当前位置： SCI文献检索 > JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION期刊下所有文献 > Treatment of pituitary macroadenomas secreting PRL, HGH or ACTH with long-acting bromocriptine.

Treatment of pituitary macroadenomas secreting PRL, HGH or ACTH with long-acting bromocriptine.

Abstract：

:Long-acting im bromocriptine was administered to 7 patients with pituitary macroadenomas (4 acromegalics, 1 Nelson's syndrome and 2 prolactinomas), with good tolerance except during the first 24 h. During a 42-day period hormonal, CT-scan and visual field variations were followed. In acromegalics HGH decrease was not evident, except in some isolated sample. In Nelson's syndrome ACTH showed a 94% fall on day 14, even though a spontaneous oscillation cannot be ruled out, and recovery took place from day 21 on. PRL remained undetectable in both. In prolactinomas, PRL suffered a great decrease (91.8% and 96.3% on days 21 and 28 respectively) and remained well below its initial values up to the end of the study, in spite of partial recovery. In these 2 patients CT-scan evidenced shrinkage of tumor mass, which was not observed in the remaining 5 cases. Visual fields did not improve in the 2 cases initially affected (Nelson's syndrome and 1 prolactinoma). Long-acting bromocriptine seems to have the same therapeutic uses of the oral form with the possible advantage of a better tolerance of full initial doses.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Halperin I,Rodriguez MD,Cardenal C,Casamitjana R,Martinez Osaba MJ,Lienas V,Vilardell E

doi

10.1007/BF03348130

subject

Has Abstract

pub_date

1987-06-01 00:00:00

pages

277-82

issue

3

eissn

0391-4097

issn

1720-8386

journal_volume

10

pub_type

杂志文章

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