Abstract:
BACKGROUND/AIMS:Aldosterone and the mineralocorticoid receptor (MR) play a major role in sodium balance and blood pressure control. They are also involved in adipocyte metabolism. The aim of this study was to analyze the association between the MR p.I180V polymorphism with hypertension and markers of cardiovascular risk. DESIGN AND METHODS:Case-control study nested within a cohort of 2063 subjects followed since birth to date. All subjects (age 23-25 yr old) from the entire cohort with systolic and diastolic hypertension (no.=126) were paired with 398 normotensive controls. MR p.I180V genotype association with anthropometric and biochemical markers of cardiometabolic risk was tested. RESULTS:There was a significant association of the MR p.I180V genotype with body mass index (BMI) and LDL-cholesterol level (p<0.01). Hypertensive subjects carrying the polymorphic G allele (AG or GG genotypes) presented significantly higher BMI (30.0+/-6.0 vs 28.7+/-5.6 kg/m(2); p<0.01) and higher LDL-cholesterol (139.9+/-60.3 vs 109.9+/-35.5 mg/dl; p<0.01). The frequency of the polymorphism MR p.I180V was similar between hypertensive subjects and controls (p=0.15). CONCLUSIONS:The MR p.I180V polymorphism seems to be associated with cardiovascular risk factors including BMI and LDL-cholesterol levels. This original in vivo finding reinforces the role of MR in adipocyte biology and in cardiovascular disease.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Fernandes-Rosa FL,Bueno AC,de Souza RM,de Castro M,dos Santos JE,Foss MC,Zennaro MC,Bettiol H,Barbieri MA,Antonini SRdoi
10.1007/BF03346627subject
Has Abstractpub_date
2010-07-01 00:00:00pages
472-7issue
7eissn
0391-4097issn
1720-8386pii
6718journal_volume
33pub_type
杂志文章abstract:OBJECTIVE:The determination of (a) iodine deficiency, and (b) the relation between the iodized salt consumption in the Isparta province of Turkey. METHODS:Five hundred students between 6-11 yr of age were evaluated. With a questionnaire, the subjects were asked whether they were using iodine-containing salt or not. Af...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03344181
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Thyroid gland is highly dependent on dietary intake of iodine for normal function, so it is particularly subjected to "endocrine disruptor" action. The human sodium/iodide symporter (hNIS) is an integral plasma membrane glycoprotein mediating the active transport of iodide into thyroid follicular cells, a cr...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347061
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Fine needle cytology aspirates (FNA) classified as THY4 are a heterogeneous group suspicious for malignancy [papillary thyroid cancer (PTC)], which is confirmed in 50-80% of cases after surgery. AIM:To better stratify THY4 FNA specimens for the relative risk of malignancy. METHODS:We retrospectively analyz...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/8958
更新日期:2013-11-01 00:00:00
abstract::To evaluate the effect of weight loss and diet therapy on plasma sex hormone behavior in male obesity, 9 men with a BMI of 43.4 +/- 6.3 participated in an 8-week semistarvation program [whose energy content ranged from 320 to 500 k calorie/day (proteins 44 to 60 g and carbohydrates 54 to 81 g per day)] followed by a t...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350136
更新日期:1988-03-01 00:00:00
abstract::Somatostatin and its derivatives have been predominantly studied and succesfully used in endocrinological diseases. This article reviews the rationale of the use of somatostatin and its derivatives in ophthalmology based on current understanding of its action in the eye and summarizes previously published controlled s...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:We aimed to investigate the differences in emotional and behavioral problems and to explore the association between the level of psychiatric problems and the metabolic control in Type 1 diabetes. METHODS:The children with Type 1 diabetes (no.=42) and the "healthy" control group (no.=42), their parents and en...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03345721
更新日期:2009-04-01 00:00:00
abstract::Iodine balance during pregnancy and lactation was investigated by measuring iodine concentration in the urine of 11 pregnant women, born and living in a moderately iodine deficient endemic goiter area in Northeastern Sicily, collected during the last week of pregnancy, and between the 5th and 7th day after delivery, a...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348681
更新日期:1992-02-01 00:00:00
abstract::Osteocalcin (OC) concentration, a specific index of bone formation, was measured in 29 female patients with microprolactinoma (serum prolactin, PRL: 105 +/- 10.9 ng/ml; mean +/- SE). Mean OC levels were significantly lower than in controls (1.7 +/- 0.2 vs 5.1 +/- 0.3 ng/ml; p less than 0.001), being below the normal r...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350694
更新日期:1990-05-01 00:00:00
abstract::Type 2 diabetes (T2D) and obesity are the major public health problems. Substantial efforts have been made to define loci and variants contributing to the individual risk of these disorders. However, the overall risk explained by genetic variation is very modest. Epigenetics is one of the fastest growing research area...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/s40618-016-0473-1
更新日期:2016-10-01 00:00:00
abstract::Ectopic ACTH production accounts for 15% of Cushing's syndrome presentations and is characterized by the presence of an excess of ACTH precursors. However in the case presented here ectopic ACTH production was from functional pituitary tissue within an ovarian dermoid cyst. Endocrine investigations showed that the pro...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03343930
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Visfatin [pre-B cell colony- enhancing factor (PBEF)] is a cytokine highly expressed in visceral fat that exhibits insulin-mimetic properties. However, its role in insulin-resistant states, such as in metabolic syndrome (MetS), remains largely unknown. OBJECTIVE:To investigate the possible differences of pl...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346300
更新日期:2007-04-01 00:00:00
abstract::Diagnosis of endogenous hyperinsulinism caused by insulinoma is based on confirmation of hypoglycemia during the symptoms associated to elevated insulin levels. Patients with insulinoma may demonstrate an excessive insulin response and subsequent hypoglycemia after 1 mg of glucagon iv injection. Glucagon test was perf...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/7879
更新日期:2012-06-01 00:00:00
abstract::Anorexia nervosa (AN) is an eating disorder characterized by self-induced starvation due to fear of adiposity. Ghrelin, gastric peptide with potent orexigenic, adipogenic, GH-releasing and metabolic properties, is elevated in AN. We have previously shown that intervention with exogenous ghrelin is not effective in ter...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350816
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:To determine whether glycated hemoglobin (HbA1c) could be used to diagnose Type 2 diabetes mellitus in She Chinese People and to assess the role of HbA1c in the development of cardiovascular disease. RESEARCH DESIGN AND METHODS:An ethnically representative sample of 687 (277 males and 410 females) adults, 20...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,随机对照试验
doi:10.3275/7749
更新日期:2012-01-01 00:00:00
abstract::Pegvisomant, a GH receptor antagonist, is a new pharmaceutical approach to acromegaly. It enables IGF-I levels to return in the age- and sex-reference range in approximately 90% of patients. This new approach is particularly beneficial in those patients who do not experience control of hormone hypersecretion after sur...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:
更新日期:2003-01-01 00:00:00
abstract::D-aspartic acid (D-Asp), aromatase enzyme activity and the putative D-Asp involvement on aromatase induction have been studied in the testis of mature boars. The peroxidase-antiperoxidase and the indirect immunofluorescence methods, applied to cryostat and paraffin sections, were used to evaluate D-Asp and aromatase d...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03344087
更新日期:2006-02-01 00:00:00
abstract::Thyroid function tests were evaluated in 34 patients with acute viral hepatitis (AVH) and in 38 healthy controls (C). As expected, AVH patients displayed a significant increase in T4, rT3 and TBG serum levels with respect to C, while FT4 and TSH concentrations were similar. A positive correlation between TBG and T4 wa...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349947
更新日期:1989-03-01 00:00:00
abstract::Follicular thyroid carcinoma may spread distant metastases in sites such as bone, lung and brain. In our series of 448 patients with follicular thyroid carcinoma, distant metastases were present in 25% of cases. We report here a case of follicular thyroid carcinoma with a single metastasis at the right adrenal gland, ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347667
更新日期:1993-02-01 00:00:00
abstract:UNLABELLED:Hypercalcemia occurring in patients with advanced breast cancer (BC) is generally due to osteolytic metastases or to the activity of circulating tumor-derived products. In these conditions, the production of endogenous PTH is reduced. The frequency of hypercalcemia due to primary hyperparathyroidism in breas...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03343867
更新日期:2001-05-01 00:00:00
abstract::A 33-year-old female presented in 1966 with striking pigmentation, typical of Addison's disease, and amenorrhea. Endocrine assessment then showed normal basal serum cortisol and urinary hydroxysteroid levels, but serum cortisol did not respond to stimulation with either exogenous ACTH or lysine vasopressin. Steroid re...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349957
更新日期:1989-03-01 00:00:00
abstract::Typical modifications of cardiovascular activity and water and salt homeostasis throughout female reproductive life are well known. Differences in plasma levels of calcitonin gene-related peptide (CGRP) and atrial natriuretic peptide (ANP) have been observed in conditions characterized by different estrogenic levels, ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347311
更新日期:1998-04-01 00:00:00
abstract::The long-acting somatostatin analogue SMS 201-995 has been used efficaciously in the therapy of metastatic carcinoid tumor, vasoactive intestinal peptide producing islet cell carcinoma, acromegaly, and TSH secreting pituitary tumors. We report the development of a gallstone in a patient treated for 23 months with a lo...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348589
更新日期:1990-01-01 00:00:00
abstract::Dopamine agonists have been associated with increased risk of cardiac valve regurgitation in patients with Parkinson's disease. Whether these drugs might be harmful for patients with hyperprolactinemia is still unsettled. Occasional case reports and 7 studies on the relationship between cabergoline and cardiac valve r...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,meta分析,评审
doi:10.1007/BF03345662
更新日期:2008-12-01 00:00:00
abstract::Volume receptors are situated in many organs and are capable of modulating ADH secretion. We have evaluated the variation of plasma ADH concentration after an experimentally induced increase of cerebrospinal fluid (CSF) pressure (PCSF). The experiment was performed in controlled environmental conditions to avoid pain ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349891
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:Chronic alcohol abuse is a risk factor for osteoporosis and fractures, whose pathogenesis is still unclear. We investigated the influence of alcoholism and other risk factors on calcium and skeletal metabolism, bone mineral density (BMD), and fractures. MATERIALS AND METHODS:In 51 chronic male alcoholics wi...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346365
更新日期:2008-04-01 00:00:00
abstract::Recent evidence suggests that patients with traumatic brain injury (TBI) are at substantial risk of hypopituitarism. The pathomechanisms, however, are not completely understood yet. Little is known about the association of morphological changes in the sella region with pituitary function in TBI. In this study, we asse...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346291
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:Increased inhibin A serum and plasma levels in the second trimester are significantly associated with the development of preeclampsia. The measurement of inhibin A during early pregnancies may be helpful to predict those at risk of this disorder. The purpose of this study was to determine whether the 769G>A v...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346418
更新日期:2008-08-01 00:00:00
abstract::Non-classical congenital adrenal hyperplasia (NCAH) is a morbid condition sustained by the reduced function of one of the enzymes involved in the adrenal steroid biosynthesis pathway, mainly the 21-hydroxylase. Different degrees of enzyme activity impairment determine different clinical pictures, with childhood or pos...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/7410
更新日期:2011-10-01 00:00:00
abstract::The outcome of radioiodine therapy of Graves' hyperthyroidism was retrospectively evaluated in 274 consecutive patients treated from 1975 to 1984. At 1-yr follow-up, permanent hypothyroidism occurred in 36.9% of patients and the cumulative incidence of hypothyroidism progressively increased up to 79.3% after 7-10 yr. ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348615
更新日期:1990-06-01 00:00:00
abstract::The unlimited availability of GH obtained by recombinant DNA technology has allowed optimization of treatment in GH-deficient (GHD) children. At the same time it has prompted a number of studies in conditions not characterized by GHD such as Turner syndrome, intrauterine growth retardation, chronic renal failure and o...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/BF03345367
更新日期:2005-02-01 00:00:00