1997-07-01 00:00:00

abstract：:The study was conducted to assess the GH-IGF-I axis in non-obese women with functional hyperandrogenism (FH). Eighteen FH women aged 18-35 yr with a body weight within 20% of ideal body weight and 10 weight-matched controls were included in the study. Basal serum GH, GH-binding protein (GHBP), IGF-I, IGF-binding prote...

journal_title：Journal of endocrinological investigation

authors： Legan M,Kocijancic A,Prezelj J,Osredkar J,Fisker S

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:In vitro data have shown conflicting results in terms of the effect of leptin on granulosa cells steroidogenesis. AIM:The aim of the present study was to investigate the effect of low and high doses of leptin on basal and FSH-induced steroids secretion by human luteinized granulosa cells in culture. MATERI...

journal_title：Journal of endocrinological investigation

authors： Karamouti M,Kollia P,Kallitsaris A,Vamvakopoulos N,Kollios G,Messinis IE

更新日期：2009-05-01 00:00:00

abstract：:Prolactin, LH and FSH circadian secretion were studied in a group of 20 boys in various pubertal stages and in 13 normal male adults. Prolactin 24-hour integrated concentration was similar in all groups except in stage 2 boys, in which it was significantly higher with respect to stage 3-4 boys. This pattern was observ...

journal_title：Journal of endocrinological investigation

authors： Minuto F,Barreca A,Ferrini S,Del Monte P,Bernasconi D,Giordano G

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND:Successful parathyroidectomy (PTX) often results in a dramatic drop in the parathyroid hormone (PTH) levels, relieves the patient from clinical symptoms, and reduces mortality. Although PTX is generally a successful treatment for progressive secondary hyperparathyroidism (SHPT) patients subjected to surgery,...

journal_title：Journal of endocrinological investigation

authors： Xu D,Yin Y,Hou L,Dai W

更新日期：2016-05-01 00:00:00

abstract：:The changes occurring in the levels of circulating thyroid microsomal antibody (M-Ab) and antithyroglobulin antibody (Tg-Ab) during antithyroid drug therapy were studied in 32 patients receiving methimazole for Graves' disease. M-Ab was determined by competitive binding radioassay and Tg-Ab by a sandwich radiometric m...

journal_title：Journal of endocrinological investigation

authors： Marcocci C,Chiovato L,Mariotti S,Pinchera A

更新日期：1982-01-01 00:00:00

abstract：:The intravenous injection of calcium gluconate (0.11 mM/kg body weight) into conscious thyroidectomized pigs elicits a 30% rise in both ionized and total calcium concentrations of plasma, which return to basal levels within 180 min. The administration of calcitonin (2.5-10 MRC U/kg body weight) reduces this time to 30...

journal_title：Journal of endocrinological investigation

authors： Jaros GG,Van Hoorn-Hickman R,Maier H,Newman E

更新日期：1983-04-01 00:00:00

abstract：:Long-acting im bromocriptine was administered to 7 patients with pituitary macroadenomas (4 acromegalics, 1 Nelson's syndrome and 2 prolactinomas), with good tolerance except during the first 24 h. During a 42-day period hormonal, CT-scan and visual field variations were followed. In acromegalics HGH decrease was not ...

journal_title：Journal of endocrinological investigation

authors： Halperin I,Rodriguez MD,Cardenal C,Casamitjana R,Martinez Osaba MJ,Lienas V,Vilardell E

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:In vitro islet expansion has recently drawn interest for its potential application in diabetes therapy, while how islet cells adapt to in vitro circumstances is not quite clear. AIM:Proteomics changes of cultivated islet cells under different conditions were examined in this study. MATERIAL/SUBJECTS AND ME...

journal_title：Journal of endocrinological investigation

authors： Li G,Yang X,Zhang Y,Liu H,Zhang W,Shen Y,Fan W,Lu Z,Lu D

更新日期：2011-12-01 00:00:00

abstract：:Carbenoxolone is a derivative of glycyrrhetinic acid used for the treatment of peptic ulcer and gastritis, with salt and water retention a very common side-effect. To investigate this drug-induced pseudohyperaldosteronism we have studied 6 male volunteers before, during and after treatment with carbenoxolone for 7 day...

journal_title：Journal of endocrinological investigation

authors： Armanini D,Scali M,Zennaro MC,Karbowiak I,Wallace C,Lewicka S,Vecsei P,Mantero F

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVE:Thyroid hormone resistance (RTH β) is a rare genetic disorder characterized by an altered response of target tissue to the action of thyroid hormone. Few studies on RTH β have been carried out in southern European populations. We aimed to describe the clinical and genetic characteristics at the time of diagno...

journal_title：Journal of endocrinological investigation

authors： Vela A,Pérez-Nanclares G,Ríos I,Rica I,Portillo N,Castaño L,Spanish Group for the Study of RTH.

更新日期：2019-08-01 00:00:00

abstract：:Dopamine in humans inhibits the secretion of luteinizing hormone (LH), follicular stimulating hormone (FSH), thyroid stimulating hormone (TSH) and prolactin (PRL), and is a stimulator of growth hormone (GH) secretion. Dopamine-D1 receptor stimulation with fenoldopam increases basal PRL levels, suppresses TSH, and incr...

journal_title：Journal of endocrinological investigation

authors： Grodum E,Andersen M,Hangaard J,Koldkjaer O,Hagen C

更新日期：1998-05-01 00:00:00

abstract：:The case of a 34-yr-old Caucasian male with Graves' disease presenting with a flaccid quadriplegia and severe hypokalemia is reported. The weakness was prevalent at the lower extremities and began during nocturnal sleep, after a strenuous physical exertion performed during the day. Correction of hypokalemia promptly r...

journal_title：Journal of endocrinological investigation

authors： Celani MF,Bonati ME,Cavalli M

更新日期：1995-03-01 00:00:00

abstract：:Leptin may be a possible trigger for puberty. In normal males, it has been shown that leptin increases from the pre-pubertal to the early pubertal stage, and then declines in the late pubertal stage. We examined leptin levels in six male adolescents (mean age 16.3+/-0.6 yr; range 14.2-17.6 yr) with delayed puberty (co...

journal_title：Journal of endocrinological investigation

authors： Giusti M,Guido R,Valenti S,Giordano G

更新日期：1999-01-01 00:00:00